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| 1 | 大豆主要营养品质性状相关分子标记的育种应用潜力评价显示文摘大豆营养品质性状多为数量性状,受多基因调控。目前,已定位到大量与营养品质性状相关的分子标记,但经过大豆育种群体验证的可用标记却很少。本研究以288份黄淮海地区选育的大豆品种和19份野生/半野生大豆种质为材料组成大豆自然群体,利用近红外光谱法、气相色谱法和高效液相色谱法分析其蛋白质、脂肪、脂肪酸和异黄酮组分含量;选用已报道的与营养品质性状紧密连锁的18个SSR标记,采用毛细管电泳方法进行基因型鉴定。采用关联分析方法验证分子标记的选择效果,共检测出与脂肪含量关联的标记3个,与蛋脂总和关联的标记3个,与棕榈酸关联的标记1个,与硬脂酸关联的标记1个,与油酸关联的标记2个,与亚麻酸关联的标记2个,同时发掘出这些位点的优异等位变异,表明上述验证的分子标记可用于大豆营养品质分子育种中。 | 怀园园 张晟瑞 武婷婷 AZAM Muhammad 李静 孙石 韩天富 李斌 孙君明 | 2022 | 作物学报2022，48，8： | 6 |
| 2 | Profiling of seed fatty acid composition in 1025 Chinese soybean accessions from diverse ecoregions显示文摘The stability of soybean(Glycine max L.Merrill)oil is determined mainly by its fatty acid(FA)composition.We evaluated the FA composition of 1025 Chinese soybean accessions collected from diverse ecoregions and grown in multiple locations and years.We observed highly significant differences(P<0.001)between accessions in palmitic acid(PA),stearic acid(SA),oleic acid(OA),linoleic acid(LA),and linolenic acid(LNA)contents.Growth year affected(P<0.001)the abundance of all FAs except PA.The mean PA,SA,OA,LA,and LNA contents were 12.2%,3.8%,21.5%,54.2%,and 8.3%,respectively.The geographical origin of the accession influenced seed FA composition,indicating that accessions originating in each ecoregion tend to have distinct FA composition.We observed significant positive correlations among the three locations and between the two years,suggesting the high heritability and stability of individual accessions across contrasting environments.We also observed a relatively high negative correlation between the contents of OA and both LA and LNA(r=-0.90 and-0.59,respectively,each significant at P<0.001),providing a potential entry point for developing strains producing oil with higher OA and lower LA and LNA levels.These would be appropriate for specialized use in the food industry.Our results will be useful in breeding soybean with improved quality to meet human nutritional and industrial needs. | Ahmed M.Abdelghany Shengrui Zhang Muhammad Azam Abdulwahab S.Shaibu Yue Feng Yanfei Li Yu Tian Huilong Hong Bin Li Junming Sun | 2020 | The Crop Journal2020，8，4： | 4 |
| 3 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 4 | Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool显示文摘AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance colonoscopy.METHODS This is a retrospective single center observational study.We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk.We calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence status.RESULTS The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth quintile.The odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was 3.60.CONCLUSION Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities. | Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen Shehi Elona Maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar Ahmed Baiomi Danial Shaikh Jasbir Makker | 2018 | World Journal of Gastroenterology2018，24，34： | 3 |
| 5 | Autoregressive neural networks with exogenous variables for indoor temperature prediction in buildings显示文摘Thermal models of buildings are helpful to forecast their energy use and to enhance the control of their mechanical systems.However,these models are building-specific and require a tedious,error-prone and time-consuming development effort relying on skilled building energy modelers.Compared to white-box and gray-box models,data-driven(black-box)models require less development time and a minimal amount of information about the building characteristics.In this paper,autoregressive neural network models are compared to gray-box and black-box linear models to simulate indoor temperatures.These models are trained,validated and compared to actual experimental data obtained for an existing commercial building in Montreal(QC,Canada)equipped with roof top units for air conditioning.Results show that neural networks mimic more accurately the thermal behavior of the building when limited information is available,compared to gray-box and black-box linear models.The gray-box model does not perform adequately due to its under-parameterized nature,while the linear models cannot capture non-linear phenomena such as radiative heat transfer and occupancy.Therefore,the neural network models outperform the alternative models in the presented application,reaching a coefficient of determination R2 up to 0.824 and a root mean square error down to 1.11℃,including the error propagation over time for a 1-week period with a 5-minute time-step.When considering a 50-hour time horizon,the best neural networks reach a much lower root mean square error of around 0.6℃,which is suitable for applications such as model predictive control. | Benoit Delcroix Jérôme Le Ny Michel Bernier Muhammad Azam Bingrui Qu Jean-Simon Venne | 2021 | Building Simulation2021，14，1： | 3 |
| 6 | Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds显示文摘Background:Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in the healing of diabetic wounds in rats,we aimed to investigate the regenerative effects of curcumin preconditioned adipose-derived mesenchymal stem cells(ASCs)for better recovery of acid inflicted burns in this study.Methods:ASCs were preconditioned with 5μM curcumin for 24 hours and assessed for proliferation,migration,paracrine release potential and gene expression comparative to naive ASCs.Subsequently,the healing capacity of curcumin preconditioned ASCs(Cur-ASCs)versus naive ASCs was examined using acidic wounds in rats.For this,acid inflicted burns of 20 mm in diameter were made on the back of male Wistar rats.Then,2×10^(6) cells of Cur-ASCs and naive ASCs were intradermally injected in the wound periphery(n=6)for comparison with an untreated saline control.Post-transplantation,wounds were macroscopically analysed and photographed to evaluate the percentage of wound closure and period of re-epithelization.Healed wound biopsies were excised and used for histological evaluation and expression analysis of wound healing markers at molecular level by quantitative PCR and western blotting.Results:We found that Cur-ASCs exhibited greater proliferation,migration and paracrine potential in vitro.Further,Cur-ASCs showed more effective recovery than naive ASCs as exhibited by gross morphology,faster wound closure and earlier re-epithelialization.Masson’s trichrome and hematoxylin and eosin staining demonstrated the improved architecture of the healing burns,as evidenced by reduced infiltration of inflammatory cells,compact collagen and marked granulation in Cur-ASC treated rats.Corroborating these findings,molecular assessment showed significantly reduced expressions of pro-inflammatory factors(interleukin-1 beta,interleukin-6,tumor necrosis factor alpha)a with striking upsurge of an oxidative marker(superoxide dismutase 1),proangiogenic factors(vascular endothelial growth factor,hepatocyte growth factor,hypoxia-inducible factor-1 alpha)and collagen markers(transforming growth factor beta 1,fibroblast growth factor-2,collagen type 1 alpha 1),verifying that Cur-ASCs modulate the regulation of pro-inflammatory and healing markers at burn sites.Conclusions:Treatment with Cur-ASCs resulted in faster re-epithelization of acid inflicted burns compared to the treatment with naive ASCs.Based on observed findings,we suggest the transplantation of Cur-ASCs is a valuable therapy for the potent clinical management of acidic burns. | Maryam Azam Hafiz Ghufran Hira Butt Azra Mehmood Ramla Ashfaq Asad M.Ilyas Muhammad R.Ahmad Sheikh Riazuddin | 2021 | Burns & Trauma2021，9，1： | 2 |
| 7 | Banach contraction principle on cone rectangular metric spaces 显示文摘 | Azam A Arshad Muhammad Beg Ismat | 2009 | Appl Anal Discrete Math2009，3，： | 1 |
| 8 | ComRank: Joint Weight Technique for the Identification of Influential Communities显示文摘Recently, the community analysis has seen enormous research advancements in the field of social networks. A large amount of the current studies put forward different models and algorithms about most influential people. However, there is little work to shed light on how to rank communities while considering their levels that are determined by the quality of their published contents. In this paper, we propose solution for measuring the influence of communities and ranking them by considering joint weight composed of internal and external influence of communities. To address this issue, we design a novel algorithm called Com Rank: a modification of Page Rank, which considers the joint weight in order to identify impact of each community and ranking them. We use real-world data trace in citation network and perform extensive experiments to evaluate our proposed algorithm. The comparative results depict significant improvements by our algorithm in community ranking due to the inclusion of proposed weighting feature. | Muhammad Azam Zia Zhongbao Zhang Ximing Li Haseeb Ahmad Sen Su | 2017 | China Communications2017，14，4： | 1 |
| 9 | Primary pancreatic leiomyosarcoma: a case report 显示文摘 | Muhammad SU Azam F Zuzana S | 2008 | Cases J2008，1，1： | 1 |
| 10 | Synthesis,Crystal Structure and Spectroscopic Properties of 1,2-Benzothiazine Derivatives:An Experimental and DFT Study显示文摘1,2-Benzothiazine derivatives methyl 3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2]thiazine-3-carboxylate 1,1-dioxide(1) and methyl 2-ethyl-3-hydroxy-4-oxo-3,4-dihydro-2Hbenzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide(2) were synthesized, and characterized by spectroscopic techniques; 1H-NMR and infrared(IR) spectroscopy. Crystals of 1 and 2 were grown by slow evaporation of methanol and ethyl acetate, respectively and their crystal structures were investigated by single-crystal X-ray diffraction analysis. Geometric properties were calculated by the B3 LYP method of density functional theory(DFT) at the 6-31G+(d) basis set to compare with the experimental data. Simulated properties were found in strong agreement with the experimental ones. Intermolecular forces have also been modeled in order to investigate the strength of packing and strong hydrogen bonding was observed in both compounds 1 and 2. Electronic properties such as Ionization Potential(IP), Electron Affinities(EA) and coefficients of the highest occupied molecular orbital(HOMO) and the lowest unoccupied molecular orbital(LUMO) of com- pounds 1 and 2 were simulated for the first time. | MUHAMMAD Nadeem Arshad TARIQ Mahmood ATHER Faroque Khan MUHAMMAD Zia-Ur-Rehman ABDULLAH M.Asiri ISLAM Ullah Khan RIFFAT-Un-Nisa KHURSHID Ayub AZAM Mukhtar MUHAMMAD Tariq Saeed | 2015 | Chinese Journal of Structural Chemistry2015，34，1： | 1 |
| 11 | Exploration of Influential People for Viral Marketing显示文摘Exploration of influential people is really a hot issue for effective viral marketing these days. Prior studies overlooked to consider the influence of interaction between users and the authority of users during information dissemination. In this article, we proposed an innovative concept by employing communication strength and authority in order to explore the influential people. First, we calculated communication strength by three kinds of actions including retweets, comments and mentions. Second, we deliberated authority metric by employing total times getting re-tweeted, number of tweets and followers of a user. Then, we propose a novel algorithm called Influential People Label Propagation Algorithm(IPLPA) that considers the proposed metric to explore the influential people in micro-blog networks. We performed extensive experiments to measure the influence and rank of each person within micro-blog network. The comparative study presents that IPLPA depicted effective people while baseline algorithms retrieved low influenced people at top rank. Additionally, influence dissemination also measured for obtained influential people in order to validate proposed concept. The findings of this study would be useful for viral marketing and advertisement campaigns. | Muhammad Azam Zia Zhongbao Zhang Liutong Chen Muhammad Hashim Sen Su | 2018 | China Communications2018，15，5： | 1 |
| 12 | Strict group testing and the set basis problem显示文摘 | Perter Damaschke Azam Sheikh Muhammad Gabor Wiener | 2014 | Journal of Combinatorial Theory Series A2014，126，： | 1 |
| 13 | Furazolidone, Co-amoxiclav, Colloidal Bismuth Subcitrate, and Esomeprazole for Patients Who Failed to Eradicate Helicobacter pylori with Triple Therapy显示文摘 | Zaigham Abbas Javed Yakoob Shahab Abid Wasim Jafri Muhammad Islam Zahid Azam Imran Hilal | 2009 | Digestive Diseases and Sciences2009，，9： | 1 |
| 14 | Chylous ascites after pancreatico-duodenectomy显示文摘BACKGROUND:Chylous ascites(CA) following pancreatico-duodenectomy(PD) is a rare complication secondary to disruption of the lymphatics during extended retroperitoneal lymph node dissection. The majority of cases do not develop CA,possibly due to patency of the proximal thoracic duct and good collaterals. CA may be due to a consequence of occult obstruction of the proximal thoracic duct by malignant infiltration or tumor embolus. This study was to report the incidence of CA and its outcomes of management. METHODS:A retrospective search of our liver database was performed using the 'pancreatico-duodenectomy','chylous ascites' from January 2000 to December 2005. The medical records of CA patients and their management and outcome were reviewed. RESULTS:In 138 patients who had undergone PD in our centre for pancreatic malignancy,3 were identified with CA and managed by abdominal paracentesis. CA resolved in 2 patients with low fat medium chain triglyceride diet alone and 1 patient had total parenteral nutrition(TPN) for persistent CA. Resolution of CA occurred in these 3 patients at a median follow-up of 4 weeks(range 4-12 weeks). Histologically,resected specimen confirmed pancreatic adenocarcinoma in all the patients. Two patients developed loco-regional recurrences at a median follow up of 8 months(range 6-10 months). And the other was currently disease free at a 10-month follow up. CONCLUSIONS:CA as an uncommon postoperative complication requires frequent paracentesis,prolonged hospital stay,and delayed adjuvant chemotherapy. CA istreated with low fat medium chain triglyceride diet or occasionally TPN is required. | Mansoor Ahmed Madanur Narendra Battula Muhammad Omar Azam Nigel Heaton Mohamed Rela | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，4： | 1 |
| 15 | Antinociceptive effect of the essential oil of Zingiber zerumbet in mice : Possible mechanisms 显示文摘 | Mohamed Hanief Khalid Muhammad Nadeem Akhtar Azam Shah Mohamad | 2011 | Journal of Ethnopharmacology2011，137，： | 1 |
| 16 | Strict group testing and the set basis problem显示文摘 | Discrete Algorith- Perter Damaschke Azam Sheikh Muhammad G~bor Wiener | 2014 | Journal of Combinatorial Theory Series A2014，126，： | 1 |
| 17 | Instagram Mobile Application Digital Forensics显示文摘In this research,we developed a plugin for our automated digital forensics framework to extract and preserve the evidence from the Android and the IOS-based mobile phone application,Instagram.This plugin extracts personal details from Instagram users,e.g.,name,user name,mobile number,ID,direct text or audio,video,and picture messages exchanged between different Instagram users.While developing the plugin,we identified resources available in both Android and IOS-based devices holding key forensics artifacts.We highlighted the poor privacy scheme employed by Instagram.This work,has shown how the sensitive data posted in the Instagram mobile application can easily be reconstructed,and how the traces,as well as the URL links of visual messages,can be used to access the privacy of any Instagram user without any critical credential verification.We also employed the anti-forensics method on the Instagram Android’s application and were able to restore the application from the altered or corrupted database file,which any criminal mind can use to set up or trap someone else.The outcome of this research is a plugin for our digital forensics ready framework software which could be used by law enforcement and regulatory agencies to reconstruct the digital evidence available in the Instagram mobile application directories on both Android and IOS-based mobile phones. | Muhammad Asim Mubarik Zhijian Wang Yunyoung Nam Seifedine Kadry Muhammad Azam waqar | 2021 | Computer Systems Science & Engineering2021，37，5： | 0 |
| 18 | Two novel variants in CYP1B1 gene: a major contributor of autosomal recessive primary congenital glaucoma with allelic heterogeneity in Pakistani patients显示文摘AIM: To find the CYP1 B1 mutations associated with primary congenital glaucoma(PCG) in Pakistani consanguineous pedigrees. METHODS: After getting informed consent, 11 consanguineous pedigrees belonging to different ethnic groups were enrolled. Detailed medical history was recorded and pedigrees were drawn. The standard ophthalmological examination was done to characterize the phenotype. Genomic DNA was extracted from 10 mL whole blood and coding exons and exon intron boundaries of CYP1 B1 gene were directly sequenced. Bioinformatics tools were used to model the mutant protein and predict the effect of novel variants on protein structure and function. RESULTS: Sequencing analysis revealed 5 different CYP1 B1 variants in 7 families(7/11; 64%), including two novel variants. A common mutation, p.R390 H was found in four families, whereas p.P437 L was found once in a family. Two novel variants, a homozygous non sense variant p.L13* and a compound heterozygous variant, p.P350 T along with p.V364 M were segregating with PCGin two families. All the patients had the variable onset and severity of the disease. The success rate of early clinical interventions was observed dependent on mutation types and position. Two different haplotypes were associated with frequently found mutation, p.R390 H. CONCLUSION: Identification of novel CYP1 B1 variants reassert the genetic heterogeneity of Pakistani PCG patients. The patients with missense mutations show severe phenotypic presentations and poor vision after surgical interventions as compare to patients with null variants. This may help to better understand the role of CYP1 B1 mutations in the development of PCG and its course of pathogenicity. | Yar Muhammad Waryah Muhammad Iqbal Shakeel Ahmed Sheikh Muhammad Azhar Baig Ashok Kumar Narsani Muhammad Atif Munir Ahmad Bhinder Attiq Ur Rahman Azam Iqbal Memon Muhammad Suleman Pirzado Ali Muhammad Waryah | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 0 |
| 19 | Transfer Learning-Based Semi-Supervised Generative Adversarial Network for Malaria Classification显示文摘Malaria is a lethal disease responsible for thousands of deaths worldwide every year.Manual methods of malaria diagnosis are timeconsuming that require a great deal of human expertise and efforts.Computerbased automated diagnosis of diseases is progressively becoming popular.Although deep learning models show high performance in the medical field,it demands a large volume of data for training which is hard to acquire for medical problems.Similarly,labeling of medical images can be done with the help of medical experts only.Several recent studies have utilized deep learning models to develop efficient malaria diagnostic system,which showed promising results.However,the most common problem with these models is that they need a large amount of data for training.This paper presents a computer-aided malaria diagnosis system that combines a semi-supervised generative adversarial network and transfer learning.The proposed model is trained in a semi-supervised manner and requires less training data than conventional deep learning models.Performance of the proposed model is evaluated on a publicly available dataset of blood smear images(with malariainfected and normal class)and achieved a classification accuracy of 96.6%. | Ibrar Amin Saima Hassan Samir Brahim Belhaouari Muhammad Hamza Azam | 2023 | Computers, Materials & Continua2023，，3： | 0 |
| 20 | Detection of ROS and translocation of ERP-57 in apoptotic induced human neuroblastoma(SH-SY5Y)cells显示文摘Several toxic compounds are known to induce apoptosis in mammalian cell lines.The human neuroblastoma cells(SHSH-SY5Y)were exposed to the phosphatase inhibiting toxin okadaic acid(OA)or hydrogen peroxide(H2O2)to induce apoptosis as well as generate reactive oxygen species(ROS).Mitoxantrone(MXT)was used as a positive control for apoptosis.The SHSH-SY5Y cells were transfected with eukaryotic expression plasmid pHyPer-dMito encoding mitochondrial-targeted fluorescent or pHyPer-dCito encoding cytoplasmic-targeted fluorescent sensor for hydrogen peroxide(HyPer).The ERp57,also called GRP58(Glucose-regulated protein 58),is a stress protein induced in conditions like glucose starvation and viral infection.Recently ERp57 was shown to translocate from the endoplasmatic reticulum to the cell surface in anthracycline-induced apoptotic cells.ERp57 co-translocation together with calreticulin has been suggested to be crucial for recognizing tumor cells to induce immunogenic cell death.ERp57 translocation after exposure to okadaic acid was studied using immunofluorescence and confocal microscopy.These studies indicated that okadaic acid has induced the translocation of ERp57 to the cellular membrane. | ATIF KAMIL MUBARAK ALI KHAN MUHAMMAD AASIM NADIR ZAMAN KHAN RAHAM SHER KHAN MUHSIN JAMAL WAQAR AHMAD MIR AZAM KHAN FAZAL JALIL | 2019 | BIOCELL2019，43，3： | 0 |
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