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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 3 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 4 | Tongqiao Huoxue Decoction ameliorates learning and memory defects in rats with vascular dementia by up-regulating the Ca^(2+)-CaMKII-CREB pathway显示文摘The present study was aimed at determining the effects of Tongqiao Huoxue Decoction(TQHXD) on the Ca2+-Ca MKII-CREB pathway and the memory and learning capacities of rats with vascular dementia(VD). The rat VD model was established by using an improved bilateral carotid artery ligation method. The Morris water maze experiment was used to evaluate the ethology of the VD rats following treatments with TQHXD at 3.01, 6.02, and 12.04 g·kg–1 per day for 31 days. At the end of experiment, the hippocampus were harvested and analyzed. Western blotting and RT-PCR were used to measure the expression levels of calmodulin-binding protein kinase II(Ca MKII), protein kinase A(PKA), c AMP-response element binding protein(CREB), and three N-methyl-D-aspartic acid receptor subunits(NR1, NR2 A, and NR2B). Our results revealed that TQHXD could alleviate the loss of learning abilities and increase the memory capacity(P < 0.05 and P < 0.01 vs the model group, respectively). The treatment with 6.02 and 12.04 g·kg–1 of TQHXD significantly up-regulated the Ca2+-Ca MKII-CREB pathway in the hippocampus. In conclusion, TQHXD showed therapeutic effects on a bilateral carotid artery ligation-induced vascular dementia model, through the up-regulation of calcium signalling pathways. | GE Chao-Liang WANG Xin-Ming HUANG Zhao-Gang XIA Quan WANG Ning XU Du-Juan | 2015 | Chinese Journal of Natural Medicines2015，13，11： | 15 |
| 5 | Power Matching and Energy Efficiency Improvement of Hydraulic Excavator Driven with Speed and Displacement Variable Power Source显示文摘Mobile machinery energy efficiency and emission pollution are the national and worldwide issues. This paper contributes in solving these problems by applying a speed variable power source. Unfortunately, almost all of the speed variable systems have the dynamic response problem when the motor starts with full load or heavy load. To address this problem, a hydraulic accumulator is used to balance the load of the power source for assisting starting of the motor and a matching method combined with speed and displacement control of the pump is proposed to improve the energy efficiency and dynamic performance simultaneously under different working conditions. Also, the power source/valve combined control strategy of an independent metering system is designed to realize flow matching of the whole system. Firstly, a test system is established to study the dynamic performance and energy efficiency of the speed variable power source with an auxiliary accumulator. Working performance and energy consumption of the power source under different rotating speeds and different loads are studied. And then, the hydraulic excavator test rig with the proposed system is constructed. Furthermore, the working performance of the excavator with the speed-fixed and speed-variable strategy are studied comparatively. Results show that, compared with fixed-speed strategy, the electric power consumption during the idle period and partial load condition can be reduced about 2.05 kW and 1.37 kW. The energy efficiency of speed variable power source is about 40%-71%, which is higher than that of the fixed-speed power source by 3%–10%. | Lei Ge Long Quan Xiaogang Zhang Zhixin Dong Jing Yang | 2019 | Chinese Journal of Mechanical Engineering2019，32，6： | 10 |
| 6 | Laparoscopic distal pancreatectomy with or without splenectomy: spleen-preservation does not increase morbidity显示文摘BACKGROUND: The indications for laparoscopic spleen-preserving distal pancreatectomy (LSPDP) and its morbidity compared with laparoscopic distal pancreatectomy with splenectomy (LDPS) are ill-defined. This study aimed to share the indications for spleen-preservation and investigate the safety and outcome of LSPDP at our institution. METHODS: A retrospective review of patients who were scheduled to receive laparoscopic surgery for distal pancreatic lesions was conducted. The indications, surgical procedures, intra-operative data, and outcomes of the two procedures were collected and compared by statistical analysis. RESULTS: LDPS and LSPDP were successfully performed in 16 and 21 patients respectively, whereas they were converted to open surgery in 9 patients. There were no significant differences in age, gender, operation time, blood loss, and conversion rate between the LDPS and LSPDP groups. The mean tumor size showed an inter-group difference (5.05 vs 2.53 cm, P<0.001). There were no significant differences in complication and morbidity rates between the two groups. All patients remained alive without recurrence during a follow-up of 9 to 67 months (median 35).CONCLUSION: LSPDP has a morbidity and outcome comparable to LDPS. | Yu-Pei Zhao, Xiao Du, Meng-Hua Dai, Tai-Ping Zhang, Quan Liao, Jun-Chao Guo, Lin Cong ,Ge Chen Department of General Surgery, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 8 |
| 7 | Modern pollen-vegetation relationship based on discriminant analysis across an altitudinal transect on Gongga Mountain,eastern Tibetan Plateau显示文摘Quantitative relationship between modern pollen assemblage and altitudinal vegetation belt is crucial for the reconstruction of paleovegetation in the mountain regions.Modern pollen analysis on 70 topsoil samples was conducted across an altitudinal transect(1100-4500 m) on the eastern slope of Gongga Mountain in the eastern Tibetan Plateau with an elevation interval of 50 m.Distributions of major pollen types along the transect indicated a weak correlation between Pinus pollen and the elevation.Distributions of Picea and Abies pollen(percentage sum of 2%-8%) could fairly indicate the elevation range of 2700-3700 m,as well as the subalpine dark coniferous forest and the timberline in the region.High percentage intervals of alpine types of Ericaceae,Cupressaceae and Cyperaceae were correlated to the high-elevation regions(3700-4500 m) dominated by alpine shrub meadow and alpine meadow.Seven altitudinal vegetation belts on the eastern slope of Gongga Mountain were well defined by discriminant analysis conducted on the modern pollen assemblages,as reflected by high values of probability of modern analog.Most of the modern pollen assemblages(88.5%) were typical for the vegetation types at their sampling locations.Thus,the relationship between the modern pollen assemblages and vegetation across the altitudinal transect based on discriminant analysis can be applied to the quantitative reconstruction of paleovegetation changes in the mountain regions of the eastern Tibetan Plateau. | LI Quan GE QuanSheng TONG GuoBang | 2012 | Chinese Science Bulletin2012，57，35： | 6 |
| 8 | Late Cretaceous Aquatic Angiosperms from Jiayin,Heilongjiang,Northeast China显示文摘摘要:三 taxa 近来白垩纪水的被子植物, Queruexia angulata (Lesq ) Krysht, Cobbania corrugata (Lesq ) Stockey 等。并且 Nelumbites cf。extenuinervis Upchurch 等。从 Heilongjiang 的 Jiayin, NE 中国,详细被描述。在他们之中,从在中国的上面的白垩纪的 Cobbania 和 Nelumbites 第一次被报导。Queruexia-Cobbania-Nelumbites 的水的被子植物集合看起来在 Santonian-Campanian 时间期间在 Jiayin 区域暗示季节、温暖、潮湿的环境。 | QUAN Cheng SUN Ge | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 6 |
| 9 | Impact of chronic low to moderate alcohol consumption on blood lipid and heart energy profile in acetaldehyde dehydrogenase 2-deficient mice显示文摘 | Fan FAN Quan CAO Cong WANG Xin MA Cheng SHEN Xiang-wei LIU Li-ping BU Yun-zeng ZOU Kai HU Ai-jun SUN Jun-bo GE | 2014 | Acta Pharmacologica Sinica2014，35，8： | 5 |
| 10 | Ultraviolet-to-microwave room-temperature photodetectors based on three-dimensional graphene foams显示文摘Highly sensitive broadband photodetection is of critical importance for many applications.However,it is a great challenge to realize broadband photodetection by using a single device.Here we report photodetectors(PDs)based on three-dimensional(3 D)graphene foam(GF)photodiodes with asymmetric electrodes,which show an ultra-broadband photoresponse from ultraviolet to microwave for wavelengths ranging from 10~2 to 10~6 nm.Moreover,the devices exhibit a high photoresponsivity of 10~3 A·W^-1,short response time of 43 ms,and3 d B bandwidth of 80 Hz.The high performance of the devices can be attributed to the photothermoelectric(PTE,also known as the Seebeck)effect in 3 D GF photodiodes.The excellent optical,thermal,and electrical properties of 3 D GFs offer a superior basis for the fabrication of PTE-based PDs.This work paves the way to realize ultra-broadband and high-sensitivity PDs operated at room temperature. | YIFAN LI YATING ZHANG YU YU ZHILIANG CHEN QINGYAN LI TENGTENG LI JIE LI HONGLIANG ZHAO QUAN SHENG FENG YAN ZHEN GE YUXIN REN YONGSHENG CHEN JIANQUAN YAO | 2020 | Photonics Research2020，8，3： | 4 |
| 11 | Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair显示文摘Directional axon regeneration and remyelination are crucial for repair of spinal cord injury(SCI),but existing treatments do not effectively promote those processes.Here,we propose a strategy for construction of niche-specific spinal white matter-like tissue(WMLT)using decellularized optic nerve(DON)loaded with neurotrophin-3(NT-3)-overexpressing oligodendrocyte precursor cells.A rat model with a white matter defect in the dorsal spinal cord of the T10 segment was used.The WMLT transplantation group showed significant improvement in coordinated motor functions compared with the control groups.WMLT transplants integrated well with host spinal cord white matter,effectively addressing several barriers to directional axonal regeneration and myelination during SCI repair.In WMLT,laminin was found to promote development of oligodendroglial lineage(OL)cells by binding to laminin receptors.Interestingly,laminin could also guide linear axon regeneration via interactions with specific integrins on the axon surface.The WMLT developed here utilizes the unique microstructure and bioactive matrix of DON to create a niche rich in laminin,NT-3 and OL cells to achieve significant structural repair of SCI.Our protocol can help to promote research on repair of nerve injury and construction of neural tissues and organoids that form specific cell niches. | Bi-Qin Lai Yu-Rong Bai Wei-Tao Han Bao Zhang Shu Liu Jia-Hui Sun Jia-Lin Liu Ge Li Xiang Zeng Ying Ding Yuan-Huan Ma Ling Zhang Zheng-Hong Chen Jun Wang Yuan Xiong Jin-Hua Wu Qi Quan Ling-Yan Xing Hong-Bo Zhang Yuan-Shan Zeng | 2022 | Bioactive Materials2022，7，5： | 3 |
| 12 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 13 | Inhibitory effect of vascular endothelial growth factors-targeted small interfering RNA on proliferation of gastric cancer cells显示文摘瞄准:为了检验脉管的内皮生长的效果,因素(VEGF ) 在胃的癌症房间在试管内的增长上指向了小介入的 RNA (siRNA ) 。方法:几 siRNAs 是进有 Lipofectamine 2000 的人的胃的癌症房间线 SGC-7901 的 transfected。房间不有 LipofectamineTM 2000 的 transfected 或爬(SCR ) siRNA 用作控制。VEGF mRNA 和蛋白质的表示上的 siRNA 的禁止的效果被 RT-PCR 和 ELISA 检测。MTT 试金被用来检验细胞生长的抑制率。在房间对待 siRNA 的房间骑车的变化被流动血细胞计数检测。结果:有效地指向人的 VEGF 的 siRNA 禁止了胃的癌症房间线 SGC-7901 的增长和房间周期的分发。G0/G1 阶段的百分比比在控制房间在 siRNA1-transfected 和 siRNA2-transfected 房间是显著地更高的。VEGF mRNA 的表示显著地在控制房间与那相比在 siRNA1-transfected 和 siRNA2-transfected 房间被禁止。VEGF 蛋白质显著地在 siRNA-transfected 房间减少了,但是没在 SCR siRNA 上有效果。结论:VEGF siRNA 禁止胃的癌症房间在试管内的增长。 | Wen-Hua Xu Yin-Lin Ge Quan Li Xiao Zhang Jian-Hua Duan | 2007 | World Journal of Gastroenterology2007，13，14： | 3 |
| 14 | Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury显示文摘Brain plasticity, including anatomical changes and functional reorganization, is the physiological basis of functional recovery after spinal cord injury(SCI). The correlation between brain anatomical changes and functional reorganization after SCI is unclear. This study aimed to explore whether alterations of cortical structure and network function are concomitant in sensorimotor areas after incomplete SCI. Eighteen patients with incomplete SCI(mean age 40.94 ± 14.10 years old; male:female, 7:11) and 18 healthy subjects(37.33 ± 11.79 years old; male:female, 7:11) were studied by resting state functional magnetic resonance imaging. Gray matter volume(GMV) and functional connectivity were used to evaluate cortical structure and network function, respectively. There was no significant alteration of GMV in sensorimotor areas in patients with incomplete SCI compared with healthy subjects. Intra-hemispheric functional connectivity between left primary somatosensory cortex(BA1) and left primary motor cortex(BA4), and left BA1 and left somatosensory association cortex(BA5) was decreased, as well as inter-hemispheric functional connectivity between left BA1 and right BA4, left BA1 and right BA5, and left BA4 and right BA5 in patients with SCI. Functional connectivity between both BA4 areas was also decreased. The decreased functional connectivity between the left BA1 and the right BA4 positively correlated with American Spinal Injury Association sensory score in SCI patients. The results indicate that alterations of cortical anatomical structure and network functional connectivity in sensorimotor areas were non-concomitant in patients with incomplete SCI, indicating the network functional changes in sensorimotor areas may not be dependent on anatomic structure. The strength of functional connectivity within sensorimotor areas could serve as a potential imaging biomarker for assessment and prediction of sensory function in patients with incomplete SCI. This trial was registered with the Chinese Clinical Trial Registry(registration number: Chi CTR-ROC-17013566). | Yu Pan Wei-bei Dou Yue-heng Wang Hui-wen Luo Yun-xiang Ge Shu-yu Yan Quan Xu Yuan-yuan Tu Yan-qing Xiao Qiong Wu Zhuo-zhao Zheng Hong-liang Zhao | 2017 | Neural Regeneration Research2017，12，12： | 2 |
| 15 | Double-bullet radioimmunotargeting therapy in 31 patients with primary liver cancer显示文摘Doublebuletradioimmunotargetingtherapyin31patientswithprimarylivercancerWUYingDe1,ZHOUDeNan2,GANGYouQuan2,HUXiaoHua1,LIZ... | WU Ying De 1, ZHOU De Nan 2, GANG You Quan 2, HU Xiao Hua 1, LI Zhi Ge 1, SONG Xiang Qun 1, HE Hai Ping 2, YANG Ke Zheng 1 and HUANG Bing Yan 1 1Department of Chemotherapy, Affiliated Cancer Hospital, Guangxi Medical University, | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 16 | Thermoresponsive Fluorescent Semicrystalline Polymers Decorated with Aggregation Induced Emission Luminogens显示文摘Thermoresponsive fluorescent polymers(TFPs) with unique temperature-dependent luminescent properties are of great importance for the development of new functional devices in recent years. Herein, we facilely synthesized an efficient blue-emissive polymer, abbreviated as PCB-TPE, using tetraphenylethene(TPE) as the main building block. PCB-TPE is thermally stable with a novel property of aggregation induced emission(AIE). The thermoresponsive property and mechanism of PCB-TPE were investigated. Its emission shows temperature-dependent features and reveals fine details in the thermal transitions from-10 °C to 60 °C. The polymer offers a platform for the development of efficient luminescent materials for further biological and optoelectronic applications. | Jia-Long Wu Chi Zhang Wei Qin Da-Ping Quan Ming-Liang Ge Guo-Dong Liang | 2019 | Chinese Journal of Polymer Science2019，37，4： | 2 |
| 17 | Triblock copolymer-assisted construction of 20 nm-sized ytterbium-doped TiO_2 hollow nanostructures for enhanced solar energy utilization efficiency显示文摘Rare-earth doped titania single-crystalline hollow nanoparticles of 20 nm are constructed via a simple sol-gel process. Amphiphilic ABA tri-block copolymers played a key role in assisting the formation of hollow structure, for which a hollow nanostructure growth mechanism is proposed. By introducing rare earth into the synthesis process, the as-prepared nanoparticles exhibit near-infrared light absorption properties. Photo-decomposition efficiency of Orange II azo dye can be successfully evaluated when using Yb3+-doped Ti O2 hollow nanoparticles as photocatalysts; it is more than two times higher than the pure Ti O2 hollow nanoparticles. The hollow nanostructured Yb3+-doped Ti O2 samples are exploited as photoanodes in N719- sensitized solar cells and prove able to improve the photoelectric conversion efficiency by measuring the solar cell parameters of dye-sensitized solar cells(DSSCs) under simulative sunlight. | Lin Cheng Xuefeng Xu Yuyan Fang Yan Li Jiaxi Wang Guojia Wan Xueying Ge Liangjie Yuan Keli Zhang Lei Liao Quan Yuan | 2015 | Science China Chemistry2015，58，5： | 2 |
| 18 | 显示文摘 | TIAN W QUAN MAOFA GE SAHU B B | 2004 | Phys Chem2004，108，17： | 1 |
| 19 | Gas phase par- tial oxidation of toluene over modified V2O5// TiO2 catalysts in a microreactor显示文摘 | Ge Hao Chen Guangwen Yuan Quan | 2007 | Chem Eng J2007，127，123： | 1 |
| 20 | Molecular and Phylogenetic Analyses Suggest an Additional Hepatitis B Virus Genotype' Ⅰ '显示文摘 | Hai Yu Quan Yuan Sheng-Xiang ge | | 0，，02： | 1 |
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