|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 2 | Impacts of climatic and marine environmental variations on the spatial distribution of Ommastrephes bartramii in the Northwest Pacific Ocean显示文摘Ommastrephes bartramii is an ecologically dependent species and has great commercial values among the AsiaPacific countries. This squid widely inhabits the North Pacific, one of the most dynamic marine environments in the world, subjecting to multi-scale climatic events such as the Pacific Decadal Oscillation(PDO). Commercial fishery data from the Chinese squid-jigging fleets during 1995–2011 are used to evaluate the influences of climatic and oceanic environmental variations on the spatial distribution of O. bartramii. Significant interannual and seasonal variability are observed in the longitudinal and latitudinal gravity centers(LONG and LATG) of fishing ground of O. bartramii. The LATG mainly occurred in the waters with the suitable ranges of environmental variables estimated by the generalized additive model. The apparent north-south spatial shift in the annual LATG appeares to be associated with the PDO phenomenon and is closely related to the sea surface temperature(SST)and sea surface height(SSH) on the fishing ground, whereas the mixed layer depth(MLD) might contribute limited impacts to the distribution pattern of O. bartramii. The warm PDO regimes tend to yield cold SST and low SSH, resulting in a southward shift of LATG, while the cold PDO phases provid warm SST and elevated SSH,resulting in a northward shift of LATG. A regression model is developed to help understand and predict the fishing ground distributions of O. bartramii and improve the fishery management. | YU Wei CHEN Xinjun YI Qian GAO Guoping CHEN Yong | 2016 | Acta Oceanologica Sinica2016，35，3： | 6 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Neuroligin 3 R451C位点敲入小鼠前额叶皮层的gamma振荡紊乱导致其社交行为缺陷显示文摘文章简介自闭症,又称孤独症,是一种儿童先天性的严重神经发育性疾病,发病率约1%。由于自闭症的致病机制不明,因而也缺乏有效的临床治疗方法。本研究通过一个自闭症遗传模型小鼠,阐明了自闭症中引起社交缺陷的关键脑区及工作机制。 | 曹蔚 林燊 Qiang-qiang Xia Yong-lan Du Qian Yang Meng-ying Zhang Yi-qing Lu Jing Xu Shu-min Duan Jun Xia Guoping Feng 许均瑜 罗建红 | 2019 | 科学新闻2019，0，2： | 2 |
| 5 | Hearing analysis in heterozygous and homozygous klotho gene deficient mice显示文摘Objective: To understand the crucial role of the klotho gene in hearing development in mouse models.Methods: PCR was used to identify CBA mice with different genotypes, i.e. WT, heterozygous(klotho +/-)or homozygous(klotho-/-). Mice phenotype and weight were recorded postnatal 25 days(P-25) and auditory brainstem responses(ABR) were used to determine auditory function at P-60.Results: klotho-/-mice tended to have smaller size, lighter weight and higher ABR thresholds at P-60,showing early onset age-related hearing loss(ARHL).Conclusion: Heterozygous and homozygous klotho deficient mice exhibit different degrees of hearing loss at young age, with homozygous mice(klotho-/-) showing more severe hearing loss. Our results indicate that persisted expression of klotho protein in the inner ear may potentially delay the onset of ARHL and play an important role in the protection of auditory function. | Na Yuan Shiwei Qiu Qian Wang Wei Zhuang Guoping Li Tiantian Sun Shiming Yang Yuehua Qiao Xi Shi | 2018 | Journal of Otology2018，13，4： | 2 |
| 6 | 显示文摘 | Qian JiangMiao Fang Zheng ping GuoPing Cai | 2003 | Catal Commun2003，4，： | 1 |
| 7 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 8 | Post-combustion slipstream CO_(2)-capture test facility at Jiangyou Power Plant,Sichuan,China:facility design and validation using 30% wt monoethanolamine(MEA)testing显示文摘Given the dominant share of coal in China’s energy-generation mix and the fact that>50% of the power plants in the country are currently<15 years old,efforts to significantly reduce China’s CO_(2) footprint will require the deployment of CO_(2) capture across at least part of its fleet of coal-fired power plants.CO_(2)-capture technology is reaching commercial maturity,but it is still necessary to adapt the technology to regional conditions,such as power-plant design and flexible operation in the China context.Slipstream facilities provide valuable field data to support the commercialization of CO_(2) capture.We have built a slipstream facility at Jiangyou power plant in Sichuan that will allow us to explore China-relevant issues,especially flexible operation,over the next few years.We plan to share our results with the broader CO_(2)-capture and CO_(2)-storage(CCS)community to accelerate the deployment of CCS in China.This paper describes the design of the slipstream facility and presents results from our steady-state qualification tests using a well-studied benchmark solvent:30% wt monoethanolamine(MEA).The results from our MEA tests compare favorably to results reported from other slipstream-test facilities around the world,allowing us to commission our system and establish a reference baseline for future studies. | Baodeng Wang Qian Cui Guoping Zhang Yinhua Long Yongwei Sun Xinglei Zhao Zhendong He Anthony Y.Ku | 2020 | Clean Energy2020，4，2： | 1 |
| 9 | 显示文摘 | Qian Guoping Yang Yiwen Ren Qilong | | Journal of Liquid Chromatography0，，： | 1 |
| 10 | Investigations of entrainment characteristics and shear-layer vortices evolution in an axisymmetric rear variable area bypass injector显示文摘In this study,firstly,for the axisymmetric RVABI,the change-rule of adverse pressure gradient caused by radial velocity during the transition of internal flow mode in variable geometry is summarized,and a Bypass Ratio(BR) iterative algorithm based on the empirical correlation of non-equilibrium pressure is proposed.The algorithm can estimate the nonlinear relationship between area ratio and BR,with an error range falling below 6.5%.Then,we discuss the favorable effect of uniform mixing on the thrust augmentation of mixed exhaust under variable BR conditions.From this point of view,the characteristics of vortices evolution in different shear strength jets are compared,to clarify the effect of variable cycle parameters on jet mixing.As the results suggest,when ■ is as low as 0.22,the K-H disturbance is of high-frequency wavelet property,and it is difficult to induce large-scale spanwise vortices.The macro migrations of fluid elements in span wise vortices and the diffusion effect caused by edge tearing is weak,which is not conducive to the energy exchange between the two streams.However,the low ■ jet will also correspondingly weaken the viscous dissipation effect of vortices.It is concluded that the dissipation level is proportional to the 2.31 power of the ■. | Guoping HUANG Chao LI Chen XIA Qian LI | 2022 | Chinese Journal of Aeronautics2022，35，4： | 1 |
| 11 | Multigranulation rough sets:from partition to covering 显示文摘 | LIN Guoping LIANG Jiye QIAN Yuehua | 2013 | Information Sciences2013，241，： | 1 |
| 12 | Temperature drift modeling and compensation for a dynamically tuned gyroscope by combining WT and SVM method 显示文摘 | Guoping Xu Weifeng Tian Zhihua Jin and Li Qian | 2007 | NOLOGY2007，，： | 1 |
| 13 | A novel hybridEMD-based drift denoising method for a DynamicallyTuned Gyroscope(DTG)显示文摘 | Qian Li Xu Guoping Tian Weifeng | 2009 | Measurement2009，42，： | 1 |
| 14 | Hepatic Stellate Cells Preferentially Expand Allogeneic CD4+CD25+FoxP3+ Regulatory T Cells in an IL-2-Dependent Manner显示文摘 | Guoping Jiang Horng-Ren Yang Lianfu Wang Gary M. Wildey John Fung Shiguang Qian Lina Lu | 2008 | Transplantation2008，，11： | 1 |
| 15 | NMGRS: Neighborhood-based multigranulation rough sets 显示文摘 | Lin Guoping Qian Yuhua Li Jinjin | 2012 | International Journal of Approximate Reasoning2012，53，： | 1 |
| 16 | On the origin of SARS-CoV-2——The blind watchmaker argument显示文摘In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection. | Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie Chen Zixiao Guo Yongsen Ruan Xuemei Lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 1 |
| 17 | Post-combustion slipstream CO_(2)-capture test facility at Jiangyou Power Plant, Sichuan, China: performance of a membrane separation module under dynamic power-plant operations显示文摘Membrane-based separation technologies have the potential to lower the cost of post-combustion CO_(2) capture from power-plant flue gases through reduced energy and capital costs relative to conventional solvent approaches.Studies have shown promise under controlled conditions,but there is a need for data on performance and reliability under field conditions.Coal-fired power plants in China operate in a dynamic manner,with increases and decreases in output causing changes in flue-gas composition.In this paper,we describe the first field test of a membrane-based post-combustion CO_(2)-capture system connected to a dynamically operating power plant in China.We report the performance of a Membrane Technology Research,Inc.(MTR)Polaris^(TM) membrane-based capture system over a range of plant operating loads ranging from 54%to 84%and conducted an operational stability test over a 168-h period during which the power plant was operating at an average load of 55%,but ramped as high as 79%and as low as 55%.Our results confirm the ability of a membrane capture system to operate effectively over a wide range of host-plant operating conditions,but also identity several issues related to plant integration,system control and resilience in the face of host-plant upsets that require attention as membrane separation systems move towards commercial use. | Qian Cui Baodeng Wang Xinglei Zhao Guoping Zhang Zhendong He Yinhua Long Yongwei Sun Anthony Y.Ku | 2021 | Clean Energy2021，5，4： | 1 |
| 18 | Study on tongue coating microbes of bitter taste,sticky and greasy taste in chronic atrophic gastritis显示文摘OBJECTIVE:To objectively reveal the relationship between tongue coating microbes and bitter taste,sticky and greasy taste in chronic atrophic gastritis(CAG)patients.METHODS:16S rRNA high-throughput sequencing was used to detect bacterial diversity and community composition of tongue coating microbes from samples of CAG patients.LEfSe algorithm was used for discovering the different tongue coating microbes in CAG patients with or without bitter taste,also that in CAG patients with or without sticky and greasy taste.RESULTS:We respectively compared the features of tongue coating microbes in bitter taste,sticky and greasy taste of CAG patients.At the genus level,25 tongue coating microbes were significantly different in CAG patients with bitter taste or without bitter taste;17 tongue coating microbes were significantly different in CAG patients with sticky and greasy taste or without sticky and greasy taste.Campylobacter and Rothia were closely related to CAG patients with bitter taste.Enterococcus,Serratia,Leptotrichia and Selenomonas were closely related to CAG patients with stick and greasy taste.CONCLUSION:Campylobacter and Rothia possibly contribute to bitter taste of CAG patients,and Enterococcus,Serratia,Leptotrichia and Selenomonas contribute to stick and greasy taste of CAG patients,which is potential for the diagnosis and treatment of CAG. | CAO Yang GAI Xiao ZHENG Yixin Guo Benqiong NIU Jingbin QIAN Peng LING Jianghong LIU Guoping ZHENG Yu | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员