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| 1 | Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer显示文摘 | Shuanqyan Tan Qiheng Gou Wenchen Pu Chenglin Guo Yun Yang Ke Wu Yaxin Liu Lunxu Liu Yu-Quan Wei Yong Peng | 2018 | Cell Research2018，28，6： | 24 |
| 2 | Tissue Doppler imaging study of right ventricular myocardial systolic activation in subjects with pulmonary arterial hypertension显示文摘背景织物 Doppler 成像(TDI ) 提供了一个客观工具确定全球、地区性留给室(LV ) 并且恰好室(RV ) 比常规 echocardiography 与改进精确性和更大的重制度工作。这研究被进行估计 RV 由在有肺的动脉的高血压的题目的 TDI 的心肌的收缩激活(哼) 30 个病人与全部的 .Methods A 哼并且 30 个健康志愿者,在年龄和性别全可比较,经历了标准 Doppler 回响和 TDI。用与 TDI 相结合的搏动的 Doppler echocardiography,下列地区性的参数在三个不同心肌的片断被评估(RV 基础侧面的墙,基础氏族,并且 LV 基础侧面) 在顶端的 4 房间上看法:收缩(Sm ) ,早心脏舒张、迟了心脏舒张(他们并且) 山峰速度。RV 心肌的收缩激活延期及时被定义为差别到在 RV 基础侧面的墙之间的山峰 TDI 收缩速度并且基础氏族。另外, RV 结束心脏舒张、结束收缩的区域被测量计算 RV 从一样的顶端的 4 房间 view.Results 的部分区域变化与控制组,相比病人与哼显示出的增加的 RA 和 RV 结束心脏舒张的直径(RA :(4.5 吗?? | YOU Xiang-dong PU Zhao-xia PENG Xian-jing ZHENG Sheng-zhou | 2007 | Chinese Medical Journal2007，，13： | 18 |
| 3 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 4 | Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non- alcoholic steatohepatitis显示文摘Dicer1 是为 microRNA (miRNA ) 的酶必需品成熟。miRNAs 的损失源于 Dicer1 缺乏极大地贡献许多疾病的前进,包括在在非酒精的 steatohepatitis (NASH ) 的发展是批评的免费胆固醇(FC ) 的肝的累积的类脂化合物 dysregulation,而是它的角色遗体逃犯。在这研究,我们使用了肝特定的 Dicer1 大美人老鼠识别涉及肝的 FC 累积的 miRNAs。在一个广泛地使用的饮食的 NASH 模型,老鼠被喂 methionine-choline-deficient (MCD ) 节食 3 个星期,它在肝象 Dicer1 mRNA 层次的减少一样导致了肝的 FC 层次的重要增加。肝特定的 Dicer1 大美人在 5-6 星期导致了肝的 FC 累积,由增加的 mRNA 和 3-hydroxy-3-methylglutaryl 辅酶的蛋白质层次伴随了 reductase (HMGCR ) ,在肝的胆固醇合成的限制率的酶。十一预言 miRNAs 被屏蔽,表明 miR-29a/b/c 显著地压制了由指向 HMGCR mRNA 3-UTR 的 HMGCR 表示。在 SMMC-7721 房间的 miR-29a 的 Overexpression,脂肪变性肝的房间模型,显著地减少的 HMGCR 表示和 FC 铺平。而且, miR-29a 的表达式层次相反地与在 MCD 食谱鼠标的表达式层次在 vitro 在 vivo 并且在肝的房间建模的 2 脂肪变性(SMMC-7721 和 HL-7702 房间) 建模的 HMGCR 被相关。我们的结果证明那 Dicer1/miR-29/HMGCR 轴在老鼠 NASH 贡献肝的免费胆固醇累积,并且 miR-29 可以用作肝的胆固醇动态平衡的一个重要管理者。因此, miR-29a 能为非酒精的脂肪肝疾病的处理以及为与 FC 累积联系的另外的肝疾病作为一个潜在的治疗学的目标被利用。 | Ming-xia LIU Man GAO Chun-zhu LI Cun-zhi YU Hong YAN Chun PENG Yu LI Cheng-gang LI Ze-long MA Yang ZHAO Meng-fan PU Ling-ling MIAO Xin-ming QI Jin RENI | 2017 | Acta Pharmacologica Sinica2017，38，5： | 12 |
| 5 | Highly reactive, flexible yet green Se precursor for metal selenide nanocrystals: Se-octadecene suspension (Se-SUS)显示文摘在 octadecene (Se 怀疑) 的好硒粉末(100 或 200 网孔) 的暂停证明了是一位高效的、万用的、方便的、可再现的、还绿的硒先锋。Se 怀疑的优点从它的高度反应的化学性质和灵活性产生。这二个特征使与多样的作文和结构执行高质量的金属硒化物 nanocrystals 的合成可能,包括二进制代码,核心 / 壳,做的转变金属,和复杂作文 nanocrystals。这些成功进一步证明 Se 怀疑是为在高质量的硒化物 nanocrystals 的合成解决一些长期的挑战的一位强大的 Se 先锋。例如,Se怀疑成功地作为一位 Se 先锋被采用因为在高质量的核心/壳 nanocrystals 轰炸生长代替昂贵、高度有毒的先锋,例如Se磷化氢和 bis-trimethylsilyl 硒化物,与极大地降低的取向附生的温度(象 150 一样低???????????????? | Chaodan Pu Jianhai Zhou Runchen Lai Yuan Niu Wennuan Nan Xiaogang Peng | 2013 | Nano Research2013，6，9： | 12 |
| 6 | Inheritance and molecular characterization of resistance to AHAS- inhibiting herbicides in rapeseed显示文摘Rapeseed is a very important oil crop in China;however,its production is challenging due to the absence of effective weed management strategies.This is predominantly because of a shortage of herbicide resistance genes.Acetohydroxyacid synthase(AHAS) herbicides inhibit AHAS,a key enzyme involved in branched-chain amino acid synthesis that is required for plant growth.A rapeseed line designated M342 with AHAS herbicide resistance was developed through seed mutagenesis and was studied to assess the level and mode of inheritance of the resistance and to identify the molecular basis of resistance.M342 possessed a high level of cross-resistance to sulfonylureas(SUs) and imidazolinones(IMIs).This resistance was due to AHAS insensitivity to these herbicides and was inherited as a dominant trait conferred by a single nuclear-encoded gene.Molecular analysis revealed the presence of a Trp574 Leu mutation in M342,and an allele-specific cleaved amplified polymorphic sequence(AS-CAPS) marker was developed and cosegregated with herbicide resistance in the F2,BC1,and BC2 populations.This mutation altered the transcript levels of Bn AHAS1 and Bn AHAS3 in M342 compared with those in the wild type,but it did not affect the agronomic or quality traits.The simple genetic inheritance of this mutation and the availability of the cleaved amplified polymorphic sequence(CAPS) marker and herbicide resistance gene should facilitate the development of herbicide-resistant rapeseed cultivars for effective weed control in China. | HU Mao-long PU Hui-ming GAO Jian-qin LONG Wei-hua CHEN Feng ZHOU Xiao-ying ZHANG Wei PENG Qi CHEN Song ZHANG Jie-fu | 2017 | Journal of Integrative Agriculture2017，16，11： | 11 |
| 7 | Soil Organic Carbon Accumulation Increases Percentage of Soil Olsen-P to Total P at Two 15-Year Mono-Cropping Systems in Northern China显示文摘Soil organic carbon(SOC) and soil Olsen-P are key soil fertility indexes but information on their relationships is limited particularly under long-term fertilization. We investigated the relationships between SOC and the percentage of soil Olsen-P to total P(PSOPTP) under six different 15-yr(1990-2004) long-term fertilizations at two cropping systems in northern China. These fertilization treatments were(1) unfertilized control(control);(2) chemical nitrogen(N);(3) N plus chemical P(NP);(4) NP plus chemical potassium(NPK);(5) NPK plus animal manure(NPKM) and(6) high NPKM(hNPKM). Compared with their initial values in 1989 at both sites, during the 11th to 15th fertilization years annual mean SOC contents were significantly increased by 39.4-47.0% and 58.9-93.9% at Gongzhuling, Jilin Province, and Urumqi, Xinjiang, China, under the two NPKM fertilizations, respectively, while no significant changes under the no-P or chemical P fertilization. During the 11th to 15th fertilization years, annual mean PSOPTP was respectively increased by 2.6-4.2 and 5.8-14.1 times over the initial values under the two chemical P fertilizations and the two NPKM fertilizations, but was unchanged in their initial levels under the two no-P fertilizations at both sites. Over the 15-yr long-term fertilization SOC significantly positively correlated with PSOPTP(r2=0.55-0.79, P<0.01). We concluded that the combination of chemical P plus manure is an effective way to promote SOC accumulation and the percentage of soil Olsen-P to total P at the two mono-cropping system sites in northern China. | SHEN Pu HE Xin-hua XU Ming-gang ZHANG Hui-min PENG Chang GAO Hong-jun LIU Hua XU Yong-mei QIN Song XIAO Hou-jun | 2014 | Journal of Integrative Agriculture2014，13，3： | 10 |
| 8 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 9 | Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression显示文摘 | Kejie ZHANG Quan-yi LU Xiao-qing NIU Peng ZHANG Jiang-ning ZHAO Zhao WANG Jia-sheng HU Pu LI Wen-li LIU | 2009 | Acta Pharmacologica Sinica2009，30，2： | 9 |
| 10 | The Role of Exportin-5 in MicroRNA Biogenesis and Cancer显示文摘Micro RNAs(mi RNAs) are conserved small non-coding RNAs that play an important role in the regulation of gene expression and participate in a variety of biological processes. The biogenesis of mi RNAs is tightly controlled at multiple steps, such as transcription of mi RNA genes,processing by Drosha and Dicer, and transportation of precursor mi RNAs(pre-mi RNAs) from the nucleus to the cytoplasm by exportin-5(XPO5). Given the critical role of nuclear export of premi RNAs in mi RNA biogenesis, any alterations of XPO5, resulting from either genetic mutation,epigenetic change, abnormal expression level or posttranslational modification, could affect mi RNA expression and thus have profound effects on tumorigenesis. Importantly, XPO5 phosphorylation by ERK kinase and its cis/trans isomerization by the prolyl isomerase Pin1 impair XPO50 s nucleo-to-cytoplasmic transport ability of pre-mi RNAs, leading to downregulation of mature mi RNAs in hepatocellular carcinoma. In this review, we focus on how XPO5 transports pre-mi RNAs in the cells and summarize the dysregulation of XPO5 in human tumors. | Ke Wu Juan He Wenchen Pu Yong Peng | 2018 | Genomics, Proteomics & Bioinformatics2018，16，2： | 8 |
| 11 | Residue management induced changes in soil organic carbon and total nitrogen under different tillage practices in the North China Plain显示文摘Crop residue retention has been considered a practicable strategy to improve soil organic carbon(SOC)and total nitrogen(TN),but the effectiveness of residue retention might be different under varied tillage practices.To evaluate the effects of residue management on the distribution and stocks of SOC and TN under different tillage practices,a bifactorial experiment with three levels for tillage practices(no-tillage,rotary tillage,and conventional tillage)and two levels for residue managements(residue retention and residue removal)was conducted in the North China Plain(NCP).Results showed that after a short experimental duration(3–4 years),concentrations of SOC and TN in the 0–10 cm layer were higher under no-tillage than under conventional tillage,no matter whether crop residues were retained or not.Residue retention increased SOC and TN concentrations in the upper layers of soil to some degree for all tillage practices,as compared with residue removal,with the greatest increment of SOC concentration occurred in the 0–10 cm layer under rotary tillage,but in the 10–30 cm layer under conventional tillage.The stocks of SOC in the 0–50 cm depth increased from 49.89 Mg ha–1 with residue removal to 53.03 Mg ha–1 with residue retention.However,no-tillage did not increase SOC stock to a depth of 50 cm relative to conventional tillage,and increased only by 5.35%as compared with rotary tillage.Thus,residue retention may contribute more towards SOC sequestration than no-tillage.Furthermore,the combination between residue retention and no-tillage has the greatest advantage in enhancing SOC and TN in the NCP region. | PU Chao KAN Zheng-rong LIU Peng MA Shou-tian QI Jian-ying ZHAO Xin ZHANG Hai-lin | 2019 | Journal of Integrative Agriculture2019，18，6： | 8 |
| 12 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 13 | Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese显示文摘Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6% vs.21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P<0.01) and to elevated blood glucose in the elderly group (HR=1.39,P<0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD. | ZHANG Ming Liang HOU Xu Hong ZHU Yun Xia LU Jun Xi PENG Liang Pu GU Hui Lin JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 7 |
| 14 | Construction of ecological security patterns and ecological restoration zones in the city of Ningbo,China显示文摘Studying an ecological restoration zoning process under the background of ecological security patterns is of great significance to the rapid adjustment and optimization of a landscape pattern.In this study,a remote sensing ecological index and a morphological spatial pattern analysis method were used to assess the quality of habitats and identify ecological sources in the city of Ningbo;ecological corridors,ecological pinch points,and ecological barrier points were extracted by using a circuit theory to construct ecological security patterns and ecological restoration zones.The results indicate:(1)There were 47 ecological sources,and 83 key ecological corridors in Ningbo,and the ecological land area was about 1898.39 km^(2),accounting for 19.89%of the total study area.(2)The ecological source areas were distributed in“one patch and three belts”,and the low-resistance ecological corridors were concentrated in southern Yuyao city,western Haishu district,and central and western Fenghua district;the ecological network in the western and southern regions was dense.(3)There were four types of ecological restoration zones that need to be established,which were prioritized restoration zones,prioritized protection zones,key conservation zones,and general conservation zones distributed hierarchically from inner part towards outside.(4)Ninghai county,Yuyao city,and Fenghua district had large ecological land areas,however,prioritized restoration and protection zones in Ninghai and Fenghua were also large.The analysis results are expected to provide a reference for optimizing a territorial ecological space in a city. | ZHANG Haitao LI Jialin TIAN Peng PU Ruiliang CAO Luodan | 2022 | Journal of Geographical Sciences2022，32，4： | 7 |
| 15 | Effects of High Temperature on Antioxidant Enzymes and Lipid Peroxidation in Flag Leaves of Wheat During Grain Filling Period显示文摘On the basis of the phytotron, the effects of high temperature (daily average temperature 25, 30, 35 and 40°C, respectively) on antioxidant enzymes and lipid peroxidation in flag leaves of wheat at 50% relative air moisture during grain fastest filling stage [19-21 days after anthesis (DAA)] were studied. The wheat cultivars tested were Yangmai 9 with weak-gluten and Yangmai 12 with medium-gluten. Compared with 25°C, the higher the temperature was, the higher was the MDA content in flag leaves, while lower were the SOD, POD, and CAT activities. SOD and CAT activities in Yangmai 12 appeared to be more sensitive to high temperature than that in Yangmai 9. But POD activity in Yangmai 12 was less sensitive to high temperature. MDA content in Yangmai 12 was higher than that in Yangmai 9. The 1 000-grain weight declined with increase in temperature. | LIU Ping GUO Wen-shan PU Han-chun FENG Chao-nian ZHU Xin-kai PENG Yong-xin | 2006 | Agricultural Sciences in China2006，5，6： | 7 |
| 16 | MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1显示文摘以前的研究证明了 microRNA-1304 (miR-1304 ) 是在癌症的某些类型的 dysregulated,包括非小的房间肺癌症(NSCLC ) ,并且可能涉及肿瘤幸存或生长。在这研究,我们在 vitro 在 NSCLC 调查了 miR-1304 和它的功能的直接目标。人的肺腺癌房间线(A549 和 NCI-H1975 ) 被学习。房间增长和幸存经由房间数, MTT 和殖民地形成试金被调查。房间 apoptosis 和房间周期用分别地染色试金的 annexin V-PE/7-AAD 和 PI 被检验。双酶的记者试金被用来由 miR-1304 验证 heme oxygenase-1 (HO-1 ) 的 post-transcriptional 规定。CRISPR/Cas9 被用来弄空内长的 miR-1304。MiR-1304 的 Overexpression 显著地减少了 NSCLC 房间和殖民地形成的数字和生存能力,和导致的房间 apoptosis 和 G 0/G1 阶段房间骑车拘捕。HO-1 被表明是在 NSCLC 房间的 miR-1304 的一个直接目标。由 hemin (20 mol/L ) 的 HO-1 表示的恢复在细胞生长上废除了 miR-1304 的抑制并且在 A549 细胞救了 miR-1304-induced apoptosis。有 anti-1304 的内长的 miR-1304 的抑制显著地增加了 HO-1 表示并且在 A549 房间支持了房间生长和幸存。在 17 件人的 NSCLC 织物样品, miR-1304 表示显著地被减少,当 HO-1 表示显著地作为与正常的肺纸巾相比被增加时。MicroRNA-1304 是肿瘤 suppressor, HO-1 是它在 NSCLC 的直接目标。结果为 NSCLC 作为一个治疗学的目标为 miR-1304 建议潜力。 | Cheng-gang LI Meng-fan PU Chun-zhu LI Man GAO Ming-xia LIU Cun-zhi YU Hong YAN Chun PENG Yang ZHAO Yu LI Ze-long MA Xin-ming QI Yi-zheng WANG Ling-ling MIAO Jin REN | 2017 | Acta Pharmacologica Sinica2017，38，1： | 6 |
| 17 | Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network显示文摘Additional sex combs-like 1(ASXL1)interacts with BRCA1-associated protein 1(BAP1)deubiquitinase to oppose the polycomb repressive complex 1(PRC1)-mediated histone H2A ubiquitylation.Germline BAP1 mutations are found in a spectrum of human malignancies,while ASXL1 mutations recurrently occur in myeloid neoplasm and are associated with poor prognosis.Nearly all ASXL1 mutations are heterozygous frameshift or nonsense mutations in the middle or to a less extent the C-terminal region,resulting in the production of C-terminally truncated mutant ASXL1 proteins.How ASXL1 regulates specific target genes and how the C-terminal truncation of ASXL1 promotes leukemogen-esis are unclear.Here,we report that ASXL1 interacts with forkhead transcription factors FOXK1 and FOXK2 to regulate a subset of FOXK1/K2 target genes.We show that the C-terminally truncated mutant ASXL1 proteins are expressed at much higher levels than the wild-type protein in ASXL1 heterozygous leukemia cells,and lose the ability to interact with FOXK1/K2.Specific deletion of the mutant allele eliminates the expression of C-termi-nally truncated ASXL1 and increases the association of wild-type ASXL1 with BAP1,thereby restoring the expression of BAP1-ASXL1-FOXK1/K2 target genes,particularly those involved in glucose metabolism,oxygen sensing,and JAK-STAT3 signaling pathways.In addition to FOXK1/K2,we also identify other DNA-bind-ing transcription regulators including transcription factors(TFs)which interact with wild-type ASXL1,but not C-terminally truncated mutant.Our results suggest that ASXL1 mutations result in neomorphic alleles that contribute to leukemogenesis at least in part through dominantly inhibiting the wild-type ASXL1 from interacting with BAP1 and thereby impairing the function of ASXL1-BAP1-TF in regulating target genes and leukemia cell growth. | Yu-Kun Xia Yi-Rong Zeng Meng-Li Zhang Peng Liu Fang Liu Hao Zhang Chen-Xi He Yi-Ping Sun Jin-Ye Zhang Cheng Zhang Lei Song Chen Ding Yu-Jie Tang Zhen Yang Chen Yang Pu Wang Kun-Liang Guan Yue Xiong Dan Ye | 2021 | Protein & Cell2021，12，7： | 6 |
| 18 | Ethnic Differences in Preterm Birth Risks for Pregnant Women with Thyroid Dysfunction or Autoimmunity:A Meta-analysis显示文摘Objective Abnormal maternal thyroid function is associated with preterm birth.However,this association stays dubious in relevant individual studies for ethnic difference reasons and lack of direct supporting data.This study aimed to evaluate the relationship between preterm birth and thyroid dysfunction or autoimmunity based on ethnic differences.Methods Relevant studies were identified through searches of MEDLINE,Excerpta Medica,Wan Fang,China Biological Medicine disc,and China National Knowledge Infrastructure from inception to June 15,2016.Original articles in which an incidence or prevalence of thyroid dysfunction or autoimmunity before second trimester of pregnancy could be extracted were included.Results Thirty-two unique studies were included for the final meta-analysis.Patients involved were divided into two groups:Group 1(G1) and Group 2(G2) comprising of Asian and Caucasian populations,respectively.Positive thyroid antibodies were associated with the occurrence of preterm birth in both G1 [odds ratio(OR):3.62,95% confidence interval(CI):2.83-4.65] and G2(OR:1.35,95% CI:1.17-1.56);hypothyroidism,only in G2(OR:1.20,CI:1.09-1.33);and subclinical hypothyroidism or hypothyroxinemia,in neither group.Conclusion Thyroid autoimmunity may be a more favorable factor leading to preterm birth among pregnant women of different ethnicities,compared with thyroid dysfunction. | LI Min WANG Shao Wei WU Feng Li SHI Jin YU Pu Lin PENG Xiu Ling SUN Liang | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 19 | Surface and intrinsic contributions to extinction properties of ZnSe quantum dots显示文摘This work studies extinction properties of ZnSe quantum dots terminated with either Se-surface or Zn-surface(Se-ZnSe or Zn-ZnSe QDs).In addition to commonly observed photoluminescence quenching by anionic surface sites,Se-ZnSe QDs are found to show drastic signatures of Se-surface states in their UV-visible(Vis)absorption spectra.Similar to most QDs reported in literature,monodisperse Zn-ZnSe QDs show sharp absorption features and blue-shifted yet steep absorption edge respect to the bulk bandgap.However,for monodisperse Se-ZnSe QDs,all absorption features are smeared and a low-energy tail is identified to extend to an energy window below the bulk ZnSe bandgap.Along increasing their size,a cyclic growth of ZnSe QDs switches their surface from Zn-terminated to Se-terminated ones,which confirms that the specific absorption signatures are reproducibly repeated between those of two types of the QDs.Though the extinction coefficients per unit of Se-ZnSe QDs are always larger than those of Zn-ZnSe QDs with the same size,both of them approach the same bulk limit.In addition to contribution of the lattice,extinction coefficients per nanocrystal of Zn-ZnSe QDs show an exponential term against their sizes,which is expected for quantum-confinement enhancement of electron-hole wavefunction overlapping.For Se-ZnSe QDs,there is the third term identified for their extinction coefficients per nanocrystal,which is proportional to the square of size of the QDs and consistent with surface contribution. | Shangxin Lin Jiongzhao Li Chaodan Pu Hairui Lei Meiyi Zhu Haiyan Qin Xiaogang Peng | 2020 | Nano Research2020，13，3： | 5 |
| 20 | Optimization of Formula of Matsutake Highland Barley Biscuit by Response Surface Methodology显示文摘Taking refined flour,matsutake powder,and highland barley powder as main raw materials,this experiment studied the optimal formula of matsutake highland barley biscuit. Besides,single factor experiment was carried out for the amount of highland barley powder,white granulated sugar,and shortening. Then,the response surface optimization analysis was made on crispness and sensory score of the biscuit. The experiment indicates that taking the refined flour as the base 100 g( 100%),the formula of 20% highland barley powder,25% white granulated sugar,and 26% shortening can bake crisp biscuit with complete shape,pure flavor and high quality. | Xuedong GU Li PU Peng LEI Qiong XI Changzhong MA Zhang LUO | 2017 | Asian Agricultural Research2017，9，11： | 5 |
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