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| 1 | Cytotoxic and antibacterial substances against multi-drug resistant pathogens from marine sponge symbiont:Citrinin,a secondary metabolite of Penicillium sp.显示文摘Objective:To Isolate,purify,characterize,and evaluate the bioaclive compounds from the sponge-derived fungus Penicillium sp.FF001 and to elucidate its structure.Methods:The fungal strain FF001 with an interesting bioactivity profile was isolated from a marine Fijian sponge Melophlus sp.Based on conidiophores aggregation,conidia development and mycelia morphological characteristics,the isolate FF001 was classically identified as a Penicillium sp.The bioactive compound was identified using various spectral analysis of UV,high resolution electrospray ionization mass spectra,1H and 13C NMR spectral data.Further minimum inhibitory concentrations(MICs)assay and brine shrimp cytotoxicity assay were also carried out to evaluate the biological properties of the purified compound.Results:Bioassay guided fractionation of the EtOAc extract of a static culture of this Penicillium sp.by different chromatographic methods led the isolation of an antibacterial,anticryptococcal and cytotoxic active compound,which was identified as citrinin(1).Further,citrinin(1)is reported for its potent antibacterial activity against methicillin-resistant Staphylococcus aureus(S.aureus),rifampicin-resistant 5.aureus,wild type S.aureus and vancomycin-resistant Enterococcus faecium showed MICs of 3.90,0.97,1.95 and7.81μg/mL,respectively.Further citrinin(1)displayed significant activity against the pathogenic yeast Cryptococcus neoformans(MIC 3.90μg/mL),and exhibited cytotoxicity against brine shrimp larvae LD_(50)of 96μg/mL.Conclusions:Citrinin(1)is reported from sponge associated Penicillium sp.from this study and for its strong antibacterial activity against multi-drug resistant human pathogens including cytotoxicity against brine shrimp larvae,which indicated that sponge associated Penicillium spp.are promising sources of natural bioactive metabolites. | Ramesh Subramani Rohitesh Kumar Pritesh Prasad William Aalbersberg | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，4： | 6 |
| 2 | Flexible high energy density zinc-ion batteries enabled by binder-free MnO_(2)/reduced graphene oxide electrode显示文摘We demonstrate a rechargeable zinc-ion battery with high energy density and cyclability using MnO_(2)and reduced graphene oxide(MnO_(2)/rGO)electrode.The flexible and binder free electrode,with high MnO_(2)mass ratio(80 wt%of MnO_(2)),is fabricated using vacuum filtration without any additional additives other than rGO.Compared to batteries with conventional MnO_(2)electrodes,the Zn-MnO_(2)/rGO battery shows a significant enhanced capacity(332.2 mAh g^(-1)at 0.3 A g^(-1)),improved rate capability(172.3 mAh g^(-1)at 6 A g^(-1))and cyclability.The capacity retention remains 96%after 500 charge/discharge cycles at 6 A g^(-1).The high MnO_(2)mass ratio makes MnO_(2)/rGO electrode advantageous when the capacity is normalized to the whole electrode,particularly at high rates.The calculated gravimetric energy density of Zn-MnO_(2)/rGO battery is 33.17Wh kg^(-1),which is comparable to the existing commercial lead-acid batteries(30-40Wh kg^(-1)).Furthermore,the discharge profile and capacity of our Zn-MnO_(2)/rGO battery shows no deterioration during bending test,indicating good flexibility.As a result,zinc-ion battery is believed to be a promising technology for powering next generation flexible electronics. | Yuan Huang Jiuwei Liu Qiyao Huang Zijian Zheng Pritesh Hiralal Fulin Zheng Dilek Ozgit Sikai Su Shuming Chen Ping-Heng Tan Shengdong Zhang Hang Zhou | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 3 | Development of a sensitive and rapid method for quantitation of (S)-(-)- and (R)-(+)-metoprolol in human plasma by chiral LC–ESI–MS/MS显示文摘A selective, sensitive and high throughput liquid chromatography-tandem mass spectrometry(LC–ESI–MS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2(250 mm 4.6 mm, 5 mm) column. Solid phase extraction of(S)-()- and(R)-(t)-metoprolol and rac-metoprolol-d6 as an internal standard(IS)was achieved on Lichrosep DVB HL cartridges employing 200 mL human plasma. Both the analytes were chromatographically separated with a resolution factor of 2.24 using 15 mM ammonium acetate in water, pH 5.0 and 0.1%(v/v) diethyl amine in acetonitrile(50:50, v/v) as the mobile phase within 7.0 min. The precursor-product ion transitions for the enantiomers and IS were monitored in the multiple reaction monitoring and positive ionization mode. The method was validated over the concentration range of 0.500–500 ng/mL for both the enantiomers. Matrix effect was assessed by post-column analyte infusion experiment and the mean extraction recovery was greater than 94.0% for both the enantiomers at all quality control levels. The stability of analytes was evaluated in plasma and whole blood under different storage conditions. The method was successfully applied to a clinical study in 14 healthy volunteers after oral administration of200 mg metoprolol tablet under fasting conditions. The assay reproducibility is shown by reanalysis of 68 incurred samples. The suitability of the developed method was assessed in comparison | Primal Sharma Pritesh Contractor Swati Guttikar Daxesh P.Patel Pranav S.Shrivastav | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 3 |
| 4 | Characterization of colloidal arsenic at two abandoned gold mine sites in Nova Scotia, Canada, using asymmetric flow-field flow fractionation-inductively coupled plasma mass spectrometry显示文摘Asymmetric flow-field flow fractionation-inductively-coupled plasma-mass spectrometry was used to determine whether colloidal arsenic(As) exists in soil pore water and soil extract samples at two arsenic-contaminated abandoned gold mines(Montague and Goldenville, Nova Scotia). Colloidal arsenic was found in 12 out of the 80 collected samples(= 15%), and was primarily associated with iron(Fe) in the encountered colloids. The molar Fe/As ratios indicate that the colloids in some samples appeared to be discrete iron–arsenic minerals, whereas in other samples, they were more consistent with As-rich iron(oxy)hydroxides. Up to three discrete size fractions of colloidal As were encountered in the samples, with mean colloid diameters between 6 and 14 nm. The pore water samples only contained one size fraction of As-bearing colloids(around 6 nm diameter), while larger As-bearing colloids were only encountered in soil extracts. | Kathryn J Tindale Pritesh J Patel Dirk Wallschlager | 2016 | Journal of Environmental Sciences2016，28，11： | 3 |
| 5 | Kinetic analysis of iron ore powder reaction with hydrogen-carbon monoxide显示文摘Iron ore powder was isothermally reduced at 1023-1373 Kwith hydrogen/carbon monoxide gas mixture(from 0vol%H_(2)/100vol%CO to 100vol%H_(2)/0vol%CO).Results indicated that the whole reduction process could be divided into two parts that proceed in series.The first part represents a double-step reduction(Fe_(2)O_(3)→Fe_(3)O_(4)→FeO),in which the kinetic condition is more feasible compared with that in the second part representing a single-step reduction(FeO→Fe).The influence of hydrogen partial pressure on the reduction rate gradually increases as the reaction proceeds.The average reduction rate of hematite ore with pure hydrogen is about three and four times higher than that with pure carbon monoxide at 1173 and 1373 K,respectively.In addition,the logarithm of the average rate is linear to the composition of the gas mixture.Hydrogen can prominently promote carbon deposition to about 30%at 1023 K.The apparent activation energy of the reduction stage increases from about 35.0 to 45.4 kJ/mol with the increase in hydrogen content from 20vol%to 100vol%.This finding reveals that the possible rate-controlling step at this stage is the combined gas diffusion and interfacial chemical reaction. | Xudong Mao Pritesh Garg Xiaojun Hu Yuan Li Samik Nag Saurabh Kundu Jianliang Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，10： | 2 |
| 6 | Antifertility effect of chronically administered Tabernaemontana divaricata leaf extract on male rats显示文摘Objective:To investigate the antifertility effect of chronically administered Tabernaemontana divarkala(T.divaricata) leaf extract on male rats.Methods:The effect of 50%ethanol extract of T.divaricata leaves on reproduction was studied on male rats.The study was divided into four groups of five animals each.The first groups(1) received vehicle alone to serve as control. The second,third and fourth groups(Ⅱ,ⅡandⅣ) of animals were administered the leaf extract daily at 50 mg/kg body weight,p.o.,100 nig/kg body weight,p.o.,and 200 mg/kg body weight, p.o.,respectively,for a period of 60 days.Results:Significant decreases in the weight of testes, epididymis,seminal vesicle and ventral prostate were observed.A dose related reduction in the testicular sperm count,epididymal sperm count and motility,number of fertile male,ratio between delivered and inseminated females and numbers of pups were observed.The testis showed a clear correlation between the dose and severity of lesions of seminiferous epithelium. In general,the seminiferous tubules appear reduced in size with a frequently filled eosinophilic material.Spermatogenesis arrested at the secondary spermatocyte stage.Pachytene spermatocytes were undergoing degeneration.Disorganisation and sloughing of immature germ cell were visible. Leydinf cells were atrophied.No morphological changes were observed in Sertoli cells.Significant reduction in serum concentration of luteinizing hormone and testosterone were observed.No distinct change in serum FSH concentration was recorded.The final body weights of all groups were elevated markedly.No alterations were recorded in any hematologiocal parameters. Conclusions:It is concluded that the 50%ethanol extract of T.divaricata leaf produced dose related effect on male reproduction without altering general bodv metabolism. | Sachin Jain Ankit Jain Pritesh Paliwal Shailendra Singh Solanki | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 1 |
| 7 | Impact of sex on the survival of patients with hepatocellular carcinoma: A Surveillance, Epidemiology, and End Results analysis显示文摘 | Dongyun Yang Diana L. Hanna Josh Usher Jordan LoCoco Pritesh Chaudhari Heinz‐Josef Lenz V. Wendy Setiawan Anthony El‐Khoueiry | 2014 | Cancer2014，，23： | 1 |
| 8 | Thin Films of VO2 on Glass by Atomic Layer Deposition: Microstructure and Electrical Properties 显示文摘 | Pritesh Dagur Anil U Mane Shivashankar S A | 2005 | Journal of Crystal Growth2005，275，： | 1 |
| 9 | Medullary thyroid cancer: early detection and novel treatments显示文摘 | Sanziana Roman Pritesh Mehta Julie Ann Sosa | 2009 | Current Opinion in Oncology2009，，1： | 1 |
| 10 | Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression显示文摘 | Rex A. Parker Ricardo Garcia Carol S. Ryan Xiaoqin Liu Petia Shipkova Valentin Livanov Pritesh Patel Siew P. Ho | 2013 | The Journal of Lipid Research2013，，9： | 1 |
| 11 | Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy显示文摘 | Matthew Silva Michele L. Matthews Courtney Jarvis Nicole M. Nolan Paul Belliveau Michael Malloy Pritesh Gandhi | 2007 | Clinical Therapeutics2007，，2： | 1 |
| 12 | Buccal Drug Delivery of Pravastatin Sodium显示文摘 | Supriya S. Shidhaye Pritesh V. Thakkar Neha M. Dand Vilasrao J. Kadam | 2010 | AAPS PharmSciTech2010，，1： | 1 |
| 13 | Withania somnifera (Ashwagandha):a Novel Source of L-asparaginase显示文摘Different parts of plant species belonging to Solanaceae and Fabaceae families were screened for L-asparaginase enzyme (E.C.3.5.1.1.). Among 34 plant species screened for L-asparaginase enzyme, Withania somnifera L. was identified as a potential source of the enzyme on the basis of high specific activity of the enzyme. The enzyme was purified and characterized from W. somnifera, a popular medicinal plant in South East Asia and Southern Europe. Purification was carried out by a combination of protein precipitation with ammonium sulfate as well as Sephadex-gel filtration. The purified enzyme is a homodimer, with a molecular mass of 72 ± 0.5 kDa as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresisand size exclusion chromatography. The enzyme has a pH optimum of 8.5 and an optimum temperature of 37-C. The Km value for the enzyme is 6.1 × 10-2 mmol/L. This is the first report for L-asparaginase from W. somnifera, a traditionally used Indian medicinal plant. | Vishal P.Oza Shraddha D.Trivedi Pritesh P.Parmar R.B.Subramanian | 2009 | Journal of Integrative Plant Biology2009，51，2： | 1 |
| 14 | HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein显示文摘 | Kristine Y. Chan Elizabeth S. Boucher Pritesh J. Gandhi Matthew A. Silva | 2004 | American Journal of Health-System Pharmacy2004，，16： | 1 |
| 15 | Determination of ergocalciferol in human plasma after Diels-Alder derivatization by LC-MS/MS and its application to a bioequivalence study显示文摘An accurate, sensitive and selective method is developed for determination of ergocalciferol(vitamin D_2) in human plasma using LC–MS/MS. After liquid-liquid extraction with n-hexane, ergocalciferol was derivatized by reacting with 4-phenyl-1,2,4-triazoline-3,5-dione(PTAD), a strong dienophile based on Diels-Alder reaction.Ergocalciferol and its deuterated internal standard, ergocalciferol-d6, were analyzed on X Select CSH C_(18)(100 mm×4.6 mm, 2.5 μm) column using acetonitrile and 0.1%(v/v) formic acid in water containing 0.14% methylamine within 6.0 min under gradient elution mode. Tandem mass spectrometry in positive ionization mode was used to quantify ergocalciferol by multiple reaction monitoring(MRM). Entire data processing was done using Watson LIMS^(TM) software which provided excellent data integrity and high throughput with improved operational efficiency. The major advantage of this method includes higher sensitivity(0.10 ng/mL),superior extraction efficiency(≥83%) and small sample volume(100 μL) for processing. The method was linear in the concentration range of 0.10–100 ng/mL for ergocalciferol. The intra-batch and inter-batch accuracy and precision(% CV) values varied from 97.3% to 109.0% and 1.01% to 5.16%, respectively. The method was successfully applied to support a bioequivalence study of 1.25 mg ergocalciferol capsules in 12 healthy subjects. | Pritesh Contractor Abhishek Gandhi Gajendra Solanki Priyanka A. Shah Pranav S. Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，6： | 1 |
| 16 | Thin Films of VO2 on Glass by Atomic Layer Deposition: Microstructure and Electrical Properties显示文摘 | Pritesh Dagura Anil U Maneb Shivashankara S A | 2005 | Journal of Crystal Growth2005，275，： | 1 |
| 17 | Mechanistic model for CaSO4 fouling on nanofltration membrane 显示文摘 | Lin Che-Jen Saqib S Pritesh R | 2005 | J Environ Eng2005，131，： | 1 |
| 18 | Postpartum psychosis in a non-native language-speaking patient: A perspective on language barriers and cultural competency显示文摘SUMMARY Postpartum psychosis is a condition characterised by rapid onset of psychotic symptoms several weeks after childbirth. Outside of its timing and descriptions of psychotic features, minimal research exists due to its relative rarity (1 to 2 per 1000 births in the USA), with greater emphasis on postpartum sadness and depression. With the existi叩 literature, cultural differences and language barriers previously have not been taken into consideration as there are no documented cases of postpartum psychosis in a non-English-speaki叩 patient. Correctly differentiating postpartum psychosis from other postpartum psychiatric disorders requires adeptly evaluating for the presence of psychotic symptoms with in-depth history taking. | Tatsuhiko Naito Justin Chin Jun Lin Pritesh J Shah Christine M Lomiguen | 2019 | General Psychiatry2019，32，3： | 0 |
| 19 | Production and purification of a bioactive substance against multi-drug resistant human pathogens from the marine-sponge-derived Salinispora sp.显示文摘Objective:To isolate,purify,characterize,elucidate structure and evaluate bioactive compounds from the sponge-derived Salinispora sp.FS-0034.Methods:The symbiotic actinomycete strain FS-0034 with an interesting bioactivity profile was isolated from the Fijian marine sponge Theonella sp.Based on colony morphology and obligatory requirement of seawater for growth,and mycelia morphological characteristics the isolate FS-0034 was identified as a Salinispora sp.The bioactive compound was identified by using various spectral analysis of ultraviolet,high resolution electrospray ionization mass spectroscopy,H nuclear magnetic resonance,correlated spectroscopy and heteronuclear multiple bond coherence spectral data.A minimum inhibitory concentration assay were performed to evaluate the biological properties of the pure compound against multi-drug resistant pathogens.Results:Bioassay guided fractionation of the ethyl acetate extract of the culture of Salinispora sp.FS-0034 by different chromatographic methods yielded the isolation of an antibacterial compound,which was identified as rifamycin W(compound 1).Rifamycin W was reported for its potent antibacterial activity against methicillin-resistant Staphylococcus aureus,wild type Staphylococcus aureus and vancomycin-resistant Enterococcus faecium and displayed minimum inhibitory concentrations of 15.62,7.80 and 250.00 μg/mL,respectively.Conclusions:The present study reported the rifamycin W from sponge-associated Salinispora sp.and it exhibited appreciable antibacterial activity against multi-drug resistant human pathogens which indicated that sponge-associated Actinobacteria are significant sources of bioactive metabolites. | Satyendra Singh Pritesh Prasad Ramesh Subramani William Aalbersberg | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，10： | 0 |
| 20 | 越南辞旧迎新显示文摘2021年是对越南充满挑战的一年:新冠肺炎疫情重创之下,该国实施严格的封锁政策,影响经济增长。新冠病毒和供应链中断的持续压力,可能继续影响到2022年。但是,随着越南缓慢重新开放,外国投资者对越南市场保持乐观的前景,预计2022年越南的国内生产总值(GDP)将达到6.5%。 | Pritesh Samuel | 2022 | 进出口经理人2022，，2： | 0 |
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