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| 1 | 救心汤与美托洛尔联用治疗慢性心衰的疗效观察显示文摘目的 观察救心汤与美托洛尔联用治疗慢性心力衰竭的临床疗效及效果分析。方法 选取本院2015年2月至2017年2月收治于心内科的慢性心力衰竭患者共148例,随机分为观察组和对照组,各74例。观察组应用救心汤与美托洛尔联合治疗,对照组应用美托洛尔单独治疗。观察两组患者心功能分级、EF、BNP的变化情况并分析两组疗效。结果 治疗后,观察组患者心功能分级Ⅲ级6.8%、Ⅳ级4.1%均少于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率93.2%,高于对照组60.8%,差异有统计学意义(P<0.05);治疗后,观察组BNP值为(159.44±84.01)pg/ml,显著小于对照组(364.83±91.67)pg/ml;EF值为(54.36±10.11)%,显著大于对照组(41.13±9.83)%,差异有统计学意义(P<0.01)。结论 救心汤与美托洛尔联用治疗慢性心力衰竭具有良好的临床疗效,能够改善慢性心力衰竭症状,增强心脏功能,改善左室收缩障碍,减轻交感神经系统紊乱,值得临床推广。 | 谢春红 武美英 | 2018 | 国际医药卫生导报2018，24，18： | 4 |
| 2 | Simultaneous enantioseparation and simulation studies of atenolol,metoprolol and propranolol on Chiralpak^■IG column using supercritical fluid chromatography显示文摘Enantioseparation of threeβ-blockers,i.e.,atenolol,metoprolol and propranolol,was studied on amylose tris(3-chloro-5-methylphenylcarbamate)immobilized chiral stationary phase using supercritical fluid chromatography(SFC).The effect of organic modifiers(methanol,isopropanol and their mixture),column temperature and back pressure on chiral separation ofβ-blockers was evaluated.Optimum chromatographic separation with respect to resolution,retention,and analysis time was achieved using a mixture of CO_(2) and 0.1%isopropyl amine in isopropanol:methanol(50:50,V/V),in 75:25(V/V)ratio.Under the optimized conditions,the resolution factors(Rs)and separation factors(a)were greater than3.0 and 1.5,respectively.Further,with increase in temperature(25-45℃)and pressure(100-150 bars)there was corresponding decrease in retention factors(k),a and Rs.However,a reverse trend(a and Rs)was observed for atenolol with increase in temperature.The thermodynamic data from van’t Hoff plots revealed that the enantioseparation was enthalpy driven for metoprolol and propranolol while entropy driven for atenolol.To understand the mechanism of chiral recognition and the elution behavior of the enantiomers,molecular docking studies were performed.The binding energies obtained from simulation studies were in good agreement with the elution order found experimentally and also with the free energy values.The method was validated in the concentration range of 0.5-10μg/m L for all the enantiomers.The limit of detection and limit of quantitation ranged from 0.126 to 0.137μg/m L and 0.376-0.414μg/m L,respectively.The method was used successfully to analyze these drugs in pharmaceutical preparations. | Pranav A.Pandya Priyanka A.Shah Pranav S.Shrivastav | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 0 |
| 3 | Selective and rapid determination of raltegravir in human plasma by liquid chromatography–tandem mass spectrometry in the negative ionization mode显示文摘A selective and rapid high-performance liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of raltegravir using raltegravir-d3 as an internal standard(IS). The analyte and IS were extracted with methylene chloride and n-hexane solvent mixture from 100 mL human plasma. The chromatographic separation was achieved on a Chromolith RP-18 e endcapped C18(100 mm 4.6 mm) column in a run time of 2.0 min. Quantitation was performed in the negative ionization mode using the transitions of m/z 443.1-316.1 for raltegravir and m/z 446.1-319.0 for IS. The linearity of the method was established in the concentration range of 2.0–6000 ng/m L.The mean extraction recovery for raltegravir and IS was 92.6% and 91.8%, respectively, and the IS-normalized matrix factors for raltegravir ranged from 0.992 to 0.999. The application of this method was demonstrated by a bioequivalence study on 18 healthy subjects. | Ajay Gupta Swati Guttikar Priyanka A.Shah Gajendra Solanki Pranav S.Shrivastav Mallika Sanyal | 2015 | Journal of Pharmaceutical Analysis2015，5，2： | 0 |
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