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| 1 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 2 | Visual homing for a car-like vehicle显示文摘 | USHER K | 1999 | Kinematics and Dynamics of Multi-Body Systems1999，26，8： | 1 |
| 3 | Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes 显示文摘 | Flier JS Mueckler MM Usher P | 1987 | Science1987，235，： | 1 |
| 4 | On the light variations of seyfert galaxy 3C120显示文摘 | Jurkevich I Usher P D Shen B S P | | 0，，03： | 1 |
| 5 | Application of plastic wrap to improve temperatures in infants born less than 30 weeks gestation:a randomized controlled trial显示文摘 | Smith J Usher K Alcock G | 2013 | Neonatal Netw2013，32，4： | 1 |
| 6 | Gene Expression Profiling of Human Diseases by Serial Analysis of Gene Expression显示文摘 | YES Q USHER D C ZHANG L Q | 2002 | J Biomed Sci2002，9，5： | 1 |
| 7 | Biological invasions of mature reserves: a search for generalizations显示文摘 | USHER M B | 1988 | Biological Conservation1988，44，： | 1 |
| 8 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
| 9 | Toll-like receptor (TLR) 2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaecharide responses 显示文摘 | Sabroe I Jones E C Usher L R | 2002 | The Journal of Immunology2002，168，9： | 1 |
| 10 | Marlex mesh:a new plastic mesh for replacing tissue defects显示文摘 | Usher FC Fries JG Ochsner CL | 1959 | Arch Surg1959，78，1： | 1 |
| 11 | Marine sponges as microbial fermenters 显示文摘 | Hentschel U Usher K M Taylor M W | 2006 | FEMS Microbiology Ecology2006，55，2： | 1 |
| 12 | Malignant fibrous histiocytoma of the retroperitoneum and genitourinary tract: A clinlcopathological correlation and review of the literature显示文摘 | USHER SM BECKLEY S MERRIN CE | 1979 | J Urol1979，122，： | 1 |
| 13 | A Global Survey of University Ranking and League Tables 显示文摘 | USHER A SAVINOM | 2007 | Higher Education in Europe2007，32，1： | 1 |
| 14 | Robust trajectory tracking for a revers?ing tractor trailer 显示文摘 | PRADALIER C USHER K | 2008 | Journal of Field Robotics2008，25，6： | 1 |
| 15 | The changing pattern of fetal death,1961-1988显示文摘 | Fretts RC Boyd ME Usher RH | 1992 | Obstet Gynecol1992，79，： | 1 |
| 16 | Insurance and liability for the engineering profession in Western Australia显示文摘 | Richard Usher | | Western Australia Division0，，： | 1 |
| 17 | Heterogeneous uptake of sulfur dioxide on aluminum and magnesium oxide particles显示文摘 | Goodman A L Li P Usher C R | 2001 | Journal of Physical Chemistry A2001，105，25： | 1 |
| 18 | Maximum Likelihood Analysis of Component Reliability Using Masked System Life Data显示文摘 | Usher J S Hodgson T J | 1988 | IEEE Transactins on Reliability1988，37，5： | 1 |
| 19 | A comparables approach to measuring cash flow-at-risk for non-financial firms显示文摘 | Stein J Usher S E La G Youngen J | | 0，，4： | 1 |
| 20 | Impact of sex on the survival of patients with hepatocellular carcinoma: A Surveillance, Epidemiology, and End Results analysis显示文摘 | Dongyun Yang Diana L. Hanna Josh Usher Jordan LoCoco Pritesh Chaudhari Heinz‐Josef Lenz V. Wendy Setiawan Anthony El‐Khoueiry | 2014 | Cancer2014，，23： | 1 |
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