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| 1 | Hepatitis B vaccine in celiac disease:Yesterday,today and tomorrow显示文摘Some studies showed that in celiac patients the immunological response to vaccination is similar to that one found in general population except for vaccine against hepatitis B virus (HBV).The non-responsiveness to HBV vaccine has also been described in healthy people,nevertheless the number of non-responders has been demonstrated to be higher in celiac disease (CD) patients than in healthy controls.Several hypothesis explaining this higher rate of unresponsiveness to HBV vaccine in CD patients have been described,such as the genetic hypothesis,according with CD patients carrying the disease-specific haplotype HLA-B8,DR3,and DQ2,show a lower response to HBV vaccine both in clinical expressed CD patients and in healthy people carrying the same haplotype.On the other hand,it has been demonstrated that the gluten intake during the vaccination seems to influence the response to the same vaccine.Moreover,it has been demonstrated a possible genetic predisposition to hepatitis B vaccine nonresponsiveness likely due to the presence of specific human leukocyte antigen haplotypes and specific single nucleotide polymorphism in genes of cytokine/cytokinereceptors and toll like receptors,but the pathogenic mechanism responsible for this low responsiveness still remains unclear.The aim of this review is to focus on the possible pathogenic causes of unresponsiveness to HBV vaccine in CD patients and to propose an alternative vaccination schedule in order to improve the responsiveness to HBV vaccine in this at-risk patients. | Giovanna Vitaliti Andrea Domenico Praticò Carla Cimino Giovanna Di Dio Elena Lionetti Mario La Rosa Salvatore Leonardi | 2013 | World Journal of Gastroenterology2013，19，6： | 3 |
| 2 | Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children显示文摘AIM:To compare intradermal(ID) and intramuscular(IM) booster doses,which have been used in healthy and high risk subjects,such as healthcare workers,haemodialysis patients,human immunodeficiency virus patients,and renal transplant recipients unresponsive to initial hepatitis B vaccination,in celiac individuals.METHODS:We conducted our study on 58 celiac patients,vaccinated in the first year of life,whose blood analysis had showed the absence of protective hepatitis B virus(HBV) antibodies.All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year.In all patients we randomly performed an HBV vaccine booster dose by ID or IM route.Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine(Engerix B) 2 g by the ID route,while 28 celiac patients were revaccinated with Engerix B 10 g by the IM route.Four weeks after every booster dose,the anti-hepatitis B surface(HBs) antibody titer was measured by an enzyme-linked immuneadsorbent assay.We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose.The cut off value for a negative anti-HBs antibody titer was 10 IU/L.Patients with values between 10 and 100 IU/L were considered 'low responders' while patients with an antibody titer higher than 1000 IU/L were considered 'high responders'.RESULTS:No significant difference in age,gender,duration of illness,and years of gluten intake was found between the two groups.We found a high percentage of 'responders' after the first booster dose(ID = 76.7%,IM = 78.6%) and a greater increase after the third dose(ID = 90%,IM = 96.4%) of vaccine in both groups.Moreover we found a significantly higher number of high responders(with an anti-HBs antibody titer > 1000 IU/L) in the ID(40%) than in the IM(7.1%) group,and this difference was evident after the first booster dose of vaccination(P < 0.01).No side effects were recorded in performing delivery of the vaccine by either the ID or IM route.CONCLUSION:Our study suggests that both ID and IM routes are effective and safe options to administer a booster dose of HBV vaccine in celiac patients.However the ID route seems to achieve a greater number of high responders and to have a better cost/benefit ratio. | Salvatore Leonardi Andrea Domenico Praticò Elena Lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa | 2012 | World Journal of Gastroenterology2012，18，40： | 2 |
| 3 | Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis显示文摘AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were enrolled.They underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of treatment.Each patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 mo.Two endoscopists evaluated in a blinded manner the number and size of duodenal polyps.Upper GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman score.Polyps>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and T2.The examined area was divided into 3 segments:duodenal bulb,second and third portion duodenum.Biopsy specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular pattern.Histology was classified according to the updated Vienna criteria.RESULTS:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was 7.1.After polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was 6.4.After 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal polyps.The mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was 6.6.Interrater agreement was measured.Lesions>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in the duodenal mucosa,resulted effective in reducing polyps number of 32%and size of 51%. | Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia Lorenzo Gentilini Gilberto Poggioli Paolo Gionchetti Massimo Campieri Fernando Rizzello | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 4 | Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium显示文摘 | C. Praticò D. Quattrone T. Lucanto A. Amato O. Penna C. Roscitano V. Fodale | 2005 | Medical Hypotheses2005，，5： | 2 |
| 5 | Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study显示文摘 | Paolo Salvi Raffaele Ruffini Davide Agnoletti Elena Magnani Gabriele Pagliarani Giulia Comandini Antonino Praticò Claudio Borghi Athanase Benetos Paolo Pazzi | 2010 | Journal of Hypertension2010，，8： | 1 |
| 6 | Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy:lights and shadows显示文摘 | Pratic D | 2008 | Ann N Y AcadSci2008，1147，： | 1 |
| 7 | Is hyperhomocysteinemia an Alzheimer' s disease (AD) risk factor, an AD marker, or neither? 显示文摘 | Zhuo JM Wang H Praticò D | 2011 | Trends Pharmacol Sci2011，32，9： | 1 |
| 8 | Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice显示文摘 | Praticò D Tillmann C Zhang ZB | | 0，，： | 1 |
| 9 | Permanent Scatterers in SAR Interferometry显示文摘 | Ferretti A PratiC Rocca F | 2001 | IEEE Transactions on Geoscienceand Remote Sensing2001，39，1： | 1 |
| 10 | The 5-1ipoxygenase enzymatic pathway in the mouse brain: young versus old显示文摘 | Chinnici CM Yao Y Pratic 1) | 2007 | Neurobiol Aging2007，28，： | 1 |
| 11 | Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice显示文摘 | Praticò D Uryu K Sung S | 2002 | FASEB J2002，16，11： | 1 |
| 12 | Prevention and Control of Influenza显示文摘 | Recommendations of the Advisory Committee on Immunization pratices (ACIP) | 2002 | Morbidity and Mortality Weekly Report(MMWR)2002，51，03： | 1 |
| 13 | Evidence of oxidative stress in Alzheimer′s disease brain and antioxidant therapy:lights and shadows显示文摘 | Praticò D | 2008 | Ann N Y Acad Sci2008，1147，1： | 1 |
| 14 | Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium显示文摘 | Praticò D Quattrone T Lucanto A | 2005 | Med Hypotheses2005，，5： | 1 |
| 15 | Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium显示文摘 | Praticò C Quattrone D Lucanto T | | 0，，： | 1 |
| 16 | Effect of low-dose aspirin on vascular inflammation,plaque stability,and atherogenesis in low-density lipoprotein receptor-deficient mice显示文摘 | Cyrus T Sung S Zhao L Funk CD Tang S Praticò D | 2002 | Circulation2002，106，10： | 1 |
| 17 | Modulation of monocyte-endothelial cel interactions by platelet microparticles显示文摘 | Barry OP Praticò D Savani RC | | 0，，01： | 1 |
| 18 | Deletion of the High-Density Lipoprotein Receptor Scavenger Receptor BI in Mice Modulates Thrombosis Susceptibility and Indirectly Affects Platelet Function by Elevation of Plasma Free Cholesterol显示文摘 | Suzanne J.A. Korporaal Illiana Meurs Arnaud D. Hauer Reeni B. Hildebrand Menno Hoekstra Hugo Ten Cate Domenico Praticò Jan-Willem N. Akkerman Theo J.C. Van Berkel Johan Kuiper Miranda Van Eck | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，1： | 1 |
| 19 | The 5-lipoxygenase enzymatic pathway in the mouse brain:young versus old显示文摘 | Chinnici CM Yao Y Praticò D | 2007 | Neurobiol Aging2007，28，9： | 1 |
| 20 | Drug of anesthesia acting on central cholinergic system may cause post-operative dysfunction and delirium显示文摘 | Praticò C Quattrone D Lucanto T | 2005 | Med Hypotheses2005，65，5： | 1 |
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