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| 1 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 2 | The interferon inducing pathways and the hepatitis C virus显示文摘The innate immune response is triggered by a variety of pathogens, including viruses, and requires rapid induction of typeⅠ?interferons (IFN), such as IFNβ and IFNα. IFN induction occurs when specific pathogen motifs bind to specific cellular receptors. In non-professional immune, virally-infected cells, IFN induction is essentially initiated after the binding of dsRNA structures to TLR3 receptors or to intracytosolic RNA helicases, such as RIG-Ⅰ/MDA5. This leads to the recruitment of specific adaptors, such as TRIF for TLR3 and the mitochondrial-associated IPS-1/VISA/MAVS/CARDIF adapter protein for the RNA helicases, and the ultimate recruitment of kinases, such as MAPKs, the canonical IKK complex and the TBK1/IKKε kinases, which activate the transcription factors ATF-2/ c-jun, NF-κB and IRF3, respectively. The coordinated action of these transcription factors leads to induction of IFN and of pro-inflammatory cytokines and to the establishment of the innate immune response. HCV can cleave both the adapters TRIF and IPS-1/VISA/MAVS/ CARDIF through the action of its NS3/4A protease. This provokes abrogation of the induction of the IFN and cytokine pathways and favours viral propagation and presumably HCV chronic infection. | Eliane F Meurs Adrien Breiman | 2007 | World Journal of Gastroenterology2007，13，17： | 8 |
| 3 | Embankment Widening with the Gap-method 显示文摘 | A N G Van Meurs A Van Den Berg et | 1999 | Rotterdam:Geotechnical Engineering for Transportation Infrastructure1999，，： | 2 |
| 4 | Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness 显示文摘 | Meurs H Maarsingh H Zaagsma J | 2003 | Trends Pharmacol Sci2003，24，9： | 1 |
| 5 | Inhaled nitric oxide for premature infants with severe respiratory failure显示文摘 | Van Meurs KP Wright LL Ehrenkranz RA | 2005 | N Engl J Med2005，353，1： | 1 |
| 6 | Specialization scenarios: A pragmatic approach to declaring program specialization 显示文摘 | Anne-Francoise Le Meur Julia L Lawall Charles Consel | 2004 | Higher-order and Symbolic Computation2004，17，12： | 1 |
| 7 | dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection显示文摘 | Dabo S Meurs EF | 2012 | Viruses2012，4，： | 1 |
| 8 | The Effects of Person–Organization Ethical Fit on Employee Attraction and Retention: Towards a Testable Explanatory Model显示文摘 | David A. Coldwell Jon Billsberry Nathalie Meurs Philip J. G. Marsh | 2008 | Journal of Business Ethics2008，，4： | 1 |
| 9 | Liver-brain proinflammatory signalling in acute liver failure: Role in the pathogenesis of hepatic encephalopathy and brain edema显示文摘 | Chantal Bémeur Roger F. Butterworth | 2013 | Metabolic Brain Disease2013，，2： | 1 |
| 10 | The incidence of endometrial hypcrplasia and cancer in 1031 patients with a gran- ulosa cell tumor of the ovary :long - term follow - up in a population - based cohort study 显示文摘 | van Meurs HS Bleeker MC van der Velden J | 2013 | Int J Gynecol Cancer2013，23，8： | 1 |
| 11 | Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic 显示文摘 | Rosker C Meur G Taylor EJ | 2009 | J Biol Chem2009，284，8： | 1 |
| 12 | Polyethylene chain growth on zinc catalyzed by olefin polymerization catalysts: a comparative investigation of highly active catalyst systems across the transition series显示文摘 | Meurs M V Britovsek G J P Gibson V C | 2005 | J Am Chem Soc2005，127，27： | 1 |
| 13 | Treatment evolution in high-risk congenital diaphragmatic hernia:Ten years'experience with diaphragmatic agenesis显示文摘 | Lally KP Lally PA Van Meurs KP | 2006 | Ann Surg2006，244，4： | 1 |
| 14 | Cytokines in vitreous humor:interleukin-6 is elevated in proliferative vitreoretinopathy显示文摘 | Kauffmann DJ van Meurs JC Mertens DA | 1994 | Invest Ophthalmol Vis Sci1994，35，3： | 1 |
| 15 | The dsRNA protein kinase PKR: virus and cell control显示文摘 | Garcla MA Meurs EF Esteban M | 2007 | Biochimie2007，89，： | 1 |
| 16 | Venoarterial versus venovenousECMO for neonatal respiratory failure 显示文摘 | Rais-Bahrami K Van Meurs KP | 2014 | Semin Perinatol2014，38，2： | 1 |
| 17 | Familial subvalvular aortic stenosis in golden retrievers:inheritance and echocardiographic findings显示文摘 | Stern JA Meurs KM Nelson OL | 2012 | J Small Anim Pract2012，53，4： | 1 |
| 18 | A comparision of traditional textbook and interactive computer learning of neuromuscular block显示文摘 | Ohm MA Van Oostrom JH Van Meurs WL | 1997 | Anesth Analg1997，84，3： | 1 |
| 19 | Genetics and biology of vitamin D receptor polymorphisms显示文摘 | Uitterlinden AG Fang Y Van Meurs JB | 2004 | Gene2004，338，： | 1 |
| 20 | Genetics and biology of vitamin D receptor polymorphisms显示文摘 | Uitterlinden AG Fang Y Van Meurs JB | 2004 | Gene2004，338，2： | 1 |
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