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| 1 | Diagnostic and therapeutic potential of exosomal miRNAs in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a primary cause of dementia.AD is a neurodegenerative disorder,characterized by synapses loss,extracellular amyloid plaques composed of the amyloid-βpeptide(Aβ)and intracellular aggregates of hyperphosphorylated tau protein.AD is a complex disease linked to multiple interacting factors,both environmental and genetic,which can contribute to the onset and severity of the disease.Longitudinal studies have highlighted several cardiovascular risk factors that can increase the risk of AD.The genetic landscape of AD has changed dramatically in recent decades.Early studies identified mutations in the amyloid precursor protein gene(APP)as well as proteins that are involved in the enzymatic cleavage of APP to toxicβ-amyloid(Aβ),namely presenilin-1 and presnilin-2.However,these mutations were found in familial cases of early-onset AD,while the causes of sporadic late-onset AD are still unknown.The latest advances in Genomewide Association Studies(GWAS),sequencing,and bioinformatics have begun to unravel the complex genetic architecture of the sporadic form of AD.GWAS were able to uncover common variants with high frequency in the population that individually carried low risk(Robinson et al.,2017).The advent of next-generation and thirdgeneration sequencing platforms shows great promise in further unravelling the genetics of AD. | Ida Manna Selene De Benedittis Enrico Iaccino Andrea Quattrone Aldo Quattrone | 2021 | Neural Regeneration Research2021，16，11： | 3 |
| 2 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 3 | Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium显示文摘 | C. Praticò D. Quattrone T. Lucanto A. Amato O. Penna C. Roscitano V. Fodale | 2005 | Medical Hypotheses2005，，5： | 2 |
| 4 | Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium 显示文摘 | Pratico C Quattrone D Lucanto T | 2005 | Med Hypothese2005，65，5： | 1 |
| 5 | Sleep-induced masticatory myoclonus: a rare parasomnia associated with insomnia 显示文摘 | Aguglia U Gambardella A Quattrone A | 1991 | Sleep1991，14，： | 1 |
| 6 | Exploitation of semantic relationships and hierarchical data struc- tures to support a user in his annotation and browsing activities in folksonomies 显示文摘 | MEO P D QUATTRONE G URSINO D | 2009 | Information Systems2009，34，6： | 1 |
| 7 | Progonostic factors in micro- invasive cervical squamous cell cancer:long-term results显示文摘 | Raspagliesi F Ditto A Quattrone P | 2005 | Int J Gy- necol Cancer2005，15，1： | 1 |
| 8 | Alzheimer's disease and anesthesia: implications for the central cholinergic system 显示文摘 | Fodale V Quattrone D Trecroci C | 2006 | BJA2006，97，4： | 1 |
| 9 | Prognostic factors in microinvasive cervical squamous cell cancer:long-term results显示文摘 | Raspagliesi F Ditto A Quattrone P | 2005 | Gynecol Cancer2005，15，： | 1 |
| 10 | Relaxin depresses small bowel motility through a nitric oxide-mediated mechanism:Studies in mice显示文摘 | Bani D Baccari MC Quattrone S | 2002 | Biol Reprod2002，66，3： | 1 |
| 11 | Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture显示文摘 | Quattrone S Chiappini L Scapagnini G | 2004 | Mol Hum Reprod2004，10，5： | 1 |
| 12 | Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment:preliminary experience显示文摘 | Gelmini S Quattrone S Malentacchi F et a1 | | 0，，07： | 1 |
| 13 | Integration of the HL7 standard in a multiagent system to support personal- ized access to e-health services 显示文摘 | DE MEO P QUATTRONE G URSINO D | 2011 | IEEE Trans Knowl Data Eng2011，23，8： | 1 |
| 14 | Durgs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium显示文摘 | Pretico C Quattrone D Lucanto T | 2005 | Med Hypothese2005，65，5： | 1 |
| 15 | Hippocampal sclerosis worsens autosomal dominant nocturnal frontal lobe epilepsy ( ADNFLE ) phenotype related to CHRNB2 mutation显示文摘 | A. Labate L. Mumoli A. Fratto A. Quattrone A. Gambardella | 2012 | Eur J Neurol2012，，3： | 1 |
| 16 | Drugs of anesthesia acting on central cholinergic system may cause postoperative cognitive dysfunction and delirium显示文摘 | Pratico C Quattrone D Lucanto T | 2005 | Med Hypothese2005，65，5： | 1 |
| 17 | What does organizational change mean? Speculations on a taken for granted category 显示文摘 | Quattrone P Hopper T | 2001 | Management Accounting Research2001，12，4： | 1 |
| 18 | Cutaneous ulcers associated with hydroxyurea therapy显示文摘 | Quattrone F Dini V Barbanera S | 2013 | J Tissue Viability2013，22，4： | 1 |
| 19 | Reversion of the invasive phenotype of transformed human fibroblasts by antbmessenger oligonucleotide inhibition of urokinase receptor gene expression显示文摘 | Fibbi G Anichini E | 1995 | Cancer Res1995，55，1： | 1 |
| 20 | Drugs of anesthesia acting on central cholinergic system may cause post operative cognitive dysfunction and delirium显示文摘 | Pratico C Quattrone D Lucanto T | 2005 | Med Hypotheses2005，65，5： | 1 |
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