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| 1 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 2 | High frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in preterm neonates with hyaline membrane disease: A randomized controlled trial显示文摘 | S. Singh G. Malik G. Prashanth Anita Singh Mala Kumar | 2012 | Indian Pediatrics2012，，5： | 3 |
| 3 | Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain显示文摘Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that limit the pathological changes and improve the behavioral outcome have been well explained in different experimental models of neuropathy but translation of such strategies to clinics has been disappointing. Experimental evidences revealed the role of free radicals, especially peroxynitrite after the nerve injury. They provoke oxidative DNA damage and consequent over-activation of the poly(ADP-ribose) polymerase(PARP) upregulates pro-inflammatory pathways, causing bioenergetic crisis and neuronal death. Along with these changes, it causes mitochondrial dysfunction leading to neuronal apoptosis. In related preclinical studies agents that neutralize the free radicals and pharmacological inhibitors of PARP have shown benefits in treating experimental neuropathy. This article reviews the involvement of PARP over-activation in trauma induced neuropathy and therapeutic significance of PARP inhibitors in the experimental neuropathy and neuropathic pain. | Prashanth Komirishetty Aparna Areti Ranadeep Gogoi Ramakrishna Sistla Ashutosh Kumar | 2016 | Neural Regeneration Research2016，11，10： | 2 |
| 4 | Ther- mal and electrical properties of rare-earth co-doped ceria ce- ramics 显示文摘 | Prashanth Kumar V Reddy Y S Kistaiah P | 2008 | Mater Chem Phys2008，112，2： | 1 |
| 5 | Secondary electron yield measurements from materials with application to collectors of high-power microwave devices显示文摘 | Zameroski N D Prashanth Kumar Christopher Watts | 2006 | IEEE Trans Plasma Sci2006，34，3： | 1 |
| 6 | Malignant infantile osteopetrosis 显示文摘 | Kumar KJ Bandaru K Prashanth SN | 2013 | Indian J Hum Genet2013，19，1： | 1 |
| 7 | Dento - alveolar distraction osteogenesis for rapid Orthodontic canine retraction 显示文摘 | Kumar N Prashanthe GS Raikar S | 2013 | J Int Oral Health2013，5，6： | 1 |
| 8 | The Role of Endorectal Ultrasound and Magnetic Resonance Imaging in the Management of Early Rectal Lesions in a Tertiary Center显示文摘 | Rikesh Kumar Patel Adele Elizabeth Sayers Prashanth Kumar Sam Khulusi Abdul Razack Iain Andrew Hunter | 2014 | Clinical Colorectal Cancer2014，，： | 1 |
| 9 | Investigations of the effects of particle morphology on granular material behaviors using a multi-sphere approach显示文摘This article studies the influences of particle morphology on the behaviors of granular materials at both macroscopic and microscopic levels based on the discrete element method(DEM).A set of numerical tests under drained triaxial compression was performed by controlling two morphological descriptors,i.e.ratio of the smallest to the largest pebble diameter,x,and the maximum pebbleepebble intersection angle,b.These descriptors are vital in generating particle geometry and surface textures.It was found that the stress responses of all assemblies exhibited similar behavior and showed post-peak strainsoftening.The normalized stress ratio and volumetric strains flatten off and tended to reach a steady value after an axial strain of 40%.While the friction angles at peak state varied with different morphological descriptors,the friction angles at critical state showed no significant variation.Moreover,evolution of the average coordination numbers showed a dramatic exponential decay until an axial strain of about 15%after which it stabilized and was unaffected by further increase of axial strain.In addition,stress ratio q/p and strong fabric parameter fs d=fs m were found to follow an approximately linear relationship for each assembly.These findings emphasized the significance of the influences of particle morphology on the macroscopic and microscopic responses of granular materials. | Shiva Prashanth Kumar Kodicherla Guobin Gong Lei Fan Stephen Wilkinson Charles K.S.Moy | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，6： | 1 |
| 10 | Malignant infantile ostcope- trosis显示文摘 | Kumar KJ Bandaru K Prashanth SN | 2013 | Indian J Hum Genet2013，19，1： | 1 |
| 11 | Discrete element modelling of strength and critical state characteristics of granular materials under axial compression and axial extension stress path tests显示文摘The critical state soil mechanics(CSSM)framework has been widely used across a range of problems in geomechanics involving complex loading conditions.However,the uniqueness of the critical state has been disputed for many years and it remains a controversial issue.Motivated by previous investigations,a series of discrete element method(DEM)simulations were performed under both axial compression(AC)and axial extension(AE)stress paths.All samples were isotropically compressed at varying mean normal effective stresses(confining pressures)and sheared to a large axial strain of approximately 60%.It is found that there exist unique values of critical void ratios and stress ratios under critical state,which are independent of the samples’initial packings but dependent on stress paths.And the critical strength(stress ratio)for the AC stress path tests is higher than that for the AE stress path.The critical state lines(CSLs)are found to path-dependent but unique for each stress path.A unique linear relationship between the critical coordination numbers and critical void ratios is identified under the AC and AE stress paths respectively,but such a relationship depends on the stress paths.It is also found that there exist unique values of microscopic parameters in terms of deviator fabric under critical state,which are independent of the samples’initial packings but dependent on stress paths.All these simulation results lead to the conclusion of non-uniqueness of CSLs from both macroscopic and microscopic viewpoints. | Shiva Prashanth Kumar Kodicherla Guobin Gong Lei Fan Stephen Wilkinson Charles K.S.Moy | 2021 | Particuology2021，19，3： | 1 |
| 12 | Malignant infantile osteopetrosis显示文摘 | Kumar KJ Bandaru K Prashanth SN | 2013 | Indian J Hum Genet2013，19，1： | 1 |
| 13 | The Utility of Second Look Microlaryngoscopy after Trans Oral Laser Resection of Laryngeal Cancer显示文摘 | Ashok Shenoy V. Prashanth T. Shivakumar Purushottam Chavan S. Akshay Rekha Kumar Saraswati Devi | 2012 | Indian Journal of Otolaryngology and Head & Neck Surgery2012，，2： | 1 |
| 14 | Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro显示文摘 | PRASHANTH K V SHASHIDHARA S KUMAR M M | 2001 | Fitoterapia2001，72，5： | 1 |
| 15 | Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis显示文摘 | Oury Franck Ferron Mathieu Huizhen Wang Confavreux Cyrille Xu Lin Lacombe Julie Srinivas Prashanth Chamouni Alexandre Lugani Francesca Lejeune Herve Kumar T Rajendra Plotton Ingrid Karsenty Gerard | 2013 | Journal of Clinical Investigation2013，，6： | 1 |
| 16 | A comparative study of post-traumatic stress disorderl anxiety, depression and change in sexual functioning of patients with facial injuries and patients with extremity injuries 显示文摘 | Prashanth NT Raghuveer HP Kumar D | 2015 | J Contemp Dent Pract2015，16，11： | 1 |
| 17 | Cytoprotective role of Solanum nigrum against gentamicin- induced kidney cell ( vero cells ) damage in vitro 显示文摘 | Prashanth K V Shashidhara S Kumar M M | 2001 | Fitoterapia2001，72，5： | 1 |
| 18 | Optical and photocatalytic properties of solar light active Nd-substituted Ni ferrite catalysts: For environmental pro- tection显示文摘 | Harish K N Bhojya Naik H S Prashanth kumar P N | 2013 | ACS Sustain Chem Eng2013，1，9： | 1 |
| 19 | Superiorly based perforator plus fl ap for inguinal defects显示文摘Aim:Inguinal block dissections for metastasis to inguinal lymph nodes and occasionally trauma are always associated with soft tissue loss over the groin region.A clinical study was undertaken to demonstrate the ability to utilize a superiorly-based perforatorflap with reliable vascularity and less donor site morbidity to cover defects in the inguinal region.Methods:A prospective study was performed on 7 patients with inguinal soft tissue defects managed in our institution from January 2013 to September 2013.During the study period,a“superiorly-based perforator plusflap”was used for soft tissue coverage over the femoral vessels in the inguinal region.Hyperbaric oxygen therapy was administered postoperatively.The postoperative period,hospital course,and follow-up after radiotherapy was documented in patients with inguinal block dissection.Results:Seven patients presented with soft tissue defects in the inguinal region.Five of the defects were secondary to prior surgery,and 2 were secondary to trauma.A superiorly-based perforator plusflap was performed in all patients.The defect sizes ranged from 9 cm×4 cm to 17 cm×8 cm.Theflap dimensions ranged from 12 cm×5 cm to 20 cm×10 cm.No secondary procedures were necessary following surgery.Postoperatively,there was no evidence of partial or totalflap loss.Noflap revisions were required,and no complications were experienced at either the donor or recipient site following radiotherapy.Patients were followed-up for 10-18 months.Conclusion:Inguinal defects require stable soft tissue coverage to withstand radiotherapy following inguinal block dissection surgery,and are susceptible to wound complications.The superiorly-based perforator plusflap technique is simple,requires little operative time,and is a reliableflap for coverage of the femoral vessels and inguinal region with improved tolerance to postoperative radiotherapy. | Pradeoth Mukundan Korambayil Prashanth Varkey Ambookan Vinoth Kumar Dilliraj | 2014 | Plastic and Aesthetic Research2014，1，1： | 0 |
| 20 | DEM simulations of critical state behaviour of granular materials under various drained triaxial stress path tests显示文摘The present study investigates the critical state behaviour of granular assemblies composed of clumped particles under four different drained axisymmetric triaxial stress paths,using the discrete element method(DEM).A series of numerical samples were prepared at initial states with different density indexes(1D)and different initial confining pressures(ρ′0).These samples were sheared to large strains,at which constant stresses and volumes were maintained to reach the critical state.The evolution of stress ratio under the same loading mode(for the same intermediate principal stress ratio,b)is shown to yield an almost identical behaviour independent of stress paths,whereas the stress-strain response depends on the stress paths.Four different axisymmetric stress paths all share the same unique friction angle at critical state,indicating the Mohr-Coulomb failure criterion is the appropriate critical state strength criterion,which is at least true for the axisymmetric stress conditions.A unique coordination number(CN)is achieved at the critical state for a given po,which is independent of the stress path.The critical state CN is found to increase with the increase in po,which could be attributed to the decrease in the critical state void ratio(ec)as mean effective stress(ρ′0)increases.Interestingly,a unique linear functional relationship is found between the critical state values of cN and ec,and a unique polynomial functional relationship is found between the critical state values of CN andρ′.These functional relationships indicate no dependency on the stress paths or loading modes,thus characterizing unique features at critical states at both macroscopic and microscopic levels for a given type of granular material. | Shiva Prashanth Kumar Kodicherla Guobin Gong Stephen Wilkinson | 2023 | Particuology2023，，10： | 0 |
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