|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A randomized controlled trial of omega-3 fatty acids in dry eye syndrome显示文摘AIM:To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye syndrome.METHODS:A prospective,interventional,placebo controlled,double blind randomized trial was done at two referral eye centers.Two hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule(500mg)two times a day containing 325mg EPA and 175mg DHA for 3 months(omega-3 group).The omega-3 group was compared to a group of patients(n=254)who received a placebo(placebo group).There were 4 patient visits(at baseline,1 month,2 months and3 months).On each visit,recording of corrected distance visual acuity(CDVA),slit lamp examination and questionnaire based symptom evaluation and scoring was done.A symptomatic score of 0-6 was mild,6.1-12moderate and 12.1-18 severe dry eye.Response to intervention was monitored by routine tear function tests like Schirmer I test,tear film break-up time(TBUT),Rose Bengal staining and most notably,conjunctival impression cytology.RESULTS:Sixty-five percent of patients in the omega-3group and 33%of patients in placebo group had significant improvement in symptoms at 3 months(P=0.005).There was a significant change in both Schirmer's test value and TBUT values in the omega-3group(P<0.001),both comparisons.However,there was a larger drift in TBUT values in omega-3 than the placebo group,in comparison to Schirmer's test values.The mean TBUT score was 2.54±2.34 in the omega-3group and 0.13±0.16 in placebo group,respectively.The mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebogroup(P<0.001).Despite a slight increase mean score,the Schirmer scores did not correlate well with symptomatic improvement.CONCLUSION:Omega-3 fatty acids have a definite role for dry eye syndrome.The benefit seems to be more marked in conditions such as blepharitis and meibomian gland disease.The role of omega fatty acids in tear production and secretion needs further evaluation. | Rahul Bhargava Prachi Kumar Manjushrii Kumar Namrata Mehra Anurag Mishra | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 14 |
| 2 | Phacoemulsification versus small incision cataract surgery in patients with uveitis显示文摘AIM: To compare the safety and efficacy of phacoemulsification and small incision cataract surgery(SICS) in patients with uveitic cataract.·METHODS: In a prospective, randomized multi-centric study, consecutive patients with uveitic cataract were randomized to receive phacoemulsification or manual SICS by either of two surgeons well versed with both the techniques. A minimum inflammation free period of 3mo(defined as less than 5 cells per high power field in anterior chamber) was a pre-requisite for eligibility for surgery. Superior scleral tunnel incisions were used for both techniques. Improvement in visual acuity post-operatively was the primary outcome measure and the rate of post-operative complications and surgical time were secondary outcome measures, respectively. Means of groups were compared using t-tests. One way analysis of variance(ANOVA) was used when there were more than two groups. Chi-square tests were used for proportions. Kaplan Meyer survival analysis was done and means for survival time was estimated at 95%confidence interval(CI). A P value of <0.05 was considered statistically significant.·RESULTS: One hundred and twenty-six of 139 patients(90.6%) completed the 6-month follow-up. Seven patients were lost in follow up and another six excluded due to either follow-up less than six months(n=1) or inability implant an intraocular lens(IOL) because of insufficient capsular support following posterior capsule rupture(n=5). There was significant improvement in vision after both the procedures(paired t-test; P <0.001). On first postoperative day, uncorrected distance visual acuity(UDVA) was 20/63 or better in 31(47%)patients in Phaco group and 26(43.3%) patients in SICS group(P=0.384). The mean surgically inducedastigmatism(SIA) was 0.86 ±0.34 dioptres(D) in the phacoemulsification group and 1.16 ±0.28 D in SICS group. The difference between the groups was significant(t-test, P =0.002). At 6mo, corrected distance visual acuity(CDVA) was 20/60 or better in 60(90.9%) patients in Phaco group and 53(88.3%) in the manual SICS group(P =0.478). The mean surgical time was significantly shorter in the manual SICS group(10.8±2.9 versus 13.2±2.6min)(P <0.001). Oral prednisolone, 1 mg/kg body weight was given 7d prior to surgery, continued post-operatively and tapered according to the inflammatory response over 4-6wk in patients with previously documented macular edema, recurrent uveitis, chronic anterior uveitis and intermediate uveitis. Rate of complications like macular edema(Chi-square, P =0.459),persistent uveitis(Chi-square, P =0.289) and posterior capsule opacification(Chi-square, P =0.474) were comparable between both the groups.·CONCLUSION: Manual SICS and phacoemulsification do not differ significantly in complication rates and final CDVA outcomes. However, manual SICS is significantly faster. It may be the preferred technique in settings where surgical volume is high and access to phacoemulsification is limited, such as in eye camps. It may also be the appropriate technique for uveitic cataract under such circumstances. | Rahul Bhargava Prachi Kumar Shiv Kumar Sharma Manoj Kumar Avinash Kaur | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 8 |
| 3 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 4 | Understanding peroral absorption:regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles显示文摘Oral drug absorption is a process influenced by the physicochemical and biopharmaceutical properties of the drug and its inter-relationship with the gastrointestinal tract. Drug solubility, dissolution and permeability across intestinal barrier are the key parameters controlling absorption. This review provides an overview of the factors that affect drug absorption and the classification of a drug on the basis of solubility and permeability. The biopharmaceutical classification system(BCS) was introduced in early90's and is a regulatory tool used to predict bioavailability problems associated with a new entity, thereby helping in the development of a drug product. Strategies to combat solubility and permeability issues are also discussed. | Prachi B.Shekhawat Varsha B.Pokharkar | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 4 |
| 5 | Antidiabetic activity of 50% ethanolic extract of Ricinus communis and its purified fractions显示文摘 | Poonam Shokeen Prachi Anand Y. Krishna Murali Vibha Tandon | 2008 | Food and Chemical Toxicology2008，，11： | 3 |
| 6 | Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma显示文摘AIM To investigate the effect of lycopene extracted from tomatoes(LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine(NDEA)-induced hepatocarcinogenesis. METHODS Female BALB/c mice were randomly divided into four groups: The Control, NDEA(200 mg NDEA/kg b.w. given i.p.), LycT(5 mg/kg b.w. given orally on alternate days) and Lyc T + NDEA group. The m RNA and protein expression of various cell proliferation markers(PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively. The ultrastructure of hepatic tissue was analyzed using scanning and transmission electron microscopy. The enzymatic activity of glycolytic enzymes was estimated using standardized protocols, while glucose-6-phosphate dehydrogenase activity level was estimated using a kit obtained from Reckon Diagnostic P. Ltd.(India). RESULTS Uncontrolled proliferation in the liver of NDEA(P ≤ 0.001) mice was evident from the high expression of cell-proliferation associated genes(PCNA, Cyclin D1, and p21) when compared to control and Lyc T mice. In addition, enhanced activities of hexokinase, phosphoglucoisomerase, aldolase, glucose-6-phosphatedehydrogenase and hypoxia-inducible factor-1α were observed in NDEA mice as compared to control(P ≤ 0.001) and Lyc T(P ≤ 0.001) mice. The alterations in hepatic ultrastructure observed in the NDEA group correlated with the changes in the above parameters. Lyc T pre-treatment in NDEA-challenged mice ameliorated the investigated pathways disrupted by NDEA treatment. Moreover, hepatic electron micrographs from the Lyc T + NDEA group showed increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma(HCC) in comparison to undifferentiated HCC as observed in the NDEA treated group. CONCLUSION This study demonstrates that dietary supplementation with Lyc T has a multidimensional role in preventing HCC development. | Prachi Gupta Nisha Bhatia Mohinder Pal Bansal Ashwani Koul | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 7 | Feasibility of Grid-connected Solar-wind Hybrid System with Electric Vehicle Charging Station显示文摘Recently,renewable power generation and electric vehicles(EVs)have been attracting more and more attention in smart grid.This paper presents a grid-connected solar-wind hybrid system to supply the electrical load demand of a small shopping complex located in a university campus in India.Further,an EV charging station is incorporated in the system.Economic analysis is performed for the proposed setup to satisfy the charging demand of EVs as well as the electrical load demand of the shopping complex.The proposed system is designed by considering the cost of the purchased energy,which is sold to the utility grid,while the power exchange is ensured between the utility grid and other components of the system.The sizing of the component is performed to obtain the least levelized cost of electricity(LCOE)while minimizing the loss of power supply probability(LPSP)by using recent optimization techniques.The results demonstrate that the LCOE and LPSP for the proposed system are measured at 0.038$/k Wh and0.19%with a renewable fraction of 0.87,respectively.It is determined that a cost-effective and reliable system can be designed by the proper management of renewable power generation and load demands.The proposed system may be helpful in reducing the reliance on the over-burdened grid,particularly in developing countries. | Shakti Singh Prachi Chauhan Nirbhow Jap Singh | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 2 |
| 8 | Management of polytrauma patients in emergency department:An experience of a tertiary care health institution of northern India显示文摘BACKGROUND:In a tertiary care institute of northern India,the emergency department receives an average of 6-7 patients with poly trauma every day.Of these patients,some come directly and many are referred from other hospitals from the region.Various problems are faced in the management of patients with poly trauma.This study aimed to elicit various complaints,suggestions and possible solutions in the management of patients with poly trauma.METHODS:A retrospective cross sectional study was done on 210 patients in the emergency OPD for a period of 2 months.All the records of the patients with poly trauma were studied and the problems during their management were measured against 6 predetermined steps(step Ⅰ to step Ⅵ).RESULTS:In the younger generation,males were predominantly the primary victims of poly trauma injury,and road traffic accident was the major etiological factor.Injuries involving more than2 specialties induced many problems during the management of patients with poly trauma.Of 210 patients we studied,32 patients had problems at various steps and maximum problems in step Ⅲ,i.e.co-ordination between various specialties in the management of patients with poly trauma.CONCLUSION:A proper poly trauma management team and a well defined standard operative procedure are the keys to effective management of patients with poly trauma by minimizing the problems encountered. | Puri Payal Goel Sonu Gupta Anil K Verma Prachi | 2013 | World Journal of Emergency Medicine2013，4，1： | 2 |
| 9 | Comparative studies on the biodesulfurization of crude oil with other desulfurization techniques and deep desulfurization through integrated processes显示文摘 | Prachi Agarwal Sharma D K | 2010 | Energy Fuels2010，24，： | 1 |
| 10 | Overcoming the hurdles to producing etha- nol from cellulose显示文摘 | Prachi Patel Predd | 2006 | Environ Sci Technol :2006，40，13： | 1 |
| 11 | Performance Comparison of Face Recognition Using DCT Against Face Recognition Using Vector Quantization Algorithms LBG,KPE,KMCG,KFCG显示文摘 | Shachi J Natu Prachi J Natu Tanuja K Sarode | 2010 | International journal of Image Processing2010，51，4： | 1 |
| 12 | Treatments for patients with comorbid epilepsy and depression: A systematic literature review显示文摘 | Prachi Mehndiratta Martha Sajatovic | 2013 | Epilepsy & Behavior2013，，1： | 1 |
| 13 | The expression of a naturally occurring, truncated allele of an α-SNAP gene suppresses plant parasitic nematode infection显示文摘 | Prachi Matsye Gary Lawrence Reham Youssef Kyung-Hwan Kim Katheryn Lawrence Benjamin Matthews Vincent Klink | 2012 | Plant Molecular Biology2012，，2： | 1 |
| 14 | Usefulness of Right Ventricular Free Wall Strain to Predict Quality of Life in “Repaired” Tetralogy of Fallot显示文摘 | Jimmy C. Lu Maryam Ghadimi Mahani Prachi P. Agarwal Timothy B. Cotts Adam L. Dorfman | 2013 | The American Journal of Cardiology2013，，11： | 1 |
| 15 | Genealogy and phylogeography of Cyprinid fish Labeo rohita (Hamilton, 1822) inferred from ATPase 6 and 8 mitochondrial DNA gene analysis显示文摘 | Rupesh K. LUHARIYA Kuldeep K. LAL Rajeev K. SINGH Vindhya MOHINDRA Arti GUPTA Prachi MASIH Arvind K. DWIVEDI Rakhi DAS U. K. CHAUHAN J. K. JENA | 2014 | Current Zoology2014，60，4： | 1 |
| 16 | Foetal volumetry using Magnetic Resonance Imaging in intrauterine growth restriction显示文摘 | Mellisa S. Damodaram Lisa Story Elisanda Eixarch Prachi Patkee Abhilasha Patel Sailesh Kumar Mary Rutherford | 2012 | Early Human Development2012，，： | 1 |
| 17 | Lead sorptive removal using magnetic and nonmagnetic fast pyrolysis energy cane biochars显示文摘 | Dinesh Mohan Prachi Singh Ankur Sarswat Philip H. Steele Charles U. Pittman | 2014 | Journal of Colloid And Interface Science2014，，： | 1 |
| 18 | Protective activity of the CnaBE3 domain conserved among Staphylococcus aureus Sdr proteins显示文摘 | Becherelli M Prachi P Vieiani E | 2013 | PLoS One2013，8，74： | 1 |
| 19 | ' Cystosarcoma phyllodes with lymph node metastasis' 显示文摘 | Prachi P Agrawal D NB | 2006 | Community Oncol2006，3，： | 1 |
| 20 | Development of ker- atin-chitosan-gelatin composite scaffold for soft tissue engineering显示文摘 | Prachi Kakkar Sudhanshu Verma I Manjubala | 2014 | Materials Science and Engineering C2014，45，0： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员