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High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-α in mixed cryoglobulinemia

查看全文 作　　者：Alessandro [1]Antonelli;Clodoveo [2]Ferri;Silvia Martina [1]Ferrari;Fabio [1]Galetta;Ferdinando [1]Franzoni;Gino [1]Santoro;Salvatore De [3]Marco;Emiliano [1]Ghiri;Poupak [1]Fallahi 高影响力作者 机构地区：[1]Department of Internal Medicine,University of Pisa,School of Medicine;[2]Department of Internal Medicine,Rheumatology Unit,University of Modena & Reggio E.,School of Medicine;[3]Division of Medicine V,Cisanello Hospital高影响力机构 出　　处：《World Journal of Gastroenterology》索引2009年第15卷第40期,共6页高影响力期刊 摘　　要：AIM: To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor α (TNF-α) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCV).METHODS: Serum NTproBNP and TNF-α levels were assayed in 50 patients with MC+HCV, and in 50 sex- and age-matched controls. RESULTS: Cryoglobulinemic patients showed signifi cantly higher mean NTproBNP and TNF-α levels than controls (P < 0.001; Mann-Whitney U test). By defining high NTproBNP level as a value higher than 125 pg/mL (the single cut-off point for outpatients under 75 years of age), 30% of MC+HCV and 6% of controls had high NTproBNP (χ2, P < 0.01). With a cut-off point of 300 pg/mL (used to rule out heart failure (HF) in patients under 75 years of age), 8% of MC+HCV and 0 controls had high NTproBNP (χ2, P < 0.04). With a cut-off point of 900 pg/mL (used for ruling in HF in patients aged 50-75 years; such as thepatients of our study), 6% of MC+HCV and 0 controls had high NTproBNP (χ2, P = 0.08).CONCLUSION: The study demonstrates high levels of circulating NTproBNP and TNF-α in MC+HCV patients. The increase of NTproBNP may indicate the presence of a subclinical cardiac dysfunction. 关 键 词：肿瘤坏死因子Α 球蛋白 α混合 循环 丙型肝炎病毒 脑钠肽 TNF 心力衰竭
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