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| 1 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 2 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 3 | Thyroid involvement in hepatitis C-associated mixed cryoglobulinemia显示文摘 | Fallahi P Ferrari SM Giuggioli D | 2014 | Hormones(Athens)2014，13，1： | 1 |
| 4 | Yates theory of home range estimation from displacement measurements of animal populations显示文摘 | GIUGGIOLI L ABRAMSON G KENKRE V M | 2006 | Journal of Theoretical Biology2006，240，1： | 1 |
| 5 | D-penicillamine in the treatment of eosinophilic fasciitis:case reports and review of the literature 显示文摘 | Manzini CU Sebastiani M Giuggioli D | 2012 | Clinical rheumatology2012，31，1： | 1 |
| 6 | Parotid sialography and lip biopsy in the evaluation of oral component in sjogren' s syndrome显示文摘 | Vitali C Monti P Giuggioli C | 1989 | Clin Exp Rheumatol1989，7，2： | 1 |
| 7 | Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases显示文摘 | Antonelli A Ferrari SM Giuggioli D | 2014 | Autoimmun Rev2014，13，3： | 1 |
| 8 | Chemokine ( C-X-C mo- tif) ligand (CXCL) 10 in autoimmune diseases 显示文摘 | Antonelli A Ferrari SM Giuggioli D | 2014 | Autoimmun Rev2014，13，3： | 1 |
| 9 | Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases 显示文摘 | AntoneUi A Ferrari S M Giuggioli D | 2014 | Autoimmun Rev2014，13，3： | 1 |
| 10 | D-penieillamine in the treatment of eosinophilic fasciitis : case reports and review of the litera- ture显示文摘 | Manzini CU Sebastiani M Giuggioli D | 2012 | Clin Rheumato12012，31，： | 1 |
| 11 | Chemokine (C-X- C motif) ligand (CXCL) 10 in autoimmune diseases 显示文摘 | Antonelli A Ferrari S M Giuggioli D | 2014 | Au- toimmunRev2014，13，3： | 1 |
| 12 | Reaetive arthritis induced by intravesical BCG therapy for bladder cancer: Our clinical experience and systematic review of the literature显示文摘 | Luigi Bemini Carlo Umberto Manzini Dilia Giuggioli | 2013 | Autoimmunity Reviews2013，6，29： | 1 |
| 13 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 14 | Recombinant human erythropoie-tin stimulates vasculogenesis and wound healing in a patient with sys-temic sclerosis complicated by severe skin ulcers显示文摘 | Ferri C Giuggioli D Manfredi A | 2010 | Clin Exp Derma-tol2010，35，8： | 1 |
| 15 | Systemic sclerosis and cryoglobulinemia: our experience with overlapping syndrome of scleroderma and severe cryoglobulinemic vasculitis and review of the literature显示文摘 | GIUGGIOLI D MANFREDI A COLACI M | 2013 | Autoimmun Rev2013，12，11： | 1 |
| 16 | Multi-objective optimization by genetic algorithms: application to safety systems显示文摘 | Giuggioli B P Marseguerra M Zio E | 2001 | Reliability Engineering and System Safety2001，，72： | 1 |
| 17 | Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients显示文摘 | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Massimiliano Cazzato Giovanni Longombardo Alessandro Antonelli Rodolfo Puccini Claudio Michelassi Anna Linda Zignego | 2004 | Seminars in Arthritis and Rheumatism2004，，6： | 1 |
| 18 | Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases 显示文摘 | Antonelli A Ferrari SM Giuggioli D | 2014 | Autoimmun Rev2014，13，3： | 1 |
| 19 | Systemic sclerosis and cryoglobulinemia:Our experience with overlapping syndrome of scleroderma and severe cryoglobulinemic vasculitis and review of the literature显示文摘 | Giuggioli D Manfredi A Colaci M | 2013 | Autoimmun Rev2013，12，： | 1 |
| 20 | Role of CXCLIO in eryoglobulinemia 显示文摘 | Mazzi V Ferrari SM Giuggioli D | 2015 | Clin Exp Rheumatol2015，33，3： | 1 |
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