|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 基于WebofScience分类的跨学科测度研究显示文摘在全球知识经济发展的大背景下,跨学科研究的深度和广度已经成为影响创新进程的一个重要因素,对于国家的社会经济发展和学术成长具有重要的影响。本文在梳理当前国内外跨学科测度研究的基础上,基于汤森路透(Thomson Reuters)科学引文索引(SCI)以及社会科学引文索引(SSCI)中的Web of Science分类,从学科专业化指数、学科集成指数和学科扩散指数三个方面来衡量研究的跨学科性,并通过科学地图可视化的方法来展示跨学科研究的学科分布特征。最后,本文选取2005年至2014年诺贝尔物理学奖获得者所著文献作为实证案例,通过构建的测度指标来研究这些顶级学者论文的跨学科特征。研究结果表明物理学的创新性成果具有明显的学科特征,诺贝尔物理学奖获得者们的研究成果总体上专注于物理学科领域,学科的集成程度和扩散程度还处于较低水平。 | 黄颖 高天舒 王志楠 汪雪锋 Alan L. Porter 朱东华 | 2016 | 科研管理2016,37,3: | 36 |
| 2 | 钛制弹性髓内钉内固定治疗儿童尺桡骨双骨折显示文摘目的探讨采用钛制弹性髓内钉内固定治疗儿童尺桡骨双骨折的临床疗效。方法回顾性分析自2010-08—2016-08采用闭合复位钛制弹性髓内钉内固定治疗的29例儿童前臂尺桡骨双骨折。桡骨与尺骨均采用Lascombes法置钉。结果本组手术时间35~75 min,平均53.5 min;术中出血量15~50 ml,平均27.5 ml。29例均得到随访,随访时间平均18(12~36)个月。骨折达到临床愈合,愈合时间平均10(8~12)周。取出弹性髓内钉的时间为术后平均28(16~60)周。末次随访时疗效采用肘关节功能Flynn评分标准评定:优26例,良3例,优良率100%。结论钛制弹性髓内钉内固定治疗儿童尺桡骨双骨折具有创伤小、术后恢复快、并发症少等优点,值得临床推广应用。 | 曹轶伦 吕振邦 刘傥 何正斌 王占长 梁杰 张湘生 Daniel Porter | 2019 | 中国骨与关节损伤杂志2019,34,3: | 22 |
| 3 | 上海26万妇女乳房自我检查随机试验显示文摘目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30~64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后的4年中,使用BSE录像带进行二次强化教育,并定期进行BSE指导和在医务人员监察下进行BSE操作。本研究进行5年,全部活动均被记录。队列人群随访到2000年7月,乳腺癌患者的生存状况随访到2001年12月。统计分析采用Kaplan-Meier方法、Logrank检验以及Cox模型。结果指导组检出乳腺癌864例,其中死于乳腺癌133例;对照组检出乳腺癌896例,其中死于乳腺癌130例。两组乳腺癌病例的肿块大小、TNM分期和累积死亡率的差异均无统计学意义(P均>0.05)。但是指导组比对照组有较多和较小的纤维腺瘤被检出(P<0.01)。结论对人群开展BSE教育和指导,未能降低人群的乳腺癌死亡率;接受BSE教育的妇女比没有接受教育的妇女可检出较多的和较小的良性乳房肿块。 | 高道利 David BThomas Roberta M Ray 王文婉 Charlene J Allison 陈范良 Peggy Porter 胡永伟 赵关林 潘雷达 李雯瑾 武春园 Zakia Coriaty Ilonka Evans 林明纲 Helge Stalsberg Steven Gself | 2005 | 中华肿瘤杂志2005,27,6: | 14 |
| 4 | 单侧椎弓根外入路与椎弓根入路PVP治疗胸腰段骨质疏松性椎体压缩骨折显示文摘目的比较单侧椎弓根外入路与椎弓根入路经皮椎体成形术(PVP)治疗胸腰段骨质疏松性椎体压缩骨折的临床疗效。方法回顾性分析自2018-10—2019-02诊治的60例胸腰段骨质疏松性椎体压缩骨折,30例采用椎弓根外入路PVP手术治疗(观察组),30例采用经椎弓根入路PVP手术治疗(对照组),比较2组手术时间、术中透视次数、正位穿刺到达中线情况以及术后2d疼痛VAS评分。结果60例均顺利完成手术并获得完整随访,随访时间平均6.5(3~12)个月。观察组手术时间较对照组短,术中透视次数较对照组少,差异有统计学意义(P<0.05)。2组正位穿刺到达中线情况比较差异无统计学意义(P>0.05)。观察组出现2例骨水泥分布不均,1例上位椎间盘骨水泥少量渗漏;对照组出现1例椎体后缘骨水泥少量渗漏,均无特殊不适。2组术后2d疼痛VAS评分比较差异无统计学意义(P>0.05)。结论胸腰段PVP单侧经椎弓根外入路是安全的、有效的,与经椎弓根入路相比,可减少手术时间与透视次数,并且术中穿刺较易到达中线,是值得推广的一种穿刺途径。 | 徐建彪 王占长 梁宁 Daniel Porter | 2020 | 中国骨与关节损伤杂志2020,35,5: | 14 |
| 5 | The determinants of national innovative capacity显示文摘 | Jeffrey L Furman Michael E Porter Scott Stern | 2002 | Research Policy2002,,6: | 12 |
| 6 | 单髁与全膝关节置换治疗内侧间室膝骨关节炎:5年假体在位率比较显示文摘背景:单髁置换越来越多的被应用于治疗单纯内侧胫股间室型膝关节骨关节炎。目的:比较膝关节单髁置换与全膝关节置换对膝关节单纯内侧间室骨关节炎的修复效果。方法:纳入单纯内侧间室型膝关节骨关节炎患者109例,根据修复方式分为两组,单髁置换组41例,全膝关节置换组68例。比较两组患者的平均住院时间、置换后并发症发生率、身体健康总评分、精神健康总评分、牛津膝关节评分以及置换后5年假体在位率。结果与结论:单髁置换组患者平均住院时间(4.21±2.44)d,较全膝关节置换组(6.11±2.23)d短(P=0.001)。两组患者置换后并发症发生率、身体健康总评分、精神健康总评分、牛津膝关节评分等方面差异均无显著性意义(P>0.05)。置换后5年,单髁置换组假体在位率(90%)较全膝关节置换组(100%)低(P<0.05)。提示对于单纯内侧胫股间室型膝关节骨关节炎患者,单髁置换与全膝关节置换具有相似的修复效果,但单髁置换后5年假体在位率稍低。 | 梁宁 Samuel Yih Shyan Wong Nick Clement Deborah MacDonald Daniel E Porter | 2015 | 中国组织工程研究2015,19,53: | 12 |
| 7 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017,25,11: | 12 |
| 8 | From filaments to function: The role of the plant actin cytoskeleton in pathogen perception,signaling and immunity显示文摘The eukaryotic actin cytoskeleton is required for numerous cellular processes, including cell shape, development and movement, gene expression and signal transduction, and response to biotic and abiotic stress. In recent years,research in both plants and animal systems have described a function for actin as the ideal surveillance platform, linking the function and activity of primary physiological processes to the immune system. In this review, we will highlight recent advances that have defined the regulation and breadth of function of the actin cytoskeleton as a network required for defense signaling following pathogen infection. Coupled with an overview of recent work demonstrating specific targeting of the plant actin cytoskeleton by a diversity of pathogens,including bacteria, fungi and viruses, we will highlight the importance of actin as a key signaling hub in plants, one that mediates surveillance of cellular homeostasis and the activation of specific signaling responses following pathogen perception. B4 ased on the studies highlighted herein, we propose a working model that posits changes in actin filament organization is in and of itself a highly specific signal, which induces, regulates and physically directs stimulus-specific signaling processes, most importantly, those associated with response to pathogens. | Katie Porter Brad Day | 2016 | Journal of Integrative Plant Biology2016,58,4: | 12 |
| 9 | 骨水泥注入量对经皮椎体后凸成形术后相邻椎体应力影响的有限元分析显示文摘目的采用三维有限元法分析骨水泥注入量对椎体后凸成形术(PKP)后患椎相邻椎体生物力学的影响。方法经PKP治疗的骨质疏松性椎体压缩性骨折(OVCF)患者69例,根据骨水泥注入量分为低剂量(>2.0 m L且<3.0 m L)组(22例)、中剂量(≥3.0 m L且<6.0 m L)组(28例)、高剂量(≥6 m L)组(19例),采用视觉模拟量表(VAS)评分评价术前、术后的疼痛程度。收集患者手术前后的CT数据,利用Mimics 10.01和Abaqus 6.8软件建立三维有限元模型,在患椎的上终板分别施加0.3 MPa(低压力)、1.0 MPa(中压力)、4.0 MPa(高压力)的轴向压力,观察不同载荷下的应力改变。结果所有患者术后VAS评分与术前相比均明显降低,差异有统计学意义(P<0.05);3组患者术后VAS评分差异无统计学意义(P>0.05)。骨水泥渗漏5例(7.25%),均未出现神经症状;低剂量组1例,中剂量组2例,高剂量组2例,3组间差异无统计学意义(P>0.05)。末次随访未发现相邻椎体再发骨折。在低压力(中立位)时,患椎下位椎体的应力较术前增加约22%,上位椎体的应力增加约15%。在中压力(正常活动)、高压力(突然摔倒)时,高剂量组患椎上、下位椎体的应力较低压力时均明显增加,差异有统计学意义(P<0.05),而中剂量组和低剂量组的患椎上、下位椎体的应力与低压力时相比,差异无统计学意义(P>0.05)。结论 PKP术后可引起患椎上、下相邻节段生物力学的改变,相邻椎体所受的应力随着轴向负荷和骨水泥注入量的增加呈增加趋势。 | 徐建彪 张伟学 王鸿晨 杜传超 王占长 PORTER Daniel | 2017 | 脊柱外科杂志2017,15,3: | 11 |
| 10 | 下胫腓联合损伤的术中分型和内固定选择显示文摘目的探讨踝关节骨折中下胫腓联合损伤的术中分型对内固定选择的指导作用。方法对2010年1月至2015年1月收治且获得随访的116例WeberB、C型踝关节骨折患者资料进行回顾性分析,男60例,女56例;年龄18~78岁,平均45.6岁;术中在腓骨骨折复位固定后,通过腓骨牵拉试验结合影像检查结果判断下胫腓联合的损伤程度和稳定性,并将下胫腓联合损伤分为3型:下胫腓联合部位间隙〈4mm诊断为I型,下胫腓联合部位间隙4—7mm诊断为Ⅱ型,下胫腓联合部位间隙〉7mm诊断为Ⅲ型。根据分型结果选择适当的螺钉固定方式。采用美国足踝外科协会(AOFAS)的踝一后足评分评定疗效。结果本组116例患者中合并下胫腓联合损伤82例(70.7%),其中稳定的I型患者30例(25.9%)未进行下胫腓联合螺钉固定。下胫腓联合损伤后不稳定者(Ⅱ、Ⅲ型)52例(44.8%):48例Ⅱ型患者中有4例经Volkmann骨折块固定后变为稳定型,未给予下胫腓联合螺钉固定,其余44例给予1枚螺钉固定;4例Ⅲ型患者给予2枚螺钉固定。本组患者术后获时间12—60个月随访,无发生骨折不愈合、下胫腓联合固定螺钉断裂发生,无螺钉取出后下胫腓联合分离复发病例,AOFAS的踝.后足评分优良率为93.1%(108/116)。结论新型的下胫腓联合稳定性术中分型能正确判断下胫腓联合的损伤程度,指导选择适当固定螺钉,提高了踝关节手术治疗的效果。 | 邱海滨 江军 Daniel Porter | 2017 | 中华创伤骨科杂志2017,19,9: | 10 |
| 11 | 高黏度骨水泥治疗骨质疏松性椎体压缩骨折的疗效显示文摘目的观察经皮椎体成形术(PVP)中使用高黏度骨水泥治疗骨质疏松性椎体压缩骨折的疗效及并发症。方法对60例骨质疏松性椎体压缩骨折患者(98个椎体)采用高黏度骨水泥PVP治疗。观察手术前后腰痛VAS评分、脊椎功能障碍指数(ODI)、骨水泥渗漏及邻近椎体骨折等并发症发生率。结果 60例均获得随访,时间3-6(4.2±1.4)年。VAS评分由术前6-10(8.4±1.2)分降低到末次随访时0-3(0.7±0.8)分(P〈0.001);ODI由术前45%-91%(63.7%±15.9%)降低到末次随访时2%-31%(8.4%±6.6%)(P〈0.001)。共8个椎体(8.2%)发生骨水泥静脉渗漏,6个椎体(6.1%)发生椎间盘渗漏,8个椎体(8.2%)发生椎旁渗漏,2例(3.3%)发生邻近椎体骨折。结论采用高黏度骨水泥行PVP治疗骨质疏松性椎体压缩骨折可获得满意的临床疗效,骨水泥渗漏率及邻近椎体骨折发生率均较低。 | 李非 陈阳 PORTER Daniel 王占长 | 2016 | 临床骨科杂志2016,19,4: | 8 |
| 12 | 1544例乳腺浸润性导管癌临床特点和生存率的多因素分析显示文摘目的 分析乳腺浸润性导管癌的临床特点和预后因素。方法 1 544 例浸润性导管癌全部为九十年代新发病例。采用观察生存率、死亡危险比、Log rank检验和拟合多因素Cox比例风险回归模型等进行单因素和多因素分析,评估各种预后因素与乳腺癌的联系强度。结果 浸润性导管癌占女性乳腺癌的82.5%,腋淋巴结转移率44.2%。外上象限发病最多,占47.7%。肿块位中央区,腋淋巴结阳性率最高,占61.7%。Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例分别占30.0%,59.4%,9.4%,1.2%;5年和10年生存率分别为94.9%,78.1%;48.1%,8.6%和87.2%,67.1%;31.2%,0.0%。单因素分析:发病年龄、肿块大小、腋淋巴结转移数、TNM分期、治疗方式与生存率有关;ER、PR、Her- 2/neu、手术类型与生存率无关。多因素分析显示:发病年龄、腋淋巴结转移数、治疗方式与生存率有关。结论 腋淋巴结状况是制定治疗方案和评估预后的最主要指标。50 岁以下发病的患者以及接受综合治疗的患者生存率较高。九十年代与八十年代相比,上海市区女性乳腺癌的诊治水平有了较大的提高。 | 高道利 王文婉 郁领娣 胡永伟 陆重志 David B.Thomas Roberta M.Ray Peggy Porter | 2005 | 肿瘤2005,25,2: | 8 |
| 13 | 经腹机器人辅助腹腔镜肾部分切除术治疗T2期肾肿瘤的国际多中心临床研究显示文摘目的通过国际多中心研究探讨临床T2期肾肿瘤行经腹机器人辅助腹腔镜肾部分切除术的安全性及有效性。方法回顾性分析2012年1月至2017年12月国际19家泌尿中心378例临床T2期肾肿瘤行经腹机器人肾部分切除术和经腹机器人根治性肾切除术患者的临床资料。根据手术方式不同,分为部分切除组和根治组。部分切除组159例,男118例,女41例;年龄(59.3±13.2)岁,体重指数(28.7±5.4) kg/m^2,术前GFR (77.3±22.1)ml/min;肿瘤位于左侧72例,右侧87例;肿瘤直径(83±16)mm;R.E.N.A.L.评分(8.6±2.2)分。根治组219例,男156例,女63例;年龄(62.0±12.9)岁,体重指数(28.7±6.1) kg/m^2,术前GFR (71.4±20.3)ml/min;肿瘤位于左侧112例,右侧105例,双侧2例;肿瘤直径(92±25)mm;R.E.N.A.L.评分(9.7±1.5)分。两组患者性别、体重指数、肿瘤位置的差异均无统计学意义(P〉0.05)。部分切除组患者年龄、肿瘤直径、R.E.N.A.L.评分均低于根治组(P〈0.05),术前GFR优于根治组(P=0.012)。比较两组围手术期资料、肿瘤病理类型、随访时间、复发时间及术后GFR等。结果378例手术均顺利完成。部分切除组手术时间中位值150 min(65-353 min),短于根治组[180 min(85-361 min),P〈0.001],术中出血量中位值150 ml(40-3 000 ml),多于根治组[100 ml (10-1 100 ml),P〈0.001]。术中并发症发生率部分切除组为5.7%(9/159),根治组为3.2%(7/219),两组差异无统计学意义(P=0.240)。部分切除组术后并发症发生率高于根治组[19.5%(31/159)与10.5%(23/219),P=0.014],但≥3级并发症发生率的差异无统计学意义[4.4%(7/159)与2.3%(5/219),P=0.246]。部分切除组无复发生存率高于根治组[91.4%(117/128)与81.9%(167/204),P=0.013]。部分切除组术后GFR降低值16.9 ml/min(10.4-84.7 ml/min)明显少于根治组29.0 ml/min(14.0-54.0 ml/min),肾部分切除术更利于术后肾功能的保护(P〈0.001)。结论临床T2期肾肿瘤行机器人肾部分切除术可获得有效的肿瘤控制率,同时可以更好地保护肾功能,可作为临床T2期肾肿瘤有效的手术方式。 | 过菲 张超 王富博 王林辉 杨庆 叶华茂 吕晨 肖成武 汪洋 Giuseppe Simone Ithaar Derweesh Andrea Minervini Daniel Eun Francesco Porpiglia Sisto Perdona James Porter Matteo Ferro Alexandre Mottrie Robert Uzzo Luigi Schips Wesley White Ken Jacobsohn Prokar Dasgupta Riccardo Autorino Clayton Lau Chandru Sundaram Umberto Capitanio 孙颖浩 杨波 | 2018 | 中华泌尿外科杂志2018,39,6: | 8 |
| 14 | The geology, structure and mineralisation of the Oyu Tolgoi porphyry copper-gold-molybdenum deposits, Mongolia: A review显示文摘The Oyu Tolgoi cluster of seven porphyry Cu-Au-Mo deposits in southern Mongolia,define a narrow,linear,12 km long,almost continuously mineralised trend,which contains in excess of 42 Mt of Cu and1850 t of Au,and is among the largest high grade porphyry Cu-Au deposits in the world.These deposits lie within the Gurvansayhan island-arc terrane,a fault bounded segment of the broader Silurian to Carboniferous Kazakh-Mongol arc,located towards the southern margin of the Central Asian Orogenic Belt,a collage of magmatic arcs that were periodically active from the late Neoproterozoic to PermoTriassic,extending from the Urals Mountains to the Pacific Ocean.Mineralisation at Oyu Tolgoi is associated with multiple,overlapping,intrusions of late Devonian(~372 to 370 Ma) quartzmonzodiorite intruding Devonian(or older) juvenile,probably intra-oceanic arc-related,basaltic lavas and lesser volcaniclastic rocks,unconformably overlain by late Devonian(~370 Ma) basaltic to dacitic pyroclastic and volcano sedimentary rocks.These quartz-monzodiorite intrusions range from earlymineral porphyritic dykes,to larger,linear,syn-,late- and post-mineral dykes and stocks.Ore was deposited within syn-mineral quartz-monzodiorites,but is dominantly hosted by augite basalts and to a lesser degree by overlying dacitic pyroclastic rocks.Following ore deposition,an allochthonous plate of older Devonian(or pre-Devonian) rocks was overthrust and a post-ore biotite granodiorite intruded at^365 Ma.Mineralisation is characterised by varying,telescoped stages of intrusion and alteration.Early A-type quartz veined dykes were followed by Cu-Au mineralisation associated with potassic alteration,mainly K-feldspar in quartz-monzodiorite and biotite-magnetite in basaltic hosts.Downward reflux of cooled,late-magmatic hydrothermal fluid resulted in intense quartz-sericite retrograde alteration in the upper parts of the main syn-mineral intrusions,and an equivalent chlorite-muscovite/illite-hematite assemblage in basaltic host rocks.Uplift,facilitated by syn-mineral longitudinal faulting,brought sections of the porphyry deposit to shallower depths,to be overprinted and upgraded by late stage,shallower,advanced argillic alteration and high sulphidation mineralisation.Key controls on the location,size and grade of the deposit cluster include(i) a long-lived,narrow faulted corridor;(ii) multiple pulses of overlapping intrusion within the same structure;and(iii) enclosing reactive,mafic dominated wall rocks,focussing ore. | T.M.(Mike) Porter | 2016 | Geoscience Frontiers2016,7,3: | 7 |
| 15 | 《剑桥医学史》序言显示文摘 | Roy Porter 张大庆 | 2001 | 医学与哲学2001,22,9: | 6 |
| 16 | PKP术中应用骨水泥温度梯度灌注技术的可行性分析显示文摘目的利用骨水泥在不同温度下的凝固特点,探讨采用温度梯度灌注技术降低PKP手术中骨水泥渗漏率的可行性。方法自2013-01-2016-01,采用温度梯度灌注技术行PKP手术治疗骨质疏松性椎体压缩性骨折83例89椎,作为观察组;另选取同期采用传统PKP手术治疗的75例83椎作为对照组,进行两组间的疗效和安全性对比。结果两组患者PKP术后的VAS评分、ODI评分等疗效观察指标,以及伤椎后凸角、伤椎前缘相对高度等影像学指标的改善程度均相对一致(P>0.05);观察组骨水泥渗漏率仅为4.49%,显著低于对照组的13.25%,差异有统计学意义(P<0.05)。结论在PKP手术中利用骨水泥温度梯度灌注技术,可有效降低其骨水泥渗漏率,进一步提高该手术的安全性。 | 陈阳 李非 梁杰 Daniel Porter | 2019 | 颈腰痛杂志2019,40,1: | 5 |
| 17 | Comparing the reinforcement capacity of welded steel mesh and a thin spray-on liner using large scale laboratory tests显示文摘Steel mesh is used as a passive skin confinement medium to supplement the active support provided by rock bolts for roof and rib control in underground coal mines. Thin spray-on liners(TSL) are believed to have the potential to take the place of steel mesh as the skin confinement medium in underground mines.To confirm this belief, large scale laboratory experiments were conducted to compare the behaviour of welded steel mesh and a TSL, when used in conjunction with rock bolts, in reinforcing strata with weak bedding planes and strata prone to guttering, two common rock conditions which exist in coal mines. It was found that while the peak load taken by the simulated rock mass with weak bedding planes acting as the control sample(no skin confinement) was 2494 kN, the corresponding value of the sample with 5 mm thick TSL reinforcement reached 2856 kN. The peak load of the steel mesh reinforced sample was only2321 kN, but this was attributed to the fact that one of the rock bolts broke during the test. The TSL reinforced sample had a similar post-yield behaviour as the steel mesh reinforced one. The results of the large scale guttering test indicated that a TSL is better than steel mesh in restricting rock movement and thus inhibiting the formation of gutters in the roof. | Zhenjun Shan Porter Ian Nemcik Jan Baafi Ernest | 2014 | International Journal of Mining Science and Technology2014,24,3: | 5 |
| 18 | Effect of No-Reflow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction on Six-Month Mortality显示文摘 | David Brosh Abid R. Assali Aviv Mager Avital Porter David Hasdai Igal Teplitsky Eldad Rechavia Shmuel Fuchs Alexander Battler Ran Kornowski | 2007 | The American Journal of Cardiology2007,,4: | 4 |
| 19 | 微创与开放椎间盘切除术治疗腰椎椎间盘突出症的Meta分析显示文摘目的对微创与开放椎间盘切除术治疗腰椎椎间盘突出症的临床疗效进行Meta分析。方法使用数据库和网上资源检索,再辅以手工检索,中文检索词选择'椎间盘突出症''微创''开放',英文检索词选择'minimally invasive discectomy''open discectomy''mircodiscectomy',纳入关于微创与开放手术治疗腰椎椎间盘突出症的前瞻性随机对照研究(RCT)文献。采用Jadad量表进行文献质量评价。数据的合并采用Review Manager 5.3软件。应用Gradepro软件对每项研究指标进行证据分级。主要提取的数据包括病例的基本特征、手术相关指标、随访时间、术后并发症、功能改善。结果经过检索筛选共纳入10篇文献,文献质量评价均为高质量RCT。两种手术方式在术中出血量、住院时间、术后感染等方面差异有统计学意义,微创手术优于开放手术;而在手术时间、术后下肢疼痛、术后Oswestry功能障碍指数(ODI)、术后腰部疼痛、术后并发症、术后复发等方面差异无统计学意义。结论微创手术的住院时间、术中出血量、术后感染优于开放手术,但总体疗效二者无显著差异。 | 徐建彪 张伟学 王鸿晨 杜传超 王占长 Daniel Porter | 2017 | 脊柱外科杂志2017,15,1: | 4 |
| 20 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022,12,1: | 4 |