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您的检索式：作者名="David B.Thomas"
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| 1 | 1544例乳腺浸润性导管癌临床特点和生存率的多因素分析显示文摘目的 分析乳腺浸润性导管癌的临床特点和预后因素。方法 1 544 例浸润性导管癌全部为九十年代新发病例。采用观察生存率、死亡危险比、Log rank检验和拟合多因素Cox比例风险回归模型等进行单因素和多因素分析,评估各种预后因素与乳腺癌的联系强度。结果 浸润性导管癌占女性乳腺癌的82.5%,腋淋巴结转移率44.2%。外上象限发病最多,占47.7%。肿块位中央区,腋淋巴结阳性率最高,占61.7%。Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例分别占30.0%,59.4%,9.4%,1.2%;5年和10年生存率分别为94.9%,78.1%;48.1%,8.6%和87.2%,67.1%;31.2%,0.0%。单因素分析:发病年龄、肿块大小、腋淋巴结转移数、TNM分期、治疗方式与生存率有关;ER、PR、Her- 2/neu、手术类型与生存率无关。多因素分析显示:发病年龄、腋淋巴结转移数、治疗方式与生存率有关。结论 腋淋巴结状况是制定治疗方案和评估预后的最主要指标。50 岁以下发病的患者以及接受综合治疗的患者生存率较高。九十年代与八十年代相比,上海市区女性乳腺癌的诊治水平有了较大的提高。 | 高道利 王文婉 郁领娣 胡永伟 陆重志 David B.Thomas Roberta M.Ray Peggy Porter | 2005 | 肿瘤2005，25，2： | 8 |
| 2 | Physiological and Growth Responses of C_3 and C_4 Plants to Reduced Temperature When Grown at Low CO_2 of the Last Ice Age显示文摘During the last ice age,CO2 concentration (CO2 ) was 180-200 μmol/mol compared with the modern value of 380 μmol/mol,and global temperatures were ~8 ·°C cooler.Relatively little is known about the responses of C3 and C4 species to long-term exposure to glacial conditions.Here Abutilon theophrasti Medik.(C3) and Amaranthus retroflexus L.(C4) were grown at 200 μmol/mol CO2 with current (30/24 °C) and glacial (22/16 °C) temperatures for 22 d.Overall,the C4 species exhibited a large growth advantage over the C3 species at low CO2.However,this advantage was reduced at low temperature,where the C4 species produced 5× the total mass of the C3 species versus 14× at the high temperature.This difference was due to a reduction in C4 growth at low temperature,since the C3 species exhibited similar growth between temperatures.Physiological differences between temperatures were not detected for either species,although photorespiration/net photosynthesis was reduced in the C3 species grown at low temperature,suggesting evidence of improved carbon balance at this treatment.This system suggests that C4 species had a growth advantage over C3 species during low CO2 of the last ice age,although concurrent reductions in temperatures may have reduced this advantage. | Joy K.Ward David A.Myers Richard B.Thomas | 2008 | Journal of Integrative Plant Biology2008，50，11： | 5 |
| 3 | Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: A case‐cohort study显示文摘 | Chin‐KuoChang GeorgeAstrakianakis David B.Thomas Noah S.Seixas Janice E.Camp Roberta M.Ray DaoLi Gao Karen J.Wernli WenjinLi E. DawnFitzgibbons Thomas L.Vaughan HarveyCheckoway | 2006 | Am J Ind Med2006，，8： | 1 |
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