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| 1 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 2 | Asphaltenes: Separations, structural analysis and applications显示文摘Asphaltenes, complex aromatic compounds from various carbonaceous sources, could be obtained by solvent dissolution, filtration and adsorption. It was difficult to clarify the molecular structures and chemical properties of asphaltene due to its structural similarity, composition complexity and source dependences. Many techniques, like Mass spectrometry, Chromatography, Nuclear magnetic resonance spectroscopy, Infrared spectroscopy, Roman spectroscopy, Fluorescence spectroscopy, X-ray diffraction analysis and Small-angle scattering techniques and so on, have revealed some valuable descriptions of asphaltenes chemical compositions and fundamental structures. Moreover, advanced Mass spectrometry,Atomic force microscopy and Scanning tunneling microscopy could provide more clear and essential molecular compounds and structures in asphaltenes. In addition, several asphaltenes models have succeeded to illustrate aggregation properties asphaltene. In this work, the progress on asphaltene separation, characterization and application was summarized, and the similarities and differences between coal-derived asphaltenes and petroleum asphaltenes were compared. Furthermore, the reactivity of asphaltenes has been discussed in the aspect of hydroprocessing, pyrolysis and gasification. Asphaltene was excellent carbon precursor for functional carbon material due to its high aromaticity and carbon yield;several porous carbon nanosheets from asphaltenes that would be prospective electrode materials after being graphitized were shown. Pitch-based carbon fiber derived from coal-derived asphaltenes displayed a tensile strength of 1.0 GPa and elastic modulus of 350 MPa, respectively. These powerful advances will provide asphaltenes promising developments. | Pingping Zuo Shijie Qu Wenzhong Shen | 2019 | Journal of Energy Chemistry2019，28，7： | 7 |
| 3 | Variations in silicate concentration affecting photosynthetic carbon fixation by spring phytoplankton assemblages in surface water of the Strait of Malacca显示文摘The Strait of Malacca (SoM), the world's busiest sea-route, is increasingly polluted as the rapid development of world trades, affecting phytoplankton primary productivity therein. The variations of surface phytoplankton biomass, size-structure and carbon fixation were investigated across the SoM during the spring period (May 4 to 9, 2011). Chlorophyll a concentration increased from 0.12 μg/L at the northwest entrance of the SoM to a maximal 0.63 μg/L at narrowest section, and decreased to 0.10 μg/L at the southeast entrance. Photosynthetic carbon fixation by phytoplankton coincided well with Chl a biomass, and increased from 10.8 to 22.3 μg C/(L d), then decreased to 9.21 μg C/(L d); while the carbon fixation rate showed an inverse pattern to the changes of Chl a, and decreased from 87.1 to 35.5 μg C/(μg Chl a d) and increased thereafter to 95.3 μg C/(μg Chla·d). Picophytoplankton cells (<3 μm) contributed to more than 60% and 50% of the total Chl a and carbon fixation at both the entry waters; while the contributions of pico-cells decreased sharply to the minimum of 18.3% and 27.5% at the narrowest part of the SoM. In particular, our results showed that the silicate concentration positively regulated Chl a biomass and carbon fixation, reflecting that the higher silicate favoured the growth of phytoplankton and thus led to higher primary production in this strait. | LI Gang LIN Qiang SHEN Pingping NI Guangyan SONG Xingyu WANG Shengfu FAN Yanzhi HUANG Liangmin TAN Yehui | 2013 | Acta Oceanologica Sinica2013，32，4： | 4 |
| 4 | Experimental investigations on the fluid flow mechanism in porous media of enhanced oil recovery by alkli/surfactant/polymer flooding显示文摘The fluid flow mechanism in porous media of enhanced oil recovery by Alkli/ Surfactant/ Polymer (ASP) flooding is investigated by measuring production performance, pressure distribution and saturation distribution through installing differential pressure transducers and saturation measuring probes in a physical model of vertical heterogeneous reservoir. The fluid flow variation in porous media is the main reason of enhanced oil recovery of ASP flooding. The pressure field and saturation field are nonlinearly coupled together and the interaction between them results in the fluid flow variation in the reservoir. In a vertical heterogeneous reservoir, the ASP agents initially flow in the high permeability layer, and fluid changes the flow direction toward the low and the middle permeability layers because the resistance in the high permeability layer is increased under the physical and chemical action of adsorption, retention and emulsion. ASP flooding displaces out not only the residual oil in the high permeability layer, but also the remaining oil in the low and the middle permeability layers by increasing swept volume and displacing efficiency. | WANG Jialu SHEN Pingping CHEN Yongzhong ZHANG Zubo JIA Xu TIAN Yuling | 2005 | Science China(Technological Sciences)2005，48，4： | 3 |
| 5 | Identification of nitrogen-polyaromatic compounds in asphaltene from co-processing of coal and petroleum residue using chromatography with mass spectrometry显示文摘 | Pingping Zuo Wenzhong Shen | 2017 | International Journal of Coal Science & Technology2017，4，3： | 3 |
| 6 | Composition and Distribution of Planktonic Ciliates in the Southern South China Sea During Late Summer: Comparison Between Surface and 75 m Deep Layer显示文摘Ciliates are very important components in most marine ecosystem.They are trophic link between the microbial food web and grazing food chain.In this study,ciliates were collected from 11 sites in the southern South China Sea(SCS) during August 25 to September 28,2011.Their composition and distribution at the surface and 75 m deep depth of the ocean were studied.A total of 30 species belonging to 22 genera were identified,and 22 species of 15 genera were Tintinnids.Eutintinnus fraknoii and E.stramentus were the most common species.The other dominants were strombidiids ciliates including Strombidium conicum and S.globosaneum,which were followed by the tide form,Mesodinium pulex.Ciliates abundance ranged from 46 ind L^(-1) to 368 ind L^(-1) in the open sites,46–368 ind L^(-1) at surface and 73–198 ind L^(-1) at 75 m deep layer.In the Yongshu reef,ciliates abundance ranged from 167 ind L^(-1) to 365 ind L^(-1) in the water column,similar to that in Sanya coral reef waters.Ciliates composition showed obvious difference between surface and 75 m deep layer at station S2(P < 0.05),while no similar result was observed at other sites.At 75 m deep layer,salinity was negatively related to mixed layer depth(P < 0.05),but positively to chlorophyll a concentration(P < 0.05),indicating that the change of vertical mixing in water column influenced vertical distribution of ciliates in the southern SCS. | LIU Huaxue SHEN Pingping LI Chunhou CHEN Zuozhi QI Zhanhui HUANG Honghui | 2016 | Journal of Ocean University of China2016，15，1： | 3 |
| 7 | Heteropolyanion-based ionic hybrid solid: A green bulk-type catalyst for hydroxylation of benzene with hydrogen peroxide显示文摘 | Yan Leng Jun Wang Dunru Zhu Lei Shen Pingping Zhao Mingjue Zhang | 2011 | Chemical Engineering Journal2011，，2： | 2 |
| 8 | Longitudinal patterns of spring-intermonsoon phytoplankton biomass,species compositions and size structure in the Bay of Bengal显示文摘Vertical distributions of phytoplankton biomass,compositions and size structure were investigated during the spring-intermonsoon (April 22 to 30) of 2010 along transact 10 N of the Bay of Bengal,northern Indian Ocean.Surface phytoplankton biomass (Chl a) was (0.065 ± 0.009) μg/L,being greater than 80% of which was contributed by pico-phytoplankton (<3 μm).The Chl a concentration vertically increased to the maximal values at deep chlorophyll maximum (DCM) layer that shoaled eastwards from 75 to 40 m.The Chl a biomass at DCM layer generally varied between 0.2 and 0.4 μg/L,reaching the maximum of 0.56 μg/L with micro-phytoplankton cells (>20 μm) accounting for 58% and nano-(3-20 μm) or pico-cells for 15% and 27%,respectively.In particular,the cells concentration coupling well with phosphate level was observed at middle layer (75-100 m) of 87 to 89 E,dominated by micro-cells diatoms (e.g.,Chaetoceros atlanticus v.neapolitana,Chaetoceros femur and Pseudonitzschia sp.) and cyanobacteria (i.e.,Trichodesmium hildebrandtii),with the cells concentration reached as high as 4.0 × 10 4 and 4.3 × 10 4 cells/L.At the rest of the transact however,dinoflagellates (e.g.,Amphisdinium carterae and Prorocentrum sp.) were the dominant species,with the cells concentration varying from 0.3 × 10 3 to 6.8 × 10 3 cells/L.Our results also indicate that the regulation of large cells (micro-,nano-) on phytoplankton biomass merely occurred at DCM layer of the Bay. | LI Gang KE Zhixin LIN Qiang NI Guangyan SHEN Pingping LIU Huaxue YIN Jianqiang LI Kaizhi HUANG Liangmin TAN Yehui | 2012 | Acta Oceanologica Sinica2012，31，2： | 2 |
| 9 | Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages显示文摘Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has considerable clinical significance. The existence of a necrosis-to-apoptosis switch induced by hydrogen peroxide in macrophage cell line RAW 264.7 cells was confirmed by using flow cytometry and fluorescence microscopy. With the help of computational simulations, this study predicted that negative feedbacks between NF-κB and MAPKs are implicated in converting necrosis into apoptosis in macrophages exposed to hydrogen peroxide, which has significant implications. | LIN XuZhu, SUN TingZhe, CAI MeiHong & SHEN PingPing* State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, School of Life Science, Nanjing University, Nanjing 210093, China | 2010 | Science China(Life Sciences)2010，53，10： | 2 |
| 10 | High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway显示文摘The excessive accumulation of reactive oxygen species(ROS)under osteoporosis precipitates a microenvironment with high levels of oxidative stress(OS).This could significantly interfere with the bioactivity of conventional titanium implants,impeding their early osseointegration with bone.We have prepared a series of strontium(Sr)-doped titanium implants via micro-arc oxidation(MAO)to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic(high OS levels)conditions.Apart from the chemical composition,all groups exhibited similar physicochemical properties(morphology,roughness,crystal structure,and wettability).Among the groups,the low Sr group(Sr25%)was more conducive to osteogenesis under normal conditions.In contrast,by increasing the catalase(CAT)/superoxide dismutase(SOD)activity and decreasing ROS levels,the high Sr-doped samples(Sr75% and Sr100%)were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells,thus enhancing early osseointegration.Furthermore,the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples(especially Sr100%)had positive effects on osteoimmunomodulation under the OS microenvironment.Ultimately,the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations. | Xinkun Shen Kai Fang Kendrick Hii Ru Yie Zixin Zhou Yiding Shen Shuyi Wu Yue Zhu Zhennan Deng Pingping Ma Jianfeng Ma Jinsong Liu | 2022 | Bioactive Materials2022，7，4： | 2 |
| 11 | Peroxisome proliferator‐activated receptor‐γ activation inhibits hepatocellular carcinoma cell invasion by upregulating plasminogen activator inhibitor‐1显示文摘 | Xiaojuan Pang Yinna Wei Ya Zhang Minyue Zhang Yan Lu Pingping Shen | 2013 | Cancer Sci2013，，6： | 1 |
| 12 | An experimen- tal study of the influence of interfacial tension on water-oil two- phase relative permeability显示文摘 | Pingping Shen Bin Zhu Xianbin Li Yushu Wu | 2010 | Transport in Porous Media2010，，85： | 1 |
| 13 | The integrated characterization techniques on reservoir fractures 显示文摘 | Xinmin Song Pingping Shen Shiyi Yuan | 2000 | SPE 647662000，，： | 1 |
| 14 | Primary cilia support cartilage regeneration after injury显示文摘In growing children,growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb growth arrest.Interestingly,one type of fracture injuries within the growth plate achieve amazing self-healing,however,the mechanism is unclear.Using this type of fracture mouse model,we discovered the activation of Hedgehog(Hh)signaling in the injured growth plate,which could activate chondrocytes in growth plate and promote cartilage repair. | Dike Tao Lei Zhang Yunpeng Ding Na Tang Xiaoqiao Xu Gongchen Li Pingping Niu Rui Yue Xiaogang Wang Yidong Shen Yao Sun | 2023 | International Journal of Oral Science2023，15，2： | 1 |
| 15 | Ultralow Interracial Tension for Enhanced Oil Recovery at Very Low Surfactant Concentrations显示文摘 | Rosen M J Wang Hongzhuang Shen Pingping | 2005 | Langmuir2005，21，9： | 1 |
| 16 | NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways显示文摘 | Jun Cui Liang Zhu Xiaojun Xia Helen Y. Wang Xavier Legras Jun Hong Jiabing Ji Pingping Shen Shu Zheng Zhijian J. Chen Rong-Fu Wang | 2010 | Cell2010，，3： | 1 |
| 17 | Improved Oil Recovery Technology in China:Status & Outlook显示文摘 | Shen Pingping Song Jie Zhu Bin | 2005 | China Oil & Gas2005，12，4： | 1 |
| 18 | Quantitative description for the heterogeneity of pore structure by using mercury capillary pressure curves 显示文摘 | Shen Pingping Li Kevin Jia Fenshu | 1995 | SPE 299961995，，： | 1 |
| 19 | Expression and purification of chicken beta interferon and its antivirus immunological activity显示文摘 | Cai Meihong Zhu Feng Shen Pingping | 2012 | Protein Expression and Purification2012，84，1： | 1 |
| 20 | Effects of Recycled Aggregate Content on Pervious Concrete Performance显示文摘A recycled aggregate(RA)was prepared by crushing and sieving demolished discarded concrete pavements and was subsequently tested and analyzed to determine its various physical properties.On this basis,pervious concrete(PC)mix proportions were designed.Coarse RA particles with sizes of 5–10 and 10–20 mm were selected.Concrete specimens were prepared with a water–cement ratio of 0.3,an aggregate–cement ratio of 4.5,the substitute rates of RA with 0,25%,50%,75%and a single-/double-gap-graded RA mix(mass ratio of particles with sizes of 5–10 mm to particles with sizes of 10–20 mm:1:1,1:2,2:1,2:3 and 3:2).Various properties of the RA-containing PC(RPC)were determined by analyzing the compressive strength,splitting tensile strength,effective porosity,permeation coefficient and impact and abrasion resistance of the specimens.The results showed the following:The density of the RPC decreased with an increasing RA replacement ratio.The density of the RPC prepared with a double-gapgraded RA mix was lower than that prepared with a single-gap-graded RA(particle size:10–20 mm)mix.The permeation coefficient of the RPC increased with increasing porosity.The splitting tensile strength of the RPC was positively correlated with its compressive strength.The compressive strength of the RPC decreased with increasing porosity.The regression analysis showed that the impact and abrasion resistance of the RPC increased with increasing compressive strength.In addition,all of the RPC specimens met the strength and permeation requirements.This study can provide theoretical support for the application of RPC. | Lei Guo Zi Guan Lixia Guo Weiping Shen Zhilong Xue Pingping Chen Mingru Li | 2020 | Journal of Renewable Materials2020，8，12： | 1 |
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