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| 1 | Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish显示文摘Graphene possesses unique physical and chemical properties, which have inspired a wide range of potential biomedical applications. However, little is known about the adverse effects of graphene on the human body and ecological environment. The purpose of our work is to make assessment on the toxicity of graphene oxide (GO) against human cell line (human bone marrow neuroblastoma cell line and human epithelial carcinoma cell line) and zebrafish (Danio rerio) by comparing the toxic effects of GO with its sister, multi-walled carbon nanotubes (MWNTs). The results show that GO has a moderate toxicity to organisms since it can induce minor (about 20%) cell growth inhibition and slight hatching delay of zebrafish embryos at a dosage of 50 mg/L, but did not result in significant increase of apoptosis in embryo, while MWNTs exhibit acute toxicity leading to a strong inhibition of cell proliferation and serious morphological defects in developing embryos even at relatively low concentration of 25 mg/L. The distinctive toxicity of GO and MWNTs should be ascribed to the different models of interaction between nanomaterials and organisms, which arises from the different geometric structures of nanomaterials. Collectively, our work suggests that GO does actual toxicity to organisms posing potential environmental risks and the result is also shedding light on the geometrical structure-dependent toxicity of graphitic nanomaterials. | CHEN LiQiang HU PingPing ZHANG Li HUANG SiZhou LUO LingFei HUANG ChengZhi | 2012 | Science China Chemistry2012，55，10： | 12 |
| 2 | 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation显示文摘Vitamin D_3 has been found to produce therapeutic effects on obesity-associated insulin resistance and dyslipidemia through its potent anti-inflammatory activity, but the precise immunomodulatory mechanism remains poorly understood. In the present study we found that 1,25-dihydroxyvitamin D_3[1,25(OH)_2D_3], the biologically active form of vitamin D_3, significantly attenuated monosodium glutamate(MSG)-induced obesity and insulin resistance as indicated by body weight reduction, oral glucose tolerance improvement, and a glucose infusion rate increase as detected with hyperinsulinemiceuglycemic clamp. Moreover, 1,25(OH)_2D_3 not only restored pancreatic islet functions but also improved lipid metabolism in insulin-targeted tissues. The protective effects of 1,25(OH)_2D_3 on glycolipid metabolism were attributed to its ability to inhibit an obesity-activated inflammatory response in insulin secretory and targeted tissues, as indicated by reduced infiltration of macrophages in pancreas islets and adipose tissue while enhancing the expression of Tgf-β1 in liver tissue, which was accompanied byincreased infiltration of Treg cells in immune organs such as spleen and lymph node as well as in insulintargeted tissues such as liver, adipose, and muscle. Together, our findings suggest that 1,25(OH)_2D_3 serves as a beneficial immunomodulator for the prevention and treatment of obesity or metabolic syndrome through its anti-inflammatory effects. | Wen Jin Bing Cui Pingping Li Fang Hua Xiaoxi Lv Jichao Zhou Zhuowei Hu Xiaowei Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 9 |
| 3 | Optimal design of wind machine impeller for frost protection based on CFD and its field test on airflow disturbance显示文摘Wind machines have been increasingly applied to prevent frost damage through airflow disturbance in tea fields and orchards.An impeller is the most important component of the machine.However,there are few studies on customized impeller design or airflow disturbance performance.The objective of this study was to design a new impeller for frost protection wind machines based on reverse engineering and CFD simulation.The characteristic parameters of an impeller include blade cross-section shape,installation angle,sweep angle,hub ratio and blade number.The optimal combination of the above parameters was obtained through the simulation of the impeller’s aerodynamic performance.Field tests were conducted in a tea field to evaluate airflow disturbance performance of the designed impeller.The result shows that at a certain rotation speed and rotation diameter,the optimal combination of impeller parameters was:single arc cross-section ofϕ2400 mm,installation angle of 15°,sweep angle of 87°,hub ratio of 0.3 and blade number of 4,of which the impeller could achieve the highest usage of 0.56,the least consumed power of 1.363 kW and more uniform distribution of surface pressure on the windward side.Compared with other commercial frost protection wind machines,the maximum airflow velocity of the developed impeller was higher at 12 m in front of it.The probability of airflow velocity above 3.0 m/s within 30 min was the highest(71.7%),indicating its improvement of airflow stability.Without swing the new impeller could cover an effective area of 300 m2,which was similar to that of the commercial ones. | Wu Wenye Hu Yongguang Yang Shuo Mao Kangqian Zhu Xiaoyong Li Pingping | 2015 | International Journal of Agricultural and Biological Engineering2015，8，5： | 3 |
| 4 | Responses of electrical properties of tea leaves to low-temperature stress显示文摘Critical temperature is one of the most important parameters for the control of crop frost protection through airflow disturbance.It changes with complex weather conditions,thus it is difficult to be determined.A method of testing electrical property of tea leaves under cold stress was put forward to indicate critical temperature.The testing system was established to measure the capacitance,impedance,resistance and reactance of the samples under different air temperatures,air humidities and airflow velocities.The variation of the electrical property was also analyzed.The results show that at humidity below 70%and airflow velocity of 0 m/s the impedance and resistance increased slowly,while the reactance kept steady when air temperature decreased from 8.0°C to around−6.3°C,and then increased rapidly from around−6.3°C to−15.0°C.There were no significant differences of the above parameters and variation trend under different airflow velocities.There was an exponential relationship between the impedance and the temperature.The capacitance was rather small and almost no change occurred with air temperature under different conditions of air velocity and humidity,except a few abrupt peaks.The maximum peak capacitance was representative of its response at certain humidity and airflow velocity.The typical temperatures were close to a range,where the other three parameters began to increase rapidly.The typical temperature dropped to the lowest of−7.8°C at the airflow velocity of 0 m/s.Therefore,the characteristic response of the capacitance could indicate critical temperature of tea leaves. | Lu Yongzong Hu Yongguang Zhang Xiliang Li Pingping | 2015 | International Journal of Agricultural and Biological Engineering2015，8，5： | 2 |
| 5 | TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target显示文摘Pulmonary fibrosis(PF)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic strategies.We recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of PF.Here,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and degradation.Elevated GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting PF development.Activated C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in AMs.The knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective PF treatment.Our study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for PF. | Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li Jiali Min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 6 | Controllable time delay using slow/fast light in active fiber ring resonators with gain manipulation显示文摘We propose to generate controllable time delay using slow/fast light in fiber ring resonators with gain manipulation.The dispersion and group delay of active fiber ring resonator can be controlled by manipulating its gain level below the lasing threshold.Controllability of the negative group delay in the undercoupled regime and the positive group delay in the overcoupled regime is theoretically demonstrated.Besides,large group delay can be obtained accompanied by signal gain in active ring resonators.In addition,we describe wide bandwidth and large group delay in 4-stage cascaded ring resonators. | XIAO PingPing HU HongWu QI Min | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 1 |
| 7 | An Exploratory Study of English Writing Strategies显示文摘 | Hu Pingping | 2006 | 中国英语教学2006，，： | 1 |
| 8 | Insights into the mechanism of Sub3 inhibiting Fusarium moniliforme infection in maize显示文摘Fusarium moniliforme(F.moniliforme) and its secondary metabolite fumonisin pose a severe threat to food safety,and searching for effective antimicrobial agents is a focus of current research.In this study,the secondary structure of Sub3 was analyzed by circular dichroism,meanwhile,the inhibition rate of Sub3 against spores,mycelia of F.moniliforme and infected maize was studied.To explore the possible inhibition mechanisms,morphological and structural changes of spores treated with Sub3 at0,1/2 MIC(minimum inhibitory concentration) and MIC were observed by scanning electron microscopy and transmission electron microscopy;the cell wall integrity,membrane integrity,reactive oxygen species,mitochondrial membrane potential,ATP synthase activity,redox reactions,and the nuclear damage of F.moniliforme were also investigated.The results showed that Sub3 was mostly in the state of random in deionized water,while mainly showed the β-sheet structure in the hydrophobic environment of 50% Trifluoroethanol(TFE) solution,indicating that Sub3 might generate partial structure deformation when acting on the cell membrane;and its MIC on F.moniliforme spores was 0.2 g/L.Under the 1/2 MIC and MIC,the inhibition rates of Sub3 against F.moniliforme infected maize were 34.3% and75.6%,respectively.The results of inhibition mechanisms revealed that the defective pathogenicity of F.moniliforme caused by Sub3 was attributed to damages on both the cell wall and the cell membrane,which might upset balance of intracellular redox system and mitochondrial energy metabolism and trigger nucleus damage,ultimately leading to cell death.Meanwhile,Sub3 could diminished ATP synthase enzyme activity in a dose-dependent manner.The results provided direct evidence for inhibition of F.moniliforme infection of maize by Sub3,and useful knowledge applicable for food preservation. | Haojie Yang Wei Zhang Pingping Tian Bangbang Li Shan Wei Shuaibing Zhang Na Li Yangyong Lyu Yuansen Hu | 2022 | Grain & Oil Science and Technology2022，5，1： | 1 |
| 9 | Epitope Prediction Based on Random Peptide Library Screening:Benchmark Dataset and Prediction Tools Evaluation 显示文摘 | SUN Pingping CHEN Wenhan HU Yanxin | 2011 | Molecules2011，16，6： | 1 |
| 10 | High circulating VEGF level predicts poor overall survival in lung cancer显示文摘 | Pingping Hu Weidong Liu Liguang Wang Miaomiao Yang Jiajun Du | 2013 | Journal of Cancer Research and Clinical Oncology2013，，： | 1 |
| 11 | Sterols are required for cell‐fate commitment and maintenance of the stomatal lineage in A rabidopsis显示文摘 | Pingping Qian Bing Han Edith Forestier Zhihong Hu Na Gao Wenwen Lu Hubert Schaller Jia Li Suiwen Hou | 2013 | Plant J2013，，6： | 1 |
| 12 | Sprinkler irrigation system for tea frost protection and the application effect显示文摘A sprinkler irrigation system was designed and applied for a tea field to achieve frost protection through latent heat release when water turning into ice.Frost protection effects during night were tested at different irrigation application rates by monitoring air temperature around tea canopy(Tc).Temperature sensors were arranged at different distances from the sprinkler.The preliminary results showed that,when the sprinkler system worked continuously at the application rate of 2-4 mm/h before sunrise,tea canopy was covered with ice and Tc remained around 0℃,preventing tea plants from frost damage.But no more temperature rise was obviously observed at the application rates above 4 mm/h,which means less cost effectiveness.The system was stopped after sunrise when background air temperature rose back to 0℃and Tc increased by 2.2℃in one hour,while Tc of non-irrigated area increased by 4.8℃,which might cause thawing injuries to tea plants.The leaf surface temperature was lower than Tc,and the difference between the leaf surface temperature and Tc decreased with the increase of application rate.Therefore,the sprinkler irrigation system could achieve tea frost protection,and the recommended application rate was 2-4 mm/h for better protection effect.The system should keep running throughout frost night till half an hour after sunrise.The start and stop of the sprinkler irrigation system should be controlled based on Tc. | Hu Yongguang Zhao Chen Liu Pengfei Asante Eric Amoah Li Pingping | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 1 |
| 13 | Transcriptome analysis suggests mechanisms for a novel flowering type: Cleistogamous wheat显示文摘Wheat is one of the most important staple crops worldwide.Fusarium head blight severely reduces wheat yield and quality.Cultivation of a novel type of cleistogamous wheat mutant,ZK001,which was created by static magnetic field treatment,is a new strategy for controlling Fusarium head blight.However,little is known about the mechanism of cleistogamy in wheat.The present study demonstrated that anthers of ZK001 were retained on the glumes at all flowering stages,whereas those of YM18 were extruded from the paleae and lemmae.There was a clear difference in the morphological characteristics of lodicules between YM18 and ZK001.Lodicule calcium and potassium contents were significantly higher in YM18 than in ZK001 from white to yellow anther stages.In Fusarium head blight resistance,the diseased kernel rate and deoxynivalenol content of ZK001 were markedly lower than those of YM18 and QM725.Comparative transcriptome analysis of YM18 and ZK001 was performed to identify regulatory mechanisms of cleistogamy.The main differentially expressed genes identified in the spikelets of YM18 and ZK001 at the green anther stage were associated with cell walls,carbohydrates,phytohormones,water channel,and ion binding,transport,and homeostasis.These differentially expressed genes may play an important role in regulating cellular homeostasis,osmotic pressure,and lodicule development.The results indicate that ZK001 lost the ability to push the lemmae and paleae apart during the flowering stage because of the thin lodicules.ZK001 was speculated to provide structural barriers for Fusarium head blight during the flowering stage.The thin lodicule of ZK001 results from low levels of soluble sugar,calcium ions,and potassium ions in the lodicules.These levels are regulated by differentially expressed genes. | Caiguo Tang Minghao Li Minghui Cao Ruiju Lu Huilan Zhang Chenghong Liu Shengwei Huang Pingping Zhang Hao Hu Weiwei Zhao Lifang Wu | 2020 | The Crop Journal2020，8，2： | 1 |
| 14 | The Roles of p38 MAPK/MSK1 Signaling Pathway in the Neuroprotection of Hypoxic Postconditioning Against Transient Global Cerebral Ischemia in Adult Rats显示文摘 | Pingping Zhu Lixuan Zhan Tingna Zhu Donghai Liang Jiaoyue Hu Weiwen Sun Qinghua Hou Huarong Zhou Baoxing Wu Yanmei Wang En Xu | 2014 | Molecular Neurobiology2014，，3： | 1 |
| 15 | Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology显示文摘Immune cells play key roles in cancer and chronic inflammatory disease. A better understanding of the mechanisms and risks will help develop novel target therapies. At the 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology held in Beijing, China, on May 12, 2017, a number of speakers reported new findings and ongoing studies on immune-related diseases such as cancer, fibrotic disease, diabetes, and others. A considerably insightful overview was provided on cancer immunity, tumor microenvironments,and new immunotherapy for cancer. In addition, chronic inflammatory diseases were discussed. These findings may offer new insights into targeted immunotherapy. | Bing Cui Xuetao Cao Weiping Zou Yonghong Wan Ning Wang Yaohe Wang Pingping Li Fang Hua Yuying Liu Xiaowei Zhang Ke Li Xiaoxi Lv Bo Huang Zhuowei Hu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 1 |
| 16 | Erratum to“Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach”[Engineering 13(2022)186–196]显示文摘There was a mistake in affiliation a,the correct one should be“MOE Key Laboratory of Marine Genetics and Breeding and Sars-Fang Center,Ocean University of China,Qingdao 266003,China”as updated above;Affiliations c and d should be reversed:Affiliation c should be“Laboratory for Marine Fisheries Science and Food Production Processes,Pilot Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China,”and the affiliation d should be“Laboratory of Tropical Marine Germplasm Resources and Breeding Engineering,Sanya Oceanographic Institution,Ocean University of China,Sanya 572000,China.” | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，，11： | 1 |
| 17 | ASIC:An Architecture for Scalable Intra-domain Control in OpenFlow显示文摘 | Pingping Lin Jun Bi Hongyu Hu | 2012 | CFI''12Proceedings of the 7th International Conference on Future Internet Technologies2012，，： | 1 |
| 18 | Senome-scale analysis of demographic history and adaptive selection显示文摘 | Qi Wu Pingping Zheng Yibu Hu Fuwen Wei | 2014 | Protein & Cell2014，5，2： | 1 |
| 19 | Anti-fungal properties of Puroindoline A against Aspergillus glaucus显示文摘Aspergillus glaucus can grow in low moisture grain,and is one of the main fungi responsible for agricultural product losses.Puroindoline A(PINA)is a tryptophan-rich alkaline adiponectin that can effectively inhibit numerous plant bacteria and fungi.However,the mechanism of PINA against A.glaucus remains unclear.Herein,we found that recombinant PINA(rPINA)could inhibit A.glaucus mycelia growth on salt Czapek dox agar(SCDA)medium and spore germination on Czapek dox(CD)medium.Scanning electron microscopy revealed that incomplete morphological characteristics of both A.glaucus spores and mycelia occurred following rPINA treatment.Laser scanning confocal microscopy(LSCM)showed that rPINA could enter the interior of spores.Flow cytometry and propidium iodide(PI)staining illustrated membranes of spores were severely damaged,especially after treatment with 0.9 mg/mL rPINA for 12 h,and spores with intact membranes were reduced by 30.7%.Additionally,rPINA reduced the mitochondrial membrane potential(MMP)by 5,5′,6,6′-tetrachlorr-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide(JC-1)staining,and caused DNA damage by 4′,6-diamidino-2-phenylindole(DAPI)staining.These results indicated that rPINA may damage cell membranes and DNA structure and reduceMMP,thereby inhibiting the growth of A.glaucus.The antifungal mechanism has been demonstrated in this study,and results show that rPINA has application potential in preventing postharvest loss in the agricultural industry. | Wenjing Yuan Pingping Tian Ang Lyu Yangyong Lyu Wei Zhang Shan Wei Yuansen Hu | 2020 | Grain & Oil Science and Technology2020，3，1： | 0 |
| 20 | Joint inventory and transshipment decisions with consumer behavioral heterogeneity显示文摘Transshipment is an effective method for reducing mismatches between supply and demand among retailers.Consumers attempting to purchase out-of-stock items may wait for transshipment,purchase at another store,or choose not to buy.In this paper,the consumer behavioral heterogeneity is characterized using the transshipment request rate and consumer switching rate.It affects the replenishment and transshipment decisions,as well as the system profits.The inventory replenishment and transshipment decisions are studied in both centralized and decentralized two-location inventory systems with consumer behavioral heterogeneity.We characterize optimal replenishment decisions in a centralized system,prove the existence of a unique Nash equilibrium in a decentralized system with a specific demand distribution,and determine the coordinating transshipment price for some decentralized systems.In numerical studies,the performance of various systems is analyzed for consumers with identical(symmetric)or differing(asymmetric)behavior between retailers.For scenarios with symmetric consumers,a higher transshipment request rate and consumer switching rate resulted in increased total profit in all systems.For scenarios with asymmetric consumers,the retailer with the higher consumer switching rate should reduce ordering in a centralized system but increase ordering in a decentralized system.Moreover,the retailer with the higher transshipment request rate reduces ordering to increase profit,whereas the other retailer increases order quantity yet earns less profit. | Pingping Feng Jian Chai Zhongquan Hu Wei Zong Feng Wu Devin J.Wang | 2023 | Journal of Management Science and Engineering2023，8，3： | 0 |
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