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| 1 | Isolation and Characterization of Bacillus Amyloliquefaciens L-1 for Biocontrol of Pear Ring Rot显示文摘Considering the heavy losses caused by pear ring rot(Botryosphaeria berengeriana) disease, the potential biocontrol agent against B. berengeriana was isolated and characterized in this work. Bacteria, isolated from pear orchard rhizosphere soil, were screened for the biological control of pear ring rot caused by B. berengeriana. Among them, strain L-1 showed noticeable inhibitory activities against B. berengeriana and six other commonly occurring postharvest pathogens. Molecular methods indicated strain L-1 was Bacillus amyloliquefaciens. The potential of strain L-1 as an effective biocontrol agent was further estimated. Results showed strain L-1 could successfully colonize in pear wounds, its colonies reached 142.35 folds on 4 days post inoculation, and maintained at a high level during storage. In addition, strain L-1 caused abnormal hyphae growth of B. berengeriana,and its inhibitory percentage against pear ring rot reached 76.55% in vivo on 11 days post inoculation. Strain L-1 significantly induced the peroxidase(POD) and catalase(CAT) activities and delayed the accumulation of malondialdehyde(MDA) in pears. What's more, strain L-1 did not impair the fruit quality. All these results suggest that B. berengeriana L-1 is a promising agent for the biocontrol of pear ring rot. | SUN Pingping CUI Jianchao JIA Xiaohui WANG Wenhui | 2017 | Horticultural Plant Journal2017，3，5： | 19 |
| 2 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 3 | Upper crustal velocity and seismogenic environment of the M7.0 Jiuzhaigou earthquake region in Sichuan, China显示文摘On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone. | DaHu Li ZhiFeng Ding Yan Zhan PingPing Wu LiJun Chang XiangYu Sun | 2021 | Earth and Planetary Physics2021，5，4： | 4 |
| 4 | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling显示文摘Alcoholic liver disease(ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine(SAMC) from aged garlic on liver cell injury. A chronic ethanol-fed ALD in vivo model(the NIAAA model) was used to test the protective functions of SAMC. It was observed that SAMC(300 mg/kg, by gavage method) effectively ameliorated ALD-induced body weight reduction, steatosis,insulin resistance, and inflammation without affecting the health status of the control mice, as demonstrated by histological, biochemical, and molecular biology assays. By using biophysical assays and molecular docking, we demonstrated that SAMC directly targeted insulin receptor(INSR) protein on the cell membrane and then restored downstream IRS-1/AKT/GSK3 b signaling. Liver-specific knock-down in mice and siRNA-mediated knock-down in AML-12 cells of Insr significantly impaired SAMC(250 mmol/L in cells)-mediated protection. Restoration of the IRS-1/AKT signaling partly recovered hepatic injury and further contributed to SAMC’s beneficial effects. Continuous administration of AKT agonist and recombinant IGF-1 in combination with SAMC showed hepato-protection in the mice model.Long-term(90-day) administration of SAMC had no obvious adverse effect on healthy mice. We conclude that SAMC is an effective and safe hepato-protective complimentary agent against ALD partly through the direct binding of INSR and partial regulation of the IRS-1/AKT/GSK3 b pathway. | Pingping Luo Ming Zheng Rui Zhang Hong Zhang Yingxia Liu Wei Li Xiaoming Sun Qian Yu George LTipoe Jia Xiao | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 4 |
| 5 | Clinical significance of extended high-risk human papillomavirus genotyping and viral load in cervical cancer and precancerous lesions显示文摘Persistent infections with specific high-risk human papillomavirus(HR-HPV)strains are the leading cause of cervical cancer and precancerous lesions.HPV-16 and HPV-18 are associated with more than 70%of cervical cancer.However,with recent widespread vaccination efforts against cervical cancer,the infection rates of HPV-16 and HPV-18 have decreased across all age groups,while the infection rates of other HR-HPV strains have increased.The non-16/18 HR-HPV strains play an important role in cervical lesions.These strains can be identified with extended genotyping,and the 2019 American Society for Colposcopy and Cervical Pathology(ASCCP)guidelines recommended an HPV-based testing to assess the risk of cervical disease in patients.We reviewed and analyzed the clinical benefits of applying extended HR-HPV genotyping,which was published by the International Agency for Research on Cancer(HPV-16,18,31,33,35,39,45,51,52,56,58,59,66,and 68),to cervical cancer screening.This review concluded that cervical cancer screening needs to include extended HR-HPV genotyping.The examination of extended HR-HPV genotyping in cervical intraepithelial lesions and cervical cancers can help guide clinical practices. | Pingping Su Jincheng Ma Lirui Yu Shuting Tang Pengming Sun | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，1： | 2 |
| 6 | Thermal evolution effects on the properties of converting Cs-polluted soil into pollucite-base glass-ceramics for radioactive cesium immobilization显示文摘The Fukushima nuclear accident in Japan on March 11,2011,produced large amounts of Cs-polluted soil which must be controlled to prevent the spread of hazardous Cs into the environment.In this paper,the effects of heat treatment on the structure and properties of Cs-containing glass-ceramics,as a simulated nuclear waste form,were systematically investigated.Cesium atoms are chemically bonded in the pollucite structure,and the amorphous phase further encapsulates the pollucite crystals in the glassceramics,thus providing an extra protective layer for the immobilized Cs.XRD analysis,Raman and FT-IR studies on the glass-ceramics synergistically indicated that the optimum crystallization temperature for pollucite is around 1000℃.The pollucite is predominantly the main crystalline phase with a narrow crystal size distribution between 0.5 and 2 mm.Standard leaching test results show that the leaching rate of Cs was very low(3.0×10^(-3) g/(m^(2)·d)).The study offers a practical method for immobilizing Cs in pollucite-base glass-ceramics.Moreover,the experimentally obtained data may provide some important references for converting Cs-polluted soil into pollucite-base glass-ceramics waste form. | Yong Yang Xin Cao Lifen Shi Zhengyi Zhang Pingping Wang Jinwei Li Yangshan Sun Shuyong Chen Tianhe Wang Liyun Ma Shou Peng | 2021 | Journal of Materiomics2021，7，6： | 2 |
| 7 | Evolution of low-frequency noise passing through a spatial filter in a high power laser system显示文摘The theoretical model of spatial noise passing through a spatial filter is established in high power laser system under the small signal approximation. The transmission characteristic for a noise signal passing through spatial filters with different magnifications is analyzed by numerical simulation, according to the actual structure of the high power laser system. The results show that the spatial modulation period of low-frequency noise getting through the pinhole will be proportional to the magnification of the spatial filter. When the magnification is less than 1, the safe low-frequency noise will be extruded into the high-frequency region, which is the fast increasing part, and finally develops into the most dangerous part which can damage the optical devices. The conclusion of this research improves the relay imaging theory of a spatial filter and provides an important theoretical basis for a general design of high power laser systems. | SUN PingPing LIU DeAn ZHANG YanLi LI XiaoYan ZHANG Yan ZHU JianQiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 2 |
| 8 | Au-catalysed free-standing wurtzite structured InAs nanosheets grown by molecular beam epitaxy显示文摘In this study,we report the growth of free-standing InAs nanosheets using Au catalysts in molecular beam epitaxy.Detailed structural characterizations suggest that wurtzite structured InAs nanosheets,with features of extensive{1120}surfaces,grown along the<1102>direction and adopted{0001}nanosheet/catalyst interfaces,are initiated from wurtzite structured[0001]nanowires as the inclined epitaxial growth due to relatively higher In concentrations in Au catalysts,and grown from these inclined nanostructures through catalyst-induced axial growth and their enhanced lateral growth under the high growth temperature.Based on the facts that the nanosheets contain large low energy{1120}surfaces and{0001}nanosheet/catalyst interfaces,the growth of our nanosheets is a thermodynamically driven process.This study provides new insights into fabricating free-standing Ⅲ-Ⅴ nanosheets for their applications in future nanoscale devices. | Qiang Sun Han Gao Xiaomei Yao Kun Zheng Pingping Chen Wei Lu Jin Zou | 2019 | Nano Research2019，12，11： | 2 |
| 9 | Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages显示文摘Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has considerable clinical significance. The existence of a necrosis-to-apoptosis switch induced by hydrogen peroxide in macrophage cell line RAW 264.7 cells was confirmed by using flow cytometry and fluorescence microscopy. With the help of computational simulations, this study predicted that negative feedbacks between NF-κB and MAPKs are implicated in converting necrosis into apoptosis in macrophages exposed to hydrogen peroxide, which has significant implications. | LIN XuZhu, SUN TingZhe, CAI MeiHong & SHEN PingPing* State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, School of Life Science, Nanjing University, Nanjing 210093, China | 2010 | Science China(Life Sciences)2010，53，10： | 2 |
| 10 | DEAP1 encodes a fasciclin-like arabinogalactan protein required for male fertility in rice显示文摘Arabinogalactan proteins(AGPs)are widely distributed in plant cells.Fasciclin-like AGPs(FLAs)belong to a subclass of AGPs that play important roles in plant growth and development.However,little is known about the biological functions of rice FLA.Herein,we report the identification of a male-sterile mutant of DEFECTIVE EXINE AND APERTURE PATTERNING1(DEAP1)in rice.The deap1 mutant anthers produced aberrant pollen grains with defective exine formation and a flattened aperture annulus and exhibited slightly delayed tapetum degradation.DEAP1 encodes a plasma membrane-associated member of groupⅢplant FLAs and is specifically and temporally expressed in reproductive cells and the tapetum layer during male development.Gene expression studies revealed reduced transcript accumulation of genes related to exine formation,aperture patterning,and tapetum development in deap1 mutants.Moreover,DEAP1 may interact with two rice D6 PROTEIN KINASE-LIKE3 s(OsD6PKL3s),homologs of a known Arabidopsis aperture protein,to affect rice pollen aperture development.Our findings suggested that DEAP1 is involved in male reproductive development and may affect exine formation and aperture patterning,thereby providing new insights into the molecular functions of plant FLAs in male fertility. | Dan Zhou Ting Zou Kaixuan Zhang Pingping Xiong Fuxing Zhou Hao Chen Gongwen Li Kaiyou Zheng Yuhao Han Kun Peng Xu Zhang Shangyu Yang Qiming Deng Shiquan Wang Jun Zhu Yueyang Liang Changhui Sun Xiumei Yu Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 11 | Tensile mechanical properties of greenhouse cucumber cane显示文摘To obtain the mechanical properties of greenhouse cucumber cane,tensile and shear properties of the greenhouse cucumber cane were studied by using computer-controlled electronic universal testing machine and homemade cutting test bench,respectively.Firstly,the root,middle and head of cucumber cane were subjected for tensile tests.The tensile stress-strain curves showed that the root of cumber cane presented the characteristics of plastic material,while the middle and head showed the characteristics of brittle material.The average tensile strength of root,middle and head of fresh cucumber cane were 7.35 MPa,6.30 MPa and 4.68 MPa,respectively.The average elastic modulus of root of fresh cucumber cane was 280.58 MPa,which was much greater than the middle and head with average elastic modulus of 198.81 MPa and 137.22 MPa,respectively.A pendulum impact cutting test-rig and a cutting force measurement system composed of a cantilever weigh sensor,a high frequency DAQ card and motion control card were developed.The cutting mechanical property experiments of different parts of greenhouse cucumber cane were carried out,and the continuous curves of cutting force were measured.The single factor test for cross-sectional area,cutting speed,cutting tool type and manner were analyzed.The results indicated that the peak cutting force increased approximately linearly with the increasing of cutting sectional area,but decreased gradually with the increasing of cutting speed.In the same conditions,the cutting force could be reduced by using straight blade cutting tool and ramp cutting way.Through the multifactor interaction impact test of the cutting way,the blade type and the cutting speed,it was found that the corresponding F-value of the three factors were 21.316,49.141 and 0.222,which suggests that the blade type is the most significant factor for the cutting force. | Xu Yunfeng Zhang Xiliang Sun Xiaojia Wang Jizhang Liu Jizhan Li Zhiguo Guo Qian Li Pingping | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 2 |
| 12 | Primary cilia support cartilage regeneration after injury显示文摘In growing children,growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb growth arrest.Interestingly,one type of fracture injuries within the growth plate achieve amazing self-healing,however,the mechanism is unclear.Using this type of fracture mouse model,we discovered the activation of Hedgehog(Hh)signaling in the injured growth plate,which could activate chondrocytes in growth plate and promote cartilage repair. | Dike Tao Lei Zhang Yunpeng Ding Na Tang Xiaoqiao Xu Gongchen Li Pingping Niu Rui Yue Xiaogang Wang Yidong Shen Yao Sun | 2023 | International Journal of Oral Science2023，15，2： | 1 |
| 13 | Detection and Prevention of Environmental Hormone显示文摘The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced. | Qili Chen Ling Pan Yanhong Xv Xuan Fu Hongzhen Sun Hongyan Li Pingping Liu | 2013 | Meteorological and Environmental Research2013，4，12： | 1 |
| 14 | Synthesis,structure and nonlinear optical properties of two novel two-photon absorption chromophores显示文摘Two triphenylamine-based derivatives that can be used as two-photon absorption chromophore,tris{4-[4-(3-trifluoromethyl-3-oxopanoyl)]phenyl}amine (1) and tris{4-[4-(3-phenyl-3-oxopanoyl)] phenyl} amine (2) were successfully synthesized and fully characterized by elemental analysis,IR,1H NMR and MS. The single crystal X-ray diffraction analysis showed that the molecules possess D-(π-A)3 structures. One-and two-photon absorption and fluorescence in various solvents were experimentally investigated. A data recording experiment proved the potential application of these chromophores. | CHENG LeHua LI Lin SUN PingPing ZHOU HongPing TIAN YuPeng TANG HuoHong | 2009 | Science China Chemistry2009，52，4： | 1 |
| 15 | Epitope Prediction Based on Random Peptide Library Screening:Benchmark Dataset and Prediction Tools Evaluation 显示文摘 | SUN Pingping CHEN Wenhan HU Yanxin | 2011 | Molecules2011，16，6： | 1 |
| 16 | U-Pb ages and Hf-O isotopes of zircons from Late Paleozoic mafic ultramafic units in the southern Central Asian Orogenic Belt:Tectonic implications and evidence for an Early-Permian mantle plume显示文摘 | Su Benxun Qin Kezhang Sakyi P A Li Xianhua Yang Yueheng Sun He Tang Dongmei Liu Pingping Xiao Qinghua Malaviarachchi S P K | | 0，，： | 1 |
| 17 | Biosen- sor based on hollow-core metal-cladding waveguide 显示文摘 | Xiao Pingping Wang Xianping Sun Jingjing | 2012 | Sens Actuators A2012，183，： | 1 |
| 18 | Research on the Pedestrian Re-Identification Method Based on Local Features and Gait Energy Images显示文摘The appearance of pedestrians can vary greatly from image to image,and different pedestrians may look similar in a given image.Such similarities and variabilities in the appearance and clothing of individuals make the task of pedestrian re-identification very challenging.Here,a pedestrian re-identification method based on the fusion of local features and gait energy image(GEI)features is proposed.In this method,the human body is divided into four regions according to joint points.The color and texture of each region of the human body are extracted as local features,and GEI features of the pedestrian gait are also obtained.These features are then fused with the local and GEI features of the person.Independent distance measure learning using the cross-view quadratic discriminant analysis(XQDA)method is used to obtain the similarity of the metric function of the image pairs,and the final similarity is acquired by weight matching.Evaluation of experimental results by cumulative matching characteristic(CMC)curves reveals that,after fusion of local and GEI features,the pedestrian re-identification effect is improved compared with existing methods and is notably better than the recognition rate of pedestrian re-identification with a single feature. | Xinliang Tang Xing Sun Zhenzhou Wang Pingping Yu Ning Cao Yunfeng Xu | 2020 | Computers, Materials & Continua2020，，8： | 1 |
| 19 | Direct Synthesis of Co-doped Graphene on Dielectric Substrates Using Solid Carbon Sources显示文摘Direct synthesis of high-quality doped graphene on dielectric substrates without transfer is highly desired for simplified device processing in electronic applications.However,graphene synthesis directly on substrates suitable for device applications,though highly demanded,remains unattainable and challenging.Here,a simple and transfer-free synthesis of high-quality doped graphene on the dielectric substrate has been developed using a thin Cu layer as the top catalyst and polycyclic aromatic hydrocarbons as both carbon precursors and doping sources.N-doped and N,F-co-doped graphene have been achieved using TPB and F16Cu Pc as solid carbon sources,respectively.The growth conditions were systematically optimized and the as-grown doped graphene were well characterized.The growth strategy provides a controllable transfer-free route for high-quality doped graphene synthesis,which will facilitate the practical applications of graphene. | Qi Wang Pingping Zhang Qiqi Zhuo Xiaoxin Lv Jiwei Wang Xuhui Sun | 2015 | Nano-Micro Letters2015，7，4： | 1 |
| 20 | Experimental investigation of crossflow characteristics in multi-jets system at small nozzle-to-plate spacing显示文摘To further extend knowledge about the detailed knowledge on the crossflow characteristics in a multi-jets system under a confined space,particle image velocimetry (PIV) was employed to investigate the flow structures together with the distributions of the mean velocity components for Reynolds numbers (Re) ranging from 6 213 to 13 418,nozzle-to-plate spacing (H/D) varying from 0. 20 to1. 25,respectively. Results show that the crossflow configuration is significantly different from those of large nozzle-to-plate spacing. In addition,a turning point H/D=0.50 is revealed in the profile of the normalized maximum radial velocity which is associated with the heat transfer distribution on the impingement plate. | ZHU Keqian SUN Tao YU Pingping LI Meixiang YUAN Ningyi DING Jianning | 2019 | 排灌机械工程学报2019，37，2： | 1 |
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