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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Existence of Qiongnan suture zone on the north margin of South China Sea显示文摘This paper aims to explore whether paleo-suture zone exists in the pre-Cenozoic basement of South China Sea (SCS). By taking advantage of integrated geophysical surveying data, including multi-channel reflection seismicity, oceanic bottom seismicity, gravity and magnetic data as well as paleomagnetism and drilling information, a comprehensive analysis on sedimentary stratigraphy, seismic stratigraphy, magmatic and metamorphic petrology, geochemistry, gravity study, magnetics, paleogeomagnetics as well as geotectonics was carried out, and the results clearly indicate that a pre-Cenozoic suture zone, i.e. “Qiongnan (south Hainan Island) suture zone”, does exist on the north margin of SCS. This suture zone starts in the west from the Jiusuo-Lingshui fault zone in the south of Hainan Island, extends eastward across the continental slope to the north of SCS, and links with Shoufeng fault in Taiwan. It is inferred that the Qiongnan suture zone was sutured approximately in Indosinian (Triassic) Epoch and is actually the vestige of “Qiongnan ocean basin”, the extension of the main paleo-Tethys ocean basin in SCS. The formation of Qiongnan suture zone marked the collision-accretion of the Qiongnan Block toward the Qiongzhong Block. The Qiongnan suture zone is linked to the west with the southward extension of the principal suture zone of the Paleo-Tethys at Bitu-Changning-Menglian-Bentong-Raub, across the southern segment of the Red River-East Vietnam-Wanna strike-slip fault zone, and connected to the east with the suture zone emplaced into the south margin of the Oki-Hida Pre-Jurassic terranes in southwest Japan, across the northerni2 e segment of the Manila trench fault zone in the northeast side of Taiwan Island. The discovery of this suture zone is believed to be potentially significant toward study of the pre-Cenozoic geotectonic pattern of SCS, the temporal and spatial distribution of the east paleo-Tethys structural domain in SCS and the relationship of recombination and superimposition between the east paleo-Tethys structural domain and the west Pacific structural domain, in addition to the oil/gas geological potentials in the pre-Cenozoic marine vestige-superimposed basin in the study area. | LIU Hailing YAN Pin LIU Yingchun DENG Hui | 2006 | Chinese Science Bulletin2006，51，B12： | 12 |
| 3 | Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza显示文摘Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this winter.However,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear.Using a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following H1N1.We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets.Moreover,mortality was increased in sequentially infected mice compared with single-infection mice.Compared with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.Combined immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 infection.Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter. | Linlin Bao Wei Deng Feifei Qi Qi Lv Zhiqi Song Jiangning Liu Hong Gao Qiang Wei Pin Yu Yanfeng Xu Yajin Qu Fengdi Li Jing Xue Shuran Gong Mingya Liu Guanpeng Wang Shunyi Wang Binbin Zhao Bin Cong Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 4 |
| 4 | Physical Mechanism and Performance Factors of Metal Oxide Based Resistive Switching Memory:A Review显示文摘This review summarizes the mechanism and performance of metal oxide based resistive switching memory The origin of resistive switching(RS) behavior can be roughly classified into the conducting filament type and the interface type. Here,we adopt the filament type to study the metal oxide based resistive switching memory,which considers the migration of metallic cations and oxygen vacancies,as well as discuss two main mechanisms including the electrochemical metallization effect(ECM) and valence change memory effect(VCM). At the light of the influence of the electrode materials and switching layers on the RS characteristics,an overview has also been given on the performance parameters including the uniformity endurance,the retention,and the multi-layer storage. Especially,we mentioned ITO(indium tin oxide electrode and discussed the novel RS characteristics related with ITO. Finally,the challenges resistive random access memory(RRAM) device is facing,as well as the future development trend,are expressed. | Cong Ye Jiaji Wu Gang He Jieqiong Zhang Tengfei Deng Pin He Hao Wang | 2016 | Journal of Materials Science & Technology2016，32，1： | 3 |
| 5 | Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many countries.However,the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.Here,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune systems.The viral protein partially co-localized with activated Mac-2+macrophages throughout the body.Moreover,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal COVID-19.Particularly,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune dysregulation.Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation.Melatonin,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted medicine.Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers. | Zhiqi Song Linlin Bao Wei Deng Jiangning Liu Erjun Ren Qi Lv Mingya Liu Feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 6 | Transcriptional Factor Snail Mediates Epithelial-Mesenchymal Transition in Human Bronchial Epithelial Cells Induced by Silica显示文摘Epithelial-mesenchymal transition(EMT)plays an important role in fibrotic diseases.We have previously showed that silica induces EMT in human bronchial epithelial cells(BECs);however,the underlying mechanism of silica-induced EMT is poorly understood.In the present study,we investigated the role of Snail in silica-induced EMT in human BECs in vitro.Human BECs were | HU Yong Bin LI Fei Feng DENG Zheng Hao PAN Pin Hua | 2015 | Biomedical and Environmental Sciences2015，28，7： | 2 |
| 7 | Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques显示文摘Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type. | Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 8 | Cellular Chain Complex of Small Covers with Integer Coefficients and Its Application显示文摘 | Deng Pin LIU | 2018 | Acta Mathematica Sinica,English Series2018，34，11： | 2 |
| 9 | Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid(PDL)for COVID-19 in vitro and in vivo显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has rapidly swept through the worldwide,with more than 3 million confirmed cases.Until now,no vaccine or effective therapeutic measures are provided to prevent the SARS-CoV-2 infection.Existing medicines have some strong advantages on pharmacokinetics,known side effects,safety and dosing regimens.1 Although remdesivir and chloroquine could effectively inhibit the replication of SARS-CoV-2 in vitro,2 no medicine candidates have been evaluated in vivo by using animal models with SARS-CoV-2 infection. | Wei Deng Yanfeng Xu Qi Kong Jing Xue Pin Yu Jiangning Liu Qi Lv Fengdi Li Qiang Wei Linlin Bao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 10 | The Efficacy of Second‐Line Anti‐ Helicobacter pylori Therapy Using an Extended 14‐Day Levofloxacin/Amoxicillin/Proton‐Pump Inhibitor Treatment – A Pilot Study显示文摘 | Seng‐Kee Chuah Wei‐Chen Tai Pin‐I Hsu Deng‐Chyang Wu Keng‐Liang Wu Chung‐Mou Kuo Yi‐Chun Chiu Ming‐Luen Hu Yeh‐Pin Chou Yuan‐Hung Kuo Chih‐Ming Liang King‐Wah Chiu Tsung‐Hui Hu | 2012 | Helicobacter2012，，5： | 2 |
| 11 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 12 | Potential Antiviral Target for SARS-CoV-2:A Key Early Responsive Kinase during Viral Entry显示文摘Currently,there is no effective antiviral medication for coronavirus disease 2019(COVID-19)and the knowledge on the potential therapeutic target is in great need.Guided by a time-course transmission electron microscope(TEM)imaging,we analyzed early phosphorylation dynamics within the first 15 min during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral entry.Based on alterations in the phosphorylation events,we found that kinase activities such as protein kinase C(PKC),interleukin-1 receptor-associated kinase 4(IRAK4),MAP/microtubule affinity-regulating kinase 3(MARK3),and TANK-binding kinase 1(TBK1)were affected within 15 min of infection.Application of the corresponding kinase inhibitors of PKC,IRAK4,and p38 showed significant inhibition of SARS-CoV-2 replication.Additionally,proinflammatory cytokine production was reduced by applying PKC and p38 inhibitors.By an acquisition of a combined image data using positiveand negative-sense RNA probes,as well as pseudovirus entry assay,we demonstrated that PKC contributed to viral entry into the host cell,and therefore,could be a potential COVID-19 therapeutic target. | Siwen Liu Lin Zhu Guangshan Xie Bobo Wing-Yee Mok Zhu Yang Shaofeng Deng Siu-Ying Lau Pin Chen Pui Wang Honglin Chen Zongwei Cai | 2022 | CCS Chemistry2022，4，1： | 1 |
| 13 | The temporal and spatial distribution of volcanism in the South China Sea region显示文摘 | Yan Pin Deng Hui Liu Hailing | 2006 | Jour nal of Asian Earth Sciences2006，27，5： | 1 |
| 14 | Sequence analysis of the drug?resistant rpoB gene in the Mycobacterium tuberculosisL?form among patients with pneumoconiosis complicated by tuberculosis显示文摘 | Jun Lu Shan Jiang Song Ye Yun Deng Shuai Ma Chao?Pin Li | 2014 | Molecular Medicine Reports2014，，4： | 1 |
| 15 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 16 | The temporal and spatial distribution of volcanism in the South China Searegion显示文摘 | YAN Pin DENG Hui LIU Hailing | 2006 | Journal of Asian Earth Sciences2006，27，5： | 1 |
| 17 | The Efficacy of Second‐Line Anti‐ Helicobacter pylori Therapy Using an Extended 14‐Day Levofloxacin/Amoxicillin/Proton‐Pump Inhibitor Treatment – A Pilot Study显示文摘 | Seng‐Kee Chuah Wei‐Chen Tai Pin‐I Hsu Deng‐Chyang Wu Keng‐Liang Wu Chung‐Mou Kuo Yi‐Chun Chiu Ming‐Luen Hu Yeh‐Pin Chou Yuan‐Hung Kuo Chih‐Ming Liang King‐Wah Chiu Tsung‐Hui Hu | 2012 | Helicobacter2012，，： | 1 |
| 18 | Structural and functional analysis of a potent human neutralizing antibody against enterovirus A71显示文摘Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to death.Currently,no vaccine is available in most endemic regions,and no licenced treatments for EV-A71 infection are available.Here,we characterize a human monoclonal antibody(Hu MAb),E1,by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection.E1 exhibits strong neutralizing activity against EV-A71 virus in cells.The cryo-electron microscopy(cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of VP1.In a mouse model,E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic treatment.In particular,E1 significantly reduces virus titers and muscle damage.E1 might represent a potential adjunct to EV-A71 treatment. | Zhe Chen Linlin Bao Bin Zhu Hua Fu Shuangli Zhu Tianjiao Ji Ying Xue Chuan Liu Xurong Wang Fengdi Li Qi Lv Feifei Qi Pin Yu Wei Deng Wenbo Xu Chuan Qin Hongrong Liu Qi Jin | 2022 | Science China(Life Sciences)2022，65，12： | 0 |
| 19 | A comparative study on imaging parameters of Chevron combined with Akin osteotomy and Scarf combined with Akin osteotomy for the correction of hallux valgus in patients at different ages显示文摘Objective:To study the imaging parameters of Chevron combined with Akin and Scarf combined with Akin for the correction of hallux valgus in patients of different ages.Methods:Eighty patients(152 feet)with hallux valgus who underwent Chevron combined with Akin and Scarf combined with Akin in our hospital were randomly selected.The patients were divided into young and middle-aged groups.Measure the hallux valgus angles(HVA),distal metatarsal articular angle(DMAA)and intermetatarsal angles(IMA)with professional X-ray measurement software and then reseach the effect of two the operation methods.Results:Young group:Chevron combined with Akin and Scarf combined with Akin significantly improved HVA and IMA,the difference had statistical significance(P<0.05),but the improvement effect of the two groups was similar,and the difference had no statistical significance(P>0.05).The improvement effect of the two groups on DMAA in young patients was not significant,and the difference had no statistical significance(P>0.05);Middle-aged group:Chevron combined with Akin and Scarf combined with Akin also significantly improved HVA and IMA(P<0.05),but the improvement effect of the two groups was similar,and the difference had no statistical significance(P>0.05).Chevron combined with Akin significantly improved DMAA in middle-aged and elderly patients,and the difference had statistical significance(P<0.05).Scarf combined with Akin did not significantly improve DMAA in middle-aged and elderly patients,and the difference had no statistical significance(P<0.05).Conclusion:Both Chevron combined with Akin and Scarf combined with Akin are effective and widely used.Chevron combined with Akin was able to improve DMAA in middle-aged and elderly patients.Therefore,Chevron combined with Akin is recommended for middle-aged and elderly patients with hallux valgus. | Kun-Ming Xie Zhao-Jun Chen Xin-Yu Li Yin-Ze Qi Jun-De Wu Zhan-Hua Ma Xu-Yue Pan Fa-Sen Huang Huan Liang Pin Deng Jing-Lu Han Jing-Wei Tao Han-Jie Zhu | 2021 | Journal of Hainan Medical University2021，27，13： | 0 |
| 20 | Analysis of brain-stem auditory evoked potential and visual evoked potential in patients with Parkinson disease显示文摘BACKGROUND: With the development of neuroelectrophysiology, it had been identified that all kinds of evoked potentials might reflect the functional status of corresponding pathway. Evoked potentials recruited in the research of PD, it can be known whether other functional pathway of nervous system is impaired. OBJECTIVE: To observe whether brainstem auditory and visual passageway are impaired in patients with Parkinson disease (PD), and compare with non-PD patients concurrently. DESIGN: A non-randomized concurrent controlled observation. SETTINGS: Henan Provincial Tumor Hospital; Anyang District Hospital. PARTICIPANTS: Thirty-two cases of PD outpatients and inpatients, who registered in the Department of Neurology, Anyang District Hospital from October 1997 to February 2006, were enrolled as the PD group, including 20 males and 12 females, aged 50-72 years old. Inclusive criteria: In accordance with the diagnostic criteria of PD recommended by the dyskinesia and PD group of neurology branch of Chinese Medical Association. Patients with diseases that could cause Parkinson syndrome were excluded by CT scanning or MRI examination. Meanwhile, 30 cases with non-neurological disease were selected from the Department of Internal Medicine of our hospital as the control group, including 19 males and 11 females, aged 45-70 years old. Including criteria: Without history of neurological disease or psychiatric disease; showing normal image on CT. And PD, Parkinson syndrome and Parkinsonism-plus were excluded by professional neurologist. All the patients were informed and agreed with the examination and clinical observation. METHODS: The electrophysiological examination and clinical observation of the PD patients and controls were conducted. The Reporter type 4-channel evoked potential machine (Italy) was used to check brain-stem auditory evoked potential (BAEP) and visual evoked potential (VEP). Why to be examined was explained to test taker. BAEP recording electrode was placed at Cz, while the reference one placed at ipsilateral ear lobe, according to international standard 10-20 system. The short sound was used to stimulate the target ear with the interval of 0.1 ms, the frequency of which was 9.9 Hz, intensity was 110 db, superposition was 2 048 times while the opposite one screened noisily, then repeated for twice or more in the same way. The latencies of waves Ⅰ-Ⅴ, and the intervals of waves Ⅰ-Ⅴ, Ⅰ-Ⅲ, Ⅲ-Ⅴ were measured. The purpose of the detection should be explained to the patients in advance. VEP recording electrode was placed at the point 5 cm above occipital tuberosity and 5 cm beside the line connecting the previous point and the preauricula point on either side, while the reference electrode placed at Fz. The whole visual chessboard-grid stimulation was used, superposition of which was 250 times, then repeated for twice or more in the same way. The results of BAEP and VEP detections were observed in the two groups.The differences of the measurement data were compared with the t test. MAIN OUTCOME MEASURES: ① Indexes of BAEP analysis: peak latencies (PL) of waves Ⅰ, Ⅲ and Ⅴ, and the inter-peak latencies (IPL) of waves Ⅰ-Ⅴ, Ⅰ-Ⅲ, Ⅲ-Ⅴ. ② The indexes of VEP analysis: P100 PL and the abnormal rate of P100 amplitude. RESULTS: All the 32 PD patients and 30 patients with non-neurological diseases were involved in the analysis of results. ① BAEP: The wave Ⅲ PL and wave Ⅴ PL of the PD patients were obviously different from those in the control group [(3.87±0.30), (5.79±0.3) ms; (3.56±0.22), (5.48±0.26) ms, t =5.83, 5.85, P < 0.01]. The abnormal rate of the PD patients was 50%, including that of wave Ⅲ PL and wave Ⅴ PL was 22% and 19% respectively. ② VEP: The P100 PL of the PD patients was obviously different from that in the control group [(105.17±12.42), (98.62±9.46) ms, t =2.49, P < 0.05]. The P100 PL was abnormal in 10 cases (31%), and P100 wave amplitude was abnormal in 14 cases (44%). CONCLUSION: ① VEP and BAEP abnormalities do occur and brainstem auditory and visual pathway are impaired. ② Besides extracorticospinal tract, the sensory system is also involved in PD patients. ③ BAEP and VEP can be taken as the objective indicators for the clinical evaluation of PD. | Qiaorong Deng Jianzhong Deng Yanmin Zhao Xiaohai Yan Pin Chen | 2006 | Neural Regeneration Research2006，1，5： | 0 |
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