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| 1 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 2 | Existence of Qiongnan suture zone on the north margin of South China Sea显示文摘This paper aims to explore whether paleo-suture zone exists in the pre-Cenozoic basement of South China Sea (SCS). By taking advantage of integrated geophysical surveying data, including multi-channel reflection seismicity, oceanic bottom seismicity, gravity and magnetic data as well as paleomagnetism and drilling information, a comprehensive analysis on sedimentary stratigraphy, seismic stratigraphy, magmatic and metamorphic petrology, geochemistry, gravity study, magnetics, paleogeomagnetics as well as geotectonics was carried out, and the results clearly indicate that a pre-Cenozoic suture zone, i.e. “Qiongnan (south Hainan Island) suture zone”, does exist on the north margin of SCS. This suture zone starts in the west from the Jiusuo-Lingshui fault zone in the south of Hainan Island, extends eastward across the continental slope to the north of SCS, and links with Shoufeng fault in Taiwan. It is inferred that the Qiongnan suture zone was sutured approximately in Indosinian (Triassic) Epoch and is actually the vestige of “Qiongnan ocean basin”, the extension of the main paleo-Tethys ocean basin in SCS. The formation of Qiongnan suture zone marked the collision-accretion of the Qiongnan Block toward the Qiongzhong Block. The Qiongnan suture zone is linked to the west with the southward extension of the principal suture zone of the Paleo-Tethys at Bitu-Changning-Menglian-Bentong-Raub, across the southern segment of the Red River-East Vietnam-Wanna strike-slip fault zone, and connected to the east with the suture zone emplaced into the south margin of the Oki-Hida Pre-Jurassic terranes in southwest Japan, across the northerni2 e segment of the Manila trench fault zone in the northeast side of Taiwan Island. The discovery of this suture zone is believed to be potentially significant toward study of the pre-Cenozoic geotectonic pattern of SCS, the temporal and spatial distribution of the east paleo-Tethys structural domain in SCS and the relationship of recombination and superimposition between the east paleo-Tethys structural domain and the west Pacific structural domain, in addition to the oil/gas geological potentials in the pre-Cenozoic marine vestige-superimposed basin in the study area. | LIU Hailing YAN Pin LIU Yingchun DENG Hui | 2006 | Chinese Science Bulletin2006，51，B12： | 12 |
| 3 | Numerical Simulation on Fluid Flow in Hot Metal Pretreatment显示文摘Basing on the commercial CFD metho d ,several models are adopted to simulate water model. The numerical simulation results are in good agreement with the experimental data of water model under the same experimental conditions. Then the numerical simulation method is presented to investigate the flow field, the vortex on gas-liquid surface and the uniform mixing time in hot metal ladles. This research shows: the vortex depth increases with increasing of immersion depth and rotation speed; Overflow appears in N=120rpm and h=3.2m; the turbulent kinetic energy increases with increasing immersion depth and rotation speed; uniform mixing time decreases with the decreasing of immersion depth and the rotation speed of stirring ; the optimal uniform mixing time is 23.5s on the conditions of N=100rpm and h=3.2m within the allowable range. | SHAO Pin, ZHANG Ting-an, LIU Yan, ZHAO Hong-liang, HE Ji-cheng (Laboratory of Ecological Untilization of Multi-Metal Intergrown Ores of Education Ministry, Shenyang 110004, Liaoning, China) | 2011 | Journal of Iron and Steel Research(International)2011，18，S2： | 8 |
| 4 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 5 | Determination of resveratrol in red wine by solid phase extraction-flow injection chemiluminescence method显示文摘一个敏感流动注射化合光方法基于 resveratrol 能极大地在硫酸媒介提高在 KMnO4 和 HCHO 之间的化合光反应的事实在红酒为 resveratrol 的察觉被开发了。Analytes 在稳固的吸着剂(C18 稳固阶段的萃取柱柱体) 上被预先集中。在最佳条件下面,建议方法在 1.32 × 的范围上允许 resveratrol 的测量 10 (? 8 )到 1.32 × 10 (? 5 )有 3.30 × 的检测极限的 mol/L 10 (? 9 ) mol/L ,并且为 1.32 × 的相对标准偏差 10 (? 5 ) mol/L resveratrol ( n = 11 )是3.8%。这个方法成功地被申请了在红酒的 resveratrol 的决心。而且,可能的反应机理也被讨论。 | Juan Juan Ren Hai Yan Liu Yu Hong Hao Pin Gang He Yu Zhi Fang | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 6 | All-transRetinoic Acid Regulates Th1/Th2 Balance in CD4+T cells When GATA-3 is Deficient显示文摘The essential effect of vitamin A on immune function occurs through various mechanisms including direct effect on Th1-Th2 balance modulation.However,it is unclear whether or not vitamin A can regulate Th1-Th2 balance under a strong Th1-polarizing condition.Therefore,the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid(ATRA)on Th1-Th2 differentiation in CD4+T cells under GATA-3 deficiency,which can induce Th1-polarizing condition.In the present study,GATA-3 deficiency T cells were induced by siRNA and checked | ZHU Yan Feng HU Jia Zhe ZHAO Pin Nan LIU Lin Xi and LI Yun | 2013 | Biomedical and Environmental Sciences2013，26，9： | 6 |
| 7 | Existence of Solutions of Boundary Value Problem Differential a Nonlinear Three-Point for Third-Order Ordinary Equations显示文摘In this paper,existence of solutions of third-order differential equation ■with nonlinear three-point boundary condition ■is obtained by embedding Leray-Schauder degree theory in upper and lower solutions method,where a,b,c ∈ R,a < b < c;f :[a,c]×R3 → R,g :R3 → R,h :R2 → R and I :R3 → R are continuous functions.The existence result is obtained by defining the suitable upper and lower solutions and introducing an appropriate auxiliary boundary value problem.As an application,an example with an explicit solution is given to demonstrate the validity of the results in this paper. | SHEN Jian He ZHOU Zhe Yan YU Zan Pin | 2009 | Journal of Mathematical Research and Exposition2009，29，1： | 6 |
| 8 | Synthesis and Crystal Structure of Rare Earth Complex withCiprofloxacin显示文摘The complex of rare earth with ciprofloxacin has been synthesized and characterized bymeans of x-ray single crystal diftraction. The structure features of the complex are decribed. | Pin YANG Jia Bin LI Yan Ni TIAN Kai Bei YU (1 Institute of molecular Science, Shanxi University, Taiyuan 0300062 Analysis and Test Cented, Chinese Academy of Sciences, Chengdu 610041) | 1999 | Chinese Chemical Letters1999，10，10： | 6 |
| 9 | An Anomalous Seamount on the Southwestern Mid-Ridge of the South China Sea显示文摘Objective The development of continental rifting and seafloor spreading can be predominated by magmatic upwelling(magma-rich)or tectonic stretching(magma-poor).Located in the terminal portion of propagating seafloor spreading of the South China Sea(SCS),the southwestern mid-ridge of the southwest sub-basin(SWSB)of the | WANG Yanlin WANG Jun YAN Pin QIU Yan | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 5 |
| 10 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 11 | Antrodia Cinnamomea ameliorates neointimal formation by inhibiting infl ammatory cell infi ltration through downregulation of adhesion molecule expression in vitro and in vivo显示文摘The increased vascular infl ammation is a key event in the development of atherosclerotic lesions.Antrodia cinnamomea has been shown to promote anticancerogenic activity through decreasing infl ammation.However,the potential role of A.cinnamomea in cardiovascular diseases remains unexplored.Herein,using carotid arterial ligation models,we found that ethanol extract from A.cinnamomea(EEAC)signifi cantly inhibited neointimal hyperplasia in a dose-dependent manner,accompanied with the reduced expression of activated p65 and infl ammatory cytokines.We also show that EEAC ameliorated TNF-α-induced phosphorylation of p65 and pro-infl ammatory cytokine expression in both vascular smooth muscle cells(VSMCs)and macrophages in vitro.Mechanistically,EEAC suppressed expression levels of intercellular adhesion molecule-1(ICAM-1)and vascular cell adhesion molecule(VCAM-1)in VSMCs,which attenuates the ability of monocytes/macrophages adhesion to VSMCs.Furthermore,the expression level of these adhesion molecules and infi ltration of monocytes/macrophages were also decreased in neointimal VSMCs of arteries pretreated with EEAC.Altogether,our results reveal a novel function of A.cinnamomea in suppressing vascular infl ammation upon ligation injury during neointimal formation,likely through inhibition of infl ammatory cell infi ltration via downregulating the adhesion molecules in VSMCs.Thus,A.cinnamomea may offer a pharmacological therapy to slow down disease progression in patients with vascular injury. | Yan Zhang Aijin Ma Hao Xi Ning Chen Rong Wang Chenhui Yang Jinbang Chen Pin Lü Fuping Zheng Wenyi Kang | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 12 | Polymorphism in the upstream regulatory region of human papilloma virus type 16 from the cervical cancer biopsies in Xinjiang Uygur women显示文摘To investigate the mutations in the upstream regulatory region (URR) of human papillomavirus type 16 (HPV-16) from the cervical cancer biopsies in Xinjiang Uygur women and its relationship to the high incidence of cervical cancer in the southern Xinjiang, the tissue DNA was extracted from the cervical cancer biopsies, and the URR segment of HPV-16 DNA was amplified, sequenced and analyzed. Thereafter, the polymorphism of URR in HPV-16 was then analyzed. It was demonstrated that the positive rate detected for the presence of URR in HPV-16 was 89.47% (17/19). Compared with the previously published sequence in URR of prototype HPV-16, some mutations were detected in the sequence of URR. The mutations in 17 URR fragments of HPV-16 could be divided into 11 patterns (XJU-1 to XJU-11) at nucleic acid level, in which each of XJU-1 and XJU-4 accounted for 23.53% (4/17), and other patterns of mutation accounted for 5.88% (1/17) . In comparison with the URR of prototype HPV-16, the DNA identity of these patterns was 98.50%-99.68% . In these 17 URR fragments, two point mutations occurred at position 7192 (G to T) and position 7520 (G to A) and they appeared to be constant in Xinjiang area. These two mutations were ubiquitous in the Asia-American type and conferred strong infection activity and carcinogenicity of this virus. In addition, the mutations at position 7729 (A to C), position 7843 (A to G) and position 7792 (C to T) could enhance its transcription activity considerably. It is concluded that some mutations occur in URR gene of HPV-16 in the cervical cancer biopsies taken from Uygur women in Xinjiang area, suggesting that certain relationship exists among the mutations in URR of HPV-16, the phylogeny of HPV-16 and the high incidence of cervical cancer in southern part of Xinjiang area. | MENG YU ZHENG HAI MA YAN PIN WANG XI DAN RE FU CHUN ZHANG | 2006 | Journal of Microbiology and Immunology2006，4，3： | 4 |
| 13 | Ethylenediurea(EDU) pretreatment alleviated the adverse effects of elevated O3 on Populus alba 'Berolinensis' in an urban area显示文摘Ethylenediurea(EDU)has been used as a chemical protectant against ozone(O3).However,its protective effect and physiological mechanisms are still uncertain.The present study aimed to investigate the changes of foliar visible injury,physiological characteristics and emission rates of volatile organic compounds(VOCs)in one-year-old Populus alba'Berolinensis'saplings pretreated with EDU and exposed to elevated O3(EO,120μg/m3).The results showed that foliar visible injury symptoms under EO were significantly alleviated in plants with EDU application(p<0.05).Under EO,net photosynthetic rate,the maximum photochemical efficiency of PSII and the photochemical efficiency of PSII of plants pretreated with 300 and600 mg/L EDU were similar to unexposed controls and significantly higher compared to EOstressed plants without EDU pretreatment,respectively.Malondialdehyde content was highest in EO without EDU and decreased significantly by 14.9%and 21.3%with 300 and600 mg/L EDU pretreatment,respectively.EDU pretreatment alone increased superoxide dismutase activity by 10-fold in unexposed plants with further increases of 88.4%and 37.5%in EO plants pretreated with 300 and 600 mg/L EDU pretreatment,respectively(p<0.05).Abscisic acid content declined under EO relative to unexposed controls with the effect partially reversed by EDU pretreatments.Similarly,VOCs emission rate declined under EO relative to unexposed plants with a recovery of emission rate observed with 300 and 600 mg/L EDU pretreatment.These findings provided significant evidence that EDU exerted a beneficial effect and protection on the tested plants against O3 stress. | Sheng Xu Xingyuan He Kent Burkey Wei Chen Pin Li Yan Li Bo Li Yijing Wang | 2019 | Journal of Environmental Sciences2019，31，10： | 4 |
| 14 | Impact of clinical research on public health policy of neonatal screening for congenital heart disease in China显示文摘Congenital heart disease(CHD)is one of the most common congenital malformations,with a prevalence of approximately 1%in live births.[1,2]Among them,1/4 to 1/3 are major CHD,including critical CHD(CCHD)and serious CHD,which require surgical or catheter intervention before 1 year of age.[3]Major CHD,if left untreated,may cause serious outcomes,such as heart failure,cardiogenic shock,acidosis,and hypoxic-ischemic brain damage,and is one of the leading causes of infant death and childhood disability.[4]The missed diagnosis rate of CCHD in four nurseries ranges from 13%to 48%in developed countries,[4,5]but in China,is>71%before serious symptoms occur after birth.[6]Therefore,screening for CHD is useful for early detection,diagnosis,and treatment and helps to improve prognosis and reduces the medical,economic,and mental burden to both the family and the society.[5,7] | Miao Yang Youping Tian Pin Jia Xiaojing Ma Xiaoling Ge Xiaojing Hu Quming Zhao Fang Liu Bing Jia Weili Yan Qing Gu Guoying Huang | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 15 | Improvement of Impeller Blade Structure for Gas Injection Refining under Mechanical Sirring显示文摘The impeller blade structure for gas injection refining under mechanical stirring has been explored by water model experiments.A sloped swept-back blade impeller is proposed for the purpose.The central part of the impeller is disk-or plate-shaped,and the blades are fitted to the side of the disk or plate.In addition,a disk is put on the top side of the impeller blades.The impeller can strengthen the radial and downward flow between the blades and weaken the swirl flow in the zone above the impeller.These effects on flow phenomena are favorable for disintegration and wide dispersion of bubbles which are injected from a nozzle attached to the center of the underside of the impeller.In addition,the sloped swept-back impeller requires less power consumption.The impeller shaft should be placed away from the vessel center so as to disperse the injected bubbles widely in the bath under mechanical stirring even with unidirectional impeller rotation and without installing baffles.The number of gas holes in the nozzle and the direction of gas injection have a little effect on the bubble disintegration and dispersion in the bath.Highly efficient gas injection refining can be established under the conditions of proper impeller size,larger nozzle immersion depth,larger eccentricity and rotation speed of the impeller.The sloped swept-back blade impeller can decrease the power consumption and yet improve the bubble disintegration and wide dispersion in the bath. | Yan LIU Zi-mu ZHANG Sano MASAMICHI Jun ZHANG Pin SHAO Ting-an ZHANG | 2014 | Journal of Iron and Steel Research(International)2014，21，2： | 3 |
| 16 | Simultaneous determination of flavonoids and anthraquinones in chrysanthemum by capillary electrophoresis with amperometry detection显示文摘有 amperometry 察觉方法(CE 广告) 的高效的毛状的电气泳动在菊为 flavonoids 和 anthraquinones (emodin, kaempferol, apigenin, luteolin 和 rhein ) 的分析被开发了。在最佳条件下面,这五 analytes 是用运用缓冲区的 boratephosphate 在 17 min 以内分开的基线(1.5 整楲杮挠牯敲慬楴湯猠数瑣潲 ' 盏?刨卌千)?? 懀吗?? | Yin Yan Zhang Zi Cheng Li Jin Kun Zhu Zhi Yong Yang Qing Jiang Wang Pin Gang He Yu Zhi Fang | 2010 | Chinese Chemical Letters2010，21，10： | 3 |
| 17 | Simultaneous determination of active ingredients in blueberry wine by CE-AD显示文摘基于结合的毛状的电气泳动,安培计的察觉(CE 广告) 第一次为 kaempferol, ferulic 酸,香子兰的酸,咖啡的酸,法国的酸和在蓝莓酒酸的 protocatechuic 的分离和决心被开发了的一个方法。为了得到分离,工作电极潜力的效果, pH 价值和运用缓冲区,分离电压和注射的集中的最佳条件,在 CE 广告上预定被调查。在最佳条件下面, analytes 能在 pH 在 Na2B4O7KH2PO4 缓冲区被分开 7.8 在 18 min 以内。300 m 直径碳磁盘电极在 +0.95 V 有好当前的回答(对 SCE ) 为所有 analytes。回答与在有察觉限制的三个数量级上的集中是线性的(S/N = 3 ) 在 108 g/mL,为 analytes 和恢复的大小在 95.8106.7% 的范围。方法能成功地与令人满意的结果被用于真实样品的分析因此由水果酒制片人的质量控制部门为使用推荐了。 | Zi Cheng Li Lang Zhu Chi Jin Kun Zhu Yin Yan Zhang Qing Jiang Wang Pin Gang He Yu Zhi Fang | 2011 | Chinese Chemical Letters2011，22，10： | 2 |
| 18 | Hydroxychavicol,a polyphenol from Piper betle leaf extract,induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells显示文摘This study aims to elucidate the antiproliferative mechanism of hydroxychavicol(HC).Its effects on cell cycle,apoptosis,and the expression of c-Jun N-terminal kinase(JNK)and P38 mitogen-activated protein kinase(MAPK)in HT-29 colon cancer cells were investigated.HC was isolated from Piper betle leaf(PBL)and verified by high-performance liquid chromatography(HPLC),nuclear magnetic resonance(NMR),and gas chromatography-mass spectrometry(GC-MS).The cytotoxic effects of the standard drug 5-fluorouracil(5-FU),PBL water extract,and HC on HT-29 cells were measured after 24,48,and 72 h of treatment.Cell cycle and apoptosis modulation by 5-FU and HC treatments were investigated up to 30 h.Changes in phosphorylated JNK(pJNK)and P38(pP38)MAPK expression were observed up to 18 h.The half maximal inhibitory concentration(IC_(50))values of HC(30μg/mL)and PBL water extract(380μg/mL)were achieved at 24 h,whereas the IC_(50)of 5-FU(50μmol/L)was obtained at 72 h.Cell cycle arrest at the G0/G1 phase in HC-treated cells was observed from12 h onwards.Higher apoptotic cell death in HC-treated cells compared to 5-FU-treated cells(P<0.05)was observed.High expression of pJNK and pP38 MAPK was observed at 12 h in HC-treated cells,but not in 5-FU-treated HT-29 cells(P<0.05).It is concluded that HC induces cell cycle arrest and apoptosis of HT-29 cells,with these actions possibly mediated by JNK and P38 MAPK. | Aiysvariyah RAJEDADRAM Kar Yong PIN Sui Kiong LING See Wan YAN Mee Lee LOOI | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，2： | 2 |
| 19 | γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer显示文摘 | Pin Wu Dang Wu Chao Ni Jun Ye Wuzhen Chen Guoming Hu Zhen Wang Changrong Wang Zhigang Zhang Wenjie Xia Zhigang Chen Ke Wang Tao Zhang Jinghong Xu Yuehua Han Ting Zhang Xianguo Wu Jianwei Wang Weihua Gong Shu Zheng Fuming Qiu Jun Yan Jian Huang | 2014 | Immunity2014，，5： | 2 |
| 20 | Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo显示文摘Antrodia cinnamomea is extensively used as a traditional medicine to prevention and treatment of liver cancer.However,its comprehensive chemical fingerprint is uncertain,and the mechanisms,especially the potential therapeutic target for anti-hepatocellular carcinoma(HCC)are still unclear.Using UPLC-Q-TOF/MS,139 chemical components were identified in A.cinnamomea dropping pills(ACDPs).Based on these chemical components,network pharmacology demonstrated that the targets of active components were significantly enriched in the pathways in cancer,which were closely related with cell proliferation regulation.Next,HCC data was downloaded from Gene Expression Omnibus database(GEO).The Cancer Genome Atlas(TCGA)and Dis Ge NET were analyzed by bioinformatics,and 79 biomarkers were obtained.Furtherly,nine targets of ACDP active components were revealed,and they were significantly enriched in PI3 K/AKT and cell cycle signaling pathways.The affinity between these targets and their corresponding active ingredients was predicted by molecular docking.Finally,in vivo and in vitro experiments showed that ACDPs could reduce the activity of PI3 K/AKT signaling pathway and downregulate the expression of cell cycle-related proteins,contributing to the decreased growth of liver cancer.Altogether,PI3 K/AKT-cell cycle appears as the significant central node in anti-liver cancer of A.Cinnamomea. | Yan Zhang Pin Lv Junmei Ma Ning Chen Huishan Guo Yan Chen Xiaoruo Gan Rong Wang Xuqiang Liu Sufang Fan Bin Cong Wenyi Kang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
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