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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | Viral vector platforms within the gene therapy landscape显示文摘Throughout its 40-year history,the field of gene therapy has been marked by many transitions.It has seen great strides in combating human disease,has given hope to patients and families with limited treatment options,but has also been subject to many setbacks.Treatment of patients with this class of investigational drugs has resulted in severe adverse effects and,even in rare cases,death.At the heart of this dichotomous field are the viral-based vectors,the delivery vehicles that have allowed researchers and clinicians to develop powerful drug platforms,and have radically changed the face of medicine.Within the past 5 years,the gene therapy field has seen a wave of drugs based on viral vectors that have gained regulatory approval that come in a variety of designs and purposes,these modalities range from vector-based cancer therapies,to treating monogenic diseases with life-altering outcomes.At present,the three key vector strategies are based on adenoviruses,adeno-associated viruses,and lentiviruses.They have led the way in preclinical and clinical successes in the past two decades.However,despite these successes,many challenges still limit these approaches from attaining their full potential.To review the viral vector-based gene therapy landscape,we focus on these three highly regarded vector platforms and describe mechanisms of action and their roles in treating human disease. | Jote T.Bulcha Yi Wang Hong Ma Phillip W.L.Tai Guangping Gao | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 5 |
| 4 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 5 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 2 |
| 6 | Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin DNA damage in ovarian cancer cell lines显示文摘 | Moufarij MA Phillips DR Cullinane C | 2003 | Mol Pharmacol)2003，63，4： | 1 |
| 7 | Bacillus subtilis sporulation and stationary phase gene expression显示文摘 | Phillips ZE Strauch MA | 2002 | Cell Mol Life Sci2002，59，3： | 1 |
| 8 | Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct显示文摘Age-related macular degeneration(AMD)causes blindness due to loss of retinal pigment epithelium(RPE)and photoreceptors(PRs),which comprise the two outermost layers of the retina.Given the small size of the macula and the importance of direct contact between RPE and PRs,the use of scaffolds for targeted reconstruction of the outer retina in later stage AMD and other macular dystrophies is particularly attractive.We developed microfabricated,honeycomb-patterned,biodegradable poly(glycerol sebacate)(PGS)scaffolds to deliver organized,adjacent layers of RPE and PRs to the subretinal space.Furthermore,an optimized process was developed to photocure PGS,shortening scaffold production time from days to minutes.The resulting scaffolds robustly supported the seeding of human pluripotent stem cell-derived RPE and PRs,either separately or as a dual celllayered construct.These advanced,economical,and versatile scaffolds can accelerate retinal cell transplantation efforts and benefit patients with AMD and other retinal degenerative diseases. | In-Kyu Lee Ruosen Xie Agustin Luz-Madrigal Seunghwan Min Jingcheng Zhu Jiahe Jin Kimberly L.Edwards M.Joseph Phillips Allison L.Ludwig David M.Gamm Shaoqin Gong Zhenqiang Ma | 2023 | Bioactive Materials2023，，12： | 1 |
| 9 | The pathologic features and mechanism of traumatic dislocation of the hip显示文摘 | Phillips AM Mbbchir MA Konchwalla MBBS | 2000 | Clin Orthop2000，377，9： | 1 |
| 10 | Stoichiometry constrains microbial response to root exudation-insights from a model and a field experiment in a temperate forest 显示文摘 | Drake JE Darby BA Giasson MA Kramer MA Phillips RP Finzi AC | 2013 | Biogeosciences2013，10，2： | 1 |
| 11 | Synthesis and modeling perspectives ofrhizosphere priming显示文摘 | Cheng WX Parton WJ Gonzalez-Meler MA Phillips R Asao S McNickle GG Brzostek E Jastrow JD | | 0，，： | 1 |
| 12 | A cautionary case: the SynerGraft vascular prosthesis显示文摘 | Sharp MA Phillips D Roberts I | 2004 | Eur J Vasc Endovasc Surg2004，27，1： | 1 |
| 13 | Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects显示文摘 | Carapeti EA Kamm MA Phillips RK | 2000 | Dis Colon Rectum2000，43，： | 1 |
| 14 | Tectonic uplift, threshold hillslopes, and denudation rates in a developing mountain range 显示文摘 | Binnie S A Phillips W M Summerfield MA | 2007 | Geology2007，35，8： | 1 |
| 15 | Nonaldehyde sterilization of biologic tissue for use in implantable medical devices 显示文摘 | Moore MA Mcllroy BK Phillips RE Jr | 1997 | ASAIO J1997，43，1： | 1 |
| 16 | PHDD,Depression,and Quality of Life:A population study显示文摘 | Goldney Robert D MD Phillips Pat J MA Fisher Laura J BA HONS | 2004 | Diabetes Care2004，27，5： | 1 |
| 17 | Cellular evaluation of syn-thesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels 显示文摘 | Shofner JP Phillips MA Peppas NA | 2010 | Macromol Biosci2010，10，3： | 1 |
| 18 | Neuroprotective effects of physical activity on the brain : a closer look at trophie factor signaling 显示文摘 | Phillips C Baktir MA Srivatsan M | 2014 | Front Cell Neurosci2014，8，： | 1 |
| 19 | Factors affecting continence after surgery for anal fistula显示文摘 | Kamm MA Phillips RK | 1994 | Br J Surg1994，81，9： | 1 |
| 20 | Curcumin activates the p38MPAK- HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC显示文摘 | Ma J Phillips L Wang Y | 2010 | BMC Complement Altern Med2010，10，： | 1 |
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