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| 1 | Beginning to understand microRNA function显示文摘MicroRNAs (miRNAs ) 是小 RNA 由植物,动物,病毒和至少一个单细胞的有机体表示了的 -22 nt,绿水藻, Chlamydomonas reinhardtii [1 ] 。MostmiRNAs 被 RNA II 作为主要 miRNAs (pri-miRNAs ) 抄录,尽管一些被 RNA III 抄录。在动物, pri-miR-NAs 被二连续 endonucleolytic 劈开变换成成熟 miRNAs [2 ] 。pri-miRNA 被 Drosha 首先切成原子核, aribonuclease III (RNase III ) 酶,与它的双 stranded 扮演 RNA 有约束力的领域(dsRBD ) 蛋白质搭挡,在脊椎动物的叫的 DGCR8 和在无脊椎动物的帕夏进一个 -70 nt 茎环,先锋 miRNA (pre-miRNA ) 。在它到由 Exportin 5 的细胞质的出口以后, pre-miRNA 是到由第二 RNase III 酶的成熟 miRNA 的角质, Dicer,哪个在有 twodsRBD 蛋白质之一的哺乳动物的搭挡—TRBP (HIV-1 焦油 RNA 有约束力的蛋白质) 或合同,或在有 thedsRBD 蛋白质的果蝇 melanogaster 多话(Loqs ) 。成熟 miRNA 然后被装进一个受动器复杂、导致 theRNA 的 silencing 建筑群(RISC ) ,其核心部件总是是 Argonaute 的一个成员(以前)指导 RNA 的 RNA 规章的蛋白质的家庭[3 ] 。最近,一条其他的处理小径在果蝇和 C 为 miRNAs 的不同亚群被识别。elegans [4, 5 ] 。这些 miRNAsexploit 拼接的 pre-mRNA 直接产生 pre-miRNA 的机械,绕过由 Drosha 处理 pri-miRNA。为这些 miRNAs, pre-miRNA 是马上成熟 miRNAand 的先锋紧缩的、充分功能的 intron,因此名字,“ mirtrons ”。 | Tingting Du Phillip D Zamore | 2007 | Cell Research2007，17，8： | 20 |
| 2 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008，18，10： | 17 |
| 3 | Transradial versus transfemoral access for anterior circulation mechanical thrombectomy: analysis of 375 consecutive cases显示文摘Objective To compare transradial artery access(TRA)to the gold standard of transfemoral artery access(TFA)in mechanical thrombectomy(MT)for stroke caused by anterior circulation large vessel occlusion.Methods The clinical outcomes,procedural speed,angiographic efficacy and safety of both techniques were analysed in 375 consecutive cases over an 18-month period in a high volume statewide neurointerventional service.Results There was no significant difference in patient characteristics,stroke parameters,imaging techniques or intracranial techniques.The median time elapsed between CT scanning and reperfusion was 96.5 min(IQR 68-123)in the TFA group and 95 min(IQR 68-123)in the TRA group(p=0.456).Of 336 patients who were independent at presentation 58%(124/214)of the TFA group and 67%(82/122)of the TRA group had a modified Rankin score of 0-2 at 90-day follow-up(p=0.093).Cross-over from radial to femoral was 4.6%(4/130)compared with 1.6%cross-over from femoral to radial(4/245),but did not meet the predetermined level of statistical significance(OR2.92,95% CI 0.81 to 10.52,p=0.088) and did not impact median procedural speed.Adequate angiographic reperfusion,first pass reperfusion,embolisation to new territory and symptomatic intracranial haemorrhage were similar in both groups.There was a significant difference in major access site complications requiring an additional procedure.None of the TRA cases had a major access site complication but 6.5%(16/245)of the TFA cases did(p=0.003).Conclusion This study suggests that using TRA for anterior circulation MT is fast,efficacious,safe and not inferior to the gold standard of TFA. | Timothy John Phillips Matthew Thomas Crockett Gregory D Selkirk Ruchi Kabra Albert Ho Yuen Chiu Tejinder Singh Constantine Phatouros William McAuliffe | 2021 | Stroke & Vascular Neurology2021，6，2： | 7 |
| 4 | 含有菊粉但不含羽扇豆的饲粮有助预防实验诱导的猪痢疾显示文摘猪痢疾是一种传染性黏膜出血的腹泻疾病,由定植于肠道的猪痢疾短螺旋体引起,能够诱发盲肠和结肠发炎。据报道饲料中添加菊苣根和甜羽扇豆可预防猪痢疾。本试验旨在验证是菊苣根中的菊粉而不是羽扇豆中的半乳糖起到保护作用的假设。 | Hansen C F Phillips N D La T.(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 2 |
| 5 | Adsorption of Salmonella enteritidis by cetylpyridinium exchanged montmorillonite clays显示文摘 | HERRERA P BURGHARDY R C PHILLIPS T D | 2000 | Microbiology2000，74，： | 2 |
| 6 | Airbome laser hydrography in Australia 显示文摘 | PENNY M F ABBOT R H PHILLIPS D M | 1986 | App Opt1986，25，13： | 2 |
| 7 | Laser Cooling and Trapping of Neutral Atoms显示文摘 | PHILLIPS W D | 1998 | Rev Mod Phys1998，70，3： | 1 |
| 8 | A Comparison of Geostafisfical Procedures for Spatial Analysis of Precipitation in Mountainous Terrain显示文摘 | Dolph J Marks D | 1992 | Agricultural and Forest Meteorology1992，58，： | 1 |
| 9 | Resurreccion,Consumer- Based Optimization of a Third-Generation Product Made from Peanut and Rice Flour 显示文摘 | I D Choi R D Phillips A V A | 2007 | Journal of Food Science2007，72，7： | 1 |
| 10 | High-Power Klystrons for the Next Linear Collider显示文摘 | Phillips R M Sprehn D W | 1999 | Proceedings of the IEEE1999，87，5： | 1 |
| 11 | 100 Gbit/s optical clock recovery using electrical phaselocked loop consisting of commercially available components 显示文摘 | I D Phillips A D Ellis | 2000 | Electronics Letters2000，36，7： | 1 |
| 12 | Coming to grips with radical social constructivisms显示文摘 | Phillips D C | 1997 | Science & Education1997，，6： | 1 |
| 13 | An angiogenic extract from skeletal muscle stimulates monoeyte and endothelial cell chemotaxis in vitro显示文摘 | Phillips G D Sehilb L A Fiegel V D | 1991 | Proe Soe Exp Biol Med1991，197，4： | 1 |
| 14 | Storage of light in atomic vapor显示文摘 | PHILLIPS D F FLEISCHHAUER A MAIR A ct al | 2001 | PHYS REV LETT2001，86，： | 1 |
| 15 | Finite element nonlinear analysis of concrete structures 显示文摘 | Phillips D V Zienkiewicz O C | 1976 | Proceedings Institution of Civil Engineers Part 21976，61，3： | 1 |
| 16 | Improved procedures for clearing roots and staining parasitic and vesicular-arbuscular mycorrhizal fungi for rapid assessment of infection显示文摘 | PHILLIPS J M HAYMAN D S | 1970 | Transactions of the British Mycological Society1970，，55： | 1 |
| 17 | Intermediate band photovoltaic solar cell based on ZnTe∶O显示文摘 | WANG W M LIN A S PHILLIPS J D | 2009 | Applied Phy-sics Letters2009，95，1： | 1 |
| 18 | Storage of Light in Atomic Vapor显示文摘 | Phillips D F Fleischhauer A Mair A Walsworth R L Lukin M D | 2001 | Phys Rev Lett2001，86，78： | 1 |
| 19 | Rheological and physical differences between foam and emulsion fracturing fluids显示文摘 | Blauer R E Phillips A M Craig D P | 1988 | SPE18214 MS1988，，： | 1 |
| 20 | Synthesis, characterization, and hydrodesulfurization properties of silica- supported molybdenum phosphide catalysts 显示文摘 | Phillips D C Sawhill S J Self R | 2002 | Journal of Catalysis2002，207，2： | 1 |
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