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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | NEW SOLUTION SYSTEM FOR CIRCULAR SECTOR PLATE BENDING AND ITS APPLICATION显示文摘Instead of the biharmonic type equation,a set of new governing equations and solvingmethod for circular sector plate bending is presented based on the analogy between plate bending andplane elasticity problems.So the Hamiltonian system can also be applied to plate bending problems byintroducing bending moment functions.The new method presents the analytical solution for the circu-lar,sector plate.The results show that the new method is effective. | Yao, W Zhong, WX Su, B | 1999 | Acta Mechanica Solida Sinica1999，12，4： | 15 |
| 3 | DSA analysis of hepatic arteriovenous fistula concurrent with hepatic cancer and its clinical significance显示文摘INTRODUCTIONIntervention therapy has become one of the maintherapies of hepatic cancer.Theintroduction of hepatic arterial perfusion andembolization has provided opportunities for asecondary operation on patients with intermediateand advanced cancer,thus | Guo WP Zhang HX Wang ZM Wang YQ Ni DH Li WX Guan Y | 2000 | World Journal of Gastroenterology2000，6，6： | 11 |
| 4 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 5 | Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro显示文摘 | Wang WX Ji YH | 2005 | 中国神经肿瘤杂志2005，3，2： | 9 |
| 6 | ^(99m)Tc-labeled HAb18 McAb Fab fragment for radioimmunoimaging in nude mice bearing human hepatocellular carcinoma显示文摘99mTclabeledHAb18McAbFabfragmentforradioimmunoimaginginnudemicebearinghumanhepatocelularcarcinomaQIUKai1,2,WANGBoChen1,CHE... | Qiu K Wang BC Chen ZN Fang P Liu CG Wan WX Liu YF | 1998 | World Journal of Gastroenterology1998，4，2： | 8 |
| 7 | Numb通过舌癌中的RBP-Jκ依赖性Notch1/PTEN/FAK信号传导途径抑制上皮-间质转化显示文摘景:口腔癌已被估计为全世界第六最常见的实体癌,其中舌鳞状细胞癌(TSCC)是最常见的口腔癌类型。然而,TSCC转移到淋巴结和远处部位的机制尚未完全了解。方法:本研究利用RT-qPCR方法检测Numb、PTEN和Notch1基因以及EMT相关基因的m RNA水平,利用蛋白质印迹分析检测这些基因的蛋白质水平。 | Li JY Huang WX Zhou X 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，4： | 6 |
| 8 | Antitumoral activity of low density lipoprotein-aclacinomycin complex in mice bearing H_(22) tumor显示文摘INTRODUCTIONCancer cells,which proliferate rapidly need largeamounts of cholesterol for new membrane synthesis,and high LDL receptor (LDLR) activity.LDL hasbeen proposed as a useful discriminatory vehicle forthe delivery of cytotoxic drugs to tumor cells.LDL presents many advantages as drug | Bi WX Xu SD Zhang PH Kong F | 2000 | World Journal of Gastroenterology2000，6，1： | 3 |
| 9 | The Mechanism of the Initial Dark Oxidation of Ethers and the Ether-Oxygen Contact Charge Transfer Complex显示文摘The coan cbargr transfer (CCT) absorption spectra of isopropyl ether , phenyl isopropyl ether and benzyl isopropyl ether with oxygen were measured . The mechanism of the initial dark oxidation of different ethers via ether-O2 CCT was | Zhu, JM Cao, WX Feng, XD | 1997 | Chinese Chemical Letters1997，8，10： | 2 |
| 10 | Effects of tetrandrine on cardiovascular electrophysiologic properties 显示文摘 | Yao WX Jiang MX | 2002 | Acta Pharmacol Sin2002，23，： | 1 |
| 11 | Contrast enhancement for ceramic insulator electroluminescent devices显示文摘 | Kitai AH | 1990 | J Electrochem Soc1990，137，9： | 1 |
| 12 | Endophytes:a rich source of functional metabolites显示文摘 | Tan RX Zou WX | 2001 | Nat Prod Rep2001，18，4： | 1 |
| 13 | Vascular endothelial growth factor and matrix metalloproteinase-2 expedite formation of endometriosis in the early stage ICR mouse model显示文摘 | Lu XE Ning WX Dong MY | 2006 | Fertil Steril2006，8，： | 1 |
| 14 | The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1 显示文摘 | Muthumani K Choo AY Zong WX | 2006 | Nat Cell Biol2006，8，2： | 1 |
| 15 | Experimental study on the thermal argon plasma generation and jet length change characteristics at atmosphere pressure 显示文摘 | Pan WX | 2006 | Plasma Chemistry and Plasma Processing2006，26，4： | 1 |
| 16 | Syphilis and social up-heaval in China显示文摘 | Hesketh T Zhu WX Zhou XD | 2010 | N Engl J Med2010，363，11： | 1 |
| 17 | Significant Acidification in major Chinese croplands显示文摘 | Guo JH Liu X J Zhang Y Shen JL Han WX Zhang WF Christie P Goulding KWT Vitousek PM Zhang FS | 2010 | Science2010，327，： | 1 |
| 18 | Systemic upreg ulation of CIM0 and CD40 ligand mRNA expression in muhipleselerosis 显示文摘 | Huang WX Huang P Hillert J | 2000 | Mult Seler2000，6，2： | 1 |
| 19 | The expression of mi- croRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of be- ta-site amyloid precursor protein-cleaving enzyme l显示文摘 | Wang WX Rajeev B W Stromberg AJ | 2008 | J Neuro- sci2008，28，5： | 1 |
| 20 | Autophagy reduces acute ethanol- induced hepatotoxicity and steatosis in rnice显示文摘 | Ding WX Li M Chen X | 2010 | Gastroenterology2010，139，： | 1 |
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