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| 1 | 企业执行力的概念模型及其度量方法--基于中国核电企业的实证研究显示文摘本文给出了一个关于执行力的确切定义:执行力就是有效率地决定事情并让他人去有效果地具体贯彻实施的能力。在文献综述的基础上,建立了企业执行力的理论模型,假设战略导向型、制度导向型、文化导向型、激励导向型和能力导向型这五种结构变量对企业执行力产生显著影响。通过对12家中国核电企业进行问卷调查,对理论模型进行实证检验。结果表明,企业执行力受到组织学习、组织结构、企业价值、绩效管理、市场营销和人际关系这6个变量的显著影响。通过t检验和方差分析,证明个体特征与组织特征的差异会对自变量和因变量的认知产生显著的差异性,这就为企业领导者和管理者为提升企业执行力而采取针对性较强的管理措施奠定了理论基础。 | 殷雄 吴泗宗 Philippe LE 顾明毅 | 2012 | 管理评论2012，24，2： | 13 |
| 2 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 3 | Nuclear magnetic resonance based metabolomics and liverdiseases:Recent advances and future clinical applications显示文摘Metabolomics is defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification.It is an'omics'technique that is situated downstream of genomics,transcriptomics and proteomics.Metabolomics is recognized as a promising technique in the field of systems biology for the evaluation of global metabolic changes.During the last decade,metabolomics approaches have become widely used in the study of liver diseases for the detection of early biomarkers and altered metabolic pathways.It is a powerful technique to improve our pathophysiological knowledge of various liver diseases.It can be a useful tool to help clinicians in the diagnostic process especially to distinguish malignant and non-malignant liver disease as well as to determine the etiology or severity of the liver disease.It can also assess therapeutic response or predict drug induced liver injury.Nevertheless,the usefulness of metabolomics is often not understood by clinicians,especially the concept of metabolomics profiling or fingerprinting.In the present work,after a concise description of the different techniques and processes used in metabolomics,we will review the main research on this subject by focusing specifically on in vitro proton nuclear magnetic resonance spectroscopy based metabolomics approaches in human studies.We will first consider the clinical point of view enlighten physicians on this new approach and emphasis its future use in clinical'routine'. | Roland Amathieu Mohamed Nawfal Triba Corentine Goossens Nadia Bouchemal Pierre Nahon Philippe Savarin Laurence Le Moyec | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 4 | MLVA-16 对新疆分离布鲁氏菌80/23株的鉴定与分析显示文摘为了对新疆布鲁氏菌分离株80/23株进行分型鉴定,本实验采用MLVA-16检测方法和常规生物学鉴定方法对布鲁氏80/23株进行研究,将测定结果与http://gffzzc70700eb713d4f53hu6p00w5kfp566vvv.ffgz.tsg.suse.edu.cn/MLVA net提供的530株布鲁氏菌数据库比较分析,应用UPGMA进行遗传进化树分析,并构建系统进化树。结果显示,常规分型方法鉴定为羊种3型,MLVA方法鉴定该菌株与德国分离株Bruce0261菌株的亲缘关系最近,属为东地中海3型,羊种1型,两种分型方法种属结果一致。结论:MLVA-16与常规生物学鉴定方法相比,具有更高的精确性,对布鲁氏菌生物型和株间差异有很高的鉴别力。并能为布病疫情流行株的溯源进化关系提供依据。 | 任晓莉 王慧 陈创夫 王远志 张亚丽 Philippe Le Flèche | 2013 | 石河子大学学报(自然科学版)2013，31，3： | 6 |
| 5 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 6 | Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting显示文摘瞄准:为了决定病人的 rabeprazole 测试的诊断价值,由全科医生看。方法:有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册,使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少,“ 7 点 Likert 上的症状的清楚的改进”可伸缩,测试被认为阳性。结果:为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性,积极、否定的预兆的价值是 45% 和 67% , 71% 和 71% ,和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论:禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。 | Stanislas Bruley des Varannes Sylvie Sacher-Huvelin Fabienne Vavasseur Claude Masliah Marc Le Rhun Philippe Aygalenq Sylvie Bonnot-Marlier Yves Lequeux Jean Paul Galmiche | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 7 | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice显示文摘 | Tiphaine Le Roy Marta Llopis Patricia Lepage Aurélia Bruneau Sylvie Rabot Claudia Bevilacqua Patrice Martin Catherine Philippe Francine Walker André Bado Gabriel Perlemuter Anne-Marie Cassard-Doulcier Philippe Gérard | 2013 | Gut2013，，12： | 3 |
| 8 | Liver Transplantation for Neuroendocrine Tumors in Europe—Results and Trends in Patient Selection: A 213-Case European Liver Transplant Registry Study显示文摘 | Yves Patrice Le Treut Emilie Grégoire Jürgen Klempnauer Jacques Belghiti Elisabeth Jouve Jan Lerut Denis Castaing Olivier Soubrane Olivier Boillot Georges Mantion Kia Homayounfar Manuel Bustamante Daniel Azoulay Philippe Wolf Marek Krawczyk Andreas Pasche | 2013 | Annals of Surgery2013，，5： | 3 |
| 9 | Current view and perspectives in amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis(ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors such as clinical phenotype, age at onset, gender, early presence of respiratory failure, weight loss and treatment with Riluzole(the only disease-modifying drug approved for this disease). Nowadays, there is still no curative treatment for ALS: palliative care and symptomatic treatment are therefore essential components in the management of these patients. Nevertheless, the scientific knowledge in the field of ALS motor neuron degeneration is growing, with the prospect of new treatments. Based on this physiopathological knowledge, several new therapeutic targets are being studied, involving various mechanisms such as excitotoxicity, neuroinflammation, mitochondrial dysfunction, oxidative stress, RNA metabolism and other attractive concepts. Moreover, it is also important to identify reliable biomarkers that will be essential components for future therapeutic development and study design in ALS. In this review, we present the main recent advances and promising therapeutics and biomarkers in the field of ALS. | Stéphane Mathis Philippe Couratier Adrien Julian Philippe Corcia Gwendal Le Masson | 2017 | Neural Regeneration Research2017，12，2： | 3 |
| 10 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 11 | Role of Fibrates and HMG-CoA Reductase Inhibitors in Gallstone Formation显示文摘 | Francois-Xavier Caroli-Bosc Philippe Le Gall Pascal Pugliese Benoit Delabre Corinne Caroli-Bosc Jean-Francois Demarquay Jean-Pierre Delmont Patrick Rampal J.C. Montet | 2001 | Digestive Diseases and Sciences2001，，3： | 2 |
| 12 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the F rench S urgical A ssociation显示文摘 | Pietro Addeo Jean Robert Delpero Francois Paye Elie Oussoultzoglou Pascal R Fuchshuber Alain Sauvanet Antonio Sa Cunha Yves Patrice Le Treut Mustapha Adham Jean‐Yves Mabrut Laurence Chiche Philippe Bachellier | 2014 | HPB2014，，1： | 2 |
| 13 | 欠平衡钻井技术在裂缝性花岗岩油藏开发中的应用显示文摘花岗岩储层特征与常规储层有较大差别,选用合适的钻井技术对降低储层损害、高效开发油田至关重要。也门KHA油田储层属于裂缝性花岗岩基底油藏,欠平衡钻井技术不仅可以克服常规钻井技术因固相侵入产生的储层污染,提高机械钻速,降低钻井液漏失,对保护油气层起到重要的作用,为此在KHA油田应用了欠平衡钻井技术,减少井漏风险,节约钻井成本;通过水平井开发,提高了裂缝钻遇率以及注水井的注入能力和采油井的单井产量;而且还有助于发现新的有效储层,增加油田储量,为油田开发部署和加密调整井提供了重要的参数,从而大幅度地提高了裂缝性花岗岩基底油藏的开发效果。 | 韩洪宝 Pascal Le Nen 郝洋 Philippe Souillard | 2014 | 石油钻采工艺2014，36，1： | 2 |
| 14 | Value of pelvic embolization in the management of severe postpartum hemorrhage due to placenta accreta, increta or percreta显示文摘 | Philippe Soyer Olivier Morel Yann Fargeaudou Marc Sirol Fabrice Staub Mourad Boudiaf Henri Dahan Alexandre Mebazaa Emmanuel Barranger Olivier le Dref | 2010 | European Journal of Radiology2010，，3： | 2 |
| 15 | 3D numerical simulation of seagrass movement under waves and currents with GPUSPH显示文摘The current study tries a new approach to simulating interactions between waves and seagrass through Smoothed Particle Hydrodynamics(SPH).In this model,the plants are defined as a solid that respects Hooke's law,and are assumed to have direct interaction with the fluid.Given the characteristics of the SPH method,especially in terms of computational time,the dimensions of the simulations were limited.The first goal of the current study was to optimize the approach to avoid reaching certain limits such as the rupture of the simulated plant.Plant movements under waves and/or currents have been studied by several authors in various in-situ,physical,and numerical experiments concerning various vegetation species,thus proving that plant movements can be successfully reproduced by SPH 2D/3D.Manning's roughness coefficient,n,was calculated to confirm that the results were in accordance with what had been measured in flume studies.Even though there is still room for improvement,it is shown that this method can be used to estimate Manning's coefficient for coastal vegetation(seagrass and saltmarsh vegetation)and to greatly improve the modeling and forecasting of coastal erosion and storm surge risks by including the effects of vegetation in integrated models. | Anne-Eleonore Paquier Thibault Oudart Caroline Le Bouteiller Samuel Meule Philippe Larroude Robert A.Dalrymple | 2021 | International Journal of Sediment Research2021，36，6： | 2 |
| 16 | Motility of the Roux-en-Y hepaticojejunostomy in asymptomatic patients显示文摘 | Isabelle Le Blanc-Louvry Philippe Ducrotté Jean Luc Manouvrier Christophe Peillon Jacques Testart Philippe Denis | 1999 | The American Journal of Gastroenterology1999，，9： | 2 |
| 17 | Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms显示文摘 | Laure Sarda Patrice Colin Franck Boccara Doumit Daou Rachida Lebtahi Marc Faraggi Charles Nguyen Ariel Cohen Michel S Slama Philippe G Steg Dominique Le Guludec | 2001 | Journal of the American College of Cardiology2001，，3： | 1 |
| 18 | Perineural ultrasound-guided catheter bacterial Colonization: a prospective evaluation in 747 eases显示文摘 | Aveline Christophe Le Hetet Hubert Le Roux Alain Vautier Pierre Gautier Jean Fran~ois Cognet Fabrice Auger Philippe Bonnet Francis | 2011 | Regional Anesthesia and Pain Medicine2011，36，6： | 1 |
| 19 | The VenaTech LP Permanent Caval Filter: Effectiveness and Safety in the Prevention of Pulmonary Embolism—A European Multicenter Study显示文摘 | Alain F. Le Blanche Abla Benazzouz Philippe Reynaud Rafael Oteros Fernandez Guglielmo Emanuelli Jean-Baptiste Ricco Christian Delcour | 2008 | Journal of Vascular and Interventional Radiology2008，，： | 1 |
| 20 | Prominent and Persistent Extraneural Infection in Human PrP Trausgenic Mice Infected with Variant CJD显示文摘 | Vincent Beringue Annick Le Dur Philippe Tixador | 2008 | PLoS ONF2008，，1： | 1 |
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