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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | SAFETY AND EFFICACY OF PARTIAL NEPHRECTOMY FOR ALL T1 TUMORS BASED ON AN INTERNATIONAL MULTICENTER EXPERIENCE显示文摘 | JEAN-JACQUES PATARD OLEG SHVARTS JOHN S. LAM ALLAN J. PANTUCK HYUNG L. KIM VINCENZO FICARRA LUCA CINDOLO KEN-RYU HAN ALEXANDRE DE LA TAILLE JACQUES TOSTAIN WALTER ARTIBANI CLAUDE C. ABBOU BERNARD LOBEL DOMINIQUE K. CHOPIN ROBERT A. FIGLIN PETER F.A. MULDE | 2004 | The Journal of Urology2004，，6： | 2 |
| 4 | MicroRNA-21 in pancreatic cancer:correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity显示文摘 | Giovannetti E Funel N Peters G J Del Chiaro M Erozenci LA Vasile E | | 0，，： | 1 |
| 5 | Contribution of bone marrow-derived endothelial cells to human tumor vasculature显示文摘 | Peters BA Diaz LA Polyak K | 2005 | Nat Med2005，11，3： | 1 |
| 6 | Effectiveness of the diabetic foot risk classification system of the International Working Group on the Diabetic Foot显示文摘 | Peters E J Lavery LA International Working Group on the Diabetic Foot | | 0，，08： | 1 |
| 7 | Reevaluating the way we classify the diabetic foot: restructuring the diabetic foot risk classification system of the International Working Group on the Diabetic Foot显示文摘 | Lavery LA Peters EJ Williams JR | 2008 | Diabetes Care2008，31，1： | 1 |
| 8 | Incremental Prognostic Power of Novel Biomarkers (Growth-Differentiation Factor-15, High-Sensitivity C-Reactive Protein, Galectin-3, and High-Sensitivity Troponin-T) in Patients With Advanced Chronic Heart Failure显示文摘 | Dirk J. Lok IJsbrand T. Klip Sjoukje I. Lok Pieta W. Bruggink-André de la Porte Erik Badings Jan van Wijngaarden Adriaan A. Voors Rudolf A. de Boer Dirk J. van Veldhuisen Peter van der Meer | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 9 | Risk factors for developing osteornyelitis in patieKnts with diabetic foot wounds 显示文摘 | Iavery LA Peters EJ Armstrong DG | 2009 | Diabetes Res Qin Pract2009，83，3： | 1 |
| 10 | Prognostic Implications of Baroreflex Sensitivity in Heart Failure Patients in the Beta-Blocking Era显示文摘 | Maria Teresa La Rovere Gian Domenico Pinna Roberto Maestri Elena Robbi Angelo Caporotondi Gianpaolo Guazzotti Peter Sleight Oreste Febo | 2009 | Journal of the American College of Cardiology2009，，： | 1 |
| 11 | Contribution of bone marrow-derived endothelial cells to human tumor vasculature 显示文摘 | Peters BA Diaz LA Polyak K | 2005 | Nat Med2005，11，3： | 1 |
| 12 | Contribution of bonemarrow-derived endothelial cells to human tumor vasculature 显示文摘 | Peters BA Diaz LA Polyak K | 2005 | Nat Med2005，11，3： | 1 |
| 13 | Attentional bias for drug cues in opiate dependence显示文摘 | Lubman DI Peters LA Mogg K | 2000 | Psychol Med2000，30，1： | 1 |
| 14 | Tissue factor expression in human arterial smooth muscle cells:TF is present in three cellular pools after growth factor stimulation显示文摘 | Schecter AD Peter LA Taby O | 1997 | J Clin Invest1997，100，9： | 1 |
| 15 | Effectiveness of the diabetic foot risk classification system of the International Working Group on the Diabetic Foot显示文摘 | Peters EJ Lavery LA International Working Group on the Diabetic Foot | 2001 | Diabetes care2001，24，8： | 1 |
| 16 | Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy显示文摘 | Francesca D’Addio Stefano La Rosa Anna Maestroni Peter Jung Elena Orsenigo Moufida Ben Nasr Sara Tezza Roberto Bassi Giovanna Finzi Alessandro Marando Andrea Vergani Roberto Frego Luca Albarello Annapaola Andolfo Roberta Manuguerra Edi Viale Carlo Staudac | 2015 | Cell Stem Cell2015，，4： | 1 |
| 17 | Human cathepsin L rescues the neurodegenration and lethality in cathepsin B/L double-deficent mice 显示文摘 | Sevenich L Pennacchio LA Peters C | 2006 | Biol Chem2006，387，7： | 1 |
| 18 | Contribution of bone marrow-derived endothelial cells to human tumor vasculature显示文摘 | Peters BA Diaz LA Polyak K | 2005 | Nat Med2005，11，3： | 1 |
| 19 | What are the most effective interventions in preventing diabetic foot ulcers显示文摘 | Lavery LA Peters E J Armstrong DG | | 0，，03： | 1 |
| 20 | Effect of a multifactorial intervention on mortality in type 2 diabetes显示文摘 | Peter G Henrik LA Hans-Henrik P | 2008 | N Engl J Med2008，358，6： | 1 |
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