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| 1 | 糖尿病足诊治指南显示文摘糖尿病足是糖尿病严重而又治疗费用高的慢性并发症。该文系统介绍糖尿病足的基本概念,糖尿病下肢缺血与下肢动脉硬化合并糖尿病的区别,糖尿病病变的特点与预后。着重介绍糖尿病足的治疗,包括下肢动脉介入治疗、动脉旁路重建、干细胞,移植。对大动脉、中等动脉和小动脉治疗方案的选择,以及围手术期处理等都进行了详细的论述。 | China Branch of the International Union of Angiology Diabetic Foot Committee | 2013 | 介入放射学杂志2013，22，9： | 269 |
| 2 | Characteristics of Obesity and Its Related Disorders in China显示文摘Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences.Abdominal obesity,also known as central obesity,refers to the presence of excess fat in the abdominal area.Obesity,especially abdominal obesity,contributes to many metabolic disorders including metabolic syndrome (MetS),type 2 diabetes (T2DM) and cardiovascular diseases (CVD).The incidence of obesity has increased dramatically in recent years worldwide.In China,more than one-third of adults are overweight or obese and 10%-20% of all adults are affected by MetS.The pathogenesis underlying the abdominal obesity remains unclear.The ultimate health outcome of obesity and its related metabolic disorders have prompted physicians to take aggressive treatments (lifestyle changes,pharmacological interventions and surgical therapies) before a serious consequence becomes clinically apparent.In this review,we discuss the prevalence,pathogenesis and clinic features of obesity in China. | WEI-PING JIA ,CHEN WANG,SHAN JIANG,AND JIE-MIN PAN Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai Diabetes Institute,Shanghai Clinical Center of Diabetes,Shanghai 200233,China | 2010 | Biomedical and Environmental Sciences2010，23，1： | 46 |
| 3 | Leptin: a multifunctional hormone显示文摘Leptin is the protein product encoded by the obese (ob)gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic,and diabetic. Since the cloning of leptin in 1994, our knowledge in body weight regulation and the role played by leptin has increased substantially. We now know that leptin signals through its receptor, OB-R, which is a member of the cytokine receptor superfamily. Leptin serves as an adiposity signal to inform the brain the adipose tissue mass in a negative feedback loop regulating food intake and energy expenditure. Leptin also plays important roles in angiogenesis, immune function, fertility and bone formation. Humans with mutations in the gene encoding leptin are also morbidly obese and respond to leptin treatment,demonstrating that enhancing or inhibiting leptin’s activities in vivo may have potential therapeutic benefits. | HUANG Lu, CAI LI(Tel: (214)-648-3340 Fax: (214)-648-9191 E-mail: li03@utsw.swmed.edu)(1 Touchstone Center for Diabetes Research1 Departments of Physiology and,2 Departments of Internal MedicineThe University of Texas Southwestern Medical Center5323 H. | 2000 | Cell Research2000，10，2： | 35 |
| 4 | Repair effect of diabetic ulcers with recombinant human epidermal growth factor loaded by sustained-release microspheres显示文摘In this study the w/o/w extraction–evaporation technique was adopted to prepare poly(lactic-co-glycolic acid) (PLGA) microspheres loading recombinant human epidermal growth factor (rhEGF). The micro-spheres were characterized for morphology by transmission electron microscopy (TEM) and particle size distribution. The release performances, the proliferation effects and therapeutic effects of rhEGF-loaded PLGA microspheres were all studied. The results showed that these spherical micro-spheres had a narrow size distribution and a high drug encapsulation efficiency (85.6%). RhEGF-loaded microspheres enhanced the growth rate of fibroblasts and wound healing more efficiently than pure rhEGF. The number of the proliferating cell nuclear antigen (PCNA) in the epidermis layer with the mi-crosphere treatment was significantly larger than those of the control groups. Overall locally sustained delivery of rhEGF from biodegradable PLGA microspheres may serve as a novel therapeutic strategy for diabetic ulcer repair. | DONG XiaoQing1, XU Jun2, WANG WeiCai1, Luo Hao1, LIANG XiaoFei1, Zhang Lei1, Wang HanJie1, Wang PengHua2 & CHANG Jin1 1 Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China 2 Department of Diabetic Foot, Tianjin Medical University Metabolic Disease Hospital, Tianjin 300070, China | 2008 | Science China(Life Sciences)2008，51，11： | 7 |
| 5 | Effects of intensive glucose lowering in type 2 diabetes显示文摘 | The Action to Control Cardiovascular Risk in Diabetes Study Group | | New England Journal of Medicine0，，： | 6 |
| 6 | 浙江省1994~1995年糖尿病流行病学调查报告显示文摘为阐明浙江省成人糖尿病患病率及分布状况,由5个地市的部分医院组成了糖尿病调查协作组,按全国糖尿病流行病学调查方案,于1994年11月至1995年3月,抽样调查和统计分析了25岁以上常住人口7949人,糖尿病患病率为2.75%;从45~54岁组起患病率明显增高,且随增龄而呈上升趋势;超体重人群患病率是非超体重者的3.22倍;城市患病率显著高于农村和渔村;杭州、宁波、温州三地区间患病率无统计学上差异;和1974~1981年我省第一次糖尿病调查相比,患病率上升了5. | (The Zhejiang Province Diabetes Epidemiological Investigation Group) | 1998 | 科技通报1998，14，1： | 5 |
| 7 | Standards of medical care in diabetes-2010显示文摘 | American Diabetes Association | | Diabetes Care0，，： | 5 |
| 8 | Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)显示文摘 | UK Prospective Diabetes Study (UKPDS) Group | | The Lancet0，，： | 5 |
| 9 | 福建省两次糖尿病调查对比报告显示文摘了解福建省糖尿病发病率的增长速度。方法1980年用普查法调查37158人,1995年采用抽样调查法对4075人再次调查。结果1980年糖尿病(DM)发病率及糖耐量减低(IGT)的发病率分别为0.89%及0.88%。1995年两者发病率分别为2.04%及5.23%。结论15年中DM及IGT患病率各增长2.3倍及5.9倍。 | Diabetic Cooperation Group of Fujian Province | 1997 | 福建医科大学学报1997，31，2： | 3 |
| 10 | Standards of medical care in diabetes 显示文摘 | American Diabetes Association | 2004 | Diabetes Care2004，，： | 3 |
| 11 | Standards of medicalcare in diabetes-2009显示文摘 | American Diabetes Association | | Diabetes Care0，，： | 2 |
| 12 | Diabetic nephropathy显示文摘 | Amercan Diabetes Association | 1999 | Diabetes Care1999，22，： | 2 |
| 13 | Standards of medical care in diabetes-2009显示文摘 | American Diabetes Assoeiation | | 0，，1： | 2 |
| 14 | Tight blood pressure control and risk of macrovascular and microvascular complication in type 2 diabetes,UKPDS38显示文摘 | UK Prospective Diabetes Study (UKDS) Group | 1998 | BMJ1998，317，： | 1 |
| 15 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus显示文摘 | The Diabetes Control and Complications Trial Research Group | 1993 | N Eng J Med1993，329，： | 1 |
| 16 | Diagnosis and classification of diabetes mellitus 显示文摘 | AMERICAN DIABETES ASSOCIATION | 2007 | Diabetes Care2007，30，1： | 1 |
| 17 | Management of dyslipidemia in adult with diabetes显示文摘 | | 2002 | Diabetes Care2002，25，： | 1 |
| 18 | Standards of medical care in diabetes-2007显示文摘 | American Diabetes Association | 2007 | Diabetes Care2007，30，1： | 1 |
| 19 | Focal photoconagulation treatment of diabeticmacular edema:Relationship of treatment effect to fluorescein angiographic and other retinal characteristics at baseline(ETDBS 19)显示文摘 | Early Treatment Diabetic Retinopathy Study Research Group | 1995 | Arch Ophthalmol1995，113，9： | 1 |
| 20 | The effect of intensive diabetes therapy on the development and progression of neuropathy 显示文摘 | The Diabetes Control and Complications Trial Research Group | 1995 | Ann Intern Med1995，122，8： | 1 |
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