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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 3 | Antifungal effects of yeast derived rhu GM-CSF in patients receiving high dose chemotherapy given with or without autologous stem cell transplantation:A retrospective analysis显示文摘 | Peters BG Adkins DR Harrison BR | 1996 | Bone Marrow Transplant1996，18，1： | 1 |
| 4 | Does Innovation Stimulate Employment? A Firm-level Analysis Using ComparaIde Micro-data from four European countries 显示文摘 | Harrison R J Jaumandreu J Mairesse B Peters | 2008 | NBER Working Paper 142162008，，8： | 1 |
| 5 | Uniformization and hypergraph partitioning for the distributed computation of response time densities in very large Markov models显示文摘 | Peter G Harrison William J Knottenbelt | 2004 | Journal of Parallel and Distributed Computing2004，64，： | 1 |
| 6 | Long-term retrograde amnesia… the crucial role of the hippocampus显示文摘 | Lisa Cipolotti Tim Shallice Dennis Chan Nick Fox Rachel Scahill Gail Harrison John Stevens Peter Rudge | 2001 | Neuropsychologia2001，，2： | 1 |
| 7 | A dangerous dilemnm: management of infectious intracranial aneurysms complicating endocarditis 显示文摘 | Peters PJ Harrison T Lennnx JL | 2006 | Lance! Infect Dis2006，6，74： | 1 |
| 8 | Transgenic swine: Expression of human CD39 protects against myocardial injury显示文摘 | Debra G. Wheeler Matthew E. Joseph Shouvik D. Mahamud William L. Aurand Peter J. Mohler Vincent J. Pompili Karen M. Dwyer Mark B. Nottle Sharon J. Harrison Anthony J.F. d’Apice Simon C. Robson Peter J. Cowan Richard J. Gumina | 2012 | Journal of Molecular and Cellular Cardiology2012，，5： | 1 |
| 9 | Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel 1 1 Edited by P. E. Wright显示文摘 | Richard C Moore Inyoul Y Lee Gregory L Silverman Paul M Harrison Robert Strome Cornelia Heinrich Amila Karunaratne Stephen H Pasternak M.Azhar Chishti Yan Liang Peter Mastrangelo Kai Wang Arian F.A Smit Shigeru Katamine George A Carlson Fred E Cohen Stanl | 1999 | Journal of Molecular Biology1999，，4： | 1 |
| 10 | Health advice obtained by tourists travelling to MagneticIsland:a risk area for'Irukandji'jellyfish in North Queensland,Australia显示文摘 | Leggat P.A Harrison Simone L Fenner Peter J | | 0，，01： | 1 |
| 11 | Mapping MHC-encoded susceptibility and resistance in primary sclerosing cholangitis: The role of MICA polymorphism显示文摘 | Suzanne Norris Elli Kondeatis Robert Collins Jack Satsangi Mike Clare Roger Chapman Henry Stephens Phillip Harrison Robert Vaughan Peter Donaldson | 2001 | Gastroenterology2001，，6： | 1 |
| 12 | A dangerous dilemma:Management of infectious intracranial aneurysms complicating endocarditis显示文摘 | Peters PJ Harrison T Lennox JL | 2006 | Lancet Infect Dis2006，6，： | 1 |
| 13 | Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese显示文摘 | Dr. Michael A. Heneghan Philip J. Johnson Michael Clare Stephen Ho Phillip M. Harrison Peter T. Donaldson | 2003 | International Journal of Gastrointestinal Cancer2003，，1： | 1 |
| 14 | A dangerous dilemma: management of infectious intracranial aneurysms complica- ting endocarditis 显示文摘 | Peters PJ Harrison T Lennox JL | 2006 | Lancet Infect Dis2006，6，11： | 1 |
| 15 | Nitrate removal in two relict oxbow urban wetlands: a 15 N mass-balance approach显示文摘 | Melanie D. Harrison Peter M. Groffman Paul M. Mayer Sujay S. Kaushal | 2012 | Biogeochemistry2012，，1： | 1 |
| 16 | A secondary analysis of the moderating effects of depression and multimorbidity on the effectiveness of a chronic disease self-management programme显示文摘 | Mark Harrison David Reeves Elaine Harkness Jose Valderas Anne Kennedy Anne Rogers Mark Hann Peter Bower | 2011 | Patient Education and Counseling2011，，1： | 1 |
| 17 | Antifungal effects of yeast-derived rhu-GM-CSF in patients receiving high dose chemotherapy given with or without autologous stem cell transplantation: a retrospective analysis显示文摘 | Adkins DR Harrison BR | 1996 | Bone Marrow Transplant1996，18，： | 1 |
| 18 | Bireffingence measurements on polymer melts in an axisymmetric flow cell显示文摘 | HARRISON P JANSEN L J P PETERS G W M | 2002 | Rheologica Acta2002，41，： | 1 |
| 19 | Position Statement concerning use of impressionistic likelihood terms in forensic speaker comparison cases, with a foreword by Peter French & Philip Harrison显示文摘 | Peter French Philip Harrison | 2007 | International Journal of Speech Language and the Law2007，14，1： | 1 |
| 20 | anemone, Entacmaea quadricolor host anemonefish 显示文摘 | Anna Scott Peter Harrison | 2007 | Invertebrate ment2007，50，3： | 1 |
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