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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 3 | 10-year biochemical control of prostate cancer with 125I brachytherapy显示文摘 | Peter DG John CB John ES | 2001 | Int J Radiat Oncol Biol Phys2001，51，： | 1 |
| 4 | Bench-to-bedside review : Sepsis is a disease of the microcirculation 显示文摘 | Peter ES Durk FZ Can I | 2004 | Crit Care2004，8，6： | 1 |
| 5 | Risk factors affecting hospital length of stay in patients with odontogenic maxillofacial infections 显示文摘 | Peters ES Fong B Wormuth DW | 1996 | J Oral Maxillofac Surg1996，54，12： | 1 |
| 6 | Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘 | Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John | 1999 | Gastroenterology1999，，4： | 1 |
| 7 | Treating achalasia: From Whalebone to Laparscope显示文摘 | Anita ES Peter JK | 1998 | JAMA1998，280，7： | 1 |
| 8 | Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets显示文摘 | FRANCENE S TRACY ES PETER A | 2003 | Experimental Biology and Medicine2003，228，： | 1 |
| 9 | Differential developmental expression and cell type specificity of Dictyostelium catalases and their response to oxidative stress and UV-light显示文摘 | Ma.Xenia U Garcia Christopher Foote Saskia van Es Peter N Devreotes Stephen Alexander Hannah Alexander | 2000 | BBA - Gene Structure and Expression2000，，2： | 1 |
| 10 | A clinical decision ride for identifying children with thoracic injuries after blunt torso trauma显示文摘 | James FH Peter ES Willian EB | 2002 | Ann Emerg Med2002，39，5： | 1 |
| 11 | Reactive infiltration processing (RIP) of ultra high temperature ceramics (UHTC) into porous C/C composite tubes显示文摘 | Daniel Doni Jayaseelan Rafael Guimar?es de Sá Peter Brown William E. Lee | 2010 | Journal of the European Ceramic Society2010，，3： | 1 |
| 12 | 'Sleepi- ness' is serious in adolescence:Two surveys of 3235 Canadian students显示文摘 | Gibson ES Powles AC Peter Thabane L | 2006 | BMC Public Health2006，6，1： | 1 |
| 13 | Burden of potentially human papillomavirus-associated cancem of the oropharynx and ondcavity in t IIe US,1998-2003显示文摘 | Byemon AB Peters ES Coughlin SS | 2008 | Cancer2008，113，10： | 1 |
| 14 | Implications of sentinel lymph node mapping on nodal staging and prognosis in colorectal cancer 显示文摘 | van der Zaag ES Bouma WH Peters HM | 2012 | Caloreetal Dis2012，14，6： | 1 |
| 15 | Lung CancerThat Harbors an HER2 Mutation: Epidemiologic Characteristicsand Therapeutic Perspectives显示文摘 | MAZIER ES J PETERS S LEPAGE B | 2013 | J Clin Oncol2013，31，16： | 1 |
| 16 | Acute effects of intravenous propafenone on the internal ventricular defibrillation threshold in the anesthetized dog显示文摘 | Peters W Gang ES Okazaki H | 1991 | Am Heart J1991，122，： | 1 |
| 17 | Loss of α-tocopherol in tobacco plants with decreased geranylgeranyl reductase activity does not modify photosynthesis in optimal growth conditions but increases sensitivity to high-light stress显示文摘 | Thomas Gra?es Bernhard Grimm Olga Koroleva Peter Jahns | 2001 | Planta2001，，4： | 1 |
| 18 | Treating achalasia:From Whalebone to La-parscope显示文摘 | Anita ES Peter JK | 1998 | JAMA1998，280，7： | 1 |
| 19 | The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis 显示文摘 | Martin F Aerts A Ahrén D Brun A Danchin EGJ Duchaussoy F Gibon J Kohler A Lindquist E Pereda V Salamov A Shapiro HJ Wuyts J Blaudez D Buée M Brokstein P Canb?ck B Cohen D Courty PE Coutinho PM Delaruelle C Detter JC Deveau A Difazio S Duplessis S Fraissinet-Tachet L Lucic E Frey-Klett P Fourrey C Feussner I Gay G Grimwood J Hoegger PJ Jain P Kilaru S Labbé J Lin YC Legué V Le Tacon F Marmeisse R Melayah D Montanini B Muratet M Nehls U Niculita-Hirzel H Secq MPOudot-Le Peter M Quesneville H Rajashekar B Reich M Rouhier N Schmutz J Yin T Chalot M Henrissat B Kües U Lucas S van de Peer Y Podila GK Polle A Pukkila PJ Richardson PM Rouzé P Sanders IR Stajich JE Tunlid A Tuskan G Grigoriev IV | 2008 | Nature2008，452，： | 1 |
| 20 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 1 |
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