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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization显示文摘血管肉瘤是有差的预后的肝的一个稀罕的主要的恶意的瘤。这里,我们与被紧急情况对待的一个破裂的肝的血管肉瘤报导一个病人的一个案例指导导管的 embolization,由左边的偏身出汗列在后面。 | Christine Leowardi Yura Hormann UIf Hinz Moritz N Wente Peter Hallscheidt Christa Flechtenmacher Markus W Büchler Helmut Friess Matthias HM Schwarzbach | 2006 | World Journal of Gastroenterology2006，12，5： | 4 |
| 4 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 5 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 6 | Gemcitabine: future prospects of single-agent and combination studies显示文摘 | Van Moorsel CJ Peters GJ Pinedo HM | 1997 | Oncologist1997，2，3： | 1 |
| 7 | Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy显示文摘 | Smith SM Judge HM Peters G | 2006 | Platelets2006，17，4： | 1 |
| 8 | Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil 显示文摘 | Peters GJ Van Groeningen C J Pinedo HM | 1998 | Adv Exp Med Biol1998，431，： | 1 |
| 9 | Pyelitis in toxemias of pregnancy 显示文摘 | Peters JP Lavietes PH Zinnerman HM | 1936 | AM J Obstet Gynecol1936，32，： | 1 |
| 10 | Neonatal Facial Coding System for assessing postoperative pain in infants: item reduction is valid and feasible显示文摘 | Peters JW Koot HM Grunau RE | 2003 | Clin J Pain2003，19，6： | 1 |
| 11 | Determinants of re- sistance to 2' ,2'-difluorodeoxycytidine,(gemcitabine) 显示文摘 | Bergman AM Pinedo HM Peters GJ | 2002 | Drug Resistance Updates2002，5，1： | 1 |
| 12 | Common carotid inti- ma- media thickness measurements in cardiovascular risk predic- tion :a meta -analysis显示文摘 | Den Ruijter HM Peters SA Anderson TJ | 2012 | JAMA2012，30，8： | 1 |
| 13 | Major surgery within the first 3months of life and subsequent biobehavioral pain responses to immunization at later age:a case comparison study显示文摘 | Peters JW Koot HM de Boer JB | 2003 | Pediatrics2003，111，1： | 1 |
| 14 | Combined polymorphisms in UDP-gluouronosyltranl transferases 1A1 and 1A6: implications for patient with Gilbert syndrome显示文摘 | Peter WH Temorsche RH Roelofs HM | 2003 | J Hepatol2003，38，： | 1 |
| 15 | Neonatal Facial Coding System for assessing postoperative pain in infants:Item reduction is valid and feasible显示文摘 | Peter J W Koot HM G rtnan RE | 2003 | Clin J Pain2003，19，6： | 1 |
| 16 | Prospective, randomized trial comparing laparoscopicvs. conventional surgery for refractory ileocolic crohn’s disease显示文摘 | Dr. Jeffrey W. Milson M.D. Katherine A. Hammerhofer R.N. B.S.N. Bartholomaus B?hm M.D. Ph.D. Peter Marcello M.D. Paul Elson Ph.D. Victor W. Fazio M.B. M.S. F.R.A.C.S | 2001 | Diseases of the Colon & Rectum2001，，1： | 1 |
| 17 | Common carotid intima-media thickness measurements in cardio- vascular risk prediction: a meta-analysis显示文摘 | Den Ruijter HM Peters SA Anderson TJ | 2012 | JAMA2012，308，8： | 1 |
| 18 | Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy显示文摘 | Smith SM Judge HM Peters G | 2006 | Platelets2006，17，4： | 1 |
| 19 | Mutation of BCL-6 gene in normal B ceils by the process of somatic hypermutation of Ig genes 显示文摘 | Shen HM Peters A Baron B | 1998 | Science1998，280，5370： | 1 |
| 20 | Common carotid intima-media thickness measurements in cardiovascular risk prediction:a meta-analysis显示文摘 | Den Ruijter HM Peters SA Anderson TJ | 2012 | JAMA2012，308，8： | 1 |
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