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| 1 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 2 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 3 | Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells显示文摘Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We previously found that mast cells located within healing tendons can express glutamate receptors,raising the possibility that mast cells may be sensitive to glutamate signaling.To evaluate this hypothesis,we stimulated primary mast cells with glutamate and showed that glutamate induced the profound upregulation of a panel of glutamate receptors of both the ionotropic type(NMDAR1,NMDAR2A,and NMDAR2B)and the metabotropic type(mGluR2 and mGluR7)at both the mRNA and protein levels.The binding of glutamate to glutamate receptors on the mast cell surface was confirmed.Further,glutamate had extensive effects on gene expression in the mast cells,including the upregulation of proinflammatory components such as IL-6 and CCL2.Glutamate also induced the upregulation of transcription factors,including Egr2,Egr3 and,in particular,FosB.The extensive induction of FosB was confirmed by immunofluorescence assessment.Glutamate receptor antagonists abrogated the responses of the mast cells to glutamate,supporting the supposition of a functional glutamate–glutamate receptor axis in mast cells.Finally,we provide in vivo evidence supporting a functional glutamate–glutamate receptor axis in the mast cells of injured tendons.Together,these findings establish glutamate as an effector of mast cell function,thereby introducing a novel principle for how cells in the immune system can communicate with nerve cells. | Md Abdul Alim Mirjana Grujic Paul W.Ackerman Per Kristiansson Pernilla Eliasson Magnus Peterson Gunnar Pejler | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 4 | Unloa ded rat Achilles tendons continue to grow, but lose viscoelas ticity显示文摘 | PERNILLA ELIASSON ANNA FAHLGREN | 2007 | J Appl Physiol2007，103，： | 1 |
| 5 | Pietras Kristian Functional subsets of mesenchymal cell types in the tumor microenvironment显示文摘 | Cortez Eliane Roswall Pernilla | 2014 | Semin Cancer Biol2014，25，： | 1 |
| 6 | Patients’perspectives of living with a percutaneous endoscopic gastrostomy显示文摘 | Lena Martin John Blomberg Pernilla Lagergen | 2012 | BMC Gastroenterology2012，12，： | 1 |
| 7 | Fecal Water as a Non-Invasive Biomarker in Nutritional Intervention: Comparison of Preparation Methods and Refinement of Different Endpoints显示文摘 | Annett Klinder Pernilla C. Karlsson Yvonne Clune Roisin Hughes Michael Glei Joseph J. Rafter Ian Rowland John K. Collins Beatrice L. Pool-Zobel | 2007 | Nutrition and Cancer2007，，2： | 1 |
| 8 | Workers exposed to thermal degradation products of TDI-and MDI-based polyurethane:Biomonitoring of2,4-TDA,2,6-TDA,and 4,4'-MDA in hydrolyzed urine and plasma显示文摘 | Marianne Dalene Gunnar Skarping Pernilla Lind | 1997 | American Industrial Hygiene Association Journal1997，58，： | 1 |
| 9 | Effects of increased intra- abdominal pressure and volume expansion on renal function in the rat显示文摘 | Pernilla Lindstrom Jonas Wadstrom | 2003 | Nephrol Dial Transplant2003，18，： | 1 |
| 10 | Neuro-hormonal control of bone metabolism:vasoactive intestinal peptide stimulates alkaline phosphatese activity and mRNA expression in mouse calvarias osteoblasts as well as calcium accumulation mineralized bone nodules显示文摘 | Pernilla Lundberg Ingrid Bostrom Hitoshi Mukohyama | 1999 | Regulatory Peptides1999，85，： | 1 |
| 11 | Printed biotin-functionalised polythiophene films as biorecognition layers in the development of paper-based biosensors显示文摘 | Petri Ihalainen Markus Pesonen Pernilla Sund | 2016 | Applied Surface Science2016，364，： | 1 |
| 12 | Charting cor- porate greening: environmental management trends in Sweden 显示文摘 | Pernilla Gluch Mathias Gustafsson LianeThuvander | 2014 | Build- ing research & amp information2014，2014，3： | 1 |
| 13 | Debt relief, investment and growth显示文摘 | Pernilla Johansson | 2010 | World Development2010，，9： | 1 |
| 14 | Preparation of thermoset composites from natural fibres and acrylate modified soybean oil resins显示文摘 | Dan Akesson Mikael Skrifvars Pernilla Walkenstrm | 2009 | J Appl Polym Sci2009，114，4： | 1 |
| 15 | Intestinal, adipose, and liver inflammation in diet-induced obese mice显示文摘 | Hong Li Christopher Lelliott Pernilla H?kansson Karolina Ploj Anna Tuneld Martina Verolin-Johansson Lambertus Benthem Bj?rn Carlsson Leonard Storlien Erik Micha?lsson | 2008 | Metabolism2008，，12： | 1 |
| 16 | Complications after percutaneous endoscopic gastrostomy in a prospective study显示文摘 | John Blomberg Jesper Lagergren Lena Martin Fredrik Mattsson Pernilla Lagergren | 2012 | Scandinavian Journal of Gastroenterology2012，，6： | 1 |
| 17 | Comparison of the behaviour of rare earth elements in surface waters, overburden groundwaters and bedrock groundwaters in two granitoidic settings, Eastern Sweden显示文摘 | Pernilla R?nnback Mats ?str?m Jon-Petter Gustafsson | 2008 | Applied Geochemistry2008，，7： | 1 |
| 18 | The first clinical uterus transplantation trial: a six-month report显示文摘 | Mats Br?nnstr?m Liza Johannesson Pernilla Dahm-K?hler Anders Enskog Johan M?lne Niclas Kvarnstr?m Cesar Diaz-Garcia Ash Hanafy Cecilia Lundmark Janusz Marcickiewicz Markus G?bel Klaus Groth Randa Akouri Saskia Eklind Jan Holgersson Andreas Tzakis Michael | 2014 | Fertility and Sterility2014，，： | 1 |
| 19 | Risk Factors for Esophageal Adenocarcinoma After Antireflux Surgery显示文摘 | Hedvig E. L?fdahl Yunxia Lu Pernilla Lagergren Jesper Lagergren | 2013 | Annals of Surgery2013，，： | 1 |
| 20 | Thermal shock properties of alumina reinforced with Ti(CN) whiskers显示文摘 | Pernilla Pettersson Mats Johnsson | 2003 | J Euro Cera Soc2003，23，： | 1 |
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