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| 1 | 低剂量CT结肠成像的研究进展显示文摘近年来结直肠疾病的发病率越来越高,因此对高危人群应进行定期筛查,尽量做到早发现、早治疗。大便隐血实验、X线气钡双重造影和纤维结肠镜检查仍是诊断结直肠疾病的常用方法。低剂量CT结肠成像作为一种低侵入性的检查技术,操作简单,且病人对其具有较好的耐受性,该技术为结直肠疾病诊断提供了新的思路。在有效发现病变的同时,大大降低了病人所接受的放射辐射剂量,在结直肠疾病筛查及诊断中具有一定的应用价值。 | 申敏 蒋蕴毅 | 2013 | 国际医学放射学杂志2013，36，6： | 12 |
| 2 | Early-onset colorectal cancer:A sporadic or inherited disease?显示文摘Colorectal cancer is the third most common cancer diagnosed worldwide.Although epidemiology data show a marked variability around the world,its overall incidence rate shows a slow but steady decrease,mainly in developed countries.Conversely,early-onset colorectal cancer appears to display an opposite trend with an overall prevalence in United States and European Union ranging from 3.0% and 8.6%.Colorectal cancer has a substantial proportion of familial cases.In particular,early age at onset is especially suggestive of hereditary predisposition.The clinicopathological and molecular features of colorectal cancer cases show a marked heterogeneity not only between early- and late-onset cases but also within the early-onset group.Two distinct subtypes of early-onset colorectal cancers can be identified:a 'sporadic' subtype,usually without family history,and an inherited subtype arising in the context of well defined hereditary syndromes.The pathogenesis of the early-onset disease is substantially well characterized in the inherited subtype,which is mainly associated to the Lynch syndrome and occasionally to other rare mendelian diseases,whereas in the 'sporadic' subtype the origin of the disease may be attributed to the presence of various common/rare genetic variants,so far largely unidentified,displaying variable penetrance.These variants are thought to act cumulatively to increase the risk of colorectal cancer,and presumably to also anticipate its onset.Efforts are ongoing in the attempt to unravel the intricate genetic basis of this 'sporadic' early-onset disease.A better knowledge of molecular entities and pathways may impact on family-tailored prevention and clinical management strategies. | Vittoria Stigliano Lupe Sanchez-Mete Aline Martayan Marcello Anti | 2014 | World Journal of Gastroenterology2014，20，35： | 10 |
| 3 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
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