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| 1 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Science Letters:Visual odometry for road vehicles—feasibility analysis显示文摘Estimating the global position of a road vehicle without using GPS is a challenge that many scientists look forward to solving in the near future. Normally, inertial and odometry sensors are used to complement GPS measures in an attempt to provide a means for maintaining vehicle odometry during GPS outage. Nonetheless, recent experiments have demonstrated that computer vision can also be used as a valuable source to provide what can be denoted as visual odometry. For this purpose, vehicle motion can be estimated using a non-linear, photogrametric approach based on RAndom SAmple Consensus (RANSAC). The results prove that the detection and selection of relevant feature points is a crucial factor in the global performance of the visual odometry algorithm. The key issues for further improvement are discussed in this letter. | SOTELO Miguel-angel GARCíA Roberto PARRA Ignacio FERNNDEZ David GAVILN Miguel LVAREZ Sergio NARANJO José-eugenio | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，12： | 2 |
| 4 | Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorr hage显示文摘 | Borel C O McKee A Parra A | 2003 | Stroke2003，34，2： | 1 |
| 5 | Cortically Coupled Computer Vision for Rapid Image Search显示文摘 | Parra L C Sajda P | 2006 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2006，14，2： | 1 |
| 6 | Time course of sleep - relatedbreathing disorders in first - ever stroke or transient ischemic attack显示文摘 | Parra O Arboix A Bechich S | 2000 | Am J Re-spir Crit Care Med2000，161，： | 1 |
| 7 | A fuzzy goal pro- gramming approach to portfolio selection显示文摘 | Parra M A Terol A B Uria M V R | 2001 | European Journal of Operational Research2001，133，： | 1 |
| 8 | Mierowave - assisted regeneration of activated carbons loaded with phannaeeutieah 显示文摘 | C O Ania J B Parra J A Menendez | 2007 | water research2007，41，： | 1 |
| 9 | Characterisation with stable isotopes of the presence of a lag phase in the gastric emptying of liquids显示文摘 | Gonzalez A Mugueta C Parra D | 2000 | Eur J Nutr2000，39，5： | 1 |
| 10 | Computational modeling of cyclic mobility and post-liquefaction site response 显示文摘 | Elgamal A Yang Z H Parra E | 2002 | Soil Dynamics and Earthquake Engineering2002，，22： | 1 |
| 11 | Time Course of Sleep-related Breathing Disorders in First-ever Stroke or TIA显示文摘 | Parra O Arboix A Bechich S | 2000 | Am J Respir Crit Care Med2000，161，2： | 1 |
| 12 | Strong ties,weak ties,and hu-man capital:latino immigrant employment outside the enclave显示文摘 | PFEFFER M J PARRA P A | 2009 | Rural Sociology2009，74，2： | 1 |
| 13 | Sleeprelated breathing disorders:impact on mortality of cerebrovascular disease显示文摘 | Parra O Arboix A Montserrat JM | | 0，，： | 1 |
| 14 | The amino termi- nal sequence of VP60 from rabbit hemorrhagic disease virus supports its putative subgenomic origin显示文摘 | Parra F Boga J A Matin M S | 1993 | Vi- rus Res1993，27，3： | 1 |
| 15 | Injectable acrylic bone cements for vertebroplasty based on a radiopaque hydroxyapatite: bioactivity and biocompatibility显示文摘 | Hernandez L Parra J Viizquez B et a! | 2009 | J Mater Res2009，88，1： | 1 |
| 16 | Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage显示文摘 | McGirt MJ Lynch JR Parra A | 2002 | Stroke2002，33，12： | 1 |
| 17 | Invasive infections caused by Streptococcus pneumoniae in a tertiary-level children's hospital before the introduction of the conjugate vaccine: clinical characteris- tics and serotypes involved显示文摘 | P6rez G M Parra A Casirnir L | 2013 | Archivos Argentinos Depediatria2013，111，3： | 1 |
| 18 | Xenograft rejection of procine islet-like cell clusters in normal and natural killer cell-depleted mice 显示文摘 | Ridderstad A Wallgren AC | 1996 | Transplantation1996，61，9： | 1 |
| 19 | Sleep-related breath ing disorders: impact on mortality of cerebrovascular disease显示文摘 | Parra O Arboix A Montserrat J M | 2004 | EurRespirJ2004，24，26： | 1 |
| 20 | Lipid bilayers including cholesterol as vehicles for acid dyes in wool dyeing显示文摘 | De la Maza A Parra J L Manich A | 1993 | Textile Research Journal1993，63，11： | 1 |
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