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| 1 | Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases显示文摘Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,that in turn concur to increase vascular resistance and portal hypertension and to decrease parenchymal perfusion,have been proposed to favour fibrogenic progression of the disease towards the end-point of cirrhosis.Moreover,hepatic angiogenesis has also been proposed to modulate the genesis of portal-systemic shunts and increase splanchnic blood flow,thus potentially affecting complications of cirrhosis.Hepatic angiogenesis is also crucial for the growth and progression of hepatocellular carcinoma.Recent literature has identified a number of cellular and molecular mechanisms governing the cross-talk between angiogenesis and fibrogenesis,with a specifi c emphasis on the crucial role of hypoxic conditions and hepatic stellate cells,particularly when activated to the myofibroblast-like pro-fibrogenic.Experimental anti-angiogenic therapy has been proven to be effective in limiting the progression of CLDs in animal models.From a clinical point of view,anti-angiogenic therapy is currently emerging as a new pharmacologic intervention in patients with advanced fibrosis and cirrhosis. | Claudia Paternostro Ezio David Erica Novo Maurizio Parola | 2010 | World Journal of Gastroenterology2010，16，3： | 23 |
| 2 | Elastography-based screening for esophageal varices in patients with advanced chronic liver disease显示文摘Elastography-based liver stiffness measurement(LSM) is a non-invasive tool for estimating liver fibrosis but also provides an estimate for the severity of portal hypertension in patients with advanced chronic liver disease(ACLD). The presence of varices and especially of varices needing treatment(VNT) indicates distinct prognostic stages in patients with compensated ACLD(cACLD). The Baveno VI guidelines suggested a simple algorithm based on LSM < 20 kPa(by transient elastography, TE) and platelet count > 150 G/L for ruling-out VNT in patients with cACLD. These(and other) TE-based LSM cut-offs have been evaluated for VNT screening in different liver disease etiologies. Novel point shear-wave elastography(pSWE) and two-dimensional shear wave elastography(2D-SWE) methodologies for LSM have also been evaluated for their ability to screen for 'any' varices and for VNT. Finally, the measurement of spleen stiffness(SSM) by elastography(mainly by pSWE and 2D-SWE) may represent another valuable screening tool for varices. Here, we summarize the current literature on elastography-based prediction of 'any' varices and VNT. Finally,we have summarized the published LSM and SSM cut-offs in clinically useful scale cards. | Rafael Paternostro Thomas Reiberger Theresa Bucsics | 2019 | World Journal of Gastroenterology2019，25，3： | 20 |
| 3 | Ultrasonographic study of postcibal gastro-esophageal reflux and gastric emptying in infants with recurrent respiratory disease显示文摘AIM: To check the utility of postcibal ultrasonography for the evaluation of reflux in relation to gastric emptying in infants with recurrent respiratory symptoms and to link imaging with clinical data.METHODS: Esophageal reflux (hyperechoic retrograde filling) and gastric emptying (antral areas) were quantified before and after ingestion of a standard formula in 35 untreated infants (13 with chronic cough,22 with recurrent bronchitis) and in 31 controls.RESULTS: The prevalence of abnormal (≥8 episodes)postcibal refluxes was 74% in patients and 3% in controls. Number, duration of the longest episode and extent of refluxes were significantly higher in patients compared to controls. Number of refluxes was higher in patients with symptomatic refluxes than in those without.Infants with recurrent bronchitis had more refluxes than those with chronic cough and controls. Extent and timing of gastric emptying were similar in patients and controls.CONCLUSION: Esophageal ultrasonography is a useful and physiological test in infants with recurrent respiratory diseases, which have a high prevalence of abnormal postcibal esophageal reflux and a gastric emptying similar to that of normal controls. Esophageal reflux is more severe in subjects with recurrent bronchitis than in those with chronic cough. | Agostino Di Ciaula Piero Portincasa Leonardo Di Terlizzi Domenico Paternostro Giuseppe Palasciano | 2005 | World Journal of Gastroenterology2005，11，46： | 3 |
| 4 | Cellular and molecular mechanisms in liver fibrogenesis显示文摘 | Erica Novo Stefania Cannito Claudia Paternostro Claudia Bocca Antonella Miglietta Maurizio Parola | 2013 | Archives of Biochemistry and Biophysics2013，，： | 2 |
| 5 | Generation of entangled coherent state via cross-phase-modulation in a double electromagnetically induced transparency regime 显示文摘 | Paternostro M Kim M S Ham B S | 2003 | Phys Rev2003，67，02： | 1 |
| 6 | Triterpenes from Amaracus dictamnus显示文摘 | Piozzi F Paternostro M P assannanti S 1986 | 1986 | Phytochemistry1986，25，2： | 1 |
| 7 | Quantum-state transfer in imperfect artificial spin networks 显示文摘 | Paternostro M Palma G M Kirn M S | 2005 | Phys Rev A2005，71，04： | 1 |
| 8 | Hamiltonian tomography in an access-limited setting without state initialization 显示文摘 | Di Franco C Paternostro M Kim M S | 2009 | Physical Review Letters2009，102，18： | 1 |
| 9 | Bypassing state initialization in Hamiltonian tomography on spin- chains 显示文摘 | Di Franco C Paternostro M Kim M S | 2011 | International Journal of Quantum Information2011，，： | 1 |
| 10 | Treatment of acute promyelocytic leukemia with arsenic trioxide显示文摘 | Tamm I Paternostro G Zapata J M | 1999 | N Engl J Med1999，340，16： | 1 |
| 11 | Decoherence-freequantum Information Processing with Four-photon EntangledStates 显示文摘 | PATERNOSTRO M SON W S KIM M | 2004 | Phys Rev Lett2004，92，10： | 1 |
| 12 | Creating and Pro- bing Multipartite Macroscopic Entanglement with Light 显示文摘 | Paternostro M Vitali D Gigan S | 2007 | Physical Review Letters2007，99，25： | 1 |
| 13 | Dynamical learning of a photonics quantum-state engineering process显示文摘Experimental engineering of high-dimensional quantum states is a crucial task for several quantum information protocols.However,a high degree of precision in the characterization of the noisy experimental apparatus is required to apply existing quantum-state engineering protocols.This is often lacking in practical scenarios,affecting the quality of the engineered states.We implement,experimentally,an automated adaptive optimization protocol to engineer photonic orbital angular momentum(OAM)states.The protocol,given a target output state,performs an online estimation of the quality of the currently produced states,relying on output measurement statistics,and determines how to tune the experimental parameters to optimize the state generation.To achieve this,the algorithm does not need to be imbued with a description of the generation apparatus itself.Rather,it operates in a fully black-box scenario,making the scheme applicable in a wide variety of circumstances.The handles controlled by the algorithm are the rotation angles of a series of waveplates and can be used to probabilistically generate arbitrary four-dimensional OAM states.We showcase our scheme on different target states both in classical and quantum regimes and prove its robustness to external perturbations on the control parameters.This approach represents a powerful tool for automated optimizations of noisy experimental tasks for quantum information protocols and technologies. | Alessia Suprano Danilo Zia Emanuele Polino Taira Giordani Luca Innocenti Alessandro Ferraro Mauro Paternostro Nicolo Spagnolo Fabio Sciarrino | 2021 | Advanced Photonics2021，3，6： | 1 |
| 14 | Self cooling of a micromirror by radiation pressure显示文摘 | GIGAN S BOHM H R PATERNOSTRO M | 2006 | Nature2006，444，2： | 1 |
| 15 | Creating and probing multipartite macroscopic entanglement with light 显示文摘 | PATERNOSTRO M VITALI D GIGAN S | 2007 | Physical Review Letters2007，99，25： | 1 |
| 16 | Postmitochondria| regulation of apoptosis during heart failure 显示文摘 | Reed JC Paternostro G | 1999 | Proc Natl Acad Sci USA1999，96，14： | 1 |
| 17 | A semi-automatic system for segmentation of cardiac M-mode images显示文摘 | Bertelli L Cucchiara R Paternostro G | 2006 | Pattern Analysis & Applications2006，，9： | 1 |
| 18 | Violations of Bell' s inequality for gaussian states with homodyne detection and nonlinear interactions 显示文摘 | Paternostro M Jeong H Ralph T C | 2009 | PhysRevA2009，79，01： | 1 |
| 19 | Insulin resistance in patients with cardiac hypertrophy显示文摘 | Paternostro G Pagano D Gnecchi-Ruscone T | 1999 | Cardiovasc Res1999，42，： | 1 |
| 20 | Creating and Probing Multipartite Macroscopic Entanglement with Light显示文摘 | Paternostro M Vitali D Gigan S | 2007 | Phys Rev Lett2007，99，25： | 1 |
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