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| 1 | Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress显示文摘AIM: To examine the effect of doxycycline on the activity of matrix metalloproteinases (MMPs) and oxidative stress in gastric tissues of rats following gastric injury.METHODS: Gastric ulcers were generated in rats by administration of 70% ethanol,and activity of doxycycline was tested by administration 30 min prior to ethanol.Similarly,the effect of doxycycline was tested in an indomethacin-induced gastric ulcer model.The activities and expression of MMPs were examined by zymography and Western blot analysis.RESULTS: Gastric injury in rats as judged by elevated ulcer indices following exposure to ulcerogen,either indomethacin or ethanol,was reversed significantly by doxycycline.Indomethacin-induced ulcerated gastric tissues exhibited about 12-fold higher proMMP-9 activity and about 5-fold higher proMMP-3 activity as compared to control tissues.Similarly,ethanol induced about 22-fold and about 6-fold higher proMMP-9 and proMMP-3 activities,respectively,in rat gastric tissues.Both proMMP-9 and MMP-3 activities were markedly decreased by doxycycline in ulcerogen treated rat gastric tissues.In contrast,the reduced MMP-2 activity in ulcerated tissues was increased by doxycycline during ulcer prevention.On the other hand,doxycycline inhibited significantly proMMP-9,-2 and -3 activities in vitro.In addition,doxycycline reduced oxidative load in gastric tissues and scavenged H2O2 in vitro.Our results suggest a novel regulatory role of doxycycline on MMP-2 activity in addition to inhibitory action on MMP-9 and MMP-3 during prevention of gastric ulcers.CONCLUSION: This is the first demonstration of dual action of doxycycline,that is,regulation of MMP activity and reduction of oxidative stress in arresting gastric injury. | Laishram Pradeepkumar Singh Amartya Mishra Debjit Saha Snehasikta Swarnakar | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 2 | Hepatotoxic Alterations Induced by Inhalation of Trichloroethylene (TCE) in Rats显示文摘Objective Trichloroethylene (TCE) is one of the most potent organic unsaturated solvents being used in dry cleaning, metal degreasing, thinner for paints varnishes and electroplating, etc. and has been reported to be a hepatotoxicant through oral and dermal exposure. However, its inhalation toxicity data is very limited in the literature due to the fact that the exposure levels associated with these effects were usually not reported. Hence, inhalation toxicity study was carried out for hepatotoxic studies. Method Inhalation toxicity studies was carried out by exposing rats to TCE for 8, 12 and 24 weeks in a dynamically operated whole body inhalation chamber. Sham treated control rats were exposed to compressed air in the inhalation chamber for the same period. Results Significant increase in liver weight (liver enlargement) appearance of necrotic lesions with fatty changes and marked necrosis were observed after longer duration (12 and 24 weeks) of TCE exposure. The lysosomal rupture resulted in increased activity of acid and alkaline phosphatase alongwith reduced glutathione content and total increased sulfhydryl content in liver tissue. Conclusion TCE exposure through Inhalation route induces hepatotoxicity in terms of marked necrosis with fatty changes and by modulating the lysosomal enzymes. | PRADEEPKUMAR A.K.PRASAD 等 | 2001 | Biomedical and Environmental Sciences2001，14，4： | 3 |
| 3 | Tobacco use among medical professionals in Kerela, India: the need for enhanced tobacco cessation and control efforts 显示文摘 | Mohan S Pradeepkumar AS Thresia CU | 2006 | Addict Behave2006，31，12： | 1 |
| 4 | Ureaplasma urea- lyticum and its association with chronic lung disease in Asian neo- nates显示文摘 | Agarwal P Rajadnrai VS Pradeepkumar VK | 2000 | J Paediatr Child Health2000，36，5： | 1 |
| 5 | Tobacco use among medical professionals in Kerela, India: the need for enhanced to- bacco cessation and control efforts 显示文摘 | Mohan S Pradeepkumar AS Thresia CU | 2006 | Addict Behave2006，31，12： | 1 |
| 6 | Variability in physico-chemical characteristics of mango genotypes in northern Kerala显示文摘 | Pradeepkumar T Joseph P Johnkutty I | 2006 | Journal of Tropical Agriculture2006，，44： | 1 |
| 7 | Ureaplasma urealyticum and its association with chronic lung disease in Asian neonates显示文摘 | AGARWAL P RAJADNRAI V S PRADEEPKUMAR V K | | 0，，： | 1 |
| 8 | Tobacco use among medical professionals in Kerala, India: The need for enhanced tobacco cessation and control efforts显示文摘 | Sailesh Mohan A.S. Pradeepkumar C.U. Thresia K.R. Thankappan W.S.C. Poston C.K. Haddock Megan M. Pinkston Myra L. Muramoto Mimi Nichter Mark Nichter Harry A. Lando | 2006 | Addictive Behaviors2006，，12： | 1 |
| 9 | A critical survey of the structure-function of the antlsense oligo/RNA bereroduplex as substrate for RNAse H显示文摘 | Pradeepkumar PI Chattopadhyaya J | 2001 | J Biochenm Biophys Methods2001，2848，3： | 1 |
| 10 | Hospital - based evaluation of two rapid human immunodeficiency virus antibody screening tests显示文摘 | Kannangai R Ramalingam S Pradeepkumar S | 2000 | J Clin Microbiol2000，38，9： | 1 |
| 11 | A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNAse H显示文摘 | Zamaratski E Pradeepkumar PI Chattopadhyaya J | 2001 | J Bioehenm Biophys Methods2001，2848，3： | 1 |
| 12 | Effect of Indigofera aspalathoides on complete Freund’s adjuvant-induced arthritis in rats显示文摘 | B. Rajkapoor S. Kavimani V. Ravichandiran K. Sekhar R. Senthil Kumar M. Rupesh Kumar M. Pradeepkumar John Wilking Einstein E.P. Kumar | 2009 | Pharmaceutical Biology2009，，6： | 1 |
| 13 | Fibre Optic Glucose Sensor显示文摘 | Binu S Mahadevan Pillai V P Pradeepkumar V | 2009 | Material Science and Engineering: C2009，，29： | 1 |
| 14 | Non-Darcy converging flow through coarse granularmedia显示文摘 | PRADEEPKUMAR G N VENKATARAMAN P | 1995 | Journal of the Institution of Engineers (India):Civil Engineering Division1995，76，： | 1 |
| 15 | Fibre Optic Glucose Sensor显示文摘 | Binu S Mahadevan Pillai V P Pradeepkumar V | 2009 | Material Science and Engineering:C2009，，29： | 1 |
| 16 | Synthesis and pol- ymerase-mediated bypass studies of the N2-deoxyguanosine DNA damage caused by a lucidin analogue显示文摘 | Ghodke P P Harikrishna S Pradeepkumar P I | 2015 | J Org Chem2015，80，4： | 1 |
| 17 | A critical survey of the structure-function of the antisense oligo/RN A heteroduplex as substrate for RNAse H显示文摘 | Zamaratski E Pradeepkumar PI Chattopadhyaya J | 2001 | J Biochenm Biophys Methods2001，2848，3： | 1 |
| 18 | G-quadmplex forming structural motifs in the genome of Deinococcus radiodurans and their regulatory roles in promoter functions显示文摘 | Kota S Dhamodharan V Pradeepkumar Pl | 2015 | AppI Microbiol Biotechnol2015，99，22： | 1 |
| 19 | Ex- ploring chemical modifications for siRNA therapeutics, a structural and functional outlook 显示文摘 | SHUKLA S SUMARIA C S PRADEEPKUMAR P I | 2010 | Chem Med Chem2010，5，3： | 1 |
| 20 | Smoking among tuberculosis patients in Kerala, India: proactive cessation efforts arc urgently needed显示文摘 | Pradeepkumar AS Thankappan KR Nichter M | 2008 | Int J Tuberc Lung Dis2008，12，： | 1 |
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