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| 1 | Damage evolution and dynamic response of cement asphalt mortar layer of slab track under vehicle dynamic load显示文摘The damage evolution and dynamic performance of a cement asphalt(CA)mortar layer of slab track subjected to vehicle dynamic load is investigated in this paper.Initially,a statistical damage constitutive model for the CA mortar layer is developed using continuous damage mechanics and probability theory.In this model,the strength of the CA mortar elements is treated as a random variable,which follows the Weibull distribution.The inclusion of strain rate dependence affords considering its influence on the damage development and the transition between viscosity and elasticity.Comparisons with experimental data support the reliability of the model.A three-dimensional finite element(FE)model of a slab track is then created with the commercial software ABAQUS,where the devised model for the CA mortar is implemented as a user-defined material subroutine.Finally,a vertical vehicle model is coupled with the FE model of the slab track,through the wheel-rail contact forces,based on the nonlinear Hertzian contact theory.The evolution of the damage and of the dynamic performance of the CA mortar layer with various initial damage is investigated under the train and track interaction.The analysis indicates that the proposed model is capable of predicting the damage evolution of the CA mortar layer exposed to vehicle dynamic load.The dynamic compressive strain,the strain rate,and the induced damage increase significantly with an increase in the initial damage,whereas the dynamic compressive stress exhibits a sharp decrease with the increasing initial damage.Also,it is found that the strain rate dependence significantly influences the damage evolution and the dynamic behavior of the CA mortar layer. | ZHU ShengYang FU Qiang CAI ChengBiao SPANOS Pol D | 2014 | Science China(Technological Sciences)2014，57，10： | 19 |
| 2 | Comprehensive review of telbivudine in pregnant women with chronic hepatitis B显示文摘AIM:To achieve an evidence-based conclusion regarding the safety and efficacy of telbivudine during pregnancy.METHODS:A pooled analysis of data from a literature search reported 1739 pregnancy outcomes(1673 live births)from 1725 non-overlapping pregnant women treated with telbivudine.The prevalence of live birth defects(3.6/1000)was similar to that of the nonantiviral controls(3.0/1000)and not increased as compared with overall prevalence(14.5 to 60/1000).No target organ toxicity was identified.The prevalence of spontaneous abortion in pregnant women treated with telbivudine(4.2/1000)was not increased compared with the overall prevalence(16/1000).The mother-to-child transmission rate was significantly reduced in pregnant women treated with telbivudine(0.70%)compared to those treated with the non-antiviral controls(11.9%;P<0.0001)or compared to the historical rates of hepatitis B virus(HBV)-infected population without antiviral treatment(10%-15%).RESULTS:Cumulatively 489 pregnancy cases have been reported in the telbivudine pharmacovigilance database(with a cut-off date 31 August 2014),of those,308 had known pregnancy outcomes with 249 cases of live births(239 cases of live birth without congenital anomaly and 10 cases of live birth with congenital anomaly).In the latest antiretroviral pregnancy registry report(1 January 1989 through 31 January 2015)of27 patients exposed to telbivudine during pregnancy(18,6 and 3 during first,second and third trimester,respectively)19 live births were reported and there were no cases of birth defects reported.CONCLUSION:Telbivudine treatment during pregnancy presents a favorable safety profile without increased rates of live birth defects,spontaneous abortion or elective termination,or fetal/neonatal toxicity.Exposure to telbivudine in the first,second and third trimester of pregnancy has been shown to significantly reduce the risk of HBV transmission from mother to child on the basis of standard immune prophylaxis procedure. | Teerha Piratvisuth Guo Rong Han Stanislas Pol Yuhong Dong Aldo Trylesinski | 2016 | World Journal of Hepatology2016，8，9： | 13 |
| 3 | ZnO薄膜的性能和应用显示文摘1 引言 作为半导体、光导体、压电体和光波导材料的氧化锌(ZnO)在科学和技术上有着广泛的应用。ZnO引人注目的性能包括:晶体结构方面的各向异性;非化学计量缺陷结构;宽的带隙;可分解升华及其两性的化学特性;在可见光区光学透明和相当大的折射率;大的压电常数以及大的声光、电光和非线性光学系数。 | Frans C.M.Van De Pol 陈运祥 | 1991 | 压电与声光1991，13，6： | 9 |
| 4 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 5 | Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect. | Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol | 2016 | World Journal of Hepatology2016，8，21： | 5 |
| 6 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 7 | The effects of transcranial direct current stimulation on gait in patients with Parkinson’s disease:a systematic review显示文摘Background:Gait problems are an important symptom in Parkinson’s disease(PD),a progressive neurodegenerative disease.Transcranial direct current stimulation(tDCS)is a neuromodulatory intervention that can modulate cortical excitability of the gait-related regions.Despite an increasing number of gait-related tDCS studies in PD,the efficacy of this technique for improving gait has not been systematically investigated yet.Here,we aimed to systematically explore the effects of tDCS on gait in PD,based on available experimental studies.Methods:Using the PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses)approach,PubMed,Web of Science,Scopus,and PEDro databases were searched for randomized clinical trials assessing the effect of tDCS on gait in patients with PD.Results:Eighteen studies were included in this systematic review.Overall,tDCS targeting the motor cortex and supplementary motor area bilaterally seems to be promising for gait rehabilitation in PD.Studies of tDCS targeting the dorosolateral prefrontal cortex or cerebellum showed more heterogeneous results.More studies are needed to systematically compare the efficacy of different tDCS protocols,including protocols applying tDCS alone and/or in combination with conventional gait rehabilitation treatment in PD.Conclusions:tDCS is a promising intervention approach to improving gait in PD.Anodal tDCS over the motor areas has shown a positive effect on gait,but stimulation of other areas is less promising.However,the heterogeneities of methods and results have made it difficult to draw firm conclusions.Therefore,systematic explorations of tDCS protocols are required to optimize the efficacy. | Fateme Pol Mohammad Ali Salehinejad Hamzeh Baharlouei Michael A.Nitsche | 2021 | Translational Neurodegeneration2021，10，2： | 4 |
| 8 | 人工神经元网络法提高毛细管电泳药物控制分析准确度的研究显示文摘研究了人工神经元网络法在毛细管电泳定量测定memantine中提高测定准确度的可行性 .在毛细管电泳法定量测定memantine的过程中 ,其浓度与峰高或峰面积以及与二者和内标的比值均没有良好的线性关系 .人工神经元网络具有很强的非线性校正能力 ,其最大优点是无须对分离体系及组分的迁移行为预先予以了解 .人工神经元网络的输入为memantine的峰高和峰面积 ,输出为memantine的浓度 .通过实验确定的网络结构为 2∶2∶1型 .由于人工神经元网络的通用性 。 | 李华 张雅雄 Polkov pavla Havel Josef | 2002 | 化学学报2002，60，7： | 4 |
| 9 | Early pancreatic cancer in Ig G4-related pancreatic mass:A case report显示文摘BACKGROUND IgG4-related disease can manifest diversely,including autoimmune pancreatitis and IgG4-related cholangiopathy.We are reporting a very unusual cause of pancreatic cancer triggered in a previously unknown IgG4-related disease.CASE SUMMARY A 75-year-old man was diagnosed with a 43 mm×33 mm pancreatic head tumor after consulting for abdominal pain and jaundice.A pancreaticoduodenectomy was carried out uneventfully,and the histopathology report showed an early stage of acinar-cell pancreatic cancer.The patient reconsulted on the 30th postoperative day with fever,jaundice and asthenia.Magnetic resonance cholangiopancreatography evidenced an extense bile duct stricture.A percutaneous biliary drainage proved to be ineffective,even after exchanging it with larger bore drainage.Reviewing the surgical specimen,features compatible with IgG4-related disease were observed.Consequently,empiric treatment with steroids was initiated achieving excellent results.CONCLUSION IgG4-related disease may cause chronic inflammation of the pancreas and can condition pancreatic malignancies. | Juan Glinka Francisco Calderón Martín de Santibanes Sung Ho Hyon Adrián Gadano Eduardo Mullen Melina Pol Juan Spina Eduardo de Santibanes | 2019 | World Journal of Gastrointestinal Surgery2019，11，12： | 3 |
| 10 | Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications显示文摘Traditional orthopedic metal implants,such as titanium(Ti),Ti alloys,and cobalt-chromium(Co-Cr)alloys,cannot be degraded in vivo.Fracture patients is must always suffer a second operation to remove the implants.Moreover,stress shielding,or stress protection occurs when traditional orthopedic metal implants are applied in fractures surgery.The mechanical shunt produced by traditional orthopedic metal implants can cause bone loss over time,resulting in decreased bone strength and delayed fracture healing.Biodegradable metals that‘biocorrode’are currently attracting significant interest in the orthopedics field due to their suitability as temporary implants.As one of the biodegradable metals,magnesium(Mg)and Mg alloys have gained interest in the field of medicine due to their low density,excellent biocompatibility,high bioresorbability,and proper mechanical properties.Additionally,Mg ions released from the metal implants can promote osteogenesis and angiogenesis during the degradation process in vivo,which is substantially better for orthopedic fixation than other bioinert metal materials.Therefore,this review focuses on the properties,fabrication,biological functions,and surface modification of Mg-based alloys as novel bioabsorbable biomaterials for orthopedic applications. | Fei Xing Shang Li Dongdi Yin Jichang Xie Pol Maria Rommens Zhou Xiang Ming Liu Ulrike Ritz | 2022 | Journal of Magnesium and Alloys2022，10，6： | 3 |
| 11 | Fabrication of AA7005/TiB2-B4C surface composite by friction stir processing: Evaluation of ballistic behaviour显示文摘The present work aims to enhance the ballistic resistance of AA7005 alloy by incorporating the TiB2 and B4C ceramic reinforcement particles. Surface composites with different weight fractions of TiB2 and B4C particles were processed by friction stir processing. Micro-hardness and depth of penetration tests were carried out to evaluate the ballistic properties of the surface composites. The surface hardness of the composite was found to be nearly 70 HV higher than base alloy. The depth of penetration of the steel projectile was 20e26mm in the composites as compared to 37mm in the base alloy. Ballistic mass efficiency factor of the surface composite was found to be 1.6 times higher than base alloy. This is mainly attributed to the dispersion strengthening from the reinforcement particles. | Nitinkumar Pol Gaurav Verma R.P.Pandey T.Shanmugasundaram | 2019 | Defence Technology(防务技术)2019，15，3： | 3 |
| 12 | TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading显示文摘 | Thijs W.H. Pols Mitsunori Nomura Taoufiq Harach Giuseppe Lo Sasso Maaike H. Oosterveer Charles Thomas Giovanni Rizzo Antimo Gioiello Luciano Adorini Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2011 | Cell Metabolism2011，，6： | 3 |
| 13 | Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin显示文摘AIM:To assess the long-term clinical benefit of sustained virological response(SVR)in patients with hepatitis C virus(HCV)cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.METHODS:One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis,treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included.The occurrence of clinical events hepatocellular carcinoma(HCC),decompensation and death was compared in SVR and non SVR patients.RESULTS:Seventy eight patients received bitherapy and 63 had repeat treatments.SVR was achieved in 37 patients(33%).During a mean follow-up of 7.7 years,clinical events occurred more frequently in non SVR than in SVR patients,with a significant difference for HCC(24/76 vs 1/37,P = 0.01).No SVR patient died while 20/76 non-SVR did(P = 0.002),mainly in relation to HCC(45%).CONCLUSION:In patients with HCV-related cirrhosis,SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years.This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis. | Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol Jean-Claude Trinchet | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 14 | 雏鸡运输时间长:是否值得关注显示文摘雏鸡在到达鸡场入舍前,一般会有一段时间无法采食和饮水,这会对它们随后的生长发育产生不利影响。雏鸡出壳后尽早采食和饮水可以降低这种影响。本文详细分析了在雏鸡出壳后及运输时提供饲料和饮水对其生产性能的影响。 | 孟含(译) 陈权(校) Carla van der Pol | 2020 | 国外畜牧学(猪与禽)2020，40，5： | 3 |
| 15 | Noninvasive In Vivo Liver Fibrosis Evaluation Using Supersonic Shear Imaging: A Clinical Study on 113 Hepatitis C Virus Patients显示文摘 | éric Bavu Jean-Luc Gennisson Mathieu Couade Jeremy Bercoff Vincent Mallet Mathias Fink Anne Badel Ana?s Vallet-Pichard Bertrand Nalpas Micka?l Tanter Stanislas Pol | 2011 | Ultrasound in Medicine & Biology2011，，9： | 3 |
| 16 | Body mass index as a predictor of fracture risk: A meta-analysis显示文摘 | C. Laet J. A. Kanis A. Odén H. Johanson O. Johnell P. Delmas J. A. Eisman H. Kroger S. Fujiwara P. Garnero E. V. McCloskey D. Mellstrom L. J. Melton P. J. Meunier H. A. P. Pols J. Reeve A. Silman A. Tenenhouse | 2005 | Osteoporosis International2005，，11： | 2 |
| 17 | Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis显示文摘 | Benjamin Terrier Fabrice Carrat Guillaume Geri Stanislas Pol Lionel Piroth Philippe Halfon Thierry Poynard Jean-Claude Souberbielle Patrice Cacoub | 2011 | Journal of Hepatology2011，，4： | 2 |
| 18 | Medical image matching-a review with classification 显示文摘 | VAN DEN ELSEN P A POL E J D VIERGEVER M A | 1993 | IEEE Eng in Med & Biol1993，12，1： | 2 |
| 19 | Endmember variability in Spectral Mixture Analysis: A review显示文摘 | Ben Somers Gregory P. Asner Laurent Tits Pol Coppin | 2011 | Remote Sensing of Environment2011，，7： | 2 |
| 20 | 坦桑尼亚姆托尼地区红树林沉积物中的硫酸盐还原和甲烷生成作用显示文摘在厌氧环境下的有机物的分解过程中,硫酸盐还原和甲烷生成是对端电子移动起着十分重要作用的过程.许多研究人员指出,硫酸盐还原菌(SRB)和甲烷生物共存于富硫酸盐的海洋沉积物中,而且通常为共同基层的使用而竞争[1~6]. | 高树兵 Thomas J.Lyimo Arjan Pol Huub J.M.Op den Camp | 2002 | AMBIO-人类环境杂志2002，31，7： | 2 |
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