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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 4 | The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1gene in patients with bronchial asthma显示文摘 | Micha? Panek Tadeusz Pietras Adam Antczak Artur Fabijan Marcelina Przem?cka Pawe? Górski Piotr Kuna Janusz Szemraj | 2012 | International Journal of Molecular Medicine2012，，1： | 2 |
| 5 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 6 | Hemorheological changes dependent on the time from the onset of ischemic stroke 显示文摘 | Piotr K Anna M G | 2007 | Journal of the Neurological Sciences2007，258，： | 1 |
| 7 | BISON-C Upgraded One-Dimensional Transport And Bumup Calculation Code For Unix System显示文摘 | Jerzy C Piotr G | 2000 | Nuclear Science and Engineering2000，134，： | 1 |
| 8 | The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma显示文摘 | Jerzy S Piotr G Krzysztof S | 2009 | Chest2009，136，10： | 1 |
| 9 | Comparison of the level of selected antioxidative compounds in frozen broccoli produced using traditional and modified methods显示文摘 | PIOTR G ZOFIA L | 2006 | Innovative Food Science and Emerging Technologies2006，7，： | 1 |
| 10 | A method for dead reckoning parameter correction in pedestrian navigation system显示文摘 | ROMMANEE J PIOTR P VANJA G | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，1： | 1 |
| 11 | Formationof Droplets and Bubbles in a Microfluidic T-Junction-Scaling and Mechanism of Break-up显示文摘 | Piotr G Michael J F Howard A S | 2006 | Lab on a Chip2006，6，： | 1 |
| 12 | Decomposition of microcystin-LR by Fenton oxidation 显示文摘 | Piotr G Zbigniew L Tadeusz B | 2001 | Toxicon2001，39，： | 1 |
| 13 | Fluorine content of two submerged plant species in four warta river oxbow lake reservoirs near Poznan, Poland显示文摘 | Piotr P Maria J M Hanna G | 2006 | Fluoride2006，39，4： | 1 |
| 14 | Stablization of snail by NF- κB is required for inflammation - induced cell migra- tion and invasion显示文摘 | Yadi Wu Jiong Deng Piotr G | 2009 | Cancer cell2009，5，15： | 1 |
| 15 | Targeted molecular therapy of the PI3K pathway therapeutic significance of PI3K subunit targeting in colorectal carcinoma 显示文摘 | Piotr G Rychahou MD Lindsey N | 2006 | Ann Surg2006，243，6： | 1 |
| 16 | Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery: The Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery of the European Society o显示文摘 | Don Poldermans Jeroen J Bax Eric Boersma Stefan De Hert Erik Eeckhout Gerry Fowkes Bulent Gorenek Michael G Hennerici Bernard Iung Malte Kelm Keld Per Kjeldsen Steen Dalby Kristensen Jose Lopez-Sendon Paolo Pelosi Fran?ois Philippe Luc Pierard Piotr Ponik | 2010 | European Journal of Anaesthesiology2010，，2： | 1 |
| 17 | J Power Source显示文摘 | Ren X Piotr Z Sharon T John D Shimshon G | 2000 | 86:1112000，86，： | 1 |
| 18 | Factors influencing the severity of pain during hysterosalpingography显示文摘 | Iwona S Barbara G Piotr M | 2015 | Int J Gynecol Obstet2015，129，： | 1 |
| 19 | Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients 显示文摘 | Monika B Piotr K Iwona B G | 2007 | Nephrol Dial Transplant2007，22，3： | 1 |
| 20 | Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden: Results From the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) Trial Nuclear Substudy显示文摘 | Leslee J. Shaw Daniel S. Berman David J. Maron G B. John Mancini Sean W. Hayes Pamela M. Hartigan William S. Weintraub Robert A. O'Rourke Marcin Dada John A. Spertus Bernard R. Chaitman John Friedman Piotr Slomka Gary V. Heller Guido Germano Gilbert Gosse | 2008 | Circulation2008，，10： | 1 |
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