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| 1 | Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population显示文摘AIM:To identify if methylene tetra-hydrofolatereductase(MTHFR)C677T polymorphisms are associated with oesophageal adenocarcnomas in a Caucasian population and to test whether folic acid and homocysteine levels are linked with cancer risk.METHODS:A case control study comprising of 58 non cancer and 48 cancer patients,MTHFR C667T genotyping was made and serum folate,homocysteine and vitamin B12 levels were made.Tumour stage,differentiation and survival was recorded.A P value of less than0.05 was taken to be significant.Theχ2 used to compare discrete variables and the Mantel-Cox was used to compare survival.A P value less than 0.05 was deemed to be significant.RESULTS:MTHFR polymorphisms is associated with an increased risk of several cancers.A link between MTHFR C677T polymorphisms and oesophageal squamous cell carcinoma and gastric cardia adenocarcinoma has been demonstrated in at risk Chinese populations.In a Western European population the role of the MTHFR gene has not previously been investigated in the setting of oesophageal adenocarcinoma.No association between folic acid levels and cancer patients was found.The unstable MTHFR 667 TT genotype occurred in 11%cancers and 7%controls,but statistical significance was not reached,homocysteine levels and folic acid levels were not affected,cancer patients with TT genotype displayed a trend for a shorter survival 7 mo vs 20 mo.Serum vitamin B12 levels were higher in the cancer group.The MTHFR 667 TT genotype is much lower than previous population studies.CONCLUSION:We conclude that serum folic acid and MTHFR polymorphisms are not associated with an increased risk of oesophageal adenocarcinoma,although cancers with unstable TT genotype may indicate a more aggressive disease course. | Richard Keld Manyi Thian Chia Hau Jamil Sajid Narveen Kumar Yeng Ang | 2014 | World Journal of Gastroenterology2014，20，34： | 8 |
| 2 | 丹麦农业生产中的肥料使用及其对中国的启示显示文摘现代农业中大量使用的化肥在提高作物产量的同时,也带来了一些负面影响如土壤肥力下降、土壤板结等。文章综述了丹麦先进的肥料使用和管理方面的经验。丹麦政府通过根据作物需要制定N的允许施用量和P、K的推荐施用量、对肥料的施用季节和施肥方式进行规定、根据土壤检测的结果和作物产量调整营养元素施用量等措施较好地避免了化肥污染问题,这些先进的经验为中国解决化肥污染问题提供了借鉴。作者提出中国在农业生产过程中应从限制化肥使用量、提高农民知识水平、提倡增施有机肥、改进施肥方式等方面避免对环境的污染。 | 许英杰 Keld Storm | 2010 | 中国农学通报2010，26，16： | 7 |
| 3 | Targeting key signalling pathways in oesophageal adenocarcinoma:A reality for personalised medicine?显示文摘Cancer treatments are rapidly changing.Curative treatment for oesophageal adenocarcinoma currently involves surgery and cytotoxic chemotherapy or chemoradiotherapy.Outcomes for both regimes are generally poor as a result of tumor recurrence.We have reviewed the key signalling pathways associated with oesophageal adenocarcinomas and discussed the recent trials of novel agents that attempt to target these pathways.There are many trials underway with the aim of improving survival in oesophageal cancer.Currently,phase 2 and 3 trials are focused on MAP kinase inhibition,either through inhibition of growth factor receptors or signal transducer proteins.In order to avoid tumor resistance,it appears to be clear that targeted therapy will be needed to combat the multiple signalling pathways that are in operation in oesophageal adenocarcinomas.This may be achievable in the future with the advent of gene signatures and a combinatorial approach. | Richard R Keld Yeng S Ang | 2011 | World Journal of Gastroenterology2011，17，23： | 6 |
| 4 | New human resource management practices, complementarities and the impact on innovation performance显示文摘 | Keld Laursen Nicolai J. Foss | 2003 | Cambridge Journal of Economics2003，，： | 2 |
| 5 | The effect of wind speed and bed slope on sand transport显示文摘 | James D.Iversen Keld R.Rasmussen | 2002 | Sedimentology2002，，4： | 2 |
| 6 | Integration of conducting polymer network in non-conductive polymer substrates显示文摘 | Thomas Steen Hansen Keld West Ole Hassager | 2006 | Synth Met2006，156，： | 1 |
| 7 | Perforrnance of a urea SCR system combined with a PM and fuel optimized heavy duty diesel engine able to achieve the EURO5 emission limits显示文摘 | Ioannis Gekas Par Gabrielsson Keld Johansen | 2002 | SAE Paper2002，，1： | 1 |
| 8 | An effective implementation of the Lin-Ker- nighan traveling salesman heuristic 显示文摘 | Keld Helsgaun | 2000 | European Journal of Operational Research2000，，126： | 1 |
| 9 | Regions Matter: How Localized Social Capital Affects Innovation and External Knowledge Acquisition显示文摘 | Keld Laursen Francesca Masciarelli Andrea Prencipe | 2012 | Organization Science2012，，1： | 1 |
| 10 | Nano-silver induces dose- response effects on the nematode Caenorhabditis elegans 显示文摘 | Lea EJ Keld A J Anders J | 2012 | Ecotoxicol Environ Saf2012，0，1： | 1 |
| 11 | An Effective Implementation of the Lin-Kernighan Traveling Salesman Heuristic显示文摘 | | 2000 | European Journal of Operational Research2000，126，1： | 1 |
| 12 | Direct Identification of Trace Metals in Fine and Uhrafine Particles in the Detroit Urban Atmosphere 显示文摘 | Satoshi U Keld A J Gerald J K | 2004 | Environ Sci Technol2004，38，8： | 1 |
| 13 | The Impact of Technological Opportunity on the Dynamics of Trade Performance 显示文摘 | Keld Laursen | 1999 | Structural Change and Economic Dynamics1999，10，34： | 1 |
| 14 | K Manufacturing Firms显示文摘 | Keld Laursen Open for Innovation:The Role of Openness in Explaining Innovation Performance Among U | 2006 | Strategie Management Journal2006，，27： | 1 |
| 15 | Open for innovation the role of openness in explaining innovation performance among UK manufacturing firms显示文摘 | Keld Laursen Ammon Salte | 2006 | Strategic Management Journal2006，，27： | 1 |
| 16 | PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor progno- sis in gastric adenocarcinoma显示文摘 | Keld R Guo B Downey P | 2011 | Br J Cancer2011，105，1： | 1 |
| 17 | Direct Identification of Trace Met als in Fine and Ultrafine Particles in the Detroit Urban Atmosphere显示文摘 | Satoshi U Keld A J Gerald J K | 2004 | Environ Sci Technol2004，38，8： | 1 |
| 18 | A reliability test of standard-based quantitative PCR:exogenous vs endogenous standards显示文摘 | KeLD ChenZ YungWK | 2000 | Mol Cell Probes2000，14，2： | 1 |
| 19 | New and old economy: the role of lCT in structural change and economic dynamics 显示文摘 | LAURSEN KELD | 2004 | Strctural Changee- Economic Dynamics2004，15，3： | 1 |
| 20 | Searching high and low: what types of firms use universities as a source of innovation?显示文摘 | Keld Laursen Ammon Salter | 2004 | Research Policy2004，，8： | 1 |
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