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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients显示文摘Hepatitis B (HBV) reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases.Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure.Liver transplantation (LT) currently remains the only definitive treatment option for such cases,but is generally denied to patients suffering from malignancy.Here,the authors describe 2 cases of cancer-free and HBV graft re-infection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma.These 2 cases,and some other reports in the literature,may suggest that patients suffering from hematologic malignancies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good. | Timothée Noterdaeme Luc Longrée Christian Bataille Arnaud Deroover Anne Lamproye Jean Delwaide Yves Beguin Pierre Honoré Olivier Detry | 2011 | World Journal of Gastroenterology2011，17，25： | 6 |
| 3 | Statins in Stroke Prevention and Carotid Atherosclerosis: Systematic Review and Up-to-Date Meta-Analysis显示文摘 | Pierre Amarenco Julien Labreuche Philippa Lavallée Pierre-Jean Touboul | 2004 | Stroke2004，，12： | 4 |
| 4 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 5 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 6 | Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices显示文摘瞄准:为了为生男性征的测量发现一个在试管内系统,芙蓉 macranthus (锦葵科) 和 Basella 白长袍的不同摘录完成一(Basellaceae ) 。方法:从片在二媒介,包含0.5%牛的血清白蛋白( BSA )的任何一个 Krebs-Henseleit 缓冲区或 Dubecco 孵化了的睾丸的睾丸激素的生产是修改的鹰的 medium-F12 火腿滋养的混合( DME/Ham F12 ),在5%的混合物下面,在95%空中的 CO2 也当面被决定或加 Basella 白长袍的余因子和芙蓉 macranthus 的缺席一( HMBA )摘录。结果:睾丸激素生产在在响应余因子(49%) 和水浸膏中等的 DME/Ham F12 孵化的睾丸片被增加(34%-60% 根据冲淡) 。在一样的大气的条件下面,没有到在 Krebs-Henseleit 的刺激缓冲包含 0.5% BSA 的余因子或 HMBA 摘录的睾丸片的积极反应。在与 HMBA 的效果有关的进一步的调查, DME/Ham F12 媒介被使用。从在试管内测试获得的结果证明这项活动在二氯甲烷和甲醇主要是在场的,自从这些摘录由睾丸片在睾丸激素生产导致了增加。结论:睾丸片系统是合适的被用于植物的生男性征的简历有功成分的隔离的进一步的在试管内调查。 | Paul E Moundipa Silvère Ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau | 2006 | Asian Journal of Andrology2006，8，1： | 2 |
| 7 | CLIP-170 links endocytic vesicles to microtubules显示文摘 | Pierre P Scheel J Rickard J E | 1992 | Cell1992，70，6： | 1 |
| 8 | Rare earth elements incold seep carbonates from the Niger delta 显示文摘 | Rongemaille E Bayon G Pierre C Bollinger C Chu N C Fouquet Y Riboulot V Voisset M | 2011 | Chem Geol2011，286，19： | 1 |
| 9 | Molecular characterization of two functional domains of CLIP-170 in vivo显示文摘 | Pierre P Pepperkok R Kreis T E | 1994 | Journal of Cell Science1994，107，7： | 1 |
| 10 | Experimentation of a LiBr-H2O absorption process for long-term solar thermal storage:prototype design and first results显示文摘 | N'Tsoukpoe K E Le Pierrès N Luo L | | 0，，01： | 1 |
| 11 | Newer disease - modifying anfirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis 显示文摘 | Samy S Pierre E Marie H | 2004 | The Amercann Journal of Medicine2004，117，： | 1 |
| 12 | Endovascular occlusion of vertebral arteries in the treatment of unclippable vertebrobasilar aneurysms显示文摘 | Armand AY Pierre Gobin Jonathan E | 1991 | J Neurosurg1991，74，： | 1 |
| 13 | The SurfaceTexturization of Solar Cells: A New Method Using v-grooves with Controllable Sidewall Angles显示文摘 | Pierre V Olivier E Emmanuel M | 1992 | Sol EnergyMater Sol Cells1992，26，12： | 1 |
| 14 | How good are rodent mod- els of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemo- prevention in rats, mice and men显示文摘 | CORPET D E PIERRE F | 2005 | Eur J Cancer2005，41，： | 1 |
| 15 | Maximally equidistributed combined tausworthe genera- tors显示文摘 | Pierre L E | 1996 | Mathematics of Computation1996，65，213： | 1 |
| 16 | Comparison of the structure and porous texture of alumina gels synthesized by different methods 显示文摘 | PIERRE A C ELALOUI E PAJONK G M | 1998 | Langmuir1998，14，1： | 1 |
| 17 | UV missile plume signatures model显示文摘 | Roblin Antoine Baudoux Pierre E Chervet Patrick | 2002 | SPIE2002，4718，： | 1 |
| 18 | An audiovisual talking head for augmentedspeech generation : models and animations based on a real speaker,sarticulatory data显示文摘 | Pierre B Fr6d6ric E | 2008 | Computer Science2008，，5098： | 1 |
| 19 | Evaluation of a seasonal storage system of solar energy for house heating using different absorption couples显示文摘 | Liu H N'Tsoukpoe K E Le Pierres N Luo L | | 0，，06： | 1 |
| 20 | A chemical model for the dispersion of fillers in a polymeric matrix显示文摘 | TOMAS L PIERRE G E MIROSLAV G | 2002 | Can J Chem Eng2002，80，6： | 1 |
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