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| 1 | Incidence and risk factors for early renal dysfunction after liver transplantation显示文摘AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital.METHODS: Orthotopic liver transplantations performed from January 2006 until September 2012 were retrospectively reviewed(n = 187). Patients with no renal replacement therapy(RRT) before transplantation were classified into four groups according to their highest creatinine plasma level during the first postoperative week. The first group had a peak creatinine level below 12 mg/L, the second group between 12 and 20 mg/L, the third group between 20 and 35 mg/L, and the fourth above 35 mg/L. In addition, patients who needed RRT during the first week after transplantation were also classified into the fourth group. Perioperative parameters were recorded as risk factors, namely age, sex, bodymass index(BMI), length of preoperative hospital stay, prior bacterial infection within one month, preoperative ascites, preoperative treatment with β-blocker, angiotensin-converting enzyme inhibitor or non steroidal anti-inflammatory drugs, preoperative creatinine and bilirubin levels, donor status(cardiac death or brain death), postoperative lactate level, need for intraoperative vasopressive drugs, surgical revision, mechanical ventilation for more than 24 h, postoperative bilirubin and transaminase peak levels, postoperative hemoglobin level, amount of perioperative blood transfusions and type of immunosuppression. Univariate and multivariate analysis were performed using logistic ordinal regression method. Post hoc analysis of the hemostatic agent used was also done.RESULTS: There were 78 patients in group 1(41.7%), 46 in group 2(24.6%), 38 in group 3(20.3%) and 25 in group 4(13.4%). Twenty patients required RRT: 13(7%) during the first week after transplantation. Using univariate analysis, the severity of renal dysfunction was correlated with presence of ascites and prior bacterial infection, preoperative bilirubin, urea and creatinine level, need for surgical revision, use of vasopressor, postoperative mechanical ventilation, postoperative bilirubin and urea, aspartate aminotransferase(ASAT), and hemoglobin levels and the need for transfusion. The multivariate analysis showed that BMI(OR = 1.1, P = 0.004), preoperative creatinine level(OR = 11.1, P < 0.0001), use of vasopressor(OR = 3.31, P = 0.0002), maximal postoperative bilirubin level(OR = 1.44, P = 0.044) and minimal postoperative hemoglobin level(OR = 0.059, P = 0.0005) were independent predictors of early post-liver transplantation renal dysfunction. Neither donor status nor ASAT levels had significant impact on early postoperative renal dysfunction in multivariate analysis. Absence of renal dysfunction(group 1) was also predicted by the intraoperative hemostatic agent used, independently of the extent of bleeding and of the preoperative creatinine level.CONCLUSION: More than half of receivers experienced some degree of early renal dysfunction after liver transplantation. Main predictors were preoperative renal dysfunction, postoperative anemia and vasopressor requirement. | Patricia Wiesen Paul B Massion Jean Joris Olivier Detry Pierre Damas | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | 活性炭/沸石层状床氢气纯化穿透曲线热效应显示文摘应用变压吸附技术对氢气混合气进行分离提纯是制取高纯度氢气的有效途径。本文主要研究多组分气体在活性炭/沸石层状床中穿透曲线的热效应影响,基于多物理场仿真平台Comsol,建立了多组分气体在多孔介质中的吸附、传热与传质模型。并将模拟值与实验数据进行验证分析,探索吸附过程伴随的热效应对穿透曲线的影响机理。最后针对变压吸附氢气纯化系统运行参数研究了环境温度、吸附条件和活性炭与沸石层高度比等对穿透曲线的影响。 | 彭育志 明越 肖金生 BNARD Pierre CHAHINE Richard | 2016 | 工程热物理学报2016，37，7： | 5 |
| 3 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 4 | Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites显示文摘 | Marie Vos Bénédicte Vroey Béatrice Garcia Garcia Clothilde Roy Fran?ois Kidd Jean Henrion Pierre Deltenre | 2013 | Liver Int2013，，9： | 2 |
| 5 | Severe acute toxicity associated with high - dose methotrexate (MTX) therapy:Use of therapeutic drug monitoring and test - dose to guide carboxypeptidase G2 rescue and MTX continuation 显示文摘 | Esteve MA Devictor- Pierre B Galy G | 2007 | Eur J Clin Pharmacol2007，63，1： | 1 |
| 6 | Nonlinear Normal modes, Invariance and modal dynamics approximations of nonlinear systems 显示文摘 | Nicolas B Pierre C Shaw S W | 1995 | Nonlinear Dynamics1995，8，： | 1 |
| 7 | NT-3;BDNFand NGF in the developing rat nervous system:Parallel as Well as reciprocal Pattern of expression显示文摘 | Maison Pierre PC Belluscio L Friedman B | 1990 | Neuron1990，，5： | 1 |
| 8 | Risk of heparin lock-related bleeding when use indwelling venous cather inhaemodialysis显示文摘 | Huseyin K Pierre P Daniel B | 2001 | Nephrol Dal Transplant2001，16，： | 1 |
| 9 | Abnormality de- tection using low-level co-occurringevents 显示文摘 | Yannick B Pierre M J Venkatesh S | 2011 | Pattern Recognition Letters2011，32，3： | 1 |
| 10 | Cell - cycle - dependent expression of transforming growth factor β type Ⅰ receptor correlates with differential proliferative effects if TGF - β1 in articular chondrocytes显示文摘 | Nathalie F Jean - Pierre P | 1998 | Experimental cell research1998，243，： | 1 |
| 11 | Weighted Euler deconvolution of gravitydata显示文摘 | PIERRE B K | 1998 | Society of Exploration Geophysicists1998，63，5： | 1 |
| 12 | Progress in plant metabolic engineering显示文摘 | PIERRE B CHRIS S | 2001 | Proceeding of the National Academy of Sciences of the United States of America2001，98，16： | 1 |
| 13 | Hyperhomocysteinemia induced vascular damage in the minipig显示文摘 | Pierre H Roll and AF Andre B | 1995 | Circulation1995，91，： | 1 |
| 14 | Structure-born Noise Reduction in a Truck Cab Interior Using Numerical Techniques显示文摘 | MOHANTY A R PIERRE B D | 2000 | Applied Acoustics2000，59，1： | 1 |
| 15 | Direct parameter-extraction method for HBT small-signal model显示文摘 | Bousnina Sami Mandeville Pierre Kouki Ammar B | 2002 | IEEE Transactions on Micro- wave Theory and Techniques2002，50，2： | 1 |
| 16 | Direct numerical simulation of the effect of an electric field on flame stability 显示文摘 | MEMDOUH B PASCALE D PIERRE V | 2010 | Combustion and Flame2010，157，12： | 1 |
| 17 | Precast, prestressed pedestrian bridge-World's first reactive powder concrete structure显示文摘 | Pierre B Y | 1999 | PCI Journal1999，910，： | 1 |
| 18 | Synthesis, characterization and associative properties of triblock and diblock perflu- orinated poly ( acrylamide ) s 显示文摘 | PIERRE L BERNARD B | 1999 | Polymer Bulletin1999，，43： | 1 |
| 19 | Genetic diversity among alfalfa (Medicago sativa ) cultivars coming from a breeding program, using SSR markers显示文摘 | Sandrine F Joelle R Pierre B | 2005 | Theoretical and Applied Genetics2005，111，： | 1 |
| 20 | Effects of ferrous iron toxicity on the growth and mineral composition of aninterspecific rice显示文摘 | SOPHIE D D STANLEY L PIERRE B | 2005 | Journal of Plant Nutrition2005，28，1： | 1 |
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