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| 1 | Use of androgen deprivation therapy in prostate cancer: indications and prevalence显示文摘雄激素在前列腺癌症的发展,维护和前进起一个突出的作用。进为前列腺癌症病人的治疗范例的雄激素剥夺治疗的介绍导致了与临床上局部性或局部地先进的疾病为那些从一个幸存优点的许多好处,到在为有先进疾病的病人的症状控制的改进。然而,争吵留下包围这些神经质的途径的最佳的预定,持续时间和时间表。象 abiraterone 醋酸盐那样的更新的神经质的操作也与前列腺癌症为人被调查了并且将拓宽治疗选择。这评论与支持神经质的治疗的使用的每条途径,以及模式的前列腺癌症,他们的特定的指示和证据加亮对人可得到的各种各样的指导雄激素的治疗选择。 | Roisin M Connolly Michael A Carducci Emmanuel S Antonarakis | 2012 | Asian Journal of Andrology2012，14，2： | 8 |
| 2 | Molecular markers(PECAM-1,ICAM-3,HLA-DR)determine prognosis in primary non-Hodgkin's gastric lymphoma patients显示文摘瞄准:与主要 non-Hodgkin 的胃的淋巴瘤在病人调查 PECAM-1, ICAM-3 和 HLA 医生抗原的预示的意义。方法:我们免疫组织化学地在 36 个 B 房间麦芽类型主要胃的淋巴瘤病人学习了 PECAM-1, ICAM-3 和 HLA 医生抗原表示。十非恶意并且十个健康胃的织物标本被用作控制。Clinicopathological 和幸存数据与染色的结果被相关。结果:HLA 医生抗原表示在 33 个胃的淋巴瘤病人(91.7%) 和 6 个非恶意的病人(54.5%) 被检测。PECAM-1 染色了 10 个病人(27.8%) 的肿瘤房间, 9 个病人(25%) 的 endothelial 并且煽动性有良性的胃的疾病的 4 个病人(40%) 渗入。ICAM-3 表示在 17 个病人(47.2%) 的肿瘤房间上被观察,当 5 个非恶意的病人(50%) 被染色时积极也。任何一个都没为任何学习的基因健康控制被染色。在里面多,变量分析, HLA 医生抗原和 PECAM-1 被证明是与联系的统计上重要的独立预示的因素一赞成并且不利预后分别地(P=0.009 和 P=0.003 ) 。在 univariate 分析, PECAM-1 (+)/ICAM-3 (-) 和 HLA 医生(-)/ICAM-3 (-) 病人与确切相反的基因表示模式与那些相比展出了显著地减少的全面幸存(P=0.0041 和 P=0.0091,分别地) 。是 HLA 医生(+)/ICAM-3 (+)/PECAM-1 (-)(n=8 ) 的那些病人让显著地更高的幸存与这个组(n=24 )(P=0.0289 ) 的其余部分相比评价。结论:PECAM-1, ICAM-3 和 HLA 医生分别地是肿瘤扩大潜力和主人免疫者监视的代表性的标记。他们的联合使用可以帮助我们识别能得益于更好攻击的治疗学的协议的高风险的病人。 | Alexander Darom Ilias P Gomatos Emmanuel Leandros Emmu Chatzigianni Dimitris Panousopoulos Manousos M Konstadoulakis George Androulakis | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?显示文摘Atrial fibrillation(AF)is the most common cardiac arrhythmia worldwide.The prevalence of the disease increases with age,strongly implying an age-related process underlying the pathology.At a time when people are living longer than ever before,an exponential increase in disease prevalence is predicted worldwide.Hence unraveling the underlying mechanics of the disease is paramount for the development of innovative treatment and prevention strategies.The role of voltage-gated sodium channels is fundamental in cardiac electrophysiology and may provide novel insights into the arrhythmogenesis of AF.Na_v1.5 is the predominant cardiac isoform,responsible for the action potential upstroke.Recent studies have demonstrated that Na_v1.8(an isoform predominantly expressed within the peripheral nervous system)is responsible for cellular arrhythmogenesis through the enhancement of pro-arrhythmogenic currents.Animal studies have shown a decline in Na_v1.5 leading to a diminished action potential upstroke during phase 0.Furthermore,the study of human tissue demonstrates an inverse expression of sodium channel isoforms;reduction of Na_v1.5 and increase of Na_v1.8 in both heart failure and ventricular hypertrophy.This strongly suggests that the expression of voltage-gated sodium channels play a crucial role in the development of arrhythmias in the diseased heart.Targeting aberrant sodium currents has led to novel therapeutic approaches in tackling AF and continues to be an area of emerging research.This review will explore how voltage-gated sodium channels may predispose the elderly heart to AF through the examination of laboratory and clinical based evidence. | Emmanuel Isaac Stephanie M Cooper Sandra A Jones Mahmoud Loubani | 2020 | World Journal of Cardiology2020，12，4： | 3 |
| 4 | Human intestinal parasitism,potable water availability and methods of sewage disposal among nomadic Fulanis in Kuraje rural settlement of Zamfara state显示文摘Objective:To ascertain the level of intestinal parasites vis-a-vis the quality of housing and water supply,and sanitary conditions among the people of Kuraje village in Zamfara state. Methods:The study was cross sectional in nature.Individual households were selected using systematic random sampling methods and pre-tested questionnaires were administered to all the members of each household.Stool samples were collected and processed using standard laboratory procedures.Housing conditions,sources of water and sanitary conditions of the households were also inspected.Results were analysed using Epi Info 2006 model.Results: The prevalence of intestinal parasites was 67.0%(347/519).72.3%(251/347),17.0%(59/347),and 10.7%(37/347) had one,two and three or more parasites,respectively.The associated factors with intestinal parasites were poor housing and sanitary conditions,lack of potable water and illiteracy.The commonest parasites encountered were hookworm(22.0%),Ascaris lumbricoides (18.5%),and Strongyloides stercoralis(15.6%) while the least common was Enterobius vermicularis (1.6%).Others were Giardia lamblia(5.7%),Hymenolepsis nana(5.0%),Trichuris trichiura(8.8%), Entamoeba histolytica(14.4%) and Schistosoma mansoni(8.4%).Conclusions:The infection rate of intestinal parasites in Kuraje village is high.More efforts should be intensified towards improvement in sanitary and housing standards,supply of potable water and institution of a more comprehensive literacy programme for the people of the community. | Godwin T Jombo James G Damen Hauwa Safiyanu Friday Odey Emmanuel M Mbaawuaga | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 2 |
| 5 | Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia显示文摘ObjectiveTo 在在检验生活和资源使用的质量的 17 所澳大利亚的疗养院的代表性的研究的 Australia.MethodsAs 部分住在疗养院的更老的成年人与认知功能和痴呆的诊断检验在心血管的系统药使用之间的协会,我们检验了在认知缺陷和心血管的药使用之间的协会(使用解剖治疗学的分类系统识别)用一般线性回归和逻辑 regressio 正在收到生活照顾的结束的人是包括的 excluded.ResultsParticipants 有一个平均数的 541 个居民 85.5 | Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty | 2017 | Journal of Geriatric Cardiology2017，14，6： | 2 |
| 6 | Geologically constrained probabilistic mapping of gold potential, Baguio District, Philippines 显示文摘 | Emmanuel J Carranza M Martin H | 2000 | Natural Resources Research2000，9，3： | 1 |
| 7 | Zinc?binds to the neuroprotective peptide humanin显示文摘 | Ambar A Vanessa S Emmanuelle M | 2006 | Journal of Inorganic Biochemistry2006，100，： | 1 |
| 8 | Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with a positive response显示文摘 | Emmanuel A V Shand A G Kamm M A | 2004 | Aliment Pharmacol Ther2004，19，6： | 1 |
| 9 | The SurfaceTexturization of Solar Cells: A New Method Using v-grooves with Controllable Sidewall Angles显示文摘 | Pierre V Olivier E Emmanuel M | 1992 | Sol EnergyMater Sol Cells1992，26，12： | 1 |
| 10 | Analytical far-field divergence angle of a truncated Gaussian beam显示文摘 | Emmanuel M Drvge Neal G Skinner Dale M Byrne | 2000 | Appl Opt2000，39，27： | 1 |
| 11 | Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers 显示文摘 | Emmanuel A Kamm M Roy A | 1998 | Gut1998，42，4： | 1 |
| 12 | Laser Doppler flowmetry as a measure of extrinsic colonic innervation in functional bowel disease显示文摘 | Emmanuel A Kamm M | 2000 | Gut2000，46，： | 1 |
| 13 | The role of a pharmacist on the paediatric unit of a generate hospital显示文摘 | Muzenberger P Emmanuel S I-Ieins M | 1972 | Am J Hosp Pharm1972，29，9： | 1 |
| 14 | Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation显示文摘 | AV Emmanuel M A Kamm | 2001 | Gut2001，49，： | 1 |
| 15 | Evaluation of a rapid diagnostic test (CareStartTM Malaria HRP-2/pLDH (Pf/pan) Combo test) for the diagnosis of malaria in reference setting显示文摘 | Jessica M Philippe G Emmanuel B | 2010 | Malar J2010，，9： | 1 |
| 16 | Thoracoscopic excision of mediastinal bronchogenic cysts:results in 20 cades显示文摘 | Emmanuel M Francois P Jacques A | 2000 | Ann Thorac Surg2000，69，： | 1 |
| 17 | Journal club: acute abdominal pain in elderly patients : effect of radiologist awareness of clinicobiologic information on CT accuracy显示文摘 | Ingrid M Chakib A Emmanuelle B P | 2013 | American Journal of Roentgenology2013，201，6： | 1 |
| 18 | Clinical pre- sentation and management of drug-induced agranulocyto- sis显示文摘 | Emmanuel A Jacques Z Mustapha M | 2011 | Expert Rev Hematol2011，4，2： | 1 |
| 19 | Feeding high proportions of barley grain stimulates an inflammatory response in dairy cows 显示文摘 | EMMANUEL D G DUNN S M AMETAJ B N | 2008 | J Dairy Sci2008，91，2： | 1 |
| 20 | Broiler performance, body weight variance, feed and water intake, and carcass quality at different stocking densities显示文摘 | Feddes J J R Emmanuel E J Zuidhof M J | 2002 | Poult Sci2002，81，： | 1 |
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