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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | FOLy: An integrated database for the classification and functional annotation of fungal oxidoreductases potentially involved in the degradation of Iiguin and related aromatic conq2ounda 显示文摘 | Anthony L Francois P Pedro M | 2008 | Fungal Genetics and Biology2008，45，： | 1 |
| 3 | Climate change and recent waler level variability in Patagonian proglacial lakes, Argentina 显示文摘 | Andrea I P Karina L L Pedro J D | 2008 | Global and Planetary Change2008，63，4： | 1 |
| 4 | Risk assessment scales for pressure ulcer prevention:a systematic review显示文摘 | Pedro L Hidalgo P Femandez FP | 2006 | J Adv Nurs2006，54，1： | 1 |
| 5 | RFID system: a survey on security threats and proposed solutions显示文摘 | PEDRO P L JUL10 C H C JUAN M | 2006 | Lecture Notes in Computer Science2006，42，17： | 1 |
| 6 | Fatty acid esters of triterpenes from Erythroxylum passerinum显示文摘 | MARIZETH L B JORGE M D PEDRO A P P | 2002 | J Braz Chem Soc2002，13，5： | 1 |
| 7 | Optimized heat transfer correlations for pure and blended refrigerants显示文摘 | PORTO M P PEDRO H T C MACHADO L | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 8 | Analyzing beta diversity partitioning the spatial variation of community composition data 显示文摘 | PIERRE L DANIEL B PEDRO R P | 2005 | Ecological Monographs2005，75，4： | 1 |
| 9 | Acinetobacter strains IH9 and OCI1, two rhizospheric phosphate solubilizing isolates able to promote plant growth, constitute a new genomovar ofAcinetobacter calcoaceticus显示文摘 | Alvaro P Elke L Susanne V Cathrin S Rau'lR Ignacio SR Pedro FM Eustoquio MM Claudino RB Encama V | 2009 | Systematic and Applied Microbiology2009，32，5： | 1 |
| 10 | Cavernomas in children with brain tumors: a late complication of radiotherapy 显示文摘 | Martínez-Lage J F de la Fuente I Ros de San Pedro J Fuster J L Pérez-Espejo M A Herrero M T | 2008 | Neurocirugia (Astur)2008，19，： | 1 |
| 11 | Comparative assessment of a biofilter, a biotrickling filter and a hollow fiber membrane bioreactor for odor treatment in wastewater treatment plants显示文摘 | Raquel Lebrero Ana Celina Gondim Rebeca Pérez Pedro A. García-Encina Raúl Mu?oz | 2013 | Water Research2013，，： | 1 |
| 12 | The Synthesis and Resolution of 2,2'-,4,4'-, and 6,6'-Substituted Chiral Biphenyl Derivatives for Application in the Preparation of Chiral Materials 显示文摘 | Pedro J M P Yoon S U Christopher L | 2006 | J Org Chem2006，71，16： | 1 |
| 13 | Clinical evidence for enteral nutri-tional support with glutamine:A systematic review显示文摘 | Abelarda G L Pedro P G | 2003 | Nutri2003，19，： | 1 |
| 14 | Stroke review:advances in interventional neuroradiology 2004显示文摘 | David P Tommy A Pedro L | 2005 | Stroke2005，36，： | 1 |
| 15 | Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3,AAO3 and ABA1 in response to salt stress显示文摘 | JOSE M B PEDRO L R VICTOR Q PEDRO P M JOSE L M | 2006 | Plant Cell and Environment2006，29，： | 1 |
| 16 | Assessment of the spectrophotometric method for determination of angiotensin-converting-enzyme activity:influence of the inhibition type显示文摘 | Blanca H L Pedro J M I Encarnacion P | 2003 | J Agr Food Chem2003，51，： | 1 |
| 17 | Optimized heat transfer correlations for pure and blended refrigerants显示文摘 | Porto M P Pedro H T C Machado L | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 18 | Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study显示文摘 | Karen L Kotloff James P Nataro William C Blackwelder Dilruba Nasrin Tamer H Farag Sandra Panchalingam Yukun Wu Samba O Sow Dipika Sur Robert F Breiman Abu SG Faruque Anita KM Zaidi Debasish Saha Pedro L Alonso Boubou Tamboura Doh Sanogo Uma Onwuchekwa Byo | 2013 | The Lancet2013，，9888： | 1 |
| 19 | REE distribution pattern in river sediments: Partitioning into residual and labile fractions 显示文摘 | Lydia L Jean-Luc P Pedro D | 1999 | Earth and Planetary Sciences Letters1999，329，： | 1 |
| 20 | Spurious thrombocytosis associated with cryoglobulinaemia:a case report显示文摘 | Pérez-Vila ME Pedro C Mellibovsky L | 2002 | Haematologica2002，8，87： | 1 |
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