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| 1 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease显示文摘Cytomegalovirus(CMV) infection is common in humans.The virus then enters a 'latency phase' and can reactivate to different stimuli such as immunosuppression.The clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of CD.However,CMV reactivation is frequent in severe or steroid-resistant UC.It is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe disease.Different methods are used to diagnose CMV colitis.Diagnosis is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being investigated.Polymerase chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic mucosa.Specific endoscopic features have not been described in active UC and CMV infection.CMV colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive therapy.Other antiviral drugs may be used.Multicenter controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment. | Elena Garrido Elisa Carrera Rebeca Manzano Antonio Lopez-Sanroman | 2013 | World Journal of Gastroenterology2013，19，1： | 7 |
| 3 | Z-line examination by the PillCam^(TM) SB:Prospective comparison of three ingestion protocols显示文摘AIM:To evaluate the Z-line visualization by the PillCamTM SB2 using three different ingestion protocols. METHODS:Ninety consecutive patients undergoing small bowel capsule endoscopy(SBCE)between January and May 2008 were included in the study. They swallowed the capsule in the standing(Group A= 30),supine(Group B=30)and right supine positions (Group C=30).Baseline patient characteristics, difficulties in capsule ingestion,esophageal transit times(ETT)and Z-line visualization were noted. RESULTS:No significant differences were found between the groups with regard to baseline patient characteristics,ingestion difficulties and complete SB examinations(P>0.05).At least 1 frame of the Z-line was detected in 15.8%,46.7%and 90%of patients in groups A,B and C,respectively(P<0.001).The average number of Z-line images was 0.21±0.53,3.23 ±6.59 and 5.53±7.55 and the mean%of the Z-linedetected was 71.3,25.1 and 8.3,in groups A,B and C, respectively(both P<0.001).ETT times were longer in the supine group followed by the right supine and the standing groups(median of 237 s vs 64 s and 39 s, respectively;P<0.001). CONCLUSION:Z-line visualization in patients undergoing SBCE can be accurately achieved in most cases when the capsule is swallowed in the right supine position. | Ignacio Fernandez-Urien Erika Borobio Inmaculada Elizalde Rebeca Irisarri Juan Jose Vila Jesus Maria Urman Javier Jimenez | 2010 | World Journal of Gastroenterology2010，16，1： | 7 |
| 4 | 中医药在巴拿马的发展现状与分析显示文摘巴拿马国内医疗保险普及工作已基本完成,医保覆盖率较高,但呈两极分化。导致该国成人死亡的主要疾病为缺血性心脏病、脑卒中、AD及糖尿病,近年来慢性肾脏疾病及COPD的发病率亦显著升高。巴拿马本土医学被认为是补充替代医学,已得到国内法律认可,在土著人群和农村地区使用率较高。中医药在巴拿马尚处起步阶段,无相关立法,但该国重视本土传统医学且民众接受度逐渐提高,中医药在当地发展具有巨大潜力。建议以文化为载体推进中医药传播、探索多样的中医药合作与交流形式、以传统草药研发为切入点并加大针灸推广力度,推动中医药在巴拿马的发展。 | 李皓月 石晗 Ana Rebeca Almanza 魏竞竞 杨卫彬 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，5： | 4 |
| 5 | Total hepatectomy and liver transplantation as a two-stage procedure for fulminant hepatic failure: A safe procedure in exceptional circumstances显示文摘AIM: To evaluate the outcomes of two-stage liver transplant at a single institution, between 1993 and March 2015.METHODS: We reviewed our institutional experience with emergency hepatectomy followed by transplantation for fulminant liver failure over a twenty-year period. A retrospective review of a prospectively maintained liver transplant database was undertaken at a national liver transplant centre. Demographic data, clinical presentation, preoperative investigations, cardiocirculatory parameters, operative and postoperative data were recorded.RESULTS: In the study period, six two-stage liver transplants were undertaken. Indications for transplantation included acute paracetamol poisoning(n = 3), fulminant hepatitis A(n = 1), trauma(n = 1) and exertional heat stroke(n = 1). Anhepatic time ranged from 330 to 2640 min. All patients demonstrated systemic inflammatory response syndrome in the first post-operative week and the incidence of sepsis was high at 50%. There was one mortality, secondary to cardiac arrest 12 h following re-perfusion. Two patients required re-transplantation secondary to arterial thrombosis. At a median follow-up of 112 mo, 5 of 6 patients are alive and without evidence of graft dysfunciton.CONCLUSION: Two-stage liver transplantation represents a safe and potentially life-saving treatment for carefully selected exceptional cases of fulminant hepatic failure. | Rebeca Sanabria Mateos Niamh M Hogan Dimitri Dorcaratto Helen Heneghan Venkatesh Udupa Donal Maguire Justin Geoghegan Emir Hoti | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 6 | Risk stratification in patients with unstable angina using absolute serial changes of three high sensitive Troponin Assays显示文摘 | Tobias Reichlin Raphael Twerenbold Claudia Maushart Miriam Reiter Berit Moehring Nora Schaub Cathrin Balmelli Maria Rubini Gimenez Rebeca Hoeller Konstantin Sakarikos Beatrice Drexler Philip Haaf Stefan Osswald Christian Mueller | 2012 | American Heart Journal2012，，： | 2 |
| 7 | 氮素改变辣椒初级代谢和薄壁组织厚度调控比叶面积研究显示文摘比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinense)SLA的影响,研究对两个中国辣椒商品种(Biquinho和Habanero)的初级代谢产物和形态特征进行了分析。两种基因型辣椒的SLA随着遮阴而增加,但随氮供应量的增加而下降;在氮素供应由缺乏到充足的范围内Habanero品种的SLA表现稳定。相关分析表明,高氮供应导致SLA降低是因为氨基酸、蛋白质和淀粉含量的调节,从而影响叶片密度。此外,在中度缺氮到充足供氮范围内,两种基因型辣椒的SLA表现出响应差异,Biquinho和Habanero分别在栅栏和海绵状薄壁组织上表现出差异。总之,结果表明,SLA对氮供应的反应是由某些代谢物含量和依赖于基因型的影响叶片厚度及密度的薄壁组织变化平衡调节的。 | Lucas de ávila Silva Rebeca P.Omena-Garcia Jorge A.Condori-Apfata Paulo Mafra de Almeida Costa Natália Machado Silva Fábio M.Da Matta Agustin Zsogon Wagner L.Araújo Edgard A.de Toledo Picoli Ronan Sulpice Adriano Nunes-Nesi 沈凌峰 吉雪花(译) | 2021 | 辣椒杂志2021，，3： | 2 |
| 8 | Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering显示文摘The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies.High-performance preclinical results have failed at clinical level,as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke,Alzheimer’s and Parkinson’s diseases.An unquestionable reality is the current absence of effective therapies to neuroprotect the brain,to arrest neurodegeneration and rewire the impaired brain circuits.Part of the problem might arise from the lack of adequate in vitro and in vivo models and that most of the underlying pathophysiological mechanisms are not yet clarified.Another contributing factor is the lack of efficient systems to sustain drug release at therapeutic concentrations and enhance the survival and function of grafted cells in transplantation procedures.For medical applications the use of biomaterials of different compositions and formats has experienced a boom in the last decades.Although the greater complexity of central nervous system has probably conditioned their extensive use with respect to other organs,the number of biomaterials-based applications to treat the injured brain or in the process of being damaged has grown exponentially.Hydrogel-based biomaterials have constituted a turning point in the treatment of cerebral disorders using a new form of advanced therapy.Hydrogels show mechanical properties in the range of cerebral tissue resulting very suitable for local implantation of drugs and cells.It is also possible to fabricate three-dimensional hydrogel constructs with adaptable mesh size to facilitate axonal guidance and elongation.Along this article,we review the current trends in this area highlighting the positive impact of hydrogel-based biomaterials over the exhaustive control of drug delivery,cell engraftment and axonal reinnervation in brain pathologies. | Rocío Fernández-Serra Rebeca Gallego Paloma Lozano Daniel González-Nieto | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 9 | 南海北部陆架和陆坡区小型底栖动物群落的比较研究显示文摘为了解南海北部陆架与陆坡区小型底栖动物的群落特征,以及影响群落特征的环境因素,2015年6月对南海北部海域(19.3°—21.4°N, 112.4°—115.1°E)7个站位的小型底栖动物及环境因子进行了采样,并对陆架和陆坡区小型底栖动物群落的丰度、生物量、类群组成和群落结构进行比较。结果表明,在陆架站位,小型底栖动物由13个类群组成,平均丰度为(132±130)ind./10cm^2,平均生物量为(169±79)μgdwt/10cm^2;在陆坡站位由8个类群组成,平均丰度为(33±14)ind./10cm^2,平均生物量为(56±35)μgdwt/10cm^2。单因素方差分析结果表明,陆坡区小型底栖动物的总丰度和总生物量以及线虫和多毛类的丰度均显著低于陆架区,但优势类群的相对丰度组成没有显著不同,海洋线虫占总丰度的83%,其次为多毛类和桡足类,分别占7%和3%。环境因子的主成分分析(Principal ComponentsAnalysis,PCA)将陆架和陆坡站位沿第一主分量轴分开,小型底栖生物丰度和生物量与沉积物叶绿素a和脱镁叶绿酸含量以及底层水温呈最大正相关,与水深呈负相关;聚类(Cluster)和排序(non-metric Multidimensional Scaling, MDS),以相似性系数65%将7个站位划分为2组,与按照水深划分的陆架和陆坡组基本吻合;单因素相似性分析(one-way ANOSIM)显示陆架和陆坡区小型底栖动物群落结构差异显著;生物-环境分析(Biota-Environment,BIOENV)表明影响群落结构的最佳环境因子组合为叶绿素a和底层水温。综上可知,随水深增加的食物减少和底层水温的下降是限制南海北部研究海域小型底栖动物丰度和生物量及影响群落组成和结构的主要因素。 | 周红 Saif MD Uddin 黄梦娇 刘晓收 王正茂 尹泳桐 姜钱钱 Rebeca Montero-Taboada Karim MD Abdul | 2020 | 海洋与湖沼2020，51，3： | 2 |
| 10 | Efficacy of the vaccination in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) is associated with conditions that may predispose to infections, such as the lack of an appropriate innate immune response to infectious agents, malnutrition, surgery, and immunosuppressive and biological drugs. Some of these infections may be preventable by vaccination. Therefore, for this particular patient population, the benefits of implementing a well-established immunization protocol in daily clinical practice are potentially even greater than for the general population. In recent years international consensus guidelines have been published, but in spite of theses recommendations, studies have shown that a significant number of patients with IBD remain inadequately immunized. Another important issue regarding immunization in this population is that vaccine efficacy among patients receiving immunosuppressive therapies has been variable. In a healthy population, a humoral immune response to hepatitis B vaccination (HBV) is expected in > 90%, whereas a much lower rate is achieved in the IBD patients. Immunosuppressive, anti-tumor necrosis factor therapy and disease activity have been implicated in the impaired efficacy of the vaccination. The serological response to HBV should be confirmed and patients with an inadequate response should receive a second full series of vaccine. Modified dosing regimens, including doubling the standard antigen dose, might increase the effectiveness. Response to influenza, pneumococcal and tetanus immunization is still not clear, as there are studies that show a normal response to the vaccination while others demonstrate a lack of efficacy. We pose a series of questions on the efficacy of the different vaccinations recommended for IBD patients and attempt to answer them using scientific evidence. | Elisa Carrera Rebeca Manzano Elena Garrido | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 11 | Internet retail customer loyalty: the mediating role of relational benefits 显示文摘 | Hsiu Ju Rebeca Yen Kevin P Gwinner | 2003 | International journal of service industry man- agement2003，14，5： | 1 |
| 12 | Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency显示文摘 | Sancho-Shimizu Vanessa de Diego Rebeca Pérez Lorenzo Lazaro Halwani Rabih Alangari Abdullah Israelsson Elisabeth Fabrega Sylvie Cardon Annabelle Maluenda Jerome Tatematsu Megumi Mahvelati Farhad Herman Melina Ciancanelli Michael Guo Yiqi AlS | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 13 | Production of fish protein hydrolysates with bacterial protease:yield and nutritional value显示文摘 | REBECA | 1991 | J Food Science1991，56，2： | 1 |
| 14 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 15 | Heavy metals distribution in soils surrounding an abandoned mine in NW Madrid (Spain) and their transference to wild flora显示文摘 | Eduardo M J Jesus M P Rebeca M | 2009 | Journal of Hazardous Materials2009，162，23： | 1 |
| 16 | Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra high performance liquid chromatography (UHPLC)- tandem mass spectrometry ( MS/MS ) 显示文摘 | REBECA L S MIRA P DAMIA B | 2011 | Chemosphere2011，85，8： | 1 |
| 17 | Antithrombotic and an-giotensin -converting enzyme inhibitory properties of peptides re -leased from bovine casein by Lactobacillus casei Shirota显示文摘 | Rebeca RR Alma CG Angelica FN | 2012 | Interna-tional dairy journal2012，26，2： | 1 |
| 18 | Development of a murine model of airway infammation and remodeling in experimental asthma显示文摘 | REBECA F I LAURA N N NADIA S B | 2009 | Arch Bronconeumol2009，45，9： | 1 |
| 19 | In-situ LIF Analysis of Biological and Petroleum-based Hydraulic Oils on Soil 显示文摘 | Matthias Lemke Rebeca Femandez-Trujillo Lohmannsroben Hans-Gerd | 2005 | Sensors(S1424-8220)2005，，5： | 1 |
| 20 | Synthesis and purification of structured triacylglycerols from evening primrose and viper’s bugloss seed oils显示文摘 | Miguel ángel Rincón Cervera Elena Venegas Venegas Rebeca Pilar Ramos Bueno José Luis Guil Guerrero | 2012 | Food Research International2012，，2： | 1 |
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