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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | High DHA content in Artemiais ineffective to improve Octopus vulgaris paralarvae rearing 显示文摘 | Pedro S Manuel R M Lulsa M P V | 2010 | Aquaculture2010，300，： | 1 |
| 3 | Decoupled double syn- chronous referecnce frame PLL for power converters con- trol 显示文摘 | Pedro R Josep P Joan B | 2007 | IEEE Transactions on Power Electronics2007，22，2： | 1 |
| 4 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 5 | Mitochondrial DNA variation in the malaria vector Anopheles minimus across China, Thailand and Vietnam : evolutionary hypoth- esis,population structure and population history显示文摘 | Chen B Pedro P M Harbach R E | 2011 | He- redity2011，106，2： | 1 |
| 6 | Spatial modeling: A comprehensive framework for principal coordinate anal- ysis of neighbor matrices (PCNM)显示文摘 | Stephane D Legendre P Pedro R | 2006 | Ecological Modeling2006，196，： | 1 |
| 7 | Effects of biosolarization as methylbromide alternative for Meloidogynei ncognitacontrol on quality of soil underpepper显示文摘 | Margarita R Pedro F P Jose A | 2008 | Biology and Fertility of Soils2008，45，1： | 1 |
| 8 | The value of a statistical life:a comparison of two approaches显示文摘 | Lanoie P Pedro C Latour R | 1995 | Journal of Risk and Uncertainty1995，10，4： | 1 |
| 9 | Bronchial artery ebmolization in the management of hemotysis:technical aspects and long term results显示文摘 | Uflacker R Kaemmer A Pedro D P | 1985 | Radiology1985，157，： | 1 |
| 10 | Design of a power-amplifier feed-forward RF model with physical knowledge considerations显示文摘 | CUNHA T R PEDRO J C CABRAL P M | 2007 | IEEE Trans Microwave Theory Tech2007，55，12： | 1 |
| 11 | Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/ hydrazones:Anti-Mycobacterium tuberculosis activity and cytotoxicity 显示文摘 | Fernando R P Pedro Ida S Maia | 2010 | Eur J Med Chem2010，45，5： | 1 |
| 12 | Metazihemerythin models feature a bis-benzimidazole tripped ligand structure and spectroscopy of (μ-oxo)bis(μ-benzoate)bis (bis (2-benzimidazoly methyl) amine) diiron( Ⅲ )显示文摘 | Pedro G R Nieves C P Ahmed B H | 1988 | J Am Chem Soc1988，110，： | 1 |
| 13 | The value of a statistical life: A comparison of two approaches显示文摘 | Lanoie P Pedro C Latour R | 1995 | Journal of Risk and Uncertainty1995，10，3： | 1 |
| 14 | Effects of biosolarization as methyl bromide alternative for Meloidogyne incognita control on quality of soil under pepper显示文摘 | Margarita R Pedro F P Jose A | 2008 | Biology and Fertility of Soils2008，45，1： | 1 |
| 15 | Analyzing beta diversity partitioning the spatial variation of community composition data 显示文摘 | PIERRE L DANIEL B PEDRO R P | 2005 | Ecological Monographs2005，75，4： | 1 |
| 16 | Design,synthesis and application of fluorescent 2,1,3-benzothiadiazole-triazole-linked biologically active lapachone derivatives显示文摘 | DA CRUZ EDUARDO H G CARVALHO PEDRO H P R CORRêA JOSéR | 2014 | New J Chem2014，38，： | 1 |
| 17 | Effects of bioso- larization as methyl bromide alternative for Meloidogyne incognita control on quality of soil under pepper显示文摘 | Margarita R Pedro F P Jose A | 2008 | Bi- ology and Fertility of Soil2008，45，1： | 1 |
| 18 | Metazihemerythin models feature a bis-benzimidazole tripped ligand, structure and spectroscopy of (μ-oxo) bis (μ-benzoate) bis (his (2-benzimidazoly methyl) amine) diiron (Ⅲ)显示文摘 | Pedro G R Nieves C P Ahmed B H | 1988 | Chem Soc1988，110，： | 1 |
| 19 | First report of pathogenic activity of Hirsutella thompsonii (Fischer) on the litchi erineum mite Acena litchff (Keifer)显示文摘 | Pedro R F P Marineide R V | 2013 | Cincias Agr6rias Londrina2013，34，1： | 1 |
| 20 | Optimal scheduling of a renewable micro-grid in an isolated load area using mixed-integer linear programming显示文摘 | Hugo Morais Péter Kádár Pedro Faria Zita A. Vale H.M. Khodr | 2009 | Renewable Energy2009，，1： | 1 |
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