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| 1 | Serum cytokine profile in patients with hepatitis B e antigen-negative chronic active hepatitis B and inactive hepatitis B virus carriers显示文摘An insufficient cellular immune response seems to be critical for the immunopathogenesis of chronic hepatitis B virus infection.We have previously demonstrated no differences of T-lymphocyte subsets in blood between inactive hepatitis B s antigen(HBsAg) carriers and patients with HBeAg-negative chronic active hepatitis B.This study investigated the peripheral blood cytokine profile in patients with HBeAg-negative chronic active hepatitis B infection(Group A,n = 21) and inactive HBsAg carriers(Group B,n = 13).Serum cytokines [interferon(IFN)-γ,tumor necrosis factor-α,interleukin(IL)-1b,IL-4,IL-12,IL-10,IL-2,IL-5,IL-8] were analyzed by using flow cytometry.Patients with chronic active disease presented with significantly decreased levels of IFN-γ and IL-10 compared to inac-tive carriers(P = 0.048 and P = 0.008,respectively).In HBeAg-negative chronic active hepatitis B patients,a significant negative correlation of IFN-γ levels with serum hepatitis B viral load was noted(P = 0.021).In conclusion,patients with HBeAg-negative chronic active hepatitis B and HBsAg inactive carriers display a different cytokine profile.Decreased Th1 response observed in patients with chronic active hepatitis B could be implicated in the persistence of virus replication and ongoing progression of liver disease. | Dimitra Dimitropoulou Marina Karakantza Georgios L Theodorou Lydia Leonidou Stelios F Assimakopoulos Athanasia Mouzaki Charalambos A Gogos | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 13 |
| 2 | Metabolic,autonomic and immune markers for cardiovascular disease in posttraumatic stress disorder显示文摘Posttraumatic stress disorder(PTSD) has been associated with significantly greater incidence of heart disease.Numerous studies have indicated that health problems for individuals with PTSD occur earlier in life than in the general population. Multiple mechanistic pathways have been suggested to explain cardiovascular disese(CVD)risk in PTSD,including neurochemical,behavioral,and immunological changes. The present paper is a review of recent research that examines cardiovascular and immune risk profiles of individuals with PTSD. First,we address the relatively new evidence that the constellation of risk factors commonly experienced in PTSD fits the profile of metabolic syndrome. Next we examine the findings concerning hypertension/blood pressure in particular. The literature on sympathetic and parasympathetic responsivity in PTSD is reviewed. Last,we discuss recent findings concerning immune functioning in PTSD that may have a bearing on the high rates of CVD and other illnesses. Our primary goal is to synthesize the existing literature by examining factors that overlap mechanistically to increase the risk of developing CVD in PTSD. | Jeffrey L Kibler Mischa Tursich Mindy Ma Lydia Malcolm Rachel Greenbarg | 2014 | World Journal of Cardiology2014，6，6： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Influence of sugars on the characteristics of glucono- δ -lactone-induced soy protein isolate gels 显示文摘 | XIN Gu LYDIA J CAMPBEL L | 2009 | Food Hydrocolloids2009，23，： | 1 |
| 5 | In vitro resistance to 5-nitroimidazoles and benzimidazoles in Giardia duodenalis : Variability and variation in gene expression显示文摘 | Raúl Argüello-García Maricela Cruz-Soto Lydia Romero-Montoya Guadalupe Ortega-Pierres | 2009 | Infection, Genetics and Evolution2009，，： | 1 |
| 6 | The differential expression of oestrogen receptors,progesterone receptors,bcl-2 and ki-67 in endometrial polyps显示文摘 | Lydia J Taylor Tracy L et a1 | 2003 | Br J Obstet Gynaecol2003，110，9： | 1 |
| 7 | 3D printing of patient-specific implants for osteochondral defects: workflow for an MRI-guided zonal design显示文摘Magnetic resonance imaging(MRI)is a common clinical practice to visualize defects and to distinguish different tissue types and pathologies in the human body.So far,MRI data have not been used to model and generate a patient-specific design of multilayered tissue substitutes in the case of interfacial defects.For orthopedic cases that require highly individual surgical treatment,implant fabrication by additive manufacturing holds great potential.Extrusion-based techniques like 3D plot-ting allow the spatially defined application of several materials,as well as implementation of bioprinting strategies.With the example of a typical multi-zonal osteochondral defect in an osteochondritis dissecans(OCD)patient,this study aimed to close the technological gap between MRI analysis and the additive manufacturing process of an implant based on dif-ferent biomaterial inks.A workflow was developed which covers the processing steps of MRI-based defect identification,segmentation,modeling,implant design adjustment,and implant generation.A model implant was fabricated based on two biomaterial inks with clinically relevant properties that would allow for bioprinting,the direct embedding of a patient’s own cells in the printing process.As demonstrated by the geometric compatibility of the designed and fabricated model implant in a stereolithography(SLA)model of lesioned femoral condyles,a novel versatile CAD/CAM workflow was successfully established that opens up new perspectives for the treatment of multi-zonal(osteochondral)defects. | David Kilian Philipp Sembdner Henriette Bretschneider Tilman Ahlfeld Lydia Mika Jörg Lützner Stefan Holtzhausen Anja Lode Ralph Stelzer Michael Gelinsky | 2021 | Bio-Design and Manufacturing2021，4，4： | 1 |
| 8 | Diazoxide-induced respiratory inhibition-a putative mitochondfial KArr channel independent mechanism of pharmacological preconditioning 显示文摘 | Jan M Lydia L Derek MY | 2007 | Mol Cell Biochem2007，294，12： | 1 |
| 9 | Ecology of danger-dependentcytokine-boosted spontaneous abortion in the CBA X DBA/2 mouse model 显示文摘 | Clar DA Justin M Lydia L at al | 2004 | AmJ Reprodlmmunol2004，52，6： | 1 |
| 10 | Fatal inhala- tional anthrax in a 94-year-old Connecticut woman 显示文摘 | Lydia A Barakat H L Quentze J A | 2002 | JA- MA2002，287，7： | 1 |
| 11 | Glia-neuron crosstalk in the neuroprotcctivc mechanisms of sex steroid hormones 显示文摘 | Daniel Garcia-Ovejero Inigo Azcoitia Lydia L Doncarlos | 2005 | Brain Res Brain Rcs Rev2005，48，2： | 1 |
| 12 | Mitochondria: pharmacological manipulation of cell death显示文摘 | Lisa BH Lydia L Donald DN | 2005 | J Clin Invest2005，115，10： | 1 |
| 13 | Coping as a Multisystem Construct Associated With Pathways Mediating HIV- Relevant Immune Function and Disease Progressiion 显示文摘 | Lydia R Temoshok PHD Rebecca L | 2008 | Psychosomatic Medicine2008，70，： | 1 |
| 14 | Adenomyosis: review of the lit- erature显示文摘 | Lydia G Keith L | 2011 | J Minim Invas Gynecol2011，18，4： | 1 |
| 15 | REE distribution pattern in river sediments: Partitioning into residual and labile fractions 显示文摘 | Lydia L Jean-Luc P Pedro D | 1999 | Earth and Planetary Sciences Letters1999，329，： | 1 |
| 16 | Mitochondria:pharmacological manipulation of cell death显示文摘 | Lisa BH Lydia L and Donald DN | 2005 | J Clin Invest2005，115，10： | 1 |
| 17 | Exposure to magnetic fields and childhood acute lymphocytic leukemia in S?o Paulo, Brazil显示文摘 | Victor Wünsch-Filho Daniele M. Pelissari Flávio E. Barbieri Leonel Sant’Anna Claúdia T. de Oliveira Juliana F. de Mata Luiz G. Tone Maria Lúcia de M. Lee Maria Lydia M. de Andréa Paula Bruniera Sidnei Epelman Vicente Odone Filho Leeka Kheifets | 2011 | Cancer Epidemiology2011，，6： | 1 |
| 18 | Nutritional model of steatohepatitis and metabolic syndrome in the ossabaw miniature swine显示文摘 | Lydia L Mouhamad A Romil S | 2009 | Hepatology2009，50，1： | 1 |
| 19 | Interactions of estrogen and insulin-like growth factor-I in the brain:molecular mechanisms and functional implications显示文摘 | Gloria P Cardona-Gomez Pablo Mendez Lydia L Don Carlos | | 0，，1： | 1 |
| 20 | High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle- Aged Women 显示文摘 | Cassidy A Kenneth J M Lydia L | 2013 | Circulation2013，127，2： | 1 |
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