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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | Protocolized anemia management with erythropoietin in hemodialysis patients:A randomized controlled trial显示文摘 | Scott BK Christian GR Pat M | 2003 | J Am Soc Nephrol2003，14，： | 2 |
| 3 | O-GlcNAcylation, novel postt- ranslationalmodification linking myocardial metabolism andcardio- myocyte circadian clock显示文摘 | Durgan D J Pat B M Laczy B | 2011 | J Biol Chem2011，286，44： | 1 |
| 4 | Endometrial Cancer显示文摘 | Frederic A Philippe M Pat rick N | 2005 | Lancet2005，366，9484： | 1 |
| 5 | Cutaneous concentration of ly- copene correlates significantly with the roughness of the skin显示文摘 | DARVIN M PAT A GEHSE S | 2008 | Eur J Pharm Biapharm2008，69，3： | 1 |
| 6 | Inorganic oxide core, polymer shell nanocomposites as a high k gate dielectric for flexible electronics applications显示文摘 | Maliakal Ashok Katz Howard Cotts Pat M | 2005 | J Am Chem Soc2005，127，14： | 1 |
| 7 | Protocolized anemia management with erythropoietin in hemodialysis patients:A randomized controlled trial显示文摘 | Scott BK Christian GR Pat M | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 8 | Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment显示文摘 | Sainz Bruno Alcala Sonia Garcia Elena Sanchez-Ripoll Yolanda Azevedo Maria M Cioffi Michele Tatari Marianthi Miranda-Lorenzo Irene Hidalgo Manuel Gomez-Lopez Gonzalo Can?amero Marta Erkan Mert Kleeff Jorg Garcn?i?a-Silva Susana Sancho Patricia Hermann Pat | 2015 | Gut2015，，12： | 1 |
| 9 | Immobilization of aminoacylase in polyethylenimine stabilized calcium alginate beads for L-phenylalanine production显示文摘 | LEE PAT M LEE KONG H SIAW YEW S | 1993 | Biomaterials Artificial Cells and Immobilization Biotechnology1993，21，4： | 1 |
| 10 | Including technical and security risks in the management of information systems:A programmatic risk management model显示文摘 | Robin L Dillon M Elisabeth Paté-Cornell | 2005 | Systems Engineering2005，8，4： | 1 |
| 11 | Management of delayed postoperative hemorrhage after pancreatioduodenectomy: a meta-analysis显示文摘 | Limongelli P Khorsandi SE Pat M | 2008 | Arch Surg2008，143，10： | 1 |
| 12 | Transcatheter occlusion of multiple pulmonary arterio venous malformations显示文摘 | Halkati PC Patted SV Dixit M | 2010 | Ann Pediatr Cardiol2010，3，2： | 1 |
| 13 | Live related renal transplantation:psychological social and cultural issues显示文摘 | Pat ricia M Franklin Cromble A | 2003 | Transplantation2003，76，： | 1 |
| 14 | Chiral packed column subcritical fluid chromatography on polysaccharide and macrocyclic antibiotic chiral stationary phases 显示文摘 | Andrei M Pat S Laura T | 1997 | J Chror mtogr A1997，785，12： | 1 |
| 15 | Impacts of human activities on groundwater quality of an alluvial aquifer: a case study of the Warri River, Delta State, SW, Nigeria显示文摘 | Ibe K M Agbamu Pat U | 1999 | International Journal of Environmental Health Research1999，9，4： | 1 |
| 16 | Protocolized anemia management with erythropoietin in hemodialysis patients:A randomized controlled trial显示文摘 | Scott BK Christian GR Pat M | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 17 | He-diffraction studies ofhydrogen adsorption on Pd(311) 显示文摘 | FARIAS D PATTING M RIEDER K H | 1996 | Surface Science1996，，： | 1 |
| 18 | The transitionof chemisorbed hydrogen into subsurface sites on Pd (311) 显示文摘 | FARIAS D SCHILBE P PATTING M RIEDER K H | 1999 | Journal of Chemical Physics1999，110，： | 1 |
| 19 | Cardiovascular disease :C - reactive protein and the inflammatory disease paradigm: HMG2CoA reductase inhibitors, alpha tocopherol, red yeast rice,and alive oil polyphenols :A review of literature显示文摘 | Pat rickl Uzick M | 2001 | Altern Med Re2001，6，： | 1 |
| 20 | Steam turbine control retrofit improves reliability显示文摘 | Pat Longshore P Molitor M | 1995 | Power Engineering1995，12，： | 1 |
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