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| 1 | Bulk endocytosis at neuronal synapses显示文摘Neurotransmitter-containing synaptic vesicle(SV)fusion with the nerve terminal plasma membrane initiates neurotransmission in response to neuronal excitation.Under mild stimulation,the fused vesicular membrane is retrieved via kiss-and-run and/or clathrin-mediated endocytosis,which is sufficient to maintain recycling of SVs.When neurons are challenged with very high stimulation,the number of fused SVs can be extremely high,resulting in significant plasma membrane addition.Under such conditions,a higher capacity retrieval pathway,bulk endocytosis,is activated to redress this large membrane imbalance.Despite first being described more than 40 years ago,the molecular mechanisms underpinning this important process have yet to be clearly defined.In this review,we highlight the current evidence for bulk endocytosis and its prevalence in various neuronal models,as well as discuss the underlying molecular components. | NGUYEN Tam H QIU XuFeng SUN JianYuan MEUNIER Frederic A | 2014 | Science China(Life Sciences)2014，57，4： | 3 |
| 2 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 3 | Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period, the epidemiologic data on the insulin resistance syndrome prospective study显示文摘 | Frederic F Roberte A Afshan S | 2004 | Diabetes2004，53，： | 1 |
| 4 | Circumferential decompression of the foramen magnum for the treatment of syringomyelia associated with basilar invagination显示文摘 | Frederic P Aron A | 2004 | J Neurosurg Rev2004，27，： | 1 |
| 5 | Controlling factors or simultaneous nitrification and denitrification in a two-stage intermittent aeration process treating domestic sewage 显示文摘 | Zhao Hong W Donald S Mavinic Frederic A Koch | 1999 | Water Res1999，33，4： | 1 |
| 6 | Breast cancer in preg- nancy显示文摘 | Frederic A Sibylle L Patrick N | 2012 | Lancet2012，379，： | 1 |
| 7 | The Effects of Enrichment by H2 on Propagation Speeds in Adiabatic Flat and Cellular Premixed Flames of CH4+O2+CO2 显示文摘 | Frederic H V C Alexander A K | 2008 | Fuel2008，87，： | 1 |
| 8 | Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency显示文摘 | Frederic A Anne D David L | 1998 | Science1998，280，： | 1 |
| 9 | A systematic investigation of thioxanthen9-ones and analogs as potential antitumor agents 显示文摘 | Frederic A | 1963 | J Med Chem1963，6，： | 1 |
| 10 | Endometrial Cancer显示文摘 | Frederic A Philippe M Pat rick N | 2005 | Lancet2005，366，9484： | 1 |
| 11 | IFN-γ-receptor deficiency in an infant with fatal bacille calmette-guerin infection显示文摘 | Emmanuelle J Frederic A Salma L | 1996 | N Engl J Med1996，335，26： | 1 |
| 12 | Improvement of the Output Power in TWTs by Harmonic Injection 显示文摘 | Plouin Juliette Rax Jean-Marcel Andre Frederic et a | 2005 | IEEE Trans Electron Devices2005，52，5： | 1 |
| 13 | The mammalian circadian timing system: from gene expression to physiology 显示文摘 | Frederic G Emi N Steven A | 2004 | Chromosoma2004，113，3： | 1 |
| 14 | Effect of some physiological and non-physiological compounds on the phase transition temperature of thermoresponsive polymers intended for oral controlled-drug delivery显示文摘 | Frederic E Karim A André M | 2001 | Int J Pharm2001，222，2： | 1 |
| 15 | Clinical management of uterine sarcomas 显示文摘 | Frederic A Cooosemans An Maria DR | 2009 | Lancet Oncol2009，10，12： | 1 |
| 16 | Endometrial Cancer显示文摘 | Frederic A Philippe M Patrick N | 2005 | Lancet2005，366，9484： | 1 |
| 17 | Microstmctural evolution during ageing of AI-Cu-Li-X alloys显示文摘 | VICENTE A P BAPTISTE C~ FREDERIC D G ALEXIS D JULIE M C | 2014 | Acta Materialia2014，66，： | 1 |
| 18 | 显示文摘 | Pierre E Frederic A Laurence D | 2005 | Talanta2005，67，： | 1 |
| 19 | Improvement of the Output Power in TWTs by Harmonic Injection 显示文摘 | Juliette P Marcel R J Frederic A | 2005 | IEEE Trans Electron Devices2005，52，5： | 1 |
| 20 | Polymorphism of the 5-HTEA receptor gene and food intakes in children and adoles- cents: the Stanislas Family Study 显示文摘 | Bernard H Eleonore A Frederic F | 2005 | Am J Clin Nutr2005，82，2： | 1 |
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