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| 1 | Laboratory markers in ulcerative colitis: Current insights and future advances显示文摘Ulcerative colitis(UC)and Crohn’s disease(CD)are the major forms of inflammatory bowel diseases(IBD)in man.Despite some common features,these forms can be distinguished by different genetic predisposition,risk factors and clinical,endoscopic and histological characteristics.The aetiology of both CD and UC remains unknown,but several evidences suggest that CD and perhaps UC are due to an excessive immuneresponse directed against normal constituents of the intestinal bacterial flora.Tests sometimes invasive are routine for the diagnosis and care of patients with IBD.Diagnosis of UC is based on clinical symptoms combined with radiological and endoscopic investigations.The employment of non-invasive biomarkers is needed.These biomarkers have the potential to avoid invasive diagnostic tests that may result in discomfort and potential complications.The ability to determine the type,severity,prognosis and response to therapy of UC,using biomarkers has long been a goal of clinical researchers.We describe the biomarkers assessed in UC,with special reference to acute-phase proteins and serologic markers and thereafter,we describe the new biological markers and the biological markers could be developed in the future:(1)serum markers of acute phase response:The laboratory tests most used to measure the acute-phase proteins in clinical practice are the serum concentration of C-reactive protein and the erythrocyte sedimentation rate.Other biomarkers of inflammation in UC include platelet count,leukocyte count,and serum albumin and serum orosomucoid concentrations;(2)serologic markers/antibodies:In the last decades serological and immunologic biomarkers have been studied extensively in immunology and have been used in clinical practice to detect specific pathologies.In UC,the presence of these antibodies can aid as surrogate markers for the aberrant host immune response;and(3)future biomarkers:The development of biomarkers in UC will be very important in the future.The progress of molecular biology tools(microarrays,proteomics and nanotechnology)have revolutionised the field of the biomarker discovery.The advances in bioinformatics coupled with cross-disciplinary collaborations have greatly enhanced our ability to retrieve,characterize and analyse large amounts of data generated by the technological advances.The techniques available for biomarkers development are genomics(single nucleotide polymorphism genotyping,pharmacogenetics and gene expression analyses)and proteomics.In the future,the additionof new serological markers will add significant benefit.Correlating serologic markers with genotypes and clinical phenotypes should enhance our understanding of pathophysiology of UC. | Michele Cioffi Antonella De Rosa Rosalba Serao Ilaria Picone Maria Teresa Vietri | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，1： | 14 |
| 2 | 有关正畸初始弓丝就位后的疼痛感——热激活弓丝和超弹弓丝的随机对照研究显示文摘目的:正畸热激活弓丝能够产生比超弹弓丝更轻、更符合生物学的力量.从而能够降低正畸初次就诊所产生的疼痛感。然而.该说法的证据却较少。本研究的目的即比较使用热激活弓丝(HANT)和超弹弓丝(SE)作为正畸初始弓丝就位后患者的疼痛感的差别。方法和材料:共纳入30例患者(男11例,女19例,年龄11~26岁)。上颌或下颌粘接金属托槽.随机使用0.016英寸热激活弓丝和0016英寸超弹弓丝,橡皮圈结扎入槽。要求患者使用视觉模拟量表(VAS)记录7d内不同时刻(8:00.12:00.16:00,2000.2400)的疼痛指数。结果:两组结果均显示疼痛程度最重的为第2天,疼痛程度最轻的为第7天:热激活弓丝组第2.3,4天的VAS评分均显著低于超弹弓丝组(P〈0.005)。针对服用止痛药、体育锻炼、合并其他来源的疼痛和伴随压力性事件等情况做出调整后.结果仍然相同。超弹弓丝组在第3天服用止痛药的频率明显高于热激活组(P〈0.05)。不同时间点间疼痛感未发现明显差异,牙列拥挤与疼痛程度未发现相关性.上下颔的疼痛感也无明显差异。结论:使用热激活弓丝能够降低正畸初诊疼痛感。 | Iacopo Cioffi Antonclla Piccolo Renato Tagliaferri Sergio Paduano Angela Galeotti Roberto Martina 邓金荣 高雪梅 | 2012 | 中国口腔医学继续教育杂志2012，15，6： | 8 |
| 3 | Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?显示文摘AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July 2012.The mean age of the patients was 72.28 years.Abdominal CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal plane.CT and MRI examinations were analysed for the presence of colonic abnormalities and associated findings.RESULTS:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR examinations.The MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT examination.Type Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT examination.In the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared normal.CONCLUSION:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC. | Maria Antonietta Mazzei Susanna Guerrini Nevada Cioffi Squitieri Giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe Mazzei Luca Volterrani | 2013 | World Journal of Gastroenterology2013，19，8： | 5 |
| 4 | Rethinking the Barcelona clinic liver cancer guidelines:Intermediate stage and Child-Pugh B patients are suitable for surgery?显示文摘According to Barcelona Clinic Liver Cancer recommendations,intermediate stage hepatocellular carcinomas(stage B)are excluded from liver resection and are referred to palliative treatment.Moreover,Child-Pugh B patients are not usually candidates for liver resection.However,many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection,maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver function.Several studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification,and this treatment gives good results in the setting of multinodular,large tumors in patients with portal hypertension and/or Child-Pugh B cirrhosis.In this review we explore this controversial topic,and we show through the literature analysis how liver resection may improve the short-and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma patients.However,other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection. | Fabrizio Romano Marco Chiarelli Mattia Garancini Mauro Scotti Mauro Zago Gerardo Cioffi Matilde De Simone Ugo Cioffi | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 5 | Laparoscopic and open surgical treatment of left-sided pancreatic lesions: clinical outcomes and cost-effectiveness analysis显示文摘 | Paolo Limongelli Andrea Belli Gianluca Russo Luigi Cioffi Alberto D’Agostino Corrado Fantini Giulio Belli | 2012 | Surgical Endoscopy2012，，7： | 4 |
| 6 | Acute heart failure in elderly patients:a review of invasive and non-invasive management显示文摘Acute heart failure(AHF)is a major cause of unplanned hospitalisations in the elderly and is associated with high mortality.Its prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure patients.Although international societies have provided guidelines for the management of AHF in the general population,scientific evidence for geriatric patients is often lacking,as these are underrepresented in clinical trials.Elderly have a different risk profile with more comorbidities,disability,and frailty,leading to increased morbidity,longer recovery time,higher readmission rates,and higher mortality.Furthermore,therapeutic options are often limited,due to unfeasibility of invasive strategies,mechanical circulatory support and cardiac transplantation.Thus,the in-hospital management of AHF should be tailored to each patient's clinical situation,cardiopulmonary condition and geriatric assessment.Palliative care should be considered in some cases,in order to avoid unnecessary diagnostics and/or treatments.After discharge,a strict follow-up through outpatient clinic or telemedicine is can improve quality of life and reduce rehospitalisation rates.The aim of this review is to offer an insight on current literature and provide a clinically oriented,patient-tailored approach regarding assessment,treatment and follow-up of elderly patients admitted for AHF. | Gregorio Tersalvi Alessio Gasperetti Marco Schiavone Jeroen Dauw Cecilia Gobbi Marialessia Denora Joel Daniel Krul Giacomo Maria Cioffi Gianfranco Mitacchione Giovanni B.Forleo | 2021 | Journal of Geriatric Cardiology2021，18，7： | 4 |
| 7 | Thyroid hormone analogues and derivatives:Actions in fatty liver显示文摘Fatty liver or nonalcoholic fatty liver disease(NAFLD),a problem of increasing clinical significance and prevalence worldwide,is associated with increased risk for the development of cirrhosis and hepatocellular carcinoma.Although several therapeutic approaches can be used in the context of NAFLD,dietary and physical activities are still the most frequently used strategies.Some pharmacological agents show promising results although no conclusions can be drawn from recent clinical trials.Thyroid hormones[THs;thyroxine(T4)and3,3′,5-triiodo-L-thyronine(T3)]coordinate a diverse array of physiological events during development and lipid/energy homeostasis and have some potentially therapeutic actions which include inducing weight loss,and lowering plasma cholesterol levels and tissue adiposity.The thyroid hormones exert their physiological effects by binding to specific nuclear receptors[thyroid hormone receptors(TR)]of which the TRβisoform is liver specific and has been considered a putative target for the treatment of dyslipidemia and fatty liver.In view of this,the aim of the review is(1)to provide an overview of the action of T3 on lipid metabolism with implications for liver steatosis and(2)to provide an update on the current knowledge concerning the administration of TRβselective thyromimetics(GC-1 and MB07811),as well as of 3,5-diiodo-L-thyronine and its novel functional analogue TRC150094 in animal models of overweight and related disorders including primarily fatty liver. | Maria Coppola Daniela Glinni Maria Moreno Federica Cioffi Elena Silvestri Fernando Goglia | 2014 | World Journal of Hepatology2014，6，3： | 3 |
| 8 | Endoscopic ultrasonography in the evaluation of leiomyoma and extramucosal cysts of the esophagus显示文摘 | Massari M De Simone M Cioffi U | 1998 | Hepatogastroenterology1998，45，22： | 2 |
| 9 | Direct effects of iodothyronines on excess fat storage in rat hepatocytes显示文摘 | Elena Grasselli Adriana Voci Laura Canesi Rita De Matteis Fernando Goglia Federica Cioffi Emilia Fugassa Gabriella Gallo Laura Vergani | 2010 | Journal of Hepatology2010，，6： | 2 |
| 10 | A practical Discrete Multitone Transceiver Loading Algorithm for Data Transmission over Spectrally Shaped Channels显示文摘 | P S Chow J M Cioffi | 1995 | IEEE Trans on Comm1995，43，2： | 1 |
| 11 | Restoration of body temperature to normothermia during resuscitation following trauma - hemorrhage improves the depressed cardiovascular and hepatocellular functions 显示文摘 | Mizushima Y Wang P Cioffi WG | 2000 | Arch Surg2000，135，2： | 1 |
| 12 | Filtered Multitone Modulation for very high-speed digital subscriber显示文摘 | G Cherubini E Eleftheriou S Olcer J Cioffi | 2000 | IEEE Commun Magazine2000，，： | 1 |
| 13 | Presentation and sur- gicalmanagement of bronchogenic and esophageal duplication cysts inadults显示文摘 | Cioffi U Bonavina LG De Simone M | 1998 | Chest Chicago1998，113，6： | 1 |
| 14 | Simultaneous determination of lactulose and mannitol in urine of burn patients by gas-liquid chromatography显示文摘 | Shippee RL Johnson AA Cioffi WG | 1992 | Clin Chem1992，38，3： | 1 |
| 15 | Antiproliferative oleanane saponins from Polysciasguilfoylei 显示文摘 | Cioffi G Vassatlo A Lepore L | 2008 | Nat Prod Commun2008，3，10： | 1 |
| 16 | Gene therapy vector-mediated expression of insulin-like growth factors protects cardiomyocytes from apoptosis and enhances neovascularization显示文摘 | Su EJ Cioffi CL Stefansson S | 2003 | Am J Physiol Heart Circ Physiol2003，284，4： | 1 |
| 17 | Ischemic model of optic nerve injury显示文摘 | Cioffi GA | 2005 | Trans Am Ophthalmol Soc2005，103，： | 1 |
| 18 | Video-assistedsleeve lobeetomy for mucoepidermoid carcinoma of the left lower lobar bronchus: a case report显示文摘 | Santambrogio L Cioffi U De Simone M | 2002 | Chest2002，121，2： | 1 |
| 19 | Gigabit DSL 显示文摘 | Lee B Cioffi J Jagannathan S | 2010 | IEEE Trans on Commun2010，55，9： | 1 |
| 20 | Approaching MIMO-OFDM Capacity with Zero-forcing V-BLAST Decoding and Optimized Power, Rate, and Antenna-mapping Feed- back显示文摘 | Zhang Rui Cioffi J M | 2008 | IEEE Transactions on Signal Processing2008，56，10： | 1 |
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