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| 1 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Experimental study of bone response to a new surface treatment of endosseous titanium implants显示文摘 | Sanz A Oyarzún A Farias D | 2001 | Implant Dent2001，10，2： | 1 |
| 4 | Moringa oleif-era:bioactive compounds and nutritional potential显示文摘 | FERREIRA P M P FARIAS D F OLIVEIRA J T A | 2008 | Brazilian Journal ofNutrition2008，21，4： | 1 |
| 5 | Safety analysis using finite elements显示文摘 | Farias M M Naylor D J | 1998 | Computers and Geotechnics1998，22，2： | 1 |
| 6 | Blueberry anthocyanins and pyruvic acid adducts :anticancer properties in breast cancer cell lines 显示文摘 | Faria A Pestana D Teixeira D | 2010 | Phytotherapy Research : PTR2010，24，12： | 1 |
| 7 | The linear programming approach to approximate dynamic programming显示文摘 | De Farias D P Van Roy B | 2003 | Operations Research2003，51，6： | 1 |
| 8 | Synthesis and characterization of an VOPO4-polyaniline lamellar hybrid compound显示文摘 | FARIAS R FARIAS D AIROLDI C | 2003 | Solid State Sciences2003，5，4： | 1 |
| 9 | Excessive u-rokinase-type plasminogen activator activity in the euglobu-lin fraction of patients with Alzheimer-type dementia显示文摘 | Alonso D F Farias E F Famulari A L | 1996 | JNeurol Sci1996，139，1： | 1 |
| 10 | Flavonoid Transport across Rbe4 Cells: A Blood-Brain Barrier Model显示文摘 | Faria A PD Teixeira D Azevedo J | 2010 | Cell Mol Biol Lett2010，15，2： | 1 |
| 11 | Coopetition and product innovation performance: the role of internal knowledge sharing mechanisms and formal knowledge protection mechanisms 显示文摘 | ESTRADA I FAEMS D DE FARIA P | 2015 | Industrial Marketing Man- agement2015，53，2： | 1 |
| 12 | Preparation of photoactive chitosan-niobium(Ⅴ) oxide composites for dye degradation显示文摘 | Jocilene D Elaine A Faria J | 2006 | J Photochem & Potobiology A:Chem2006，182，： | 1 |
| 13 | Genetic diversityof Brazilian pig breeds evidenced by microsatellitemarkers 显示文摘 | Sollero B P Paiva S R Faria D A | 2009 | Livest Sci2009，123，1： | 1 |
| 14 | Xylanases from Cryptococcus flavus isolate I-11:Enzymatic profile,isolation and heterologous expression of CfXYN1 in Saccharomyces cerevisiae显示文摘 | PARACHIN N S SIQUEIRA S FARIA F P D | 2009 | Journal of Molecular Catalysis B:Enzymatic2009，59，123： | 1 |
| 15 | Life- threatening thromboeytopenia and nephrotic syndrome due to focal segmental glomerulosclerosis associated with pegy- lated interferon alpha-2b and ribavirin treatment for hepatitis 显示文摘 | Alves Couto C Costa Faria L Dias Ribeiro D | 2006 | Liver Int2006，26，10： | 1 |
| 16 | Caregivers of chronically ill elderly:perceived burden显示文摘 | Faison K J Faria S H Frank D | 1999 | J Community Health Nurs1999，16，4： | 1 |
| 17 | Measuring cognitive reserve based on the decomposition of episodic memory variance显示文摘 | Reed BR Mungas D Farias ST | 2010 | Brain2010，133，： | 1 |
| 18 | On the Efficiency- Fairness Trade-off 显示文摘 | Bertsimas D Farias V F Trichakis N | 2012 | Management Science2012，58，12： | 1 |
| 19 | An ultrastruetural evaluation of pneumoeystis carinii显示文摘 | Parada D Caleiras E Farias RM | 1998 | Invest Clin1998，39，4： | 1 |
| 20 | Characterization of zirconized silica supports for HPLC显示文摘 | Faria A M Magalhaes D R Collins K E | 2005 | Analytica Chimica Acta2005，550，1： | 1 |
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