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| 1 | A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B显示文摘Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal outcome.In this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and corticosteroid.In both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became undetectable.Entecavir treatment was continued.Generally,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few weeks.During this time lag,liver cell injury continued and the disease progressed.Corticosteroid suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B. | Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata | 2009 | World Journal of Gastroenterology2009，15，13： | 16 |
| 2 | Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters显示文摘AIM: To investigate the effects of ursodeoxycholic acid (UDCA) on chenodeoxycholic acid (CDCA)-induced liver injury in hamsters, and to elucidate a correlation between liver injury and bile acid profiles in the liver. METHODS: Liver injury was induced in hamsters by administration of 0.5% (w/w) CDCA in their feed for 7 d. UDCA (50 mg/kg and 150 mg/kg) was administered for the last 3 d of the experiment. RESULTS: At the end of the experiment, serum alanine aminotransferase (ALT) increased more than 10 times and the presence of liver injury was confirmed histologically. Marked increase in bile acids was observed in the liver. The amount of total bile acids increased approximately three-fold and was accompanied by the increase in hydrophobic bile acids, CDCA and lithocholic acid (LCA). UDCA (50 mg/kg and 150 mg/kg) improved liver histology, with a significant decrease (679.3 ± 77.5 U/L vs 333.6 ± 50.4 U/L and 254.3 ± 35.5 U/ L, respectively, P < 0.01) in serum ALT level. UDCA decreased the concentrations of the hydrophobic bile acids, and as a result, a decrease in the total bile acid level in the liver was achieved. CONCLUSION: The results show that UDCA improves oral CDCA-induced liver damage in hamsters. The protective effects of UDCA appear to result from a decrease in the concentration of hydrophobic bile acids, CDCA and LCA, which accumulate and show the cytotoxicity in the liver. | Tomomichi Iwaki Kaoru Ishizaki Shuji Kinoshita Hideki Tanaka Atsushi Fukunari Makoto Tsurufuji Teruaki Imada | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 3 | Bile duct hamartomas(von Mayenburg complexes) mimicking liver metastases from bile duct cancer:MRC findings显示文摘我们在场是的有胆总管癌症的一个 72 岁的人的一个盒子开始相信了吃多重肝转移基于计算断层摄影术调查结果,并且在磁性的回声胆管造影术(MRC ) 在谁揭示胆汁管 hamartomas 的诊断。在为 pancreaticoduodenectomy 的探索,肝触诊在肝的表面揭示了传播小瘤。这些小瘤在在两片肝脑叶的表面上散布的直径显示出大约 0.5 厘米的灰色白人的榴状的损害,它被看起来像从胆汁管癌的多重肝转移。肝活体检视的冰冻切片揭示了多重胆汁管,稍微扩大的腔在多重胆汁管 hamartomas (BDH ) 的成胶的基质特征嵌入。仅仅二份报告描述了胆汁管 hamartomas 的 MRC 特征。所有成像过程, MRC 为胆汁管 hamartomas 的成像诊断提供最相关的特征。 | Yasuhiko Nagano Kenichi Matsuo Katsuya Gorai Kazuya Sugimori Chikara Kunisaki Hideyuki Ike Katsuaki Tanaka Toshio Imada Hiroshi Shimada | 2006 | World Journal of Gastroenterology2006，12，8： | 4 |
| 4 | Contrast-enhanced sonography of pancreatic carcinoma: correlations with pathological findings显示文摘 | Kazushi Numata Yutaka Ozawa Noritoshi Kobayashi Toru Kubota Hiroshi Shimada Akinori Nozawa Yukio Nakatani Kazuya Sugimori Kenichi Matsuo Toshio Imada Katsuaki Tanaka | 2005 | Journal of Gastroenterology2005，，6： | 2 |
| 5 | Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan显示文摘 | Susumu Take Motowo Mizuno Kuniharu Ishiki Takayuki Imada Tetsuji Okuno Tomowo Yoshida Kenji Yokota Keiji Oguma Masahide Kita Hiroyuki Okada Kazuhide Yamamoto | 2012 | Journal of Gastroenterology2012，，6： | 2 |
| 6 | Discovery of beta-lactam antibiotics with novel nuclei 显示文摘 | AKIVA Imada | 1984 | Antibiotics1984，9，1： | 2 |
| 7 | Expression of circadian genes correlates with liver metastasis and outcomesin colorectal cancer显示文摘 | Takashi Oshima Seiich Takenoshita Makoto Akaike Chikara Kunisaki Shoich Fujii Akito Nozaki Kazushi Numata Manabu Shiozawa Yasushi Rino Katsuaki Tanaka Munetaka Masuda Toshio Imada | 2011 | Oncology Reports2011，，5： | 2 |
| 8 | The JAK-STAT pathway显示文摘 | Imada K Leonard WJ | 2000 | Mol Immunol2000，37，1： | 1 |
| 9 | The incidence of coronary artery abnormalitiy in incomplete Kawasaki disease显示文摘 | Sonobe T Aso S Imada Y | 2003 | Pediatr Res2003，53，1： | 1 |
| 10 | Flavin catalyzed oxidations of sulfides and amines with molecualr oxygen显示文摘 | Imada Y Iida H Murahashi S I | 2003 | J Am Chem Soc2003，125，： | 1 |
| 11 | Depletion and impaired interferon-alpha-producing capacity of blood plasmacytoid dendritic cells in human T-cell leukaemia virus type Ⅰ-infected individuals 显示文摘 | Hishizawa M Imada K Kitawaki T | 2004 | Br J Haematol2004，125，5： | 1 |
| 12 | Determinants and predictors of the maximum walking speed during computer assisted gait training in hemiparetic stroke patient显示文摘 | Suzuki K Imada G Iwaya T | 1999 | Arch Phys Med Rehabil1999，80，2： | 1 |
| 13 | Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases显示文摘 | Ohguri T Imada H Kohshi K | 2007 | Int J Radiat Oncol Biol Phys2007，67，1： | 1 |
| 14 | Aerobic organocatalytic,and chemoelective methods for Baeyer-Villiger oxidation显示文摘 | Iida H Imada Y Murahashi S I | 2005 | Angew Chem Int Ed2005，44，： | 1 |
| 15 | Truncated Surface Protective Antigen(SpaA) of Erysipelothnx rhusiopathiae Serotype 1a Elicits Protection against Challenge with Serotypes 1a and 2b in Pigs显示文摘 | Imada Y Goji N Ishikawa H | 1999 | Infection and Immunity1999，67，9： | 1 |
| 16 | Mesoporous Material from Zeolite显示文摘 | Y. Goto Y. Fukushima P. Ratu Y. Imada Y. Kubota Y. Sugi M. Ogura M. Matsukata | 2002 | Journal of Porous Materials2002，，1： | 1 |
| 17 | Coordinate up- regulation of interleukin-8 and growth related gene product-alpha is present in the colonic mu- cosa of inflammatory bowel 显示文摘 | Imada A Ina K Shimada M | 2001 | Scand J Gastro- enterol2001，36，8： | 1 |
| 18 | The incidence of coronary artery abnormalities in incomplete Kawasaki disease 显示文摘 | Sonobe T Aso S Imada Y | 2003 | Pediatr Res2003，53，： | 1 |
| 19 | Targeted delivery of bone marrow mononuclear cells by ultrasound destruction of microbubbles induces both angiogenesis and arteriogenesis response 显示文摘 | Imada T Tatsumi T Mori Y | 2005 | Arterioscler Thromb Vasc Biol2005，25，10： | 1 |
| 20 | Polarization Mode Control of Two - Dimensional Photonie Crystal Laser by Unit Cell Structure Design 显示文摘 | Neda S Yogiyama M Imada M | 2001 | Science2001，293，： | 1 |
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